DK0832093T3 - Udtrykkelse af lipoproteiner - Google Patents

Udtrykkelse af lipoproteiner

Info

Publication number
DK0832093T3
DK0832093T3 DK96918793T DK96918793T DK0832093T3 DK 0832093 T3 DK0832093 T3 DK 0832093T3 DK 96918793 T DK96918793 T DK 96918793T DK 96918793 T DK96918793 T DK 96918793T DK 0832093 T3 DK0832093 T3 DK 0832093T3
Authority
DK
Denmark
Prior art keywords
protein
lipidated
disclosed
leader sequence
heterologous
Prior art date
Application number
DK96918793T
Other languages
English (en)
Inventor
Maryanne B Gray
Robert C Huebner
Lorne F Erdile
Donald J Warakomski
Robert S Becker
Derek L Pyle
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Application granted granted Critical
Publication of DK0832093T3 publication Critical patent/DK0832093T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK96918793T 1995-06-07 1996-06-05 Udtrykkelse af lipoproteiner DK0832093T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48637395A 1995-06-07 1995-06-07
US47578195A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
DK0832093T3 true DK0832093T3 (da) 2007-01-08

Family

ID=27044930

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96918793T DK0832093T3 (da) 1995-06-07 1996-06-05 Udtrykkelse af lipoproteiner

Country Status (13)

Country Link
EP (2) EP0832093B1 (da)
JP (1) JP4091112B2 (da)
AT (1) ATE339436T1 (da)
AU (1) AU721954B2 (da)
CA (2) CA2704354A1 (da)
DE (1) DE69636544T2 (da)
DK (1) DK0832093T3 (da)
ES (1) ES2271954T3 (da)
FI (1) FI974422A7 (da)
IL (1) IL118578A (da)
NO (2) NO324089B1 (da)
PT (1) PT832093E (da)
WO (1) WO1996040718A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7008625B2 (en) 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
ZA964896B (en) * 1995-06-07 1997-01-08 Connaught Lab Expression of lipoproteins
NZ525674A (en) 1998-02-03 2005-01-28 Ct Disease Contr & Prevention Recombinant lipidated PsaA protein, methods of preparation and use
AU2003204215B2 (en) * 1998-02-03 2007-01-11 Aventis Pasteur Recombinant Lipidated PsaA Protein, Methods of Preparation and Use
DK1947187T5 (da) * 2000-02-28 2011-10-24 Novartis Vaccines & Diagnostic Hybrid ekspression af neisserial-proteiner
AU2001285049A1 (en) 2000-08-18 2002-03-04 Brookhaven Sciences Associates, Llc Altered ospa of borrelia burgdorferi
MY144532A (en) 2001-08-20 2011-09-30 Lundbeck & Co As H Novel method for down-regulation of amyloid
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
ES2389562T3 (es) 2004-10-25 2012-10-29 Statens Seruminstitut Antígenos de Chlamydia trachomatis para uso en vacuna y diagnóstico
CA2836319A1 (en) 2005-06-23 2006-12-28 Statens Serum Institut Tuberculosis vaccines comprising antigens expressed during the latent infection phase
ES2542964T3 (es) 2006-01-19 2015-08-13 Mary Kay, Inc. Composiciones que comprenden extracto de ciruela kakadu y extracto de cereza morada de acai
US20090324638A1 (en) * 2006-06-12 2009-12-31 Biopeptides Corp. Live bacterial vaccine
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
ES2421885T3 (es) 2008-12-12 2013-09-06 Euroimmun Medizinische Labordiagnostika Ag Polipéptidos y procedimiento para la detección específica de anticuerpos en pacientes con una infección por Borrelia
KR20170072366A (ko) 2009-04-24 2017-06-26 스태튼스 세룸 인스티튜트 재활성화를 예방하기 위한 결핵 백신
CN102711721B (zh) 2009-08-28 2013-09-25 玫琳凯公司 皮肤护理制剂
RU2580620C2 (ru) 2010-08-23 2016-04-10 ВАЙЕТ ЭлЭлСи СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086
WO2012032489A1 (en) 2010-09-10 2012-03-15 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
CA2865745C (en) 2012-03-09 2018-01-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
RU2662968C2 (ru) 2013-09-08 2018-07-31 Пфайзер Инк. Иммуногенная композиция против neisseria meningitidis (варианты)
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
US10183070B2 (en) 2017-01-31 2019-01-22 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
EP4034157A1 (en) 2019-09-27 2022-08-03 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624926A (en) * 1981-01-02 1986-11-25 The Research Foundation Of State University Of New York Novel cloning vehicles for polypeptide expression in microbial hosts
CA2032914A1 (en) * 1989-12-26 1991-06-27 Peter C.K. Lau Use of bacterial lipoprotein amino terminus in fusion plasmids for in vivo expression of lipid modified polypeptides
EP0536335A4 (en) * 1990-06-15 1993-07-14 Yale University Compositions and methods for the prevention and diagnosis of lyme disease
ATE168132T1 (de) * 1991-02-15 1998-07-15 Uab Research Foundation Strukturgen von pneumokokken-protein
ES2194010T3 (es) * 1991-10-22 2003-11-16 Symbicom Ab Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi.
AU5958594A (en) * 1992-12-24 1994-07-19 Med Immune, Inc. Method of protection against (streptococcus pneumoniae) with transformed mycobacteria

Also Published As

Publication number Publication date
IL118578A (en) 2006-12-31
CA2223300A1 (en) 1996-12-19
PT832093E (pt) 2006-12-29
WO1996040718A1 (en) 1996-12-19
DE69636544T2 (de) 2007-06-06
FI974422L (fi) 1998-02-04
NO975619L (no) 1998-01-30
NO975619D0 (no) 1997-12-04
EP1741718A2 (en) 2007-01-10
JPH11514841A (ja) 1999-12-21
NO324089B1 (no) 2007-08-13
NO20064621L (no) 1998-01-30
EP0832093A4 (en) 2001-01-03
DE69636544D1 (de) 2006-10-26
AU6134396A (en) 1996-12-30
ATE339436T1 (de) 2006-10-15
CA2704354A1 (en) 1996-12-19
AU721954B2 (en) 2000-07-20
EP0832093A1 (en) 1998-04-01
JP4091112B2 (ja) 2008-05-28
ES2271954T3 (es) 2007-04-16
EP1741718A3 (en) 2007-03-28
EP0832093B1 (en) 2006-09-13
FI974422A7 (fi) 1998-02-04
FI974422A0 (fi) 1997-12-05
IL118578A0 (en) 1996-10-16
CA2223300C (en) 2010-07-27

Similar Documents

Publication Publication Date Title
FI974422A0 (fi) Lipoproteiinien ilmentäminen
DK0954588T3 (da) OB fusionsprotein-sammensætninger og fremgangsmåder
FR2703239B1 (fr) Agrafe pour prothèse inter-épineuse.
HUP0100813A3 (en) Enhancing the circulating half-life of antibody-based fusion proteins
EP0633388A3 (en) Drilling stabilizer.
DE68917323D1 (de) Expressions-Vektor für Fusions-Proteine und Immunogen-Proteine.
NL1002111C2 (nl) Stabilisatorcombinatie.
FI963629L (fi) Sulakyllästysmenetelmä
IT1307309B1 (it) Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono.
FI972384L (fi) Uudet dipeptidiset p-amidinobentsyyliamidit, jotka sisältävät N-terminaalisia sulfonyyli- tai amidinosulfonyyliryhmiä
FI964909A7 (fi) Substituoidut aryylialkyylitioalkyylipyridiinit Helicobacter-bakteerie n torjumiseksi
DE69933509D1 (de) Roboter Steuerungssystem
FI950112L (fi) Muovia oleva, sähköisesti hitsattava muoto-osa
DE69710703D1 (de) Servosystem
SE9003374D0 (sv) A collagen binding protein as well as its preparation
TR27243A (tr) Antimikrobiyal proteinler.
ZA200006301B (en) Recombinant baculovirus-based insecticides.
DE69327575D1 (de) Servogesteuerte Rechtwinkelschere
TR199600055A2 (tr) Eriyik isitma yöntemi.
FR2703742B1 (fr) Soufflet en materiau elastique, destine au recouvrement de joints de transmission.
FR2739622B1 (fr) Nouvelles proteines membranaires d'helicobacter pylori
ES1024282Y (es) Maquina centrifugadora perfeccionada.
FR2726373B1 (fr) Sous-lunette d'essai, sans branches, de type "lorgnon"
NL1005018A1 (nl) Tweesporig geleidingssysteem.
TR199600085A2 (tr) Sismanlamaya karsi proteinler.