ATE274594T1 - Methode zur erhöhung der enzymdiversität - Google Patents

Methode zur erhöhung der enzymdiversität

Info

Publication number
ATE274594T1
ATE274594T1 AT96919304T AT96919304T ATE274594T1 AT E274594 T1 ATE274594 T1 AT E274594T1 AT 96919304 T AT96919304 T AT 96919304T AT 96919304 T AT96919304 T AT 96919304T AT E274594 T1 ATE274594 T1 AT E274594T1
Authority
AT
Austria
Prior art keywords
sequence
enzyme
antibody
animal
variable region
Prior art date
Application number
AT96919304T
Other languages
English (en)
Inventor
Jacob N Wohlstadter
Original Assignee
Jacob N Wohlstadter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/505,528 external-priority patent/US5919681A/en
Priority claimed from US08/476,135 external-priority patent/US5914256A/en
Application filed by Jacob N Wohlstadter filed Critical Jacob N Wohlstadter
Application granted granted Critical
Publication of ATE274594T1 publication Critical patent/ATE274594T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96919304T 1995-06-07 1996-06-06 Methode zur erhöhung der enzymdiversität ATE274594T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/505,528 US5919681A (en) 1995-06-07 1995-06-07 Method for promoting enzyme diversity
US08/476,135 US5914256A (en) 1995-06-07 1995-06-07 Method for promoting enzyme diversity
PCT/US1996/009827 WO1996040960A1 (en) 1995-06-07 1996-06-06 A method for promoting enzyme diversity

Publications (1)

Publication Number Publication Date
ATE274594T1 true ATE274594T1 (de) 2004-09-15

Family

ID=27045085

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919304T ATE274594T1 (de) 1995-06-07 1996-06-06 Methode zur erhöhung der enzymdiversität

Country Status (11)

Country Link
US (2) US5922584A (de)
EP (2) EP1437414A3 (de)
JP (1) JP4102435B2 (de)
AT (1) ATE274594T1 (de)
AU (1) AU719670B2 (de)
CA (1) CA2223716C (de)
DE (1) DE69633238T2 (de)
DK (1) DK0839208T3 (de)
ES (1) ES2227594T3 (de)
WO (1) WO1996040960A1 (de)
ZA (1) ZA964889B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1327682B1 (de) * 2002-01-11 2009-05-13 BioSpring Gesellschaft für Biotechnologie mbH Verfahren zur Herstellung von DNA
WO2013134880A1 (en) * 2012-03-14 2013-09-19 Innovative Targeting Solutions Inc. Generating targeted sequence diversity in proteins
EP3121194A1 (de) 2012-03-14 2017-01-25 Innovative Targeting Solutions Inc. Erzeugung einer gezielten sequenzdiversität in fusionsproteinen

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037750A (en) * 1984-11-27 1991-08-06 Igen, Inc. Method for producing antibodies which catalyze chemical reactions
US5156965A (en) * 1983-11-29 1992-10-20 Igen, Inc. Catalytic antibodies
US4792446A (en) * 1986-06-23 1988-12-20 Igen, Inc. Production of antibody catalysts
US4963355A (en) * 1986-06-23 1990-10-16 Igen, Inc. Production of antibody catalysts
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5318897A (en) * 1989-04-25 1994-06-07 Igen, Inc. Monoclonal antibody and antibody components elicited to a polypeptide antigen ground state
JP3068180B2 (ja) * 1990-01-12 2000-07-24 アブジェニックス インコーポレイテッド 異種抗体の生成
DE69133476T2 (de) * 1990-08-29 2006-01-05 GenPharm International, Inc., Palo Alto Transgene Mäuse fähig zur Produktion heterologer Antikörper
JP3691846B2 (ja) * 1992-03-16 2005-09-07 ナサニール ホールスタッター，ヤコブ 選択方法
JPH08509612A (ja) * 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
AU6904794A (en) * 1993-04-30 1994-11-21 Scripps Research Institute, The Transgenic animals having an engineered immune response
US5914256A (en) * 1995-06-07 1999-06-22 Wohlstadter Jacob N Method for promoting enzyme diversity
US5919681A (en) * 1995-06-07 1999-07-06 Wohlstadter Jacob N Method for promoting enzyme diversity

Also Published As

Publication number Publication date
AU719670B2 (en) 2000-05-18
JPH11513884A (ja) 1999-11-30
EP1437414A3 (de) 2005-01-05
US6242236B1 (en) 2001-06-05
EP0839208A4 (de) 2002-05-15
US5922584A (en) 1999-07-13
EP1437414A2 (de) 2004-07-14
DE69633238D1 (de) 2004-09-30
AU6167496A (en) 1996-12-30
CA2223716C (en) 2012-03-13
WO1996040960A1 (en) 1996-12-19
ZA964889B (en) 1997-07-08
DE69633238T2 (de) 2005-09-15
DK0839208T3 (da) 2004-12-13
ES2227594T3 (es) 2005-04-01
EP0839208A1 (de) 1998-05-06
JP4102435B2 (ja) 2008-06-18
CA2223716A1 (en) 1996-12-19
EP0839208B1 (de) 2004-08-25

Similar Documents

Publication Publication Date Title
DK0854917T3 (da) Transgene ikke-humane dyr, som kan producere heterologe antistoffer
EP0942959A4 (de) Transgene nicht-menschliche tiere, die heterologe antikörper erzeugen können
NO2009012I1 (no) Humanisert anti-humant IL-6 reseptor monoklonalt antistoff
EP0754225A4 (de) Heterologe antikörper produzierende transgene nicht-humane tiere
KR900702049A (ko) 유전자전이 동물로부터 항체 제조방법
EP1354034B8 (de) Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern
DE3382190D1 (de) Immunogener protein- oder peptidkomplex, verfahren zur herstellung dieses komplexes und seine verwendung als immunstimulans und als impfstoff.
IL123649A0 (en) Regulated genes and uses thereof
EP0874900A4 (de) Verbesserte Nukleinsäuren, welche für eine chimäre Glycosyltransferase kodieren
ATE81153T1 (de) Expressionssystem zur herstellung von chimaeren monoklonalen antikoerpern.
IL97653A0 (en) Catalytic antibody components
DK0584715T3 (da) Fremgangsmåde til isolering og dyrkning af transformerede celler og anvendelse af disse til fremstilling af antistoffer ret
ATE331791T1 (de) Phosphodiesterase 10
EP1412388A4 (de) Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin
ES2164655T3 (es) Endo-1,4-beta-d-glucanasa.
DK1243597T3 (da) Receptorer for det humane interleukin-12
ATE274594T1 (de) Methode zur erhöhung der enzymdiversität
ATE204327T1 (de) Tyrosinaseaktivator-tyrosinase-fusions-enzym
DE59611293D1 (de) Protein mit dnase-aktivität
DE59813125D1 (de) Srcr domäne-enthaltendes protein
ATE96177T1 (de) Fibrinspezifischer antikoerper, verfahren zu seiner herstellung und seine verwendung.
DE69025761D1 (de) Verfahren zur erhöhung der rate der modifikation metastabiler bindungen
GB9704305D0 (en) Procollagen assembly

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0839208

Country of ref document: EP