DK0842166T3 - Fremgangsmåde til syntese af carbapenemsidekædemellemprodukter - Google Patents

Fremgangsmåde til syntese af carbapenemsidekædemellemprodukter

Info

Publication number: DK0842166T3
Authority: DK; Denmark
Prior art keywords: synthesis; side chain; compound; formula; chain intermediates
Prior art date: 1995-08-04

Application number

DK96926210T

Other languages

Danish (da)

English (en)

Inventor

Karel M J Brands

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-04

Filing date

1996-07-31

Publication date

2000-11-27

1996-02-13 Priority claimed from GBGB9602881.6A external-priority patent/GB9602881D0/en

1996-07-31 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2000-11-27 Application granted granted Critical

2000-11-27 Publication of DK0842166T3 publication Critical patent/DK0842166T3/da

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical group C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
239000012359 Methanesulfonyl chloride Substances 0.000 abstract 1
QPQGTZMAQRXCJW-UHFFFAOYSA-N [chloro(phenyl)phosphoryl]benzene Chemical compound C=1C=CC=CC=1P(=O)(Cl)C1=CC=CC=C1 QPQGTZMAQRXCJW-UHFFFAOYSA-N 0.000 abstract 1
125000002843 carboxylic acid group Chemical group 0.000 abstract 1
VDQVEACBQKUUSU-UHFFFAOYSA-M disodium;sulfanide Chemical compound [Na+].[Na+].[SH-] VDQVEACBQKUUSU-UHFFFAOYSA-M 0.000 abstract 1
QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
229910052979 sodium sulfide Inorganic materials 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK96926210T 1995-08-04 1996-07-31 Fremgangsmåde til syntese af carbapenemsidekædemellemprodukter DK0842166T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US189195P	1995-08-04	1995-08-04
GBGB9602881.6A GB9602881D0 (en)	1996-02-13	1996-02-13	Process for synthesizing carbapenem side chain intermediates
PCT/US1996/012552 WO1997006154A1 (en)	1995-08-04	1996-07-31	Process for synthesizing carbapenem side chain intermediates

Publications (1)

Publication Number	Publication Date
DK0842166T3 true DK0842166T3 (da)	2000-11-27

Family

ID=26308673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96926210T DK0842166T3 (da)	1995-08-04	1996-07-31	Fremgangsmåde til syntese af carbapenemsidekædemellemprodukter

Country Status (11)

Country	Link
EP (1)	EP0842166B1 (de)
JP (1)	JP3112952B2 (de)
AT (1)	ATE197456T1 (de)
AU (1)	AU704304B2 (de)
CA (1)	CA2227696C (de)
DE (1)	DE69610924T2 (de)
DK (1)	DK0842166T3 (de)
ES (1)	ES2151671T3 (de)
GR (1)	GR3034795T3 (de)
PT (1)	PT842166E (de)
WO (1)	WO1997006154A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2294342C (en) *	1997-07-09	2006-03-14	Merck & Co., Inc.	Process for synthesizing carbapenem side chain intermediates
US6063931A (en) *	1997-07-09	2000-05-16	Merck & Co., Inc.	Process for synthesizing carbapenem side chain intermediates
US5965747A (en) *	1997-07-10	1999-10-12	Merck & Co., Inc.	Crystalline forms of antibiotic side chain intermediates
US6060607A (en) *	1998-06-29	2000-05-09	Merck & Co., Inc.	Process for synthesizing carbapenem side chain intermediates
JP2003525272A (ja)	2000-03-01	2003-08-26	メルクエンドカムパニーインコーポレーテッド	抗生物質側鎖中間体の結晶形
WO2010073706A1 (ja) *	2008-12-25	2010-07-01	株式会社カネカ	カルバペネム側鎖中間体の改良された製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4321383A (en) *	1980-11-24	1982-03-23	E. R. Squibb & Sons, Inc.	Heterobicyclo intermediates
JP3091297B2 (ja) *	1992-01-10	2000-09-25	住友製薬株式会社	ピロリジン誘導体およびその製造方法

1996
- 1996-07-31 JP JP09508521A patent/JP3112952B2/ja not_active Expired - Fee Related
- 1996-07-31 CA CA002227696A patent/CA2227696C/en not_active Expired - Fee Related
- 1996-07-31 PT PT96926210T patent/PT842166E/pt unknown
- 1996-07-31 WO PCT/US1996/012552 patent/WO1997006154A1/en not_active Ceased
- 1996-07-31 DK DK96926210T patent/DK0842166T3/da active
- 1996-07-31 ES ES96926210T patent/ES2151671T3/es not_active Expired - Lifetime
- 1996-07-31 EP EP96926210A patent/EP0842166B1/de not_active Expired - Lifetime
- 1996-07-31 DE DE69610924T patent/DE69610924T2/de not_active Expired - Lifetime
- 1996-07-31 AT AT96926210T patent/ATE197456T1/de not_active IP Right Cessation
- 1996-07-31 AU AU66439/96A patent/AU704304B2/en not_active Ceased
2000
- 2000-11-09 GR GR20000402340T patent/GR3034795T3/el unknown

Also Published As

Publication number	Publication date
GR3034795T3 (en)	2001-02-28
DE69610924D1 (de)	2000-12-14
EP0842166A4 (de)	1998-11-25
JPH11510509A (ja)	1999-09-14
AU704304B2 (en)	1999-04-22
JP3112952B2 (ja)	2000-11-27
ES2151671T3 (es)	2001-01-01
EP0842166B1 (de)	2000-11-08
PT842166E (pt)	2001-04-30
WO1997006154A1 (en)	1997-02-20
DE69610924T2 (de)	2001-05-17
CA2227696A1 (en)	1997-02-20
ATE197456T1 (de)	2000-11-11
EP0842166A1 (de)	1998-05-20
CA2227696C (en)	2003-09-23
AU6643996A (en)	1997-03-05

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