DK0845032T3 - Isolerede nucleinsyremolekyler, peptider, der danner komplekser med MHC-molekyler HLA-A2, samt anvendelser - Google Patents

Isolerede nucleinsyremolekyler, peptider, der danner komplekser med MHC-molekyler HLA-A2, samt anvendelser

Info

Publication number
DK0845032T3
DK0845032T3 DK96913954T DK96913954T DK0845032T3 DK 0845032 T3 DK0845032 T3 DK 0845032T3 DK 96913954 T DK96913954 T DK 96913954T DK 96913954 T DK96913954 T DK 96913954T DK 0845032 T3 DK0845032 T3 DK 0845032T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
molecules
acid molecules
applications
isolated nucleic
Prior art date
Application number
DK96913954T
Other languages
Danish (da)
English (en)
Inventor
Thierry Boon-Falleur
Yannick Guilloux
Francine Jotereau
Sophie Lucas
Vincent Brichard
Original Assignee
Ludwig Inst Cancer Res
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res, Inst Nat Sante Rech Med filed Critical Ludwig Inst Cancer Res
Application granted granted Critical
Publication of DK0845032T3 publication Critical patent/DK0845032T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK96913954T 1995-06-07 1996-05-07 Isolerede nucleinsyremolekyler, peptider, der danner komplekser med MHC-molekyler HLA-A2, samt anvendelser DK0845032T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/487,135 US5821122A (en) 1995-06-07 1995-06-07 Isolated nucleic acid molecules, peptides which form complexes with MHC molecule HLA-A2 and uses thereof
PCT/US1996/006409 WO1996040039A2 (fr) 1995-06-07 1996-05-07 Molecules d'acide nucleique isolees, peptides formant des complexes avec la molecule du complexe majeur d'histocompatibilite (mhc) hla-a2 et leurs applications

Publications (1)

Publication Number Publication Date
DK0845032T3 true DK0845032T3 (da) 2002-05-06

Family

ID=23934549

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96913954T DK0845032T3 (da) 1995-06-07 1996-05-07 Isolerede nucleinsyremolekyler, peptider, der danner komplekser med MHC-molekyler HLA-A2, samt anvendelser

Country Status (12)

Country Link
US (3) US5821122A (fr)
EP (1) EP0845032B1 (fr)
JP (1) JP3849102B2 (fr)
AT (1) ATE209680T1 (fr)
AU (1) AU704934B2 (fr)
CA (1) CA2223694C (fr)
DE (1) DE69617440T2 (fr)
DK (1) DK0845032T3 (fr)
ES (1) ES2167561T3 (fr)
PT (1) PT845032E (fr)
WO (1) WO1996040039A2 (fr)
ZA (1) ZA963907B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0970206T3 (da) 1997-01-27 2008-10-13 Ludwig Inst Cancer Res Lage-1-tumorassocierede nukleinsyrer
US6680191B1 (en) 1997-04-25 2004-01-20 Ludwig Institute For Cancer Isolated nucleic acid molecules coding for tumor rejection antigen precursors of members of the MAGE-C and MAGE-B FAMILIES and uses thereof
US6734172B2 (en) 1998-11-18 2004-05-11 Pacific Northwest Research Institute Surface receptor antigen vaccines
AU2001229681A1 (en) * 2000-01-20 2001-07-31 Ludwig Institute For Cancer Research Mage antigenic peptides which bind hla-b35 and hla-b44
PT1188446E (pt) 2000-09-15 2009-11-10 Pasteur Institut Vectores proteinácios para a distribuição da molécula a células que expressam cd11b
CN101684158A (zh) 2001-01-17 2010-03-31 特鲁比昂药品公司 结合域-免疫球蛋白融合蛋白
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US6607151B2 (en) * 2001-08-16 2003-08-19 Morris Samelson Ultra fine dead sea mineral compound and method of manufacture
JP4694128B2 (ja) 2002-01-30 2011-06-08 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド ＴＩＭ−３、Ｔｈ１特異的細胞表面分子に関連した組成物および方法
US20070026022A1 (en) * 2004-11-19 2007-02-01 Gilles Dadaglio Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens
PL1684801T3 (pl) * 2003-11-21 2010-07-30 Pasteur Institut Rekombinowana toksyna cyklazy adenylanowej indukuje odpowiedzi komórek T przeciwko antygenom nowotworowym
KR20070056042A (ko) * 2004-06-17 2007-05-31 맨카인드 코포레이션 에피토프 유사체
KR101076578B1 (ko) 2004-06-23 2011-10-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물
WO2010080909A1 (fr) 2009-01-08 2010-07-15 Yale University Compositions et procédés d'utilisation de virus de la stomatite vésiculaire à action oncolytique
US20120171246A1 (en) 2009-09-10 2012-07-05 Yale University Immunization to reduce neurotoxicity during treatment with cytolytic viruses
WO2011056993A1 (fr) 2009-11-04 2011-05-12 Yale University Compositions et procédés destinés à traiter le cancer par des virus oncolytiques atténués
AU2013273987B2 (en) 2012-06-15 2018-08-09 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
WO2014145992A1 (fr) 2013-03-15 2014-09-18 Adaptive Biotechnologies Corporation Gènes de récepteur de l'immunité acquise réarrangés à étiquette unique dans un ensemble complexe de gènes
US10874621B2 (en) 2013-10-17 2020-12-29 The Brigham And Women's Hospital, Inc. Cationic nanoparticles for co-delivery of nucleic acids and therapeutic agents
EP3139909B1 (fr) 2014-05-09 2025-01-01 Yale University Particules enrobées de polyglycérol hyperramifié
US20180126014A1 (en) 2015-04-15 2018-05-10 Yale University Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof
WO2017095751A1 (fr) 2015-12-02 2017-06-08 Partikula Llc Compositions et procédés de modulation du métabolisme de cellules cancéreuses
WO2017173453A1 (fr) 2016-04-01 2017-10-05 The Brigham And Women's Hospital, Inc. Nanoparticules sensibles aux stimuli pour applications biomédicales
EP3512563A1 (fr) 2016-09-16 2019-07-24 The Johns Hopkins University Nanocages protéiques à pénétration de mucus améliorée pour administration tissulaire et intracellulaire ciblée
WO2018112470A1 (fr) 2016-12-16 2018-06-21 The Brigham And Women's Hospital, Inc. Co-administration d'acides nucléiques pour la suppression et l'expression simultanées de gènes cibles
US12569497B2 (en) 2017-04-27 2026-03-10 The University Of Hong Kong Use of HCN inhibitors for treatment of cancer
US11478433B2 (en) 2017-06-23 2022-10-25 Yale University Nanomaterials with enhanced drug delivery efficiency
WO2021092172A1 (fr) 2019-11-05 2021-05-14 University Of Georgia Research Foundation, Inc. Maytansinoïdes modifiés de manière fonctionnelle, compositions et procédés d'utilisation associés
JP2024527977A (ja) 2021-07-27 2024-07-26 ノヴァブ， インコーポレイテッド 免疫エフェクター機能を有する操作されたｖｌｒｂ抗体
CA3240407A1 (fr) 2021-12-08 2023-06-07 Akiko Iwasaki Compositions immunogenes de nanoparticules et methodes de vaccination
EP4469057A1 (fr) 2022-01-28 2024-12-04 University of Georgia Research Foundation, Inc. Compositions radiosensibilisantes et leurs procédés d'utilisation
CN120129696A (zh) 2022-09-01 2025-06-10 乔治亚大学研究基金公司 用于指导载脂蛋白l1诱导哺乳动物细胞死亡的组合物和方法
EP4622631A1 (fr) 2022-11-23 2025-10-01 University of Georgia Research Foundation, Inc. Compositions et méthodes d'utilisation de celles-ci pour augmenter les réponses immunitaires

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342774A (en) * 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
ES2151544T3 (es) * 1992-12-22 2001-01-01 Ludwig Inst Cancer Res Metodos para la deteccion y el tratamiento de individuos con celulas anormales que expresan antigenos peptidos hla-a2/tirosinasa.
US5620886A (en) * 1993-03-18 1997-04-15 Ludwig Institute For Cancer Research Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
US5856091A (en) * 1993-03-18 1999-01-05 Ludwig Institute For Cancer Research Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
US5554724A (en) * 1994-03-24 1996-09-10 University Of Leiden Isolated tumor rejection antigen precursor MAGE-2 derived peptides, and uses thereof
US5851523A (en) * 1994-03-24 1998-12-22 Ludwig Institute For Cancer Research. Isolated, peptides derived from MAGE tumor rejection antigen precursors which complex with HLA-A2 molecules and uses thereof
US5997870A (en) * 1994-06-03 1999-12-07 Ludwig Institute For Cancer Research Isolated peptides which bind to HLA-B44 Molecules

Also Published As

Publication number Publication date
ES2167561T3 (es) 2002-05-16
CA2223694C (fr) 2003-06-24
DE69617440D1 (de) 2002-01-10
ATE209680T1 (de) 2001-12-15
DE69617440T2 (de) 2002-08-08
EP0845032B1 (fr) 2001-11-28
JP3849102B2 (ja) 2006-11-22
WO1996040039A3 (fr) 2000-03-23
ZA963907B (en) 1997-03-11
PT845032E (pt) 2002-05-31
AU5676996A (en) 1996-12-30
EP0845032A4 (fr) 2000-05-10
AU704934B2 (en) 1999-05-06
CA2223694A1 (fr) 1996-12-19
JP2001520506A (ja) 2001-10-30
EP0845032A2 (fr) 1998-06-03
WO1996040039A2 (fr) 1996-12-19
US5886145A (en) 1999-03-23
US5821122A (en) 1998-10-13
US5958711A (en) 1999-09-28

Similar Documents

Publication Publication Date Title
ZA963907B (en) Insolated nucleic acid molecules peptides which form complexes with mhc molecule hla-a2 and uses thereof
NO955063D0 (no) Isolerte peptider som danner komplekser av MHC-molekylet HLA-C-klon 10, samt anvendelse derav
ZA958039B (en) Isolated nucleic acid molecule coding for tumor rejection antigen precursor dage and uses thereof
NO960158L (no) Fremgangsmåte til diagnostisering av en lidelse ved å bestemme ekspresjon av GAGE-tumor-rejeksjonsantigenforlöpere
FI954536A0 (fi) Eristettyjä nukleiinihappomolekyylejä, jotka koodittavat kasvainhyljintäantigeenin esiastetta MAGE-3, ja niiden hyötykäyttö
PT100515A (pt) Moleculas de acido nucleico, precursores de antigenios de rejeicao de tumores, antigenios da rejeicao de tumores e suas utilizacoes
HUP0002095A2 (hu) Vegyületek prosztatarák immunterápiás kezelésére és alkalmazásuk
DK0690675T3 (da) Nukleinsyre, der koder for en tumorafstödningsantigenprecursor
BR9908823A (pt) Compostos e processos para terapia e diagnóstico de câncer de pulmão
EA200200565A1 (ru) Применение клеток, трансфицированных днк, кодирующей лиганд мнс класса ii, и способ получения таких клеток
ATE195346T1 (de) Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionen
NZ302821A (en) isolated truncated nucleic acid molecules which code for GAGE tumour rejection antigen precursors
NZ332369A (en) Isolated nucleic acid molecules which code for GAGE tumor rejection antigen, the tumor rejection antigen, and uses thereof
UY26266A1 (es) Antigeno asociado con tumores (r11) ley 17164
HUP0004739A1 (hu) Presenilinekkel kölcsönhatásra képes fehérjéket kódoló nukleinsavak
TW372973B (en) Isolated, truncated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof
CA2165435A1 (fr) Nouveaux precurseurs d'antigenes pour le rejet des tumeurs et molecules d'acides nucleiques codant pour ces precurseurs
UA66753C2 (en) Immunostimulator and method for its production