DK0845464T3 - S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater - Google Patents

S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater

Info

Publication number: DK0845464T3
Authority: DK; Denmark
Prior art keywords: type; indolidinyl; intermediates; acid ester; butyric acid
Prior art date: 1996-10-30

Application number

DK97308549T

Other languages

English (en)

Inventor

Takayuki Kawaguchi

Sumihiro Nomura

Kenji Tsujihara

Original Assignee

Tanabe Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-30

Filing date

1997-10-27

Publication date

2003-12-01

1997-10-27 Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co

2003-12-01 Application granted granted Critical

2003-12-01 Publication of DK0845464T3 publication Critical patent/DK0845464T3/da

Links

-1 butyric acid ester compounds Chemical class 0.000 title abstract 2
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000003402 intramolecular cyclocondensation reaction Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
230000009935 nitrosation Effects 0.000 abstract 1
238000007034 nitrosation reaction Methods 0.000 abstract 1
230000008707 rearrangement Effects 0.000 abstract 1
238000006462 rearrangement reaction Methods 0.000 abstract 1
230000009467 reduction Effects 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
- G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
- G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
- G02F1/133—Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
- G02F1/1333—Constructional arrangements; Manufacturing methods
- G02F1/1345—Conductors connecting electrodes to cell terminals
- G02F1/13452—Conductors connecting driver circuitry and terminals of panels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
- G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
- G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells
- G02F1/1303—Apparatus specially adapted to the manufacture of LCDs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Physics & Mathematics (AREA)
Nonlinear Science (AREA)
Health & Medical Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
General Physics & Mathematics (AREA)
Optics & Photonics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Mathematical Physics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Manufacturing & Machinery (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)

DK97308549T 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater DK0845464T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP28807496		1996-10-30

Publications (1)

Publication Number	Publication Date
DK0845464T3 true DK0845464T3 (da)	2003-12-01

Family

ID=17725479

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK97308549T DK0845464T3 (da)	1996-10-30	1997-10-27	S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater
DK02006610T DK1236728T3 (da)	1996-10-30	1997-10-27	S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK02006610T DK1236728T3 (da)	1996-10-30	1997-10-27	S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf

Country Status (14)

Country	Link
US (7)	US5932732A (da)
EP (3)	EP0845464B1 (da)
KR (5)	KR100474496B1 (da)
CN (3)	CN1077109C (da)
AT (2)	ATE247120T1 (da)
CA (2)	CA2533685C (da)
DE (2)	DE69724081T2 (da)
DK (2)	DK0845464T3 (da)
ES (2)	ES2267879T3 (da)
HK (1)	HK1050356B (da)
ID (1)	ID18747A (da)
PT (2)	PT1236728E (da)
SG (4)	SG103322A1 (da)
TW (1)	TW464652B (da)

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EP1355634B8 (en)	2000-11-09	2009-03-04	Neopharm, Inc.	Sn-38 lipid complexes and methods of use
US20090137816A1 (en) *	2000-12-15	2009-05-28	Kurt Baum	Process for the manufacture of diaminofurazan
US6350756B1 (en)	2001-01-18	2002-02-26	California Pacific Medical Center	Camptothecin derivatives
AR035684A1 (es)	2001-02-21	2004-06-23	Yakult Honsha Kk	Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina
CN101337900B (zh) *	2001-02-21	2013-12-18	株式会社雅库路特本社	喜树碱相关化合物的合成方法
US6403604B1 (en)	2001-03-01	2002-06-11	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
US6855720B2 (en)	2001-03-01	2005-02-15	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
WO2003030864A1 (en) *	2001-05-29	2003-04-17	Neopharm, Inc.	Liposomal formulation of irinotecan
AU2003243397A1 (en) *	2002-06-03	2003-12-19	California Pacific Medical Center	Homo-camptothecin derivatives
WO2003101998A1 (en) *	2002-06-03	2003-12-11	California Pacific Medical Center	Nitrogen-based homo-camptothecin derivatives
US20060030578A1 (en) *	2002-08-20	2006-02-09	Neopharm, Inc.	Pharmaceutically active lipid based formulation of irinotecan
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JP4433918B2 (ja) *	2004-07-15	2010-03-17	コニカミノルタエムジー株式会社	画像形成方法
KR100651728B1 (ko) *	2004-11-10	2006-12-06	한국전자통신연구원	정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
CN100390177C (zh) *	2004-11-25	2008-05-28	复旦大学	6-氰基-7-甲基-1,1-(2,2-二甲基-1,3-亚丙二氧基)-5-氧-1,2,3,5-四氢吲哚哩啶(i)的制备方法
US7608740B2 (en)	2005-08-03	2009-10-27	Avra Laboratories Pvt. Ltd	Method of synthesizing key intermediates for the production of camptothecin derivatives
US7875602B2 (en) *	2005-10-21	2011-01-25	Sutter West Bay Hospitals	Camptothecin derivatives as chemoradiosensitizing agents
CN104341429B (zh) *	2013-07-29	2016-08-10	北大方正集团有限公司	(s)-喜树碱中间体的制备方法及(s)-喜树碱的制备方法
BR112020020466A2 (pt) *	2018-04-06	2021-01-12	Seattle Genetics, Inc.	Conjugados de peptídeo de camptotecina
TWI851577B (zh)	2018-06-07	2024-08-11	美商思進公司	喜樹鹼結合物
CN113041841B (zh) *	2021-03-22	2022-07-12	万华化学集团股份有限公司	一种抗污染浓水隔网的制备方法及应用

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JPH07101956A (ja) *	1993-10-05	1995-04-18	Tanabe Seiyaku Co Ltd	ヒドロキシカンプトテシン化合物の製法
KR960029336A (ko) *	1995-01-09	1996-08-17	김충환	캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
TW438775B (en) *	1995-04-07	2001-06-07	Pharmacia & Upjohn Co Llc	Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
AU5772196A (en) *	1995-05-19	1996-11-29	Chiroscience Limited	3,4-disubstituted-phenylsulphonamides and their therapeutic use
SG50747A1 (en) *	1995-08-02	1998-07-20	Tanabe Seiyaku Co	Comptothecin derivatives
US6207672B1 (en)	1995-11-13	2001-03-27	Aventis Pharma Deutschland Gmbh	Cyclic and heterocyclic N-substituted α-iminohydroxamic and carboxyclic acids
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US5731316A (en)	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
SG103322A1 (en) *	1996-10-30	2004-04-29	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
DE19719817A1 (de) *	1997-05-13	1998-11-19	Hoechst Ag	Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren

1997
- 1997-10-23 SG SG200107148A patent/SG103322A1/en unknown
- 1997-10-23 SG SG200107149A patent/SG104284A1/en unknown
- 1997-10-23 SG SG200107147A patent/SG116433A1/en unknown
- 1997-10-23 SG SG9703851A patent/SG88737A1/en unknown
- 1997-10-23 TW TW086115665A patent/TW464652B/zh not_active IP Right Cessation
- 1997-10-24 ID IDP973523A patent/ID18747A/id unknown
- 1997-10-27 AT AT97308549T patent/ATE247120T1/de not_active IP Right Cessation
- 1997-10-27 PT PT02006610T patent/PT1236728E/pt unknown
- 1997-10-27 PT PT97308549T patent/PT845464E/pt unknown
- 1997-10-27 DE DE69724081T patent/DE69724081T2/de not_active Expired - Fee Related
- 1997-10-27 ES ES02006610T patent/ES2267879T3/es not_active Expired - Lifetime
- 1997-10-27 DK DK97308549T patent/DK0845464T3/da active
- 1997-10-27 ES ES97308549T patent/ES2205134T3/es not_active Expired - Lifetime
- 1997-10-27 EP EP97308549A patent/EP0845464B1/en not_active Expired - Lifetime
- 1997-10-27 EP EP04005684A patent/EP1528062A3/en not_active Withdrawn
- 1997-10-27 AT AT02006610T patent/ATE332303T1/de not_active IP Right Cessation
- 1997-10-27 DE DE69736308T patent/DE69736308T2/de not_active Expired - Fee Related
- 1997-10-27 EP EP02006610A patent/EP1236728B1/en not_active Expired - Lifetime
- 1997-10-27 DK DK02006610T patent/DK1236728T3/da active
- 1997-10-28 US US08/958,979 patent/US5932732A/en not_active Expired - Fee Related
- 1997-10-30 CN CN97122529A patent/CN1077109C/zh not_active Expired - Fee Related
- 1997-10-30 CN CNB2006101011920A patent/CN100528879C/zh not_active Expired - Fee Related
- 1997-10-30 KR KR1019970056330A patent/KR100474496B1/ko not_active Expired - Fee Related
- 1997-10-30 CA CA002533685A patent/CA2533685C/en not_active Expired - Fee Related
- 1997-10-30 CA CA002219692A patent/CA2219692C/en not_active Expired - Fee Related
- 1997-10-30 CN CNB011109580A patent/CN100473654C/zh not_active Expired - Fee Related
1998
- 1998-10-15 US US09/172,666 patent/US6015901A/en not_active Expired - Fee Related
- 1998-12-03 HK HK03100780.1A patent/HK1050356B/en not_active IP Right Cessation
1999
- 1999-10-18 US US09/421,335 patent/US6114529A/en not_active Expired - Fee Related
2000
- 2000-05-12 US US09/570,172 patent/US6277992B1/en not_active Expired - Fee Related
2001
- 2001-07-05 US US09/898,007 patent/US6388078B1/en not_active Expired - Fee Related
2002
- 2002-04-10 US US10/118,920 patent/US7060832B2/en not_active Expired - Fee Related
2003
- 2003-01-08 US US10/337,476 patent/US6716983B2/en not_active Expired - Fee Related
2004
- 2004-04-27 KR KR1020040029222A patent/KR100525025B1/ko not_active Expired - Fee Related
- 2004-09-13 KR KR1020040072932A patent/KR100567957B1/ko not_active Expired - Fee Related
2005
- 2005-06-10 KR KR1020050049637A patent/KR100578779B1/ko not_active Expired - Fee Related
- 2005-10-29 KR KR1020050102674A patent/KR100653592B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ID18747A (id)	1998-05-07
ATE332303T1 (de)	2006-07-15
PT1236728E (pt)	2006-10-31
KR100474496B1 (ko)	2005-09-30
US6277992B1 (en)	2001-08-21
MX9708343A (es)	1998-08-30
US6114529A (en)	2000-09-05
ES2205134T3 (es)	2004-05-01
DK1236728T3 (da)	2006-10-30
EP1528062A3 (en)	2007-02-07
HK1050356B (en)	2007-01-19
DE69736308D1 (de)	2006-08-17
US20020161231A1 (en)	2002-10-31
CA2219692C (en)	2007-05-22
ATE247120T1 (de)	2003-08-15
US6716983B2 (en)	2004-04-06
EP1236728A3 (en)	2002-12-18
PT845464E (pt)	2003-12-31
DE69724081T2 (de)	2004-06-09
US20030135049A1 (en)	2003-07-17
KR20060086818A (ko)	2006-08-01
CN1915995A (zh)	2007-02-21
DE69736308T2 (de)	2007-06-14
EP1236728A2 (en)	2002-09-04
EP1236728B1 (en)	2006-07-05
KR100567957B1 (ko)	2006-04-05
SG88737A1 (en)	2002-05-21
CA2533685A1 (en)	1998-04-30
US6015901A (en)	2000-01-18
CN100528879C (zh)	2009-08-19
EP0845464A3 (en)	1999-06-23
KR19980033318A (ko)	1998-07-25
HK1050356A1 (en)	2003-06-20
SG116433A1 (en)	2005-11-28
EP0845464B1 (en)	2003-08-13
ES2267879T3 (es)	2007-03-16
CN1313286A (zh)	2001-09-19
CA2219692A1 (en)	1998-04-30
US6388078B1 (en)	2002-05-14
US5932732A (en)	1999-08-03
KR100578779B1 (ko)	2006-05-12
DE69724081D1 (de)	2003-09-18
CA2533685C (en)	2009-05-26
CN1183414A (zh)	1998-06-03
CN1077109C (zh)	2002-01-02
SG104284A1 (en)	2004-06-21
EP1528062A2 (en)	2005-05-04
US7060832B2 (en)	2006-06-13
EP0845464A2 (en)	1998-06-03
KR100653592B1 (ko)	2006-12-05
KR100525025B1 (ko)	2005-10-31
SG103322A1 (en)	2004-04-29
TW464652B (en)	2001-11-21
CN100473654C (zh)	2009-04-01
HK1011538A1 (en)	1999-07-16

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