ES2194010T3 - Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. - Google Patents

Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi.

Info

Publication number
ES2194010T3
ES2194010T3 ES92922907T ES92922907T ES2194010T3 ES 2194010 T3 ES2194010 T3 ES 2194010T3 ES 92922907 T ES92922907 T ES 92922907T ES 92922907 T ES92922907 T ES 92922907T ES 2194010 T3 ES2194010 T3 ES 2194010T3
Authority
ES
Spain
Prior art keywords
burgdorferi
dna
ospb
sample
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922907T
Other languages
English (en)
Inventor
Alan George Barbour
Sven Bergstrom
Lennart Hansson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symbicom AB
Original Assignee
Symbicom AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symbicom AB filed Critical Symbicom AB
Application granted granted Critical
Publication of ES2194010T3 publication Critical patent/ES2194010T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

METODOS PARA DIAGNOSTICAR LA BORRELIOSIS, ENFERMEDAD DE LYME, DETECTANDO LA PRESENCIA DE UN ORGANISMO BORRELIA BURGDORFERI EN UNA MUESTRA DE UN ANIMAL, INCLUYENDO EL HOMBRE, POR EL USO DE ANALISIS PCR-DNA, EN EL QUE LOS ORIGINALES SON SUBSECUENCIAS DE LAS SECUENCIAS OSPA Y OSPB DNA DE CUALQUIERA DE TRES ESPECIES B. BURGDORFERI I, II Y III, TAL COMO SECUENCIAS OSPA Y OSPB DNA DE UNA DE LAS SIGUIENTES CEPAS B. BURGDORFERI: B31, IP90 (O IPER90) Y ACAI, RESPECTIVAMENTE. EL METODO PUEDE SER USADO PARA DETECTAR LA PRESENCIA DE B. BURGDORFERI EN UNA MUESTRA CUALQUIERA DE LAS ESPECIES Y CEPAS DEL ORGANISMO B. BURGDORFERI PROPUESTO QUE ESTA EN LA MUESTRA, PERO TAMBIEN PUEDE SER USADO PARA DETECTAR CEPAS ESPECIFICAS, DEPENDIENDO DE LOS ORIGINALES ESCOGIDOS. VACUNAS QUE COMPRENDEN POLIPEPTIDOS CAPACES DE PROVOCAR UNA RESPUESTA INMUNE CONTRA OSPA O OSPB DE ORGANISMOS B. BURGDORFERI PARA ACTIVAR LA INMUNIZACION, ESTANDO LOS POLIPEPTIDOS PREFERIBLEMENTE LIPIDADOS. SECUENCIAS DNA QUE CODIFICAN LOS POLIPEPTIDOS, CON PREFERENCIA TAMBIEN CODIFICAN UN PEPTIDO DE SEÑAL LIPOPROTEINA, POR EJEMPLO, UN PEPTIDO DE SEÑAL QUE COMPRENDE L-X-Y-C EN LA REGION TERMINAL C Y UN METODO PARA PRODUCIR EL POLIPEPTIDO
ES92922907T 1991-10-22 1992-10-22 Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. Expired - Lifetime ES2194010T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77918591A 1991-10-22 1991-10-22

Publications (1)

Publication Number Publication Date
ES2194010T3 true ES2194010T3 (es) 2003-11-16

Family

ID=25115605

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922907T Expired - Lifetime ES2194010T3 (es) 1991-10-22 1992-10-22 Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi.

Country Status (7)

Country Link
EP (2) EP0650527B1 (es)
AT (1) ATE234365T1 (es)
AU (1) AU2903892A (es)
DE (1) DE69232956T2 (es)
DK (1) DK0650527T3 (es)
ES (1) ES2194010T3 (es)
WO (1) WO1993008306A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054296A (en) 1988-10-24 2000-04-25 Symbicom Ab 66 kDa antigen from Borrelia
US6113914A (en) * 1991-08-15 2000-09-05 Smithkline Beecham Biologicals (S.A.) Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
US6676942B1 (en) 1991-08-15 2004-01-13 Smithkline Beecham Biologicals (S.A.) Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
BE1006728A3 (fr) * 1993-02-19 1994-11-29 Wallone Region Sondes d'acides nucleiques specifiques au spirochete borrelia burgdorferi.
EP0686265A4 (en) * 1993-02-26 2001-08-22 Cambridge Biotech Corp METHOD FOR INDUCING IMMUNITY AGAINST LYME DISEASE AND A COLORIMETRIC TEST FOR ANTISERA'S BORRELIAZIDE ACTIVITY
US5656451A (en) * 1993-07-30 1997-08-12 Yale University OspE, OspF, and S1 polypeptides in borrelia burgdorferi
US6716591B1 (en) 1993-07-30 2004-04-06 Yale University B. burgdorferi polypeptides
US7008625B2 (en) 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
US6248562B1 (en) 1993-11-01 2001-06-19 Research Foundation State University Of New York Chimeric proteins comprising borrelia polypeptides and uses therefor
AU8127494A (en) * 1993-11-01 1995-05-23 Associated Universities, Inc. Chimeric proteins comprising borrelia polypeptides: uses therefor
DE69535059T2 (de) * 1994-04-11 2007-01-18 Wyeth Holdings Corp. Borrelia burgdorferi bacterin
US6087097A (en) * 1994-05-12 2000-07-11 Mayo Foundation For Medical Education And Research PCR detection of Borrelia burgdorferi
ZA964896B (en) 1995-06-07 1997-01-08 Connaught Lab Expression of lipoproteins
PT832093E (pt) * 1995-06-07 2006-12-29 Sanofi Pasteur Inc Expressão de lipoproteínas
US6251405B1 (en) * 1995-06-07 2001-06-26 Connaught Laboratories, Inc. Immunological combination compositions and methods
DE19605475C1 (de) * 1996-02-14 1997-11-20 Deutsches Krebsforsch Verfahren zur Erkennung des Erkrankungsrisikos nach Arthropodenstich
US6045804A (en) * 1996-03-07 2000-04-04 Mayo Foundation For Medical Educational Research Method for detecting B. burgdorferi infection
DE19632862B4 (de) 1996-08-14 2006-08-03 Mikrogen Molekularbiologische Entwicklungs-Gmbh Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe
WO1999012960A2 (en) * 1997-09-10 1999-03-18 Symbicom Ab P13 ANTIGENS FROM $i(BORRELIA)
US6224882B1 (en) 1997-11-07 2001-05-01 Protein Science Corp. Insect cells or fractions as adjuvant for antigens
ATE381575T1 (de) 2000-08-18 2008-01-15 Univ New York State Res Found Veränderte borrelia burgdorferi ospa
EP1981513B1 (en) 2006-01-19 2015-05-27 Mary Kay, Inc. Compositions comprising kakadu plum extract or acai berry extract
UA99719C2 (ru) 2006-11-03 2012-09-25 Шеринг-Плау Лтд. Вакцина для собак против болезни лайма
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP3620465B1 (en) 2007-07-03 2025-02-19 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
EP2711021B1 (en) 2008-05-02 2016-03-09 BliNK Therapeutics Limited Products and methods for stimulating an immune response
WO2010009735A2 (en) 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
US8048456B2 (en) 2009-08-28 2011-11-01 Mary Kay Inc. Skin care formulations
EP2545071A2 (en) 2010-03-09 2013-01-16 Maksyutov, Amir Polyepitope constructs and methods for their preparation and use
US9109007B2 (en) 2010-08-18 2015-08-18 Purdue Pharma L.P. MHC-I restricted epitopes containing non-natural amino acid residues
EP2805168B1 (en) 2012-01-20 2018-03-07 The Government Of The U.S.A. As Represented By The Secretary Of Health And Human Services, Centers For Disease Control And Prevention Compositions and methods relating to lyme disease
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers
CN115521987A (zh) * 2021-06-25 2022-12-27 中国人民解放军军事科学院军事医学研究院 一种基于探针法的回归热螺旋体荧光定量检测方法及其应用
EP4536836A1 (en) 2022-06-07 2025-04-16 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells
KR20250035053A (ko) 2022-06-07 2025-03-11 리제너론 파아마슈티컬스, 인크. T 세포 활성을 조절하기 위한 다중특이적 분자 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) * 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
DE4015911A1 (de) * 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
CA2084413A1 (en) * 1990-06-15 1991-12-16 Richard A. Flavell Compositions and methods for the prevention and diagnosis of lyme disease

Also Published As

Publication number Publication date
EP0650527B1 (en) 2003-03-12
AU2903892A (en) 1993-05-21
WO1993008306A1 (en) 1993-04-29
ATE234365T1 (de) 2003-03-15
DK0650527T3 (da) 2003-07-14
DE69232956D1 (de) 2003-04-17
EP0540457A1 (en) 1993-05-05
EP0650527A1 (en) 1995-05-03
DE69232956T2 (de) 2003-10-02

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