DK0868424T3 - 4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler - Google Patents

4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler

Info

Publication number: DK0868424T3
Authority: DK; Denmark
Prior art keywords: pyrimidinyl; pyrazinyl; piperazinyl; preparation; antibacterial agents
Prior art date: 1995-12-13

Application number

DK96944212T

Other languages

English (en)

Inventor

John A Tucker

Steven Joseph Brickner

Debra A Ulanowicz

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-13

Filing date

1996-12-09

Publication date

2003-05-19

1996-12-09 Application filed by Upjohn Co filed Critical Upjohn Co

2003-05-19 Application granted granted Critical

2003-05-19 Publication of DK0868424T3 publication Critical patent/DK0868424T3/da

Links

125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 title abstract 2
GERHANPDTFFPHR-UHFFFAOYSA-N 3-phenyl-4-(4-pyrazin-2-ylpiperazin-1-yl)-1,3-oxazolidin-2-one Chemical class O=C1OCC(N2CCN(CC2)C=2N=CC=NC=2)N1C1=CC=CC=C1 GERHANPDTFFPHR-UHFFFAOYSA-N 0.000 title 1
239000003242 anti bacterial agent Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
239000004599 antimicrobial Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 abstract 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK96944212T 1995-12-13 1996-12-09 4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler DK0868424T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US855495P	1995-12-13	1995-12-13
PCT/US1996/019149 WO1997021708A1 (en)	1995-12-13	1996-12-09	4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinone derivatives, their preparation and their use as anti-bacterial agents

Publications (1)

Publication Number	Publication Date
DK0868424T3 true DK0868424T3 (da)	2003-05-19

Family

ID=21732266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96944212T DK0868424T3 (da)	1995-12-13	1996-12-09	4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler

Country Status (15)

Country	Link
US (1)	US5719154A (da)
EP (1)	EP0868424B1 (da)
JP (1)	JP2000501731A (da)
KR (1)	KR19990072109A (da)
AT (1)	ATE232530T1 (da)
AU (1)	AU703784B2 (da)
CA (1)	CA2236677C (da)
DE (1)	DE69626218T2 (da)
DK (1)	DK0868424T3 (da)
ES (1)	ES2192235T3 (da)
PT (1)	PT868424E (da)
SI (1)	SI0868424T1 (da)
TW (1)	TW403749B (da)
WO (1)	WO1997021708A1 (da)
ZA (1)	ZA969622B (da)

Families Citing this family (36)

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GB9601666D0 (en) *	1996-01-27	1996-03-27	Zeneca Ltd	Chemical compounds
GB9702213D0 (en) *	1996-02-24	1997-03-26	Zeneca Ltd	Chemical compounds
GB9609919D0 (en) *	1996-05-11	1996-07-17	Zeneca Ltd	Chemical compounds
GB9614238D0 (en) *	1996-07-06	1996-09-04	Zeneca Ltd	Chemical compounds
US6037354A (en) *	1997-06-18	2000-03-14	Merck & Co., Inc.	Alpha 1a adrenergic receptor antagonists
GB9717804D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
GB9717807D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
GB9725244D0 (en)	1997-11-29	1998-01-28	Zeneca Ltd	Chemical compounds
BR9907183A (pt) *	1998-01-23	2003-06-10	Versicor Inc	Colet neas combinatórias de oxazolidinona, composições e processos de preparação
US7002020B1 (en)	1998-01-23	2006-02-21	Pharmacia & Upjohn Company	Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en)	1998-01-23	2003-05-13	Pharmacia & Upjohn Company	Oxazolidinone combinatorial libraries, compositions and methods of preparation
JP2002503655A (ja) *	1998-02-13	2002-02-05	ファルマシア・アンド・アップジョン・カンパニー	抗菌剤として有用な置換アミノフェニルイソオキサゾリン誘導体
WO1999064417A2 (en)	1998-06-05	1999-12-16	Astrazeneca Ab	Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
EP1147422A1 (en)	1999-01-27	2001-10-24	Pharmacia & Upjohn Company	Assays for modulators of "elongation factor p" activity
KR100333493B1 (ko) *	1999-05-27	2002-04-25	박호군	이소옥사졸릴 카르보닐 옥사졸리디논 유도체 및 이의 제조방법
KR100333492B1 (ko) *	1999-05-27	2002-04-25	박호군	이소옥사졸릴 메틸렌 옥사졸리디논 유도체 및 이의 제조방법
GB9928568D0 (en)	1999-12-03	2000-02-02	Zeneca Ltd	Chemical compounds
GB0009803D0 (en) *	2000-04-25	2000-06-07	Astrazeneca Ab	Chemical compounds
KR100674096B1 (ko) *	2000-06-05	2007-01-26	동아제약주식회사	피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법
GB0118407D0 (en) *	2001-07-27	2001-09-19	Cipla Ltd	Oxazolidinone derivatives as antibacterial agents
US7125568B2 (en)	2001-08-23	2006-10-24	Sung Michael T	Lipophilic drug compositions
US20050119251A1 (en) *	2001-12-21	2005-06-02	Jian-Min Fu	Nicotinamide derivatives and their use as therapeutic agents
BR0215921A (pt) *	2002-07-29	2005-09-13	Ranbaxy Lab Ltd	Derivados de oxazolidinona utilizáveis como antimicrobianos e processo de sua preparação
WO2004026848A1 (en) *	2002-09-20	2004-04-01	Lupin Limited	Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
ATE344036T1 (de)	2002-11-21	2006-11-15	Pharmacia & Upjohn Co Llc	N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
GB0229521D0 (en) *	2002-12-19	2003-01-22	Astrazeneca Ab	Chemical compounds
BRPI0515482A (pt)	2004-09-20	2008-07-22	Xenon Pharmaceuticals Inc	derivados heterocìclicos e seus usos como agentes terapêuticos
EP1827438B2 (en) *	2004-09-20	2014-12-10	Xenon Pharmaceuticals Inc.	Piperazin derivatives for inhibiting human stearoyl-coa-desaturase
MX2007003332A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
AU2005286790A1 (en) *	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD)
CN101084211A (zh)	2004-09-20	2007-12-05	泽农医药公司	杂环衍生物及其作为治疗剂的用途
MX2007003318A (es)	2004-09-20	2007-05-18	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
AU2005286728A1 (en) *	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
AU2005286647A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
BRPI0515500A (pt) *	2004-09-20	2008-07-29	Xenon Pharmaceuticals Inc	derivados piridazina para inibição de estearoil-coa-desaturase
CA2618646A1 (en) *	2005-06-03	2007-11-15	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0610265B1 (en) *	1991-11-01	1996-12-27	PHARMACIA & UPJOHN COMPANY	Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) *	1992-05-08	2003-07-01	Pharmacia & Upjohn Company	Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
US5556873A (en) *	1993-02-24	1996-09-17	Rhone-Poulenc Inc.	Pesticidal 1-aryl-5-(substituted alkyl (thio) amido)pyrazoles
CA2174107C (en) *	1993-11-22	2005-04-12	Steven J. Brickner	Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
US5609996A (en) *	1996-02-29	1997-03-11	Eastman Kodak Company	Photographic emulsion layer containing pyrazoloazole coupler exhibiting improved dye light fade
GB9614238D0 (en) *	1996-07-06	1996-09-04	Zeneca Ltd	Chemical compounds

1996
- 1996-11-15 ZA ZA9609622A patent/ZA969622B/xx unknown
- 1996-11-27 TW TW085114663A patent/TW403749B/zh not_active IP Right Cessation
- 1996-12-09 DK DK96944212T patent/DK0868424T3/da active
- 1996-12-09 KR KR1019980704424A patent/KR19990072109A/ko not_active Ceased
- 1996-12-09 JP JP09522076A patent/JP2000501731A/ja not_active Withdrawn
- 1996-12-09 EP EP96944212A patent/EP0868424B1/en not_active Expired - Lifetime
- 1996-12-09 SI SI9630589T patent/SI0868424T1/xx unknown
- 1996-12-09 US US08/762,478 patent/US5719154A/en not_active Expired - Fee Related
- 1996-12-09 AU AU14077/97A patent/AU703784B2/en not_active Ceased
- 1996-12-09 AT AT96944212T patent/ATE232530T1/de not_active IP Right Cessation
- 1996-12-09 WO PCT/US1996/019149 patent/WO1997021708A1/en not_active Ceased
- 1996-12-09 PT PT96944212T patent/PT868424E/pt unknown
- 1996-12-09 ES ES96944212T patent/ES2192235T3/es not_active Expired - Lifetime
- 1996-12-09 CA CA002236677A patent/CA2236677C/en not_active Expired - Fee Related
- 1996-12-09 DE DE69626218T patent/DE69626218T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU1407797A (en)	1997-07-03
AU703784B2 (en)	1999-04-01
DE69626218D1 (de)	2003-03-20
SI0868424T1 (en)	2003-08-31
ATE232530T1 (de)	2003-02-15
US5719154A (en)	1998-02-17
DE69626218T2 (de)	2003-08-14
EP0868424B1 (en)	2003-02-12
ZA969622B (en)	1998-05-15
EP0868424A1 (en)	1998-10-07
WO1997021708A1 (en)	1997-06-19
TW403749B (en)	2000-09-01
CA2236677C (en)	2005-05-03
JP2000501731A (ja)	2000-02-15
PT868424E (pt)	2003-06-30
KR19990072109A (ko)	1999-09-27
ES2192235T3 (es)	2003-10-01
CA2236677A1 (en)	1997-06-19

Publication	Publication Date	Title
DK0868424T3 (da)	2003-05-19	4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler
DK0865281T3 (da)	2002-07-29	Naphthylsubstituerede benzimidazolderivater som antikoagulerende midler
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
MXPA02004440A (es)	2004-09-10	Derivados de pirrol como inhibidores de la fosfodiesterasa vii.
ATE231859T1 (de)	2003-02-15	Tetrahydrothiopyran-phenyloxazolidinon-s-oxide
ES2161713T3 (es)	2001-12-16	Derivado de metotrexato.
DK0903347T3 (da)	2005-11-21	Hidtil ukendte cyclodepsipeptid PF1022-derivater
DK0752854T3 (da)	2001-10-08	Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel
ATE223411T1 (de)	2002-09-15	1-methylcarbapenem-derivate
EP0676399A4 (en)	1996-04-17	METHOTREXATE DERIVATIVES.
DE69900297D1 (de)	2001-10-25	Akarizid und insektizid wirksame, substituierte Pyrimidine und Verfahren zu ihrer Herstellung
DE69533573D1 (de)	2004-11-04	Anxiolytischer wirkstoff
ATE206125T1 (de)	2001-10-15	Furoindolizine
DK1433480T3 (da)	2011-04-11	Lægemiddel indeholdende pyrimidin-derivat
MX9704976A (es)	1998-01-31	Derivados de 1,2,3-benzotiadiazol.