DK0868424T3 - 4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler - Google Patents

4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler

Info

Publication number: DK0868424T3
Authority: DK; Denmark
Prior art keywords: pyrimidinyl; pyrazinyl; piperazinyl; preparation; antibacterial agents
Prior art date: 1995-12-13

Application number

DK96944212T

Other languages

English (en)

Inventor

John A Tucker

Steven Joseph Brickner

Debra A Ulanowicz

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-13

Filing date

1996-12-09

Publication date

2003-05-19

1996-12-09 Application filed by Upjohn Co filed Critical Upjohn Co

2003-05-19 Application granted granted Critical

2003-05-19 Publication of DK0868424T3 publication Critical patent/DK0868424T3/da

Links

125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 title abstract 2
GERHANPDTFFPHR-UHFFFAOYSA-N 3-phenyl-4-(4-pyrazin-2-ylpiperazin-1-yl)-1,3-oxazolidin-2-one Chemical class O=C1OCC(N2CCN(CC2)C=2N=CC=NC=2)N1C1=CC=CC=C1 GERHANPDTFFPHR-UHFFFAOYSA-N 0.000 title 1
239000003242 anti bacterial agent Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
239000004599 antimicrobial Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 abstract 1
125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK96944212T 1995-12-13 1996-12-09 4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler DK0868424T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US855495P	1995-12-13	1995-12-13
PCT/US1996/019149 WO1997021708A1 (en)	1995-12-13	1996-12-09	4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinone derivatives, their preparation and their use as anti-bacterial agents

Publications (1)

Publication Number	Publication Date
DK0868424T3 true DK0868424T3 (da)	2003-05-19

Family

ID=21732266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96944212T DK0868424T3 (da)	1995-12-13	1996-12-09	4-Pyrimidinyl- eller 4-pyrazinyl-piperazinyl-phenyloxazolidinonderivater, fremstilling deraf og anvendelse deraf som antibakterielle midler

Country Status (15)

Country	Link
US (1)	US5719154A (da)
EP (1)	EP0868424B1 (da)
JP (1)	JP2000501731A (da)
KR (1)	KR19990072109A (da)
AT (1)	ATE232530T1 (da)
AU (1)	AU703784B2 (da)
CA (1)	CA2236677C (da)
DE (1)	DE69626218T2 (da)
DK (1)	DK0868424T3 (da)
ES (1)	ES2192235T3 (da)
PT (1)	PT868424E (da)
SI (1)	SI0868424T1 (da)
TW (1)	TW403749B (da)
WO (1)	WO1997021708A1 (da)
ZA (1)	ZA969622B (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9601666D0 (en) *	1996-01-27	1996-03-27	Zeneca Ltd	Chemical compounds
GB9702213D0 (en)	1996-02-24	1997-03-26	Zeneca Ltd	Chemical compounds
GB9609919D0 (en)	1996-05-11	1996-07-17	Zeneca Ltd	Chemical compounds
GB9614238D0 (en) *	1996-07-06	1996-09-04	Zeneca Ltd	Chemical compounds
US6037354A (en) *	1997-06-18	2000-03-14	Merck & Co., Inc.	Alpha 1a adrenergic receptor antagonists
GB9717804D0 (en)	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
GB9717807D0 (en) *	1997-08-22	1997-10-29	Zeneca Ltd	Chemical compounds
GB9725244D0 (en)	1997-11-29	1998-01-28	Zeneca Ltd	Chemical compounds
US6562844B2 (en)	1998-01-23	2003-05-13	Pharmacia & Upjohn Company	Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en)	1998-01-23	2006-02-21	Pharmacia & Upjohn Company	Oxazolidinone combinatorial libraries, compositions and methods of preparation
WO1999037630A1 (en) *	1998-01-23	1999-07-29	Versicor, Inc.	Oxazolidinone combinatorial libraries, compositions and methods of preparation
DK1054874T3 (da) *	1998-02-13	2002-12-30	Upjohn Co	Substituerede aminophenylisoxazolinderivater, der er anvendelige som antimokrobielle midler
KR20010052615A (ko)	1998-06-05	2001-06-25	다비드 에 질레스	옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물
EP1147422A1 (en)	1999-01-27	2001-10-24	Pharmacia & Upjohn Company	Assays for modulators of "elongation factor p" activity
KR100333492B1 (ko) *	1999-05-27	2002-04-25	박호군	이소옥사졸릴 메틸렌 옥사졸리디논 유도체 및 이의 제조방법
KR100333493B1 (ko) *	1999-05-27	2002-04-25	박호군	이소옥사졸릴 카르보닐 옥사졸리디논 유도체 및 이의 제조방법
GB9928568D0 (en)	1999-12-03	2000-02-02	Zeneca Ltd	Chemical compounds
GB0009803D0 (en) *	2000-04-25	2000-06-07	Astrazeneca Ab	Chemical compounds
KR100674096B1 (ko) *	2000-06-05	2007-01-26	동아제약주식회사	피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법
GB0118407D0 (en) *	2001-07-27	2001-09-19	Cipla Ltd	Oxazolidinone derivatives as antibacterial agents
US7125568B2 (en)	2001-08-23	2006-10-24	Sung Michael T	Lipophilic drug compositions
US20050119251A1 (en) *	2001-12-21	2005-06-02	Jian-Min Fu	Nicotinamide derivatives and their use as therapeutic agents
CN1668308A (zh) *	2002-07-29	2005-09-14	兰贝克赛实验室有限公司	作为抗菌剂的噁唑烷酮衍生物
AU2002339721A1 (en) *	2002-09-20	2004-04-08	Lupin Limited	Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
WO2004045616A1 (en)	2002-11-21	2004-06-03	Pharmacia & Upjohn Company Llc	N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents
GB0229521D0 (en) *	2002-12-19	2003-01-22	Astrazeneca Ab	Chemical compounds
US20080167321A1 (en) *	2004-09-20	2008-07-10	Xenon Pharmaceuticals Inc.	Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase
MX2007003327A (es) *	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
JP4958786B2 (ja)	2004-09-20	2012-06-20	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体および治療薬としてのそれらの使用
EP1799667B1 (en) *	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as therapeutic agents
MX2007003332A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
MX2007003319A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
EP2269610A3 (en)	2004-09-20	2011-03-09	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7547698B2 (en) *	2004-09-20	2009-06-16	Xenon Pharmaceuticals Inc.	Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD)
EP2289510A1 (en)	2004-09-20	2011-03-02	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
BRPI0611187A2 (pt)	2005-06-03	2010-08-24	Xenon Pharmaceuticals Inc	derivados aminotiazàis como inibidores da estearoil-coa desaturase humana

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU667198B2 (en) *	1991-11-01	1996-03-14	Pharmacia & Upjohn Company	Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) *	1992-05-08	2003-07-01	Pharmacia & Upjohn Company	Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
US5556873A (en) *	1993-02-24	1996-09-17	Rhone-Poulenc Inc.	Pesticidal 1-aryl-5-(substituted alkyl (thio) amido)pyrazoles
JP3698724B2 (ja) *	1993-11-22	2005-09-21	ファルマシア・アンド・アップジョン・カンパニー	置換−ヒドロキシアセチルピペラジンフェニルオキサゾリジノンのエステル
US5609996A (en) *	1996-02-29	1997-03-11	Eastman Kodak Company	Photographic emulsion layer containing pyrazoloazole coupler exhibiting improved dye light fade
GB9614238D0 (en) *	1996-07-06	1996-09-04	Zeneca Ltd	Chemical compounds

1996
- 1996-11-15 ZA ZA9609622A patent/ZA969622B/xx unknown
- 1996-11-27 TW TW085114663A patent/TW403749B/zh not_active IP Right Cessation
- 1996-12-09 SI SI9630589T patent/SI0868424T1/xx unknown
- 1996-12-09 DE DE69626218T patent/DE69626218T2/de not_active Expired - Fee Related
- 1996-12-09 JP JP09522076A patent/JP2000501731A/ja not_active Withdrawn
- 1996-12-09 DK DK96944212T patent/DK0868424T3/da active
- 1996-12-09 EP EP96944212A patent/EP0868424B1/en not_active Expired - Lifetime
- 1996-12-09 AU AU14077/97A patent/AU703784B2/en not_active Ceased
- 1996-12-09 US US08/762,478 patent/US5719154A/en not_active Expired - Fee Related
- 1996-12-09 KR KR1019980704424A patent/KR19990072109A/ko not_active Ceased
- 1996-12-09 PT PT96944212T patent/PT868424E/pt unknown
- 1996-12-09 ES ES96944212T patent/ES2192235T3/es not_active Expired - Lifetime
- 1996-12-09 AT AT96944212T patent/ATE232530T1/de not_active IP Right Cessation
- 1996-12-09 WO PCT/US1996/019149 patent/WO1997021708A1/en not_active Ceased
- 1996-12-09 CA CA002236677A patent/CA2236677C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE232530T1 (de)	2003-02-15
DE69626218T2 (de)	2003-08-14
CA2236677A1 (en)	1997-06-19
EP0868424B1 (en)	2003-02-12
DE69626218D1 (de)	2003-03-20
US5719154A (en)	1998-02-17
AU703784B2 (en)	1999-04-01
PT868424E (pt)	2003-06-30
SI0868424T1 (en)	2003-08-31
AU1407797A (en)	1997-07-03
EP0868424A1 (en)	1998-10-07
TW403749B (en)	2000-09-01
CA2236677C (en)	2005-05-03
ZA969622B (en)	1998-05-15
WO1997021708A1 (en)	1997-06-19
JP2000501731A (ja)	2000-02-15
ES2192235T3 (es)	2003-10-01
KR19990072109A (ko)	1999-09-27

Publication	Publication Date	Title
PT868424E (pt)	2003-06-30	Derivados de 4-pirimidinil- ou 4-pirazinil-piperazinilfeniloxazolidinona sua preparacao e sua utilizacao como agentes antibacterianos
DK0865281T3 (da)	2002-07-29	Naphthylsubstituerede benzimidazolderivater som antikoagulerende midler
CO5280078A1 (es)	2003-05-30	Compuestos
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
MXPA02004440A (es)	2004-09-10	Derivados de pirrol como inhibidores de la fosfodiesterasa vii.
ATE231859T1 (de)	2003-02-15	Tetrahydrothiopyran-phenyloxazolidinon-s-oxide
ES2161713T3 (es)	2001-12-16	Derivado de metotrexato.
DK0903347T3 (da)	2005-11-21	Hidtil ukendte cyclodepsipeptid PF1022-derivater
DK0752854T3 (da)	2001-10-08	Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel
DE69623497D1 (de)	2002-10-10	1-methylcarbapenem-derivate
EP0676399A4 (en)	1996-04-17	METHOTREXATE DERIVATIVES.
DE69900297D1 (de)	2001-10-25	Akarizid und insektizid wirksame, substituierte Pyrimidine und Verfahren zu ihrer Herstellung
DE69533573D1 (de)	2004-11-04	Anxiolytischer wirkstoff
ATE206125T1 (de)	2001-10-15	Furoindolizine
DK1433480T3 (da)	2011-04-11	Lægemiddel indeholdende pyrimidin-derivat
MX9704976A (es)	1998-01-31	Derivados de 1,2,3-benzotiadiazol.