DK0832886T3 - Flavon-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne - Google Patents

Flavon-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne

Info

Publication number
DK0832886T3
DK0832886T3 DK97402202T DK97402202T DK0832886T3 DK 0832886 T3 DK0832886 T3 DK 0832886T3 DK 97402202 T DK97402202 T DK 97402202T DK 97402202 T DK97402202 T DK 97402202T DK 0832886 T3 DK0832886 T3 DK 0832886T3
Authority
DK
Denmark
Prior art keywords
alkyl
optionally substituted
derivatives
alkoxy
optionally
Prior art date
Application number
DK97402202T
Other languages
English (en)
Inventor
Alain Dhainaut
Guy Lewin
Emmanuel Canet
Michel Lonchampt
Yves Rolland
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK0832886T3 publication Critical patent/DK0832886T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK97402202T 1996-09-27 1997-09-23 Flavon-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne DK0832886T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9611808A FR2753969B1 (fr) 1996-09-27 1996-09-27 Nouveaux derives de flavones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK0832886T3 true DK0832886T3 (da) 2003-03-10

Family

ID=9496129

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97402202T DK0832886T3 (da) 1996-09-27 1997-09-23 Flavon-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne

Country Status (18)

Country Link
US (1) US5889003A (da)
EP (1) EP0832886B1 (da)
JP (1) JPH10114766A (da)
CN (1) CN1094936C (da)
AT (1) ATE227712T1 (da)
AU (1) AU728990B2 (da)
BR (1) BR9704900A (da)
CA (1) CA2216617C (da)
DE (1) DE69717044T2 (da)
DK (1) DK0832886T3 (da)
ES (1) ES2187738T3 (da)
FR (1) FR2753969B1 (da)
HU (1) HUP9701588A3 (da)
NO (1) NO974455L (da)
NZ (1) NZ328858A (da)
PL (1) PL322297A1 (da)
PT (1) PT832886E (da)
ZA (1) ZA978652B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2231509C (en) * 1995-09-11 2008-07-08 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
CA2341488A1 (en) 1998-08-26 2000-03-09 Smithkline Beecham Corporation Therapies for treating pulmonary diseases
WO2000017184A1 (en) * 1998-09-24 2000-03-30 Mitsubishi Chemical Corporation Hydroxyflavone derivatives as tau protein kinase 1 inhibitors
PL200923B1 (pl) 1999-08-21 2009-02-27 Nycomed Gmbh Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
US6806257B1 (en) 1999-10-20 2004-10-19 Board Of Trustees Of Southern Illinois University Flavones as inducible nitric oxide synthase inhibitors, cyclooxygenase-2 inhibitors and potassium channel activators
US6334998B1 (en) 1999-12-07 2002-01-01 Parker Hughes Institute Estrogens for treating ALS
EP1127572A3 (en) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Use of flavones for treating cycloxygenase-2 mediated diseases
US6472436B1 (en) * 2000-07-17 2002-10-29 The Salk Institute For Biological Studies Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production
DE10104350A1 (de) 2001-02-01 2002-08-14 Merck Patent Gmbh Verfahren zur Herstellung von Flavon Derivaten
DE10232595A1 (de) * 2002-07-18 2004-02-05 Merck Patent Gmbh Lichtschutzmittel
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
JP5058481B2 (ja) * 2005-11-28 2012-10-24 丸善製薬株式会社 角化細胞増殖剤、サイクリックａｍｐホスホジエステラーゼ阻害剤、及び保湿剤
US20100056791A1 (en) * 2006-09-01 2010-03-04 Yasushi Kohno Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
CN101148444A (zh) * 2006-09-20 2008-03-26 上海特化医药科技有限公司 黄酮衍生物、制备方法及应用
KR100930467B1 (ko) * 2007-06-07 2009-12-08 동아제약주식회사 점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도
JP4559531B1 (ja) * 2009-12-03 2010-10-06 ウシオケミックス株式会社 ノビレチンの製造方法
CN103059005B (zh) * 2012-11-22 2015-04-22 中南民族大学 白杨素酰胺衍生物及其医药用途
CN105906598B (zh) * 2016-05-19 2018-05-08 江苏耐雀生物工程技术有限公司 白杨素衍生物及其制备方法和应用
WO2026068627A1 (en) 2024-09-25 2026-04-02 Institut Gustave Roussy Flavonoid derivatives compounds, and their use as drugs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623808B1 (fr) * 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2689127B1 (fr) * 1992-03-31 1994-05-06 Adir Cie Nouvelles 3', 5' -ditertbutyl-4'-hydroxy flavones, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ES2187738T3 (es) 2003-06-16
CN1179422A (zh) 1998-04-22
DE69717044D1 (de) 2002-12-19
EP0832886A1 (fr) 1998-04-01
NO974455D0 (no) 1997-09-26
AU728990B2 (en) 2001-01-25
DE69717044T2 (de) 2003-07-24
US5889003A (en) 1999-03-30
AU3927197A (en) 1998-04-02
HUP9701588A3 (en) 1999-03-01
ZA978652B (en) 1998-03-27
CN1094936C (zh) 2002-11-27
BR9704900A (pt) 1998-10-27
HU9701588D0 (en) 1997-11-28
FR2753969B1 (fr) 1998-10-30
NZ328858A (en) 1998-01-26
ATE227712T1 (de) 2002-11-15
FR2753969A1 (fr) 1998-04-03
EP0832886B1 (fr) 2002-11-13
NO974455L (no) 1998-03-30
HUP9701588A2 (hu) 1998-12-28
JPH10114766A (ja) 1998-05-06
PL322297A1 (en) 1998-03-30
CA2216617A1 (fr) 1998-03-27
PT832886E (pt) 2003-03-31
CA2216617C (fr) 2002-12-03

Similar Documents

Publication Publication Date Title
ZA978652B (en) Flavone compounds, process for preparing them and pharmaceutical compositions containing them.
PT652868E (pt) Inibidores da fosfodiesterase do amp ciclico
DK0576350T3 (da) Forgrenede alkylaminothiazolderivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater, der indeholder dem
DE69918404D1 (de) Aminophenoxyessigsäure derivate als neuroschützende mittel
AU677868B2 (en) New naphthalene derivatives, processes for their preparation and the pharmaceutical compositions which contain them
NO179975C (no) Analogifremgangsmåte for fremstilling av heterocykliske derivater
BR9908764A (pt) Composto e seus sais farmaceuticamente aceitáveis ou ésteres hidrolisáveis in vivo, uso destes, processo para prepará-los, e, composição farmacêutica
FR2599740B1 (fr) Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant
DK0630366T3 (da) Substituerede heterocycliske derivater, der er nyttige som blodpladeaggregeringsinhibitorer
TR200103349T2 (tr) Purin türevleri, hazırlama usulü ve bunları içeren ispençiyari bileşimleri.
ES2172294T3 (es) Nuevos derivados del 1-indanol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2106439T3 (es) 5-(piperazinilalquil)-1,5-benzotiazepinonas utiles como antagonistas de calcio.
SE7712733L (sv) Substituerade o-fenylendiaminderivat, sett for framstellning samt anvendning derav som lekemedel
DK185984D0 (da) Disubstituerede polymethyleniminer,fremgangsmaader til deres fremstilling og farmaceutiske kompositioner indeholdende dem
DE59606328D1 (de) Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlor-imidazol-4-carbaldehyden
ES454285A1 (es) Procedimiento para preparar derivados de 4-amina trans-deca-hidroquinolina.
ES2192827T3 (es) Derivados de 8h-(2,3-b)-pirrolicin-8-ona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
YU53392A (sh) Supstituisani 3-aminohinuklidini
TH97636B (th) อนุพันธุ์เบนไซซาซีนและการใช้สารเหล่านี้