DK0859784T3 - Thiosubstituerede peptider som inhibitorer af metalloproteinaser og TNF-frigivelse - Google Patents

Thiosubstituerede peptider som inhibitorer af metalloproteinaser og TNF-frigivelse

Info

Publication number: DK0859784T3
Authority: DK; Denmark
Prior art keywords: inhibitors; thiosubstituted; metalloproteinases; peptides; tnf release
Prior art date: 1995-10-05

Application number

DK96932722T

Other languages

English (en)

Inventor

Douglas Andrew

Gary John

Alan David

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-05

Filing date

1996-10-04

Publication date

2003-04-22

1995-10-05 Priority claimed from GBGB9520354.3A external-priority patent/GB9520354D0/en

1996-04-04 Priority claimed from GBGB9607126.1A external-priority patent/GB9607126D0/en

1996-10-04 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2003-04-22 Application granted granted Critical

2003-04-22 Publication of DK0859784T3 publication Critical patent/DK0859784T3/da

Links

102000005741 Metalloproteases Human genes 0.000 title abstract 2
108010006035 Metalloproteases Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
108010016626 Dipeptides Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 abstract 1
239000002451 tumor necrosis factor inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Crystallography & Structural Chemistry (AREA)
Immunology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Tropical Medicine & Parasitology (AREA)

DK96932722T 1995-10-05 1996-10-04 Thiosubstituerede peptider som inhibitorer af metalloproteinaser og TNF-frigivelse DK0859784T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9520354.3A GB9520354D0 (en)	1995-10-05	1995-10-05	Compounds
GBGB9607126.1A GB9607126D0 (en)	1996-04-04	1996-04-04	Compounds
PCT/GB1996/002438 WO1997012902A1 (en)	1995-10-05	1996-10-04	Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation

Publications (1)

Publication Number	Publication Date
DK0859784T3 true DK0859784T3 (da)	2003-04-22

Family

ID=26307887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96932722T DK0859784T3 (da)	1995-10-05	1996-10-04	Thiosubstituerede peptider som inhibitorer af metalloproteinaser og TNF-frigivelse

Country Status (20)

Country	Link
US (1)	US5981490A (da)
EP (1)	EP0859784B1 (da)
JP (1)	JPH11512733A (da)
KR (1)	KR100472752B1 (da)
CN (1)	CN1145637C (da)
AT (1)	ATE229972T1 (da)
AU (1)	AU710072B2 (da)
BR (1)	BR9610922A (da)
CA (1)	CA2229434A1 (da)
CZ (1)	CZ289711B6 (da)
DE (1)	DE69625506T2 (da)
DK (1)	DK0859784T3 (da)
ES (1)	ES2186803T3 (da)
HU (1)	HUP0003760A3 (da)
IL (1)	IL123430A (da)
MX (1)	MX9802680A (da)
NO (1)	NO981520D0 (da)
NZ (1)	NZ319222A (da)
PL (1)	PL185312B1 (da)
WO (1)	WO1997012902A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9607120D0 (en) *	1996-04-04	1996-06-12	Chiroscience Ltd	Compounds
US6953788B1 (en)	1996-09-19	2005-10-11	Aventis Pharmaceuticals Inc.	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
CA2280134A1 (en) *	1997-03-03	1998-09-11	David Alan Owen	Selective mmp inhibitors having reduced side-effects
JP2002528461A (ja)	1998-10-23	2002-09-03	ダーウィン・ディスカバリー・リミテッド	公知ペプチドメタロプロテイナーゼインヒビターの単一形態型
NL1013404C2 (nl) *	1999-10-27	2001-05-01	Dsm Nv	Werkwijze voor de bereiding van een dipeptide en tussenproduct in een dergelijke werkwijze.
US6808902B1 (en)	1999-11-12	2004-10-26	Amgen Inc.	Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
WO2001087870A1 (en)	2000-05-15	2001-11-22	Darwin Discovery Limited	Hydroxamic acid derivatives
HUP0304058A2 (hu)	2001-01-30	2004-04-28	Bristol-Myers Squibb Company	Xa faktor szulfonamid-laktám inhibitorok és alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
WO2002088664A2 (en) *	2001-04-26	2002-11-07	Bristol-Myers Squibb Company	Control of compactability through crystallization
CA2451955C (en)	2001-06-26	2015-09-29	Abgenix, Inc.	Antibodies to opgl
AU2002356979A1 (en) *	2001-11-30	2003-06-17	Bristol-Myers Squibb Company	Method of producing n-((2s)-sulfanyl-4-(1,5,5-trimethylhydantoinyl)butanoyl)-l-leucyl-l-tert-leucine n-methylamide and intermediate thereof
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US20060167334A1 (en) *	2003-06-26	2006-07-27	Anstadt Mark P	Method and apparatus for direct mechanical ventricular actuation with favorable conditioning and minimal heart stress
KR100596360B1 (ko) *	2003-07-15	2006-07-03	한국생명공학연구원	항암 활성을 갖는 신규 2-옥소-피페리딘 유도체(ⅰ)화합물을 포함하는 암 질환 치료를 위한 약학 조성물
EP1663201A4 (en) *	2003-07-15	2009-10-28	Korea Res Inst Of Bioscience	USE OF NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
TW200630337A (en) *	2004-10-14	2006-09-01	Euro Celtique Sa	Piperidinyl compounds and the use thereof
US8247442B2 (en)	2006-03-29	2012-08-21	Purdue Pharma L.P.	Benzenesulfonamide compounds and their use
TW200812963A (en)	2006-04-13	2008-03-16	Euro Celtique Sa	Benzenesulfonamide compounds and the use thereof
TW200815353A (en)	2006-04-13	2008-04-01	Euro Celtique Sa	Benzenesulfonamide compounds and their use
US8399486B2 (en) *	2007-04-09	2013-03-19	Purdue Pharma L.P.	Benzenesulfonyl compounds and the use thereof
US8765736B2 (en)	2007-09-28	2014-07-01	Purdue Pharma L.P.	Benzenesulfonamide compounds and the use thereof
CN103254291B (zh) *	2013-05-30	2014-06-25	常州亚当生物技术有限公司	肿瘤坏死因子-α多肽抑制剂及其应用
CN103285373A (zh) *	2013-05-30	2013-09-11	苏州普罗达生物科技有限公司	肿瘤坏死因子-α多肽抑制剂制备及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8311286D0 (en) *	1983-04-26	1983-06-02	Searle & Co	Carboxyalkyl peptide derivatives
EP0358660B1 (en) *	1987-03-17	1994-05-25	Research Corporation Technologies, Inc.	Synthetic inhibitors of mammalian collagenase
DE4311021A1 (de) *	1993-03-31	1994-10-27	Diagnostikforschung Inst	Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel
FI960803L (fi) *	1993-08-23	1996-04-22	Immunex Corp	TNF-alfa-sekreetion inhibiittoreita
GB9323165D0 (en) *	1993-11-10	1994-01-05	Chiros Ltd	Compounds
ES2133807T3 (es) *	1994-10-05	1999-09-16	Darwin Discovery Ltd	Compuestos de peptidilo y su uso terapeutico como inhibidores de metaloproteasas.
AU706064B2 (en) *	1995-05-10	1999-06-10	Darwin Discovery Limited	Peptide compounds which inhibit metalloproteinase and TNF liberation, and their therapeutic use
CA2217859A1 (en) *	1995-05-10	1996-11-14	David Alan Owen	Peptidyl compounds which inhibit metalloproteinase and tnf liberation and their therapeutic use

1996
- 1996-10-04 BR BR9610922-0A patent/BR9610922A/pt unknown
- 1996-10-04 ES ES96932722T patent/ES2186803T3/es not_active Expired - Lifetime
- 1996-10-04 AU AU71398/96A patent/AU710072B2/en not_active Ceased
- 1996-10-04 CA CA002229434A patent/CA2229434A1/en not_active Abandoned
- 1996-10-04 WO PCT/GB1996/002438 patent/WO1997012902A1/en not_active Ceased
- 1996-10-04 DE DE69625506T patent/DE69625506T2/de not_active Expired - Fee Related
- 1996-10-04 NZ NZ319222A patent/NZ319222A/en unknown
- 1996-10-04 IL IL12343096A patent/IL123430A/en not_active IP Right Cessation
- 1996-10-04 PL PL96325824A patent/PL185312B1/pl not_active IP Right Cessation
- 1996-10-04 EP EP96932722A patent/EP0859784B1/en not_active Expired - Lifetime
- 1996-10-04 JP JP9514078A patent/JPH11512733A/ja active Pending
- 1996-10-04 AT AT96932722T patent/ATE229972T1/de not_active IP Right Cessation
- 1996-10-04 US US08/725,781 patent/US5981490A/en not_active Expired - Fee Related
- 1996-10-04 HU HU0003760A patent/HUP0003760A3/hu unknown
- 1996-10-04 CZ CZ19981017A patent/CZ289711B6/cs not_active IP Right Cessation
- 1996-10-04 DK DK96932722T patent/DK0859784T3/da active
- 1996-10-04 KR KR1019980702472A patent/KR100472752B1/ko not_active Expired - Fee Related
- 1996-10-04 CN CNB961974370A patent/CN1145637C/zh not_active Expired - Fee Related
1998
- 1998-04-03 MX MX9802680A patent/MX9802680A/es not_active IP Right Cessation
- 1998-04-03 NO NO981520A patent/NO981520D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0859784B1 (en)	2002-12-18
KR19990063996A (ko)	1999-07-26
CZ101798A3 (cs)	1998-08-12
IL123430A0 (en)	1998-09-24
CN1145637C (zh)	2004-04-14
NO981520L (no)	1998-04-03
JPH11512733A (ja)	1999-11-02
ATE229972T1 (de)	2003-01-15
PL185312B1 (pl)	2003-04-30
HUP0003760A3 (en)	2001-05-28
DE69625506D1 (de)	2003-01-30
NZ319222A (en)	1999-09-29
US5981490A (en)	1999-11-09
CN1198747A (zh)	1998-11-11
WO1997012902A1 (en)	1997-04-10
CA2229434A1 (en)	1997-04-10
EP0859784A1 (en)	1998-08-26
MX9802680A (es)	1998-11-30
AU7139896A (en)	1997-04-28
NO981520D0 (no)	1998-04-03
ES2186803T3 (es)	2003-05-16
IL123430A (en)	2001-04-30
AU710072B2 (en)	1999-09-16
KR100472752B1 (ko)	2006-01-27
BR9610922A (pt)	1999-12-21
PL325824A1 (en)	1998-08-03
CZ289711B6 (cs)	2002-03-13
DE69625506T2 (de)	2003-07-24
HUP0003760A2 (hu)	2001-04-28

Publication	Publication Date	Title
NO981520D0 (no)	1998-04-03	Tiosubstituerte peptider som inhibitorer for metalloproteinaser og TNF-frigjöring
DK0784629T3 (da)	1999-10-25	Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteaser
FI973360A0 (fi)	1997-08-15	Uusia dipeptidisiä amidiineja trombiininestäjiksi
DK0923585T3 (da)	2002-07-01	Phosphinatbaserede inhibitorer af matrixmetalloproteinaser
DK0938471T3 (da)	2002-01-28	Fremstillingen og anvendelsen af ortho-sulfonamido-arylhydroxamsyrer som matrix-metalloproteinase- og TACE-inhibitorer
NO20006716D0 (no)	2000-12-29	Proteaseinhibitorer
NO990548D0 (no)	1999-02-05	Inhibitorer for cystein-protease
ATE241998T1 (de)	2003-06-15	Multikatalytische protease-inhibitoren
EA199900162A1 (ru)	1999-10-28	Ингибиторы клеточной адгезии
DK0873312T3 (da)	2002-10-07	Alfa-substituerede arylsulfonamidohydroxamsyrer som TNF-alfa- og matrix-metalloproteinaseinhibitorer
NO975742D0 (no)	1997-12-05	Reversible cysteinproteasehemmere
NO992492D0 (no)	1999-05-25	Benzamidoaldehyder og deres anvendelse som cystein-protease-inhibitorer
DK1097173T3 (da)	2008-09-01	Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
DK0944590T3 (da)	2002-07-15	Aminoguanidiner og alkoxyguanidiner som proteaseinhibitorer
NO986180D0 (no)	1998-12-29	Nye amidinoderivater og deres anvendelse som trombininhibitorer
NO996313L (no)	2000-02-21	Nye amidinoderivater og deres anvendelse som trombininhibitorer
BR0110902A (pt)	2003-12-30	Inibidores de mmp-9/mmp-2
NO20001548D0 (no)	2000-03-24	Endotelinantagonist og en renin-angiotensinsystem inhibitor som et kombinert preparat
ATE258063T1 (de)	2004-02-15	Selektive mmp inhibitoren mit verringerten nebenwirkungen
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