DK0839208T3 - Fremgangsmåde til fremme af enzymdiversitet - Google Patents
Fremgangsmåde til fremme af enzymdiversitetInfo
- Publication number
- DK0839208T3 DK0839208T3 DK96919304T DK96919304T DK0839208T3 DK 0839208 T3 DK0839208 T3 DK 0839208T3 DK 96919304 T DK96919304 T DK 96919304T DK 96919304 T DK96919304 T DK 96919304T DK 0839208 T3 DK0839208 T3 DK 0839208T3
- Authority
- DK
- Denmark
- Prior art keywords
- sequence
- enzyme
- antibody
- animal
- variable region
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000001737 promoting effect Effects 0.000 title 1
- 230000003197 catalytic effect Effects 0.000 abstract 3
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 210000004602 germ cell Anatomy 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/505,528 US5919681A (en) | 1995-06-07 | 1995-06-07 | Method for promoting enzyme diversity |
| US08/476,135 US5914256A (en) | 1995-06-07 | 1995-06-07 | Method for promoting enzyme diversity |
| PCT/US1996/009827 WO1996040960A1 (en) | 1995-06-07 | 1996-06-06 | A method for promoting enzyme diversity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0839208T3 true DK0839208T3 (da) | 2004-12-13 |
Family
ID=27045085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96919304T DK0839208T3 (da) | 1995-06-07 | 1996-06-06 | Fremgangsmåde til fremme af enzymdiversitet |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5922584A (de) |
| EP (2) | EP1437414A3 (de) |
| JP (1) | JP4102435B2 (de) |
| AT (1) | ATE274594T1 (de) |
| AU (1) | AU719670B2 (de) |
| CA (1) | CA2223716C (de) |
| DE (1) | DE69633238T2 (de) |
| DK (1) | DK0839208T3 (de) |
| ES (1) | ES2227594T3 (de) |
| WO (1) | WO1996040960A1 (de) |
| ZA (1) | ZA964889B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1327682B1 (de) * | 2002-01-11 | 2009-05-13 | BioSpring Gesellschaft für Biotechnologie mbH | Verfahren zur Herstellung von DNA |
| EP2825653A4 (de) | 2012-03-14 | 2016-01-20 | Innovative Targeting Solutions Inc | Erzeugung einer gezielten sequenzdiversität in fusionsproteinen |
| WO2013134880A1 (en) * | 2012-03-14 | 2013-09-19 | Innovative Targeting Solutions Inc. | Generating targeted sequence diversity in proteins |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5156965A (en) * | 1983-11-29 | 1992-10-20 | Igen, Inc. | Catalytic antibodies |
| US5037750A (en) * | 1984-11-27 | 1991-08-06 | Igen, Inc. | Method for producing antibodies which catalyze chemical reactions |
| US4963355A (en) * | 1986-06-23 | 1990-10-16 | Igen, Inc. | Production of antibody catalysts |
| US4792446A (en) * | 1986-06-23 | 1988-12-20 | Igen, Inc. | Production of antibody catalysts |
| GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5318897A (en) * | 1989-04-25 | 1994-06-07 | Igen, Inc. | Monoclonal antibody and antibody components elicited to a polypeptide antigen ground state |
| EP1690934A3 (de) * | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Bildung von xenogenen Antikörpern |
| ATE300615T1 (de) * | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| CA2132306C (en) * | 1992-03-16 | 2012-07-10 | Jacob N. Wohlstadter | Selection methods |
| CA2161351C (en) * | 1993-04-26 | 2010-12-21 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| AU6904794A (en) * | 1993-04-30 | 1994-11-21 | Scripps Research Institute, The | Transgenic animals having an engineered immune response |
| US5919681A (en) * | 1995-06-07 | 1999-07-06 | Wohlstadter Jacob N | Method for promoting enzyme diversity |
| US5914256A (en) * | 1995-06-07 | 1999-06-22 | Wohlstadter Jacob N | Method for promoting enzyme diversity |
-
1996
- 1996-06-06 US US08/671,906 patent/US5922584A/en not_active Expired - Lifetime
- 1996-06-06 JP JP50203197A patent/JP4102435B2/ja not_active Expired - Lifetime
- 1996-06-06 AT AT96919304T patent/ATE274594T1/de active
- 1996-06-06 DE DE69633238T patent/DE69633238T2/de not_active Expired - Lifetime
- 1996-06-06 ES ES96919304T patent/ES2227594T3/es not_active Expired - Lifetime
- 1996-06-06 DK DK96919304T patent/DK0839208T3/da active
- 1996-06-06 EP EP04009086A patent/EP1437414A3/de not_active Withdrawn
- 1996-06-06 AU AU61674/96A patent/AU719670B2/en not_active Expired
- 1996-06-06 CA CA2223716A patent/CA2223716C/en not_active Expired - Lifetime
- 1996-06-06 EP EP96919304A patent/EP0839208B1/de not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009827 patent/WO1996040960A1/en not_active Ceased
- 1996-06-07 ZA ZA964889A patent/ZA964889B/xx unknown
-
1998
- 1998-12-30 US US09/223,061 patent/US6242236B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0839208A4 (de) | 2002-05-15 |
| ES2227594T3 (es) | 2005-04-01 |
| JP4102435B2 (ja) | 2008-06-18 |
| AU719670B2 (en) | 2000-05-18 |
| EP0839208B1 (de) | 2004-08-25 |
| JPH11513884A (ja) | 1999-11-30 |
| DE69633238D1 (de) | 2004-09-30 |
| CA2223716C (en) | 2012-03-13 |
| ATE274594T1 (de) | 2004-09-15 |
| US6242236B1 (en) | 2001-06-05 |
| EP1437414A2 (de) | 2004-07-14 |
| DE69633238T2 (de) | 2005-09-15 |
| ZA964889B (en) | 1997-07-08 |
| EP0839208A1 (de) | 1998-05-06 |
| EP1437414A3 (de) | 2005-01-05 |
| AU6167496A (en) | 1996-12-30 |
| US5922584A (en) | 1999-07-13 |
| CA2223716A1 (en) | 1996-12-19 |
| WO1996040960A1 (en) | 1996-12-19 |
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