DK0842279T3 - Hjælpevirus til fremstilling af rekombinante virusvektorer - Google Patents

Hjælpevirus til fremstilling af rekombinante virusvektorer

Info

Publication number
DK0842279T3
DK0842279T3 DK96927107T DK96927107T DK0842279T3 DK 0842279 T3 DK0842279 T3 DK 0842279T3 DK 96927107 T DK96927107 T DK 96927107T DK 96927107 T DK96927107 T DK 96927107T DK 0842279 T3 DK0842279 T3 DK 0842279T3
Authority
DK
Denmark
Prior art keywords
production
recombinant virus
virus vectors
auxiliary viruses
recombinase
Prior art date
Application number
DK96927107T
Other languages
English (en)
Inventor
Monika Lusky
Majid Mehtali
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Application granted granted Critical
Publication of DK0842279T3 publication Critical patent/DK0842279T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material
    • C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK96927107T 1995-07-31 1996-07-30 Hjælpevirus til fremstilling af rekombinante virusvektorer DK0842279T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9509289A FR2737501B1 (fr) 1995-07-31 1995-07-31 Nouveaux virus auxiliaires pour la preparation de vecteurs viraux recombinants
PCT/FR1996/001200 WO1997005255A2 (fr) 1995-07-31 1996-07-30 Virus auxiliaires pour la preparation de vecteurs viraux recombinants

Publications (1)

Publication Number Publication Date
DK0842279T3 true DK0842279T3 (da) 2002-02-25

Family

ID=9481555

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96927107T DK0842279T3 (da) 1995-07-31 1996-07-30 Hjælpevirus til fremstilling af rekombinante virusvektorer

Country Status (12)

Country Link
US (3) US6066478A (da)
EP (2) EP1132478A3 (da)
JP (1) JP3416143B2 (da)
AT (1) ATE207959T1 (da)
AU (1) AU715487B2 (da)
CA (1) CA2225551A1 (da)
DE (1) DE69616559T2 (da)
DK (1) DK0842279T3 (da)
ES (1) ES2164910T3 (da)
FR (1) FR2737501B1 (da)
PT (1) PT842279E (da)
WO (1) WO1997005255A2 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7045347B2 (en) 1993-06-24 2006-05-16 Advec, Inc. Helper dependent adenovirus vectors based on integrase family site-specific recombinases
US20020136708A1 (en) 1993-06-24 2002-09-26 Graham Frank L. System for production of helper dependent adenovirus vectors based on use of endonucleases
US20020146392A1 (en) * 1993-06-24 2002-10-10 Frank L. Graham Helper dependent adenovirus vectors based on site-specific recombinases
JP4216350B2 (ja) * 1994-09-19 2009-01-28 大日本住友製薬株式会社 動物細胞感染用の組換えｄｎａウイルスベクター
AU2004201152B2 (en) * 1995-06-07 2007-03-08 Advec, Inc. Helper Dependent Adenovirus Vectors Based on Site-specific Recombinases
US6265212B1 (en) 1995-06-15 2001-07-24 Introgene B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
SI0833934T2 (sl) 1995-06-15 2013-04-30 Crucell Holland B.V. Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji
US6783980B2 (en) 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
JP2002538758A (ja) * 1998-02-17 2002-11-19 ジェンザイム・コーポレイション 偽アデノウイルスベクターの製造方法
WO1999049029A1 (en) * 1998-03-20 1999-09-30 Benitec Australia Ltd Control of gene expression
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US20040214330A1 (en) * 1999-04-07 2004-10-28 Waterhouse Peter Michael Methods and means for obtaining modified phenotypes
US8598332B1 (en) * 1998-04-08 2013-12-03 Bayer Cropscience N.V. Methods and means for obtaining modified phenotypes
US6670188B1 (en) 1998-04-24 2003-12-30 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
EP1435243A3 (en) * 1998-11-13 2005-02-09 Curis, Inc. Methods of alleviating cancer symptoms
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
CA2442144A1 (en) * 2001-03-26 2002-11-21 The Board Of Trustees Of The Leland Stanford Junior University A helper dependent adenoviral vector system and methods for using the same
DE10159167A1 (de) * 2001-12-03 2003-10-02 Guenter Cichon Expressionssystem
NZ536899A (en) * 2002-05-02 2008-04-30 Univ Rochester Vectors having both isoforms of beta-hexosaminidase
US20050101961A1 (en) * 2003-11-12 2005-05-12 Huebner Randall J. Bone screws
EP1540004A4 (en) * 2002-07-31 2007-10-03 Nucleonics Inc DOUBLE-STRING RNA STRUCTURES AND CONSTRUCTS AND METHOD FOR THE PRODUCTION AND USE THEREOF
US20040203133A1 (en) * 2003-01-07 2004-10-14 Anja Ehrhardt Helper dependent adenoviral vector system and methods for using the same
US7686839B2 (en) * 2005-01-26 2010-03-30 Lumitex, Inc. Phototherapy treatment devices for applying area lighting to a wound
ES2337973B8 (es) * 2008-05-16 2011-07-21 Proyecto De Biomedicina Cima, S.L. Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad.
JP2013529913A (ja) * 2010-06-02 2013-07-25 アヴィール グリーン ヒルズ バイオテクノロジー リサーチ ディベロプメント トレード アクチエンゲゼルシャフト Ｒｎａウィルスの作製のための方法及びヘルパーウィルス

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE83008T1 (de) * 1987-07-21 1992-12-15 Du Pont Merck Pharma Verfahren fuer die herstellung von in tierischen zellen stabilen und lebensfaehigen rekombinanten viralen vektoren.
US5173414A (en) * 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
US5919676A (en) * 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
FR2707664B1 (fr) * 1993-07-13 1995-09-29 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
BR9405507A (pt) 1993-07-13 1999-05-25 Rhone Poulenc Rorer Sa Adenovirus recombinante defeituoso linhagem celular e composição farmaceutica
JP3770333B2 (ja) * 1995-03-15 2006-04-26 大日本住友製薬株式会社 組換えｄｎａウイルスおよびその製造方法

Also Published As

Publication number Publication date
US20020072120A1 (en) 2002-06-13
JPH11510049A (ja) 1999-09-07
PT842279E (pt) 2002-04-29
ES2164910T3 (es) 2002-03-01
AU6704496A (en) 1997-02-26
EP0842279A2 (fr) 1998-05-20
DE69616559D1 (de) 2001-12-06
ATE207959T1 (de) 2001-11-15
US6066478A (en) 2000-05-23
EP1132478A3 (fr) 2002-09-04
WO1997005255A3 (fr) 1997-03-06
EP0842279B1 (fr) 2001-10-31
CA2225551A1 (fr) 1997-02-13
AU715487B2 (en) 2000-02-03
US6350575B1 (en) 2002-02-26
FR2737501B1 (fr) 1997-10-24
WO1997005255A2 (fr) 1997-02-13
JP3416143B2 (ja) 2003-06-16
EP1132478A2 (fr) 2001-09-12
DE69616559T2 (de) 2002-06-27
FR2737501A1 (fr) 1997-02-07

Similar Documents

Publication Publication Date Title
DK0842279T3 (da) Hjælpevirus til fremstilling af rekombinante virusvektorer
ATE358732T1 (de) Anti-virale vektoren
PL333070A1 (en) Infectious clones of rna viruses and vaccines based on them
DE3586520D1 (de) Herpes simplex-virus als vektor.
EP1394259A3 (en) Recombinant infectious non-segmented negative strand RNA virus
FI971783A7 (fi) Adenoviruksia, joissa ei ole elinkykyisiä kontaminoivia partikkeleita, niiden valmistus ja käyttöjä
FI961146A0 (fi) Adenoassosioituja virusliposomeja ja niihin liittyviä menetelmiä
CA2157063A1 (en) Recombinant dna viral vector for transfecting animal cells
AU9338598A (en) Recombinant vector containing infectious, viral genome sequences greater than 100 kb, method for producing same and use for the mutagenesis of the viral sequences
ATE462796T1 (de) Kodon-optimierte eiav vektoren
WO1995006743A3 (en) Methods and compositions for the large scale production of recombinant adeno-associated virus
DK0749444T3 (da) Human/dyre-faktor VIII-hybrid
DE69515028D1 (de) Die hocheffiziente herstellung und isolierung von viruspartikeln
DE59911900D1 (de) Retrovirale, mit LCMV-Glykoprotein pseudotypisierte Hybrid-Vektoren
KR960001819B1 (en) Viral vector coding for a glycoprotein of the virus responsible
DK0835137T3 (da) Indkapslede celler, som danner viruspartikler
ATE424464T1 (de) Verbesserte chimäre glykoproteine und pseudotypisierte lentivirale vektoren
AU582288B2 (en) Vector and method for achieving high level expression in eukaryotic cells
DK498387A (da) Virus-dna-sekvens
NO175872C (no) Plasmidvektor, fremgangsmåte for fremstilling av peptider og myelomcelle
CA2332623A1 (en) Recombinant herpes viruses for preparing recombinant adeno-associated viruses
SE8100238L (sv) Syntetisk gen, plasmidvektor innehallande denna gen, forfaranden for genens och vektorns framstellning och anvendning samt salunda erhallna celler och peptider
FI881294L (fi) FSME-viruksen läntisen alatyypin eristettyjä DNA- ja RNA-molekyylejä, näitä sisältäviä vektoreita ja soluviljelmiä sekä menetelmä näiden koodittamien peptidien valmistamiseksi
JPS6485072A (en) Recombinant vaccinia virus
TH22679A (th) การเอ็กซ์เพรสโพลีเพพไทด์ของไวรัสก่อโรคทางระบบหายใจที่แพร่พันธุ์ได้ในสุกรในเซลล์เดียวกัน