ATE206416T1 - Trizyklische verbindungen als matrix- metalloproteinase inhibitoren - Google Patents

Trizyklische verbindungen als matrix- metalloproteinase inhibitoren

Info

Publication number: ATE206416T1
Authority: AT; Austria
Prior art keywords: tricyclic compounds; matrix metalloproteinase; metalloproteinase inhibitors; gelatinase; inhibitors
Prior art date: 1995-06-02

Application number

AT96913185T

Other languages

English (en)

Inventor

Donald Hupe

Linda Lea Johnson

Joseph Armand Picard

Andrew David White

Qi-Zhuang Ye

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-02

Filing date

1996-04-26

Publication date

2001-10-15

1995-06-02 Priority claimed from US08/460,437 external-priority patent/US5627206A/en

1995-06-02 Priority claimed from US08/460,436 external-priority patent/US5665764A/en

1996-04-26 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE206416T1 publication Critical patent/ATE206416T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000003771 matrix metalloproteinase inhibitor Substances 0.000 title 1
229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title 1
208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
102000013382 Gelatinases Human genes 0.000 abstract 1
108010026132 Gelatinases Proteins 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
102000000424 Matrix Metalloproteinase 2 Human genes 0.000 abstract 1
108010016165 Matrix Metalloproteinase 2 Proteins 0.000 abstract 1
102000000422 Matrix Metalloproteinase 3 Human genes 0.000 abstract 1
108010016160 Matrix Metalloproteinase 3 Proteins 0.000 abstract 1
102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
206010027476 Metastases Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
230000001363 autoimmune Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000009545 invasion Effects 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
230000009401 metastasis Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
208000028169 periodontal disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
230000005747 tumor angiogenesis Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Furan Compounds (AREA)

AT96913185T 1995-06-02 1996-04-26 Trizyklische verbindungen als matrix- metalloproteinase inhibitoren ATE206416T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/460,437 US5627206A (en)	1995-06-02	1995-06-02	Tricyclic inhibitor of matrix metalloproteinases
US08/460,436 US5665764A (en)	1995-06-02	1995-06-02	Tricyclic inhibitors of matrix metalloproteinases
PCT/US1996/005830 WO1996038434A1 (en)	1995-06-02	1996-04-26	Tricyclic inhibitors of matrix metalloproteinases

Publications (1)

Publication Number	Publication Date
ATE206416T1 true ATE206416T1 (de)	2001-10-15

Family

ID=27039692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96913185T ATE206416T1 (de)	1995-06-02	1996-04-26	Trizyklische verbindungen als matrix- metalloproteinase inhibitoren

Country Status (13)

Country	Link
EP (1)	EP0828726B1 (de)
JP (1)	JPH11506097A (de)
KR (1)	KR19990022171A (de)
AT (1)	ATE206416T1 (de)
AU (1)	AU717570B2 (de)
CA (1)	CA2220040A1 (de)
DE (1)	DE69615680T2 (de)
DK (1)	DK0828726T3 (de)
ES (1)	ES2165496T3 (de)
MX (1)	MX9708728A (de)
PT (1)	PT828726E (de)
WO (1)	WO1996038434A1 (de)
ZA (1)	ZA964508B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6624177B1 (en)	1996-09-04	2003-09-23	Warner-Lambert Company	Matrix metalloproteinase inhibitors and their therapeutic uses
JP2002514180A (ja)	1996-09-04	2002-05-14	ワーナー―ランバート・コンパニー	マトリックスメタロプロテイナーゼを阻害するための化合物およびその方法
NZ333063A (en) *	1996-09-04	2000-12-22	Warner Lambert Co	Dibenzofuran sulfonamide derivatives as matrix metalloproteinase inhibitors
NZ334897A (en) *	1996-12-09	2001-02-23	Warner Lambert Co	Medicaments for treating and preventing heart failure and ventricular dilatation
US6340709B1 (en) *	1996-12-17	2002-01-22	Warner-Lambert Company	Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing
EP1366765A1 (de) *	1996-12-17	2003-12-03	Warner-Lambert Company Llc	VerWendung von Matrix-Metalloproteinase Inhibitoren zur Behandlung von neurologischen Erkrankungen und zur Förderung der Wundheilung
US6399612B1 (en)	1997-10-06	2002-06-04	Warner-Lambert Company	Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
AU4229499A (en) *	1998-07-30	2000-02-21	Warner-Lambert Company	Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
KR20010072089A (ko)	1998-07-30	2001-07-31	로즈 암스트롱, 크리스틴 에이. 트러트웨인	매트릭스 메탈로프로테이나제 억제제로서 트리시클릭술폰아미드 및 그의 유도체
DOP2002000334A (es) *	2001-02-14	2002-08-30	Warner Lambert Co	Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz
BR0313384A (pt) *	2002-08-13	2005-07-12	Warner Lambert Co	Derivados de cromona como inibidores de metaloproteinases de matriz
NZ574905A (en) *	2006-08-22	2011-12-22	Ranbaxy Lab Ltd	Matrix metalloproteinase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3649651A (en) *	1969-07-02	1972-03-14	American Home Prod	Dibenzofuran derivatives and preparation thereof
US5326760A (en) *	1992-06-29	1994-07-05	Glaxo, Inc.	Aminobutanoic acid compounds having metalloprotease inhibiting properties

1996
- 1996-04-26 AT AT96913185T patent/ATE206416T1/de not_active IP Right Cessation
- 1996-04-26 AU AU55777/96A patent/AU717570B2/en not_active Ceased
- 1996-04-26 WO PCT/US1996/005830 patent/WO1996038434A1/en not_active Ceased
- 1996-04-26 EP EP96913185A patent/EP0828726B1/de not_active Expired - Lifetime
- 1996-04-26 DE DE69615680T patent/DE69615680T2/de not_active Expired - Fee Related
- 1996-04-26 PT PT96913185T patent/PT828726E/pt unknown
- 1996-04-26 CA CA002220040A patent/CA2220040A1/en not_active Abandoned
- 1996-04-26 MX MX9708728A patent/MX9708728A/es not_active IP Right Cessation
- 1996-04-26 JP JP8536475A patent/JPH11506097A/ja not_active Abandoned
- 1996-04-26 DK DK96913185T patent/DK0828726T3/da active
- 1996-04-26 KR KR1019970708650A patent/KR19990022171A/ko not_active Ceased
- 1996-04-26 ES ES96913185T patent/ES2165496T3/es not_active Expired - Lifetime
- 1996-05-31 ZA ZA964508A patent/ZA964508B/xx unknown

Also Published As

Publication number	Publication date
CA2220040A1 (en)	1996-12-05
DE69615680D1 (de)	2001-11-08
ZA964508B (en)	1996-12-09
ES2165496T3 (es)	2002-03-16
AU717570B2 (en)	2000-03-30
EP0828726A1 (de)	1998-03-18
JPH11506097A (ja)	1999-06-02
PT828726E (pt)	2002-03-28
DK0828726T3 (da)	2002-01-21
MX9708728A (es)	1997-12-31
EP0828726B1 (de)	2001-10-04
WO1996038434A1 (en)	1996-12-05
DE69615680T2 (de)	2002-07-11
KR19990022171A (ko)	1999-03-25
AU5577796A (en)	1996-12-18

Legal Events

Date	Code	Title	Description
2002-02-15	UEP	Publication of translation of european patent specification
2007-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
IL123901A (en)	2003-06-24	Sulfonamide inhibitors of matrix metalloproteinases and pharmaceutical compositions comprising them
DE69619865D1 (de)	2002-04-18	Aromatische keto-säure und ihre derivate als inhibitoren der matrix metalloproteinase
DE69615680D1 (de)	2001-11-08	Trizyklische verbindungen als matrix-metalloproteinase inhibitoren
Kivelä‐Rajamäki et al.	2003	Levels and molecular forms of MMP‐7 (matrilysin‐1) and MMP‐8 (collagenase‐2) in diseased human peri‐implant sulcular fluid
NZ509439A (en)	2002-10-25	Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
ATE170560T1 (de)	1998-09-15	Metalloproteinase-inhibitoren
NO944448D0 (no)	1994-11-21	Nye farmasöytiske anvendelser av krill-enzymer
NO972391D0 (no)	1997-05-26	2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
WO2001012592A3 (en)	2001-07-05	Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors
FR2398488A1 (fr)	1979-02-23	Matiere artificielle a usage medical douee d'activite anticoagulante
DE69824748D1 (de)	2004-07-29	Pharmazeutische zusammensetzung für die behandlung von enzündlichen darmerkrankungen
TNSN87087A1 (fr)	1990-01-01	Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant
NO20000771L (no)	2000-04-25	Anvendelse av fankinon for behandling av Alzheimers sykdom
CA2233560A1 (en)	1997-05-29	Sulfonamide inhibitors of matrix metalloproteinases
DE69332987D1 (de)	2003-06-18	Verbindungen verwendbar für die Behandlung von Allergien und Entzündungskrankheiten
SE9802836L (sv)	2000-02-27	Läkemedel för behandling av schizofreni
ES2101982T3 (es)	1997-07-16	Composicion conteniendo una alta dosis de vitamina a.
EA199800372A1 (ru)	1998-10-29	Новые макроциклические соединения-ингибиторы
IT8919833A0 (it)	1989-03-20	Struttura di un articolo per l'arredamento del bagno.