ATE241998T1 - Multikatalytische protease-inhibitoren - Google Patents

Multikatalytische protease-inhibitoren

Info

Publication number: ATE241998T1
Authority: AT; Austria
Prior art keywords: protease inhibitors; multicatalytic protease; disclosed; constituent members; multicatalytic
Prior art date: 1994-11-14

Application number

AT95939165T

Other languages

English (en)

Inventor

Mohamed Iqbal

James Diebold

Robert Siman

Sankar Chatterjee

James C Kauer

Original Assignee

Cephalon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-14

Filing date

1995-11-14

Publication date

2003-06-15

1994-11-14 Priority claimed from US08/337,795 external-priority patent/US5550262A/en

1995-11-14 Application filed by Cephalon Inc filed Critical Cephalon Inc

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241998T1 publication Critical patent/ATE241998T1/de

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
239000000470 constituent Substances 0.000 abstract 2
108091005804 Peptidases Proteins 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
- C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Crystallography & Structural Chemistry (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Macromonomer-Based Addition Polymer (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

AT95939165T 1994-11-14 1995-11-14 Multikatalytische protease-inhibitoren ATE241998T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/337,795 US5550262A (en)	1994-11-14	1994-11-14	Multicatalytic protease inhibitors
US46439895A	1995-06-05	1995-06-05
US08/552,794 US5614649A (en)	1994-11-14	1995-11-03	Multicatalytic protease inhibitors
PCT/US1995/014921 WO1996014857A1 (en)	1994-11-14	1995-11-14	Multicatalytic protease inhibitors

Publications (1)

Publication Number	Publication Date
ATE241998T1 true ATE241998T1 (de)	2003-06-15

Family

ID=27407222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95939165T ATE241998T1 (de)	1994-11-14	1995-11-14	Multikatalytische protease-inhibitoren

Country Status (17)

Country	Link
US (3)	US5614649A (de)
EP (1)	EP0789578B1 (de)
JP (2)	JP3056258B2 (de)
KR (1)	KR100420774B1 (de)
CN (1)	CN1166403C (de)
AT (1)	ATE241998T1 (de)
BR (1)	BR9509665A (de)
CA (1)	CA2202760A1 (de)
DE (1)	DE69530993T2 (de)
DK (1)	DK0789578T3 (de)
ES (1)	ES2200010T3 (de)
FI (1)	FI118325B (de)
MX (1)	MX9703564A (de)
NO (1)	NO324066B1 (de)
NZ (1)	NZ296479A (de)
PT (1)	PT789578E (de)
WO (1)	WO1996014857A1 (de)

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US6214800B1 (en)	1995-10-25	2001-04-10	Senju Pharmaceutical Co., Ltd.	Angiogenesis inhibitor
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EP2823812A1 (de) *	1998-02-02	2015-01-14	Trustees Of Tufts College	Dipeptidylpeptidase-IV-Hemmer zur Behandlung von Typ-II Diabetes
US6096711A (en) *	1998-02-25	2000-08-01	Sherman; Michael	Hsp72 induction and applications
AU762373B2 (en)	1998-10-20	2003-06-26	Millennium Pharmaceuticals, Inc.	Method for monitoring proteasome inhibitor drug action
US20030054977A1 (en) *	1999-10-12	2003-03-20	Cell Therapeutics, Inc.	Manufacture of polyglutamate-therapeutic agent conjugates
US6358928B1 (en)	1999-11-22	2002-03-19	Enzyme Systems Products	Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases
GB0003111D0 (en) *	2000-02-10	2000-03-29	Novartis Ag	Organic compounds
PT3078667T (pt)	2001-01-25	2018-12-28	The United States Of America Represented By The Sec Dep Of Health And Human Services	Formulação de compostos de ácido borónico
CA2446282A1 (en)	2001-05-30	2002-12-05	Novartis Ag	2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives
EP1487471A4 (de)	2001-11-26	2010-03-10	Tufts College	Verfahren zur behandlung von autoimmunkrankheiten und damit zusammenhängende reagentien
EP2316470A3 (de)	2001-11-26	2011-08-24	Trustees Of Tufts College	Peptidomimetikuminhibitoren von post-Prolin-spaltenden Enzymen
US7223745B2 (en) *	2003-08-14	2007-05-29	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
US7576206B2 (en) *	2003-08-14	2009-08-18	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
US7468383B2 (en) *	2005-02-11	2008-12-23	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
FR2914920B1 (fr)	2007-04-11	2011-09-09	Clariant Specialty Fine Chem F	Procede de deacetalisation d'alpha-aminoacetals.
LT2494993T (lt) *	2007-05-04	2018-12-27	Marina Biotech, Inc.	Aminorūgščių lipidai ir jų panaudojimas
FR2916441B1 (fr)	2007-05-22	2009-08-28	Clariant Specialty Fine Chem	Procede de racemisation d'alpha-aminoacetals optiquement actifs.
US7442830B1 (en)	2007-08-06	2008-10-28	Millenium Pharmaceuticals, Inc.	Proteasome inhibitors
FR2927900B1 (fr)	2008-02-27	2010-09-17	Clariant Specialty Fine Chem	Procede de preparation d'alpha-aminoacetals optiquement actifs.
HRP20150592T4 (hr)	2008-06-17	2025-02-14	Millennium Pharmaceuticals, Inc	Organoborni esterski spojevi i njihove farmaceutske kompozicije
AU2009282117B2 (en)	2008-08-11	2016-05-12	Banyan Biomarkers, Inc.	Biomarker detection process and assay of neurological condition
US12601749B2 (en)	2008-08-11	2026-04-14	Banyan Biomarkers, Inc.	Biomarker detection process and assay of neurological condition
AR075090A1 (es)	2008-09-29	2011-03-09	Millennium Pharm Inc	Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
KR20120082906A (ko)	2009-09-30	2012-07-24	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	자가포식현상-향상 유전자 생성물의 조절을 통한 자가포식현상의 조절 방법
WO2011087822A1 (en)	2009-12-22	2011-07-21	Cephalon, Inc.	Proteasome inhibitors and processes for their preparation, purification and use
US8354548B2 (en) *	2010-02-19	2013-01-15	Bristol-Myers Squibb Company	Glycine chroman-6-sulfonamides for use as inhibitors of diacylglycerol lipase
JP5933523B2 (ja)	2010-03-31	2016-06-08	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	１−アミノ−２−シクロプロピルエチルボロン酸の誘導体
SG10202003693RA (en)	2014-05-20	2020-05-28	Millennium Pharm Inc	Boron-containing proteasome inhibitors for use after primary cancer therapy
WO2015195950A1 (en) *	2014-06-20	2015-12-23	Principia Biophamram Inc.	Lmp7 inhibitors
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US5614649A (en) *	1994-11-14	1997-03-25	Cephalon, Inc.	Multicatalytic protease inhibitors

1995
- 1995-11-03 US US08/552,794 patent/US5614649A/en not_active Expired - Lifetime
- 1995-11-14 NZ NZ296479A patent/NZ296479A/xx not_active IP Right Cessation
- 1995-11-14 ES ES95939165T patent/ES2200010T3/es not_active Expired - Lifetime
- 1995-11-14 CA CA002202760A patent/CA2202760A1/en not_active Abandoned
- 1995-11-14 CN CNB951962043A patent/CN1166403C/zh not_active Expired - Fee Related
- 1995-11-14 WO PCT/US1995/014921 patent/WO1996014857A1/en not_active Ceased
- 1995-11-14 EP EP95939165A patent/EP0789578B1/de not_active Expired - Lifetime
- 1995-11-14 MX MX9703564A patent/MX9703564A/es not_active IP Right Cessation
- 1995-11-14 JP JP8516336A patent/JP3056258B2/ja not_active Expired - Fee Related
- 1995-11-14 PT PT95939165T patent/PT789578E/pt unknown
- 1995-11-14 DE DE69530993T patent/DE69530993T2/de not_active Expired - Lifetime
- 1995-11-14 BR BR9509665A patent/BR9509665A/pt not_active IP Right Cessation
- 1995-11-14 KR KR1019970703228A patent/KR100420774B1/ko not_active Expired - Fee Related
- 1995-11-14 AT AT95939165T patent/ATE241998T1/de not_active IP Right Cessation
- 1995-11-14 DK DK95939165T patent/DK0789578T3/da active
1996
- 1996-12-04 US US08/760,638 patent/US5830870A/en not_active Expired - Fee Related
1997
- 1997-03-13 US US08/816,510 patent/US5990083A/en not_active Expired - Fee Related
- 1997-05-07 NO NO19972104A patent/NO324066B1/no not_active IP Right Cessation
- 1997-05-13 FI FI972029A patent/FI118325B/fi not_active IP Right Cessation
2000
- 2000-01-11 JP JP2000002705A patent/JP2000290197A/ja active Pending

Also Published As

Publication number	Publication date
ES2200010T3 (es)	2004-03-01
FI972029A0 (fi)	1997-05-13
NO972104D0 (no)	1997-05-07
EP0789578A1 (de)	1997-08-20
US5830870A (en)	1998-11-03
NZ296479A (en)	1999-06-29
JP3056258B2 (ja)	2000-06-26
PT789578E (pt)	2003-10-31
FI118325B (fi)	2007-10-15
BR9509665A (pt)	1997-10-28
US5614649A (en)	1997-03-25
JPH10507465A (ja)	1998-07-21
FI972029L (fi)	1997-05-13
DK0789578T3 (da)	2003-09-22
CN1166403C (zh)	2004-09-15
EP0789578B1 (de)	2003-06-04
DE69530993D1 (de)	2003-07-10
MX9703564A (es)	1997-08-30
AU4110496A (en)	1996-06-06
CN1164192A (zh)	1997-11-05
CA2202760A1 (en)	1996-05-23
NO972104L (no)	1997-06-13
HK1004638A1 (en)	1998-11-13
US5990083A (en)	1999-11-23
AU710437B2 (en)	1999-09-23
KR100420774B1 (ko)	2004-07-05
NO324066B1 (no)	2007-08-06
DE69530993T2 (de)	2004-05-19
EP0789578A4 (de)	2000-09-20
WO1996014857A1 (en)	1996-05-23
JP2000290197A (ja)	2000-10-17

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