DK0845005T3 - TRAF-inhibitorer - Google Patents

TRAF-inhibitorer

Info

Publication number: DK0845005T3
Authority: DK; Denmark
Prior art keywords: traf; inhibitors; trafs; pharmaceuticals; nucleic acid
Prior art date: 1995-08-17

Application number

DK96927409T

Other languages

English (en)

Inventor

Mike Rothe

David V Goeddel

Original Assignee

Genentech Inc

Tularik Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-17

Filing date

1996-08-14

Publication date

2005-08-01

1996-08-14 Application filed by Genentech Inc, Tularik Inc filed Critical Genentech Inc

2005-08-01 Application granted granted Critical

2005-08-01 Publication of DK0845005T3 publication Critical patent/DK0845005T3/da

Links

239000003112 inhibitor Substances 0.000 title abstract 2
102100034779 TRAF family member-associated NF-kappa-B activator Human genes 0.000 abstract 1
101710140983 TRAF family member-associated NF-kappa-B activator Proteins 0.000 abstract 1
108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
108091006086 inhibitor proteins Proteins 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
238000007423 screening assay Methods 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1
102000003298 tumor necrosis factor receptor Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Cell Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK96927409T 1995-08-17 1996-08-14 TRAF-inhibitorer DK0845005T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US238295P	1995-08-17	1995-08-17
PCT/US1996/013129 WO1997007134A1 (en)	1995-08-17	1996-08-14	Traf inhibitors

Publications (1)

Publication Number	Publication Date
DK0845005T3 true DK0845005T3 (da)	2005-08-01

Family

ID=21700513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96927409T DK0845005T3 (da)	1995-08-17	1996-08-14	TRAF-inhibitorer

Country Status (13)

Country	Link
US (6)	US5789550A (da)
EP (2)	EP1568708A3 (da)
JP (2)	JP4382878B2 (da)
AT (1)	ATE291585T1 (da)
AU (1)	AU709535B2 (da)
CA (1)	CA2227174A1 (da)
DE (1)	DE69634512T2 (da)
DK (1)	DK0845005T3 (da)
ES (1)	ES2239334T3 (da)
IL (1)	IL122980A0 (da)
NZ (1)	NZ315514A (da)
WO (1)	WO1997007134A1 (da)
ZA (1)	ZA966663B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA966663B (en) *	1995-08-17	1998-02-06	Genentech Inc	Traf Inhibitors.
US6271349B1 (en)	1996-12-23	2001-08-07	Immunex Corporation	Receptor activator of NF-κB
ATE497001T1 (de) *	1996-12-23	2011-02-15	Immunex Corp	Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie
US6723517B1 (en) *	1998-06-02	2004-04-20	Minerva Biotechnologies Corporation	Use of self-assembled monolayers to probe the structure of a target molecule
WO1999067380A1 (en) *	1998-06-22	1999-12-29	Temple University - Of The Commonwealth System Of Higher Education	c-Cbl SUPPRESSION OF NEOPLASTIC TRANSFORMATION
WO2001021799A1 (en) *	1999-09-23	2001-03-29	Rigel Pharmaceuticals, Inc.	Traf4 associated cell cycle proteins, compositions and methods of use
WO2002064786A1 (fr) *	2001-02-15	2002-08-22	Mochida Pharmaceutical Co., Ltd.	Nouveau gene tcif
NZ529983A (en) *	2001-06-07	2006-09-29	Medvet Science Pty Ltd	Sphingosine kinase interacts with TRAF2 and modulates tumor necrosis factor-induced cellular activity
TR201809678T4 (tr)	2001-06-26	2018-07-23	Amgen Fremont Inc	Opgl ye karşi antikorlar.
US20030083304A1 (en) *	2001-10-09	2003-05-01	Smart Robert C.	CCAAT/enhancer binding protein-beta (C/EBPbeta) is a molecular target for cancer treatment
IL145918A0 (en) *	2001-10-14	2002-07-25	Ares Trading Sa	Method and kit for monitoring recruitment of proteins to the intracellular domain of a receptor in intact cells
JP2006509724A (ja) *	2002-08-01	2006-03-23	ワイス	炎症及びアポトーシスに関係する方法及び試薬
US20090182035A1 (en) *	2007-04-11	2009-07-16	Alcon Research, Ltd.	Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
CA2682730A1 (en) *	2007-04-11	2008-10-23	Alcon Research, Ltd.	Use of an inhibitor of tnf.alpha. plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US9486498B2 (en) *	2008-05-19	2016-11-08	Case Western Reserve University	Method of treating CD40-mediated diseases
US12319726B2 (en)	2008-05-19	2025-06-03	Case Western Reserve University	Method for treating CD40-mediated diseases
US10669345B2 (en) *	2008-05-19	2020-06-02	Case Western Reserve University	Method for treating CD40-mediated diseases
EP2389452A2 (en)	2009-01-21	2011-11-30	Vertex Pharmaceuticals Incorporated	Methods for amplifying hepatitis c virus nucleic acids
US20110082145A1 (en) *	2009-10-01	2011-04-07	Alcon Research, Ltd.	Olopatadine compositions and uses thereof
US12522633B2 (en)	2020-04-02	2026-01-13	Case Western Reserve University	Compositions and methods for treating CD40-mediated diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3613167A1 (de) *	1986-04-18	1987-10-29	Basf Ag	Verwendung von tnf zur herstellung von arzneimitteln
US5108901A (en)	1988-09-02	1992-04-28	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5395760A (en) *	1989-09-05	1995-03-07	Immunex Corporation	DNA encoding tumor necrosis factor-α and -β receptors
DE59010908D1 (de) *	1989-09-12	2000-08-10	Hoffmann La Roche	TNF-bindende Proteine
US5318890A (en)	1991-05-06	1994-06-07	The Regents Of The University Of California	Assays for inhibitors of leukocyte adhesion
WO1996020723A1 (en) *	1994-12-30	1996-07-11	Brigham & Women's Hospital	Controlling traf-mediated signals
ZA966663B (en) *	1995-08-17	1998-02-06	Genentech Inc	Traf Inhibitors.

1996
- 1996-08-06 ZA ZA9606663A patent/ZA966663B/xx unknown
- 1996-08-14 EP EP05075669A patent/EP1568708A3/en not_active Withdrawn
- 1996-08-14 ES ES96927409T patent/ES2239334T3/es not_active Expired - Lifetime
- 1996-08-14 JP JP50942797A patent/JP4382878B2/ja not_active Expired - Lifetime
- 1996-08-14 DK DK96927409T patent/DK0845005T3/da active
- 1996-08-14 EP EP96927409A patent/EP0845005B1/en not_active Expired - Lifetime
- 1996-08-14 DE DE69634512T patent/DE69634512T2/de not_active Expired - Lifetime
- 1996-08-14 IL IL12298096A patent/IL122980A0/xx unknown
- 1996-08-14 AT AT96927409T patent/ATE291585T1/de not_active IP Right Cessation
- 1996-08-14 CA CA002227174A patent/CA2227174A1/en not_active Abandoned
- 1996-08-14 NZ NZ315514A patent/NZ315514A/xx not_active IP Right Cessation
- 1996-08-14 US US08/700,749 patent/US5789550A/en not_active Expired - Lifetime
- 1996-08-14 WO PCT/US1996/013129 patent/WO1997007134A1/en not_active Ceased
- 1996-08-14 AU AU67237/96A patent/AU709535B2/en not_active Ceased
1998
- 1998-02-09 US US09/020,684 patent/US6004553A/en not_active Expired - Lifetime
- 1998-02-09 US US09/020,467 patent/US6060303A/en not_active Expired - Fee Related
- 1998-02-09 US US09/020,685 patent/US6063585A/en not_active Expired - Fee Related
- 1998-02-09 US US09/020,683 patent/US6294348B1/en not_active Expired - Fee Related
2003
- 2003-10-03 US US10/679,014 patent/US20040087774A1/en not_active Abandoned
2008
- 2008-12-12 JP JP2008317548A patent/JP2009065981A/ja active Pending

Also Published As

Publication number	Publication date
DE69634512T2 (de)	2006-02-09
ZA966663B (en)	1998-02-06
EP1568708A2 (en)	2005-08-31
ATE291585T1 (de)	2005-04-15
JP4382878B2 (ja)	2009-12-16
NZ315514A (en)	1998-12-23
US5789550A (en)	1998-08-04
AU6723796A (en)	1997-03-12
IL122980A0 (en)	1998-08-16
EP1568708A3 (en)	2005-10-12
DE69634512D1 (de)	2005-04-28
JPH11511967A (ja)	1999-10-19
US6294348B1 (en)	2001-09-25
MX9800995A (es)	1998-10-31
WO1997007134A1 (en)	1997-02-27
JP2009065981A (ja)	2009-04-02
US6060303A (en)	2000-05-09
US6004553A (en)	1999-12-21
AU709535B2 (en)	1999-09-02
US6063585A (en)	2000-05-16
US20040087774A1 (en)	2004-05-06
ES2239334T3 (es)	2005-09-16
EP0845005A1 (en)	1998-06-03
CA2227174A1 (en)	1997-02-27
EP0845005B1 (en)	2005-03-23

Publication	Publication Date	Title
ATE291585T1 (de)	2005-04-15	Traf-inhibitoren
NO961115D0 (no)	1996-03-19	Humane metabotrope glutamatreseptorsubtyper (HMR4, HMR6, HMR7) og relaterte DNA forbindelser
DK0724588T3 (da)	2000-05-15	Lægemiddelbindende protein
NO960767D0 (no)	1996-02-26	Protocadherinproteiner og deres anvendelse
CY1112101T1 (el)	2015-11-04	Νευροτροφικοι παραγοντες
NO985848D0 (no)	1998-12-14	Nytt protein og fremgangsmÕte for fremstilling av dette
DK0811063T3 (da)	2006-04-10	Kemokin-receptor 88C og dens antistoffer
FI962247A7 (fi)	1996-07-22	Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden kä yttömenetelmät
ATE463502T1 (de)	2010-04-15	Menschliche toll-homologe
DE69535274D1 (de)	2006-11-30	Verwendung eines menschlichen interleukin-11 rezeptors
EP1141286A4 (en)	2002-06-26	Cytokine receptor chain
DK0901526T3 (da)	2007-09-10	Cortistatin: neuropeptider, sammensætninger og metoder
DE69728897D1 (de)	2004-06-03	Saeugetierchemokine
DE69504795D1 (de)	1998-10-22	Methoden zur synthese und reinigung von peptiden
NO20005819L (no)	2001-01-15	Nye peptidfragmenter for rensing av proteiner
WO2001021794A3 (en)	2001-10-25	Smad associating polypeptides
RU94026276A (ru)	1997-03-10	Рецепторы интерлейкина-12 и антител
WO2000065055A3 (en)	2001-04-12	Human transporter proteins