ATE274594T1 - Methode zur erhöhung der enzymdiversität - Google Patents

Methode zur erhöhung der enzymdiversität

Info

Publication number
ATE274594T1
ATE274594T1 AT96919304T AT96919304T ATE274594T1 AT E274594 T1 ATE274594 T1 AT E274594T1 AT 96919304 T AT96919304 T AT 96919304T AT 96919304 T AT96919304 T AT 96919304T AT E274594 T1 ATE274594 T1 AT E274594T1
Authority
AT
Austria
Prior art keywords
sequence
enzyme
antibody
animal
variable region
Prior art date
Application number
AT96919304T
Other languages
English (en)
Inventor
Jacob N Wohlstadter
Original Assignee
Jacob N Wohlstadter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/476,135 external-priority patent/US5914256A/en
Priority claimed from US08/505,528 external-priority patent/US5919681A/en
Application filed by Jacob N Wohlstadter filed Critical Jacob N Wohlstadter
Application granted granted Critical
Publication of ATE274594T1 publication Critical patent/ATE274594T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96919304T 1995-06-07 1996-06-06 Methode zur erhöhung der enzymdiversität ATE274594T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/476,135 US5914256A (en) 1995-06-07 1995-06-07 Method for promoting enzyme diversity
US08/505,528 US5919681A (en) 1995-06-07 1995-06-07 Method for promoting enzyme diversity
PCT/US1996/009827 WO1996040960A1 (en) 1995-06-07 1996-06-06 A method for promoting enzyme diversity

Publications (1)

Publication Number Publication Date
ATE274594T1 true ATE274594T1 (de) 2004-09-15

Family

ID=27045085

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919304T ATE274594T1 (de) 1995-06-07 1996-06-06 Methode zur erhöhung der enzymdiversität

Country Status (11)

Country Link
US (2) US5922584A (de)
EP (2) EP0839208B1 (de)
JP (1) JP4102435B2 (de)
AT (1) ATE274594T1 (de)
AU (1) AU719670B2 (de)
CA (1) CA2223716C (de)
DE (1) DE69633238T2 (de)
DK (1) DK0839208T3 (de)
ES (1) ES2227594T3 (de)
WO (1) WO1996040960A1 (de)
ZA (1) ZA964889B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE431407T1 (de) * 2002-01-11 2009-05-15 Biospring Ges Fuer Biotechnolo Verfahren zur herstellung von dna
EP2839009B1 (de) * 2012-03-14 2019-08-21 Innovative Targeting Solutions Inc. Erzeugung einer gezielten frequenzdiversität in proteinen
EP2825653A4 (de) 2012-03-14 2016-01-20 Innovative Targeting Solutions Inc Erzeugung einer gezielten sequenzdiversität in fusionsproteinen

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037750A (en) * 1984-11-27 1991-08-06 Igen, Inc. Method for producing antibodies which catalyze chemical reactions
US5156965A (en) * 1983-11-29 1992-10-20 Igen, Inc. Catalytic antibodies
US4792446A (en) * 1986-06-23 1988-12-20 Igen, Inc. Production of antibody catalysts
US4963355A (en) * 1986-06-23 1990-10-16 Igen, Inc. Production of antibody catalysts
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5318897A (en) * 1989-04-25 1994-06-07 Igen, Inc. Monoclonal antibody and antibody components elicited to a polypeptide antigen ground state
DE69120146T2 (de) * 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
ATE158021T1 (de) * 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
WO1993019170A1 (en) * 1992-03-16 1993-09-30 Jacob Nathaniel Wohlstadter Selection methods
JPH08509612A (ja) * 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
AU6904794A (en) * 1993-04-30 1994-11-21 Scripps Research Institute, The Transgenic animals having an engineered immune response
US5919681A (en) * 1995-06-07 1999-07-06 Wohlstadter Jacob N Method for promoting enzyme diversity
US5914256A (en) * 1995-06-07 1999-06-22 Wohlstadter Jacob N Method for promoting enzyme diversity

Also Published As

Publication number Publication date
CA2223716C (en) 2012-03-13
EP1437414A3 (de) 2005-01-05
ES2227594T3 (es) 2005-04-01
EP0839208B1 (de) 2004-08-25
DE69633238D1 (de) 2004-09-30
AU719670B2 (en) 2000-05-18
JPH11513884A (ja) 1999-11-30
US5922584A (en) 1999-07-13
US6242236B1 (en) 2001-06-05
WO1996040960A1 (en) 1996-12-19
EP0839208A1 (de) 1998-05-06
ZA964889B (en) 1997-07-08
EP1437414A2 (de) 2004-07-14
AU6167496A (en) 1996-12-30
DK0839208T3 (da) 2004-12-13
JP4102435B2 (ja) 2008-06-18
CA2223716A1 (en) 1996-12-19
EP0839208A4 (de) 2002-05-15
DE69633238T2 (de) 2005-09-15

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