DK0851926T3 - Varianter af humant rekombinant gamminterferon (rhu-IFN-gamma) med forøget termisk stabilitet - Google Patents

Varianter af humant rekombinant gamminterferon (rhu-IFN-gamma) med forøget termisk stabilitet

Info

Publication number
DK0851926T3
DK0851926T3 DK96938915T DK96938915T DK0851926T3 DK 0851926 T3 DK0851926 T3 DK 0851926T3 DK 96938915 T DK96938915 T DK 96938915T DK 96938915 T DK96938915 T DK 96938915T DK 0851926 T3 DK0851926 T3 DK 0851926T3
Authority
DK
Denmark
Prior art keywords
gamma
variants
pct
thermal stability
ifn
Prior art date
Application number
DK96938915T
Other languages
Danish (da)
English (en)
Inventor
Gero Waschuetza
Volkhart Li
Bernd Otto
Original Assignee
Fraunhofer Ges Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung filed Critical Fraunhofer Ges Forschung
Application granted granted Critical
Publication of DK0851926T3 publication Critical patent/DK0851926T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK96938915T 1995-09-18 1996-08-15 Varianter af humant rekombinant gamminterferon (rhu-IFN-gamma) med forøget termisk stabilitet DK0851926T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19535853A DE19535853C2 (de) 1995-09-18 1995-09-18 Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung
PCT/DE1996/001556 WO1997011179A2 (fr) 1995-09-18 1996-08-15 VARIANTES DE L'INTERFERON-η (RHU-IFN-η) HUMAIN RECOMBINE A STABILITE THERMIQUE RENFORCEE

Publications (1)

Publication Number Publication Date
DK0851926T3 true DK0851926T3 (da) 2003-08-18

Family

ID=7773265

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96938915T DK0851926T3 (da) 1995-09-18 1996-08-15 Varianter af humant rekombinant gamminterferon (rhu-IFN-gamma) med forøget termisk stabilitet

Country Status (10)

Country Link
US (1) US6046034A (fr)
EP (1) EP0851926B1 (fr)
AT (1) ATE246247T1 (fr)
AU (1) AU7617796A (fr)
CA (1) CA2232264C (fr)
DE (2) DE19535853C2 (fr)
DK (1) DK0851926T3 (fr)
ES (1) ES2203723T3 (fr)
PT (1) PT851926E (fr)
WO (1) WO1997011179A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153943B2 (en) * 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
ES2297889T3 (es) * 1997-07-14 2008-05-01 Bolder Biotechnology, Inc. Derivados de hormona de crecimiento y proteinas relacionadas.
GB9725480D0 (en) * 1997-12-01 1998-01-28 Univ London Cytokines and their use in the treatment of established chronic infections and cancers
CN1309423C (zh) 1999-11-12 2007-04-11 马克西根控股公司 干扰素γ偶联物
CA2390292A1 (fr) * 1999-11-12 2001-05-25 Maxygen Holdings Ltd. Conjugues d'interferon gamma
IL152804A0 (en) * 2000-05-16 2003-06-24 Bolder Biotechnology Inc Methods for refolding proteins containing free cysteine residues
US7038015B2 (en) * 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
CA2491178A1 (fr) * 2002-07-03 2004-01-15 Maxygen Holdings Ltd. Variants polypeptidiques a interferon gamma pleine longueur
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
BRPI0507169A (pt) 2004-02-02 2007-06-26 Ambrx Inc polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
WO2006120580A2 (fr) * 2005-05-04 2006-11-16 Nautilus Biotech Polypeptides d'interferon-gamma modifies et procedes d'utilisation de polypeptides d'interferon-gamma modifies
EP1991679A2 (fr) * 2006-03-08 2008-11-19 Biomethodes Variants de l'interferon- gamma humain (ifngamma)
FR2898359B1 (fr) * 2006-03-08 2011-07-15 Biomethodes Variants ameliores de l'interferon-gamma humain (ifn gamma)
WO2008076933A2 (fr) * 2006-12-14 2008-06-26 Bolder Biotechnology, Inc. Protéines et peptides à action prolongée et procédés de production et d'utilisation de ces derniers
MX344166B (es) 2008-02-08 2016-12-07 Ambrx Inc Leptina-polipeptidos modificados y sus usos.
EP2527424A1 (fr) 2011-05-26 2012-11-28 Richter-Helm Bio Tec GmbH & Co. KG Expression recombinante d'interféron soluble
CN109819650A (zh) 2017-09-25 2019-05-28 春布里泽·格奥尔基·格奥尔基耶维奇 具有抗病毒和抗细菌活性的热稳定组合物及其用途
WO2020028275A1 (fr) * 2018-07-30 2020-02-06 The Board Of Trustees Of The Leland Stanford Junior University Agonistes polarisés par interféron-gamma

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6124599A (ja) * 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd 新規ヒトインタ−フエロン−ｒポリペプチド誘導体
DE3730331A1 (de) * 1987-09-10 1989-03-30 Basf Ag Neue polypeptide, verfahren zur herstellung, die vektoren dafuer und arzneimittel daraus
DE4036855C1 (en) * 1990-11-19 1992-05-27 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De Plasmid DNA (DSM-6237) and expression vectors - encoding human gamma interferon prodn., prepd. by cleavage of c-DNA
DE4036856C1 (fr) * 1990-11-19 1992-05-27 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De

Also Published As

Publication number Publication date
PT851926E (pt) 2003-12-31
DE19535853C2 (de) 1999-04-01
DE59610632D1 (de) 2003-09-04
ATE246247T1 (de) 2003-08-15
ES2203723T3 (es) 2004-04-16
US6046034A (en) 2000-04-04
EP0851926A2 (fr) 1998-07-08
CA2232264C (fr) 2010-04-13
EP0851926B1 (fr) 2003-07-30
AU7617796A (en) 1997-04-09
DE19535853A1 (de) 1997-03-20
CA2232264A1 (fr) 1997-03-27
WO1997011179A3 (fr) 1997-05-09
WO1997011179A2 (fr) 1997-03-27

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