DK0869946T3 - Phenylimidazolidiner og deres anvendelse som anti-androgent middel - Google Patents

Phenylimidazolidiner og deres anvendelse som anti-androgent middel

Info

Publication number: DK0869946T3
Authority: DK; Denmark
Prior art keywords: phenylimidazolidines; represent; androgen agents; substituted; androgen
Prior art date: 1995-12-22

Application number

DK96942431T

Other languages

English (en)

Inventor

Andre Claussner

Francois Goubet

Jean-Georges Teutsch

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-22

Filing date

1996-12-19

Publication date

2002-02-18

1996-12-19 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-02-18 Application granted granted Critical

2002-02-18 Publication of DK0869946T3 publication Critical patent/DK0869946T3/da

Links

TVPNGVPSNXPYLT-UHFFFAOYSA-N 1-phenylimidazolidine Chemical class C1NCCN1C1=CC=CC=C1 TVPNGVPSNXPYLT-UHFFFAOYSA-N 0.000 title 1
239000000051 antiandrogen Substances 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK96942431T 1995-12-22 1996-12-19 Phenylimidazolidiner og deres anvendelse som anti-androgent middel DK0869946T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9515323A FR2742749B1 (fr)	1995-12-22	1995-12-22	Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
PCT/FR1996/002029 WO1997023464A1 (fr)	1995-12-22	1996-12-19	Phenylimidazolidines et leur utilisation comme agent anti-androgene

Publications (1)

Publication Number	Publication Date
DK0869946T3 true DK0869946T3 (da)	2002-02-18

Family

ID=9485838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96942431T DK0869946T3 (da)	1995-12-22	1996-12-19	Phenylimidazolidiner og deres anvendelse som anti-androgent middel

Country Status (12)

Country	Link
US (1)	US6242611B1 (da)
EP (1)	EP0869946B1 (da)
JP (1)	JP2000502669A (da)
AT (1)	ATE207906T1 (da)
AU (1)	AU1180797A (da)
DE (1)	DE69616593T2 (da)
DK (1)	DK0869946T3 (da)
ES (1)	ES2163665T3 (da)
FR (1)	FR2742749B1 (da)
PT (1)	PT869946E (da)
WO (1)	WO1997023464A1 (da)
ZA (1)	ZA9610418B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2258342T3 (es) *	1998-10-23	2006-08-16	Aventis Pharma S.A.	Preparaciones para aplicacion topica de sustancias que tienen efecto antiandrogenico.
US20040077605A1 (en) *	2001-06-20	2004-04-22	Salvati Mark E.	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
HUP0303172A3 (en)	2000-06-28	2006-05-29	Bristol Myers Squibb Co	Selective androgen receptor modulators and methods for their identification, desing and use
US7001911B2 (en)	2000-06-28	2006-02-21	Bristol-Myers Squibb Company	Fused cyclic modulators of nuclear hormone receptor function
EP1854798A3 (en) *	2000-09-19	2007-11-28	Bristol-Myers Squibb Company	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en)	2000-09-19	2005-10-11	Bristol-Myers Squibb Company	Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en)	2001-02-27	2004-05-06	Salvati Mark E.	Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7087636B2 (en) *	2001-12-19	2006-08-08	Bristol-Myers Squibb Company	Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
US6875438B2 (en) *	2002-04-27	2005-04-05	Aventis Pharma Deutschland Gmbh	Preparations for topical administration of substances having antiandrogenic activity
EP2299266A1 (en) *	2003-12-19	2011-03-23	The Regents of the University of California	Methods and materials for assessing prostate cancer therapies
NZ550102A (en) *	2004-02-24	2010-10-29	Univ California	Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) *	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
US7709516B2 (en)	2005-06-17	2010-05-04	Endorecherche, Inc.	Helix 12 directed non-steroidal antiandrogens
BRPI0709771B1 (pt)	2006-03-27	2022-01-25	The Regents Of The University Of California	Composto e composição farmacêutica
NZ596260A (en) *	2006-03-29	2013-05-31	Univ California	Diarylthiohydantoin compounds
US8168667B2 (en)	2006-05-31	2012-05-01	Galapagos Nv	Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
US9284345B2 (en)	2007-04-12	2016-03-15	Endorecherche, Inc.	17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
TWI469971B (zh)	2007-10-26	2015-01-21	Univ California	二芳基乙內醯脲類化合物
WO2011029392A1 (en) *	2009-09-10	2011-03-17	Youzhi Tong	Androgen receptor antagonists and uses thereof
EP3124481B1 (en)	2010-02-16	2018-03-28	Aragon Pharmaceuticals, Inc.	Androgen receptor modulators and uses thereof
WO2012119559A1 (en)	2011-03-10	2012-09-13	Suzhou Kintor Pharmaceuticals,Inc.	Androgen receptor antagonists and uses thereof
WO2014052237A1 (en)	2012-09-26	2014-04-03	Aragon Pharmaceuticals, Inc.	Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
EP2945628B1 (en)	2013-01-15	2020-04-15	Aragon Pharmaceuticals, Inc.	Androgen receptor modulator in combination with abiraterone acetate and prednisone for treating prostate cancer
US9682960B2 (en)	2013-12-19	2017-06-20	Endorecherche, Inc.	Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103965112A (zh) *	2014-05-13	2014-08-06	上海孚一生物科技有限公司	一种具有抗雄激素活性的化合物、制备方法及其应用
TWI726969B (zh)	2016-01-11	2021-05-11	比利時商健生藥品公司	用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
KR20240096623A (ko)	2017-10-16	2024-06-26	아라곤 파마슈티컬스, 인코포레이티드	비-전이성 거세-저항성 전립선암의 치료를 위한 항-안드로겐

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5411981A (en) *	1991-01-09	1995-05-02	Roussel Uclaf	Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) *	1994-01-05	2003-02-21	Hoechst Marion Roussel Inc	New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2725206B1 (fr) *	1994-09-29	1996-12-06	Roussel Uclaf	Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

1995
- 1995-12-22 FR FR9515323A patent/FR2742749B1/fr not_active Expired - Fee Related
1996
- 1996-12-11 ZA ZA9610418A patent/ZA9610418B/xx unknown
- 1996-12-19 DE DE69616593T patent/DE69616593T2/de not_active Expired - Fee Related
- 1996-12-19 DK DK96942431T patent/DK0869946T3/da active
- 1996-12-19 WO PCT/FR1996/002029 patent/WO1997023464A1/fr not_active Ceased
- 1996-12-19 AU AU11807/97A patent/AU1180797A/en not_active Abandoned
- 1996-12-19 AT AT96942431T patent/ATE207906T1/de not_active IP Right Cessation
- 1996-12-19 PT PT96942431T patent/PT869946E/pt unknown
- 1996-12-19 US US09/101,027 patent/US6242611B1/en not_active Expired - Fee Related
- 1996-12-19 JP JP09523359A patent/JP2000502669A/ja not_active Abandoned
- 1996-12-19 EP EP96942431A patent/EP0869946B1/fr not_active Expired - Lifetime
- 1996-12-19 ES ES96942431T patent/ES2163665T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PT869946E (pt)	2002-04-29
EP0869946B1 (fr)	2001-10-31
ZA9610418B (en)	1997-12-11
ES2163665T3 (es)	2002-02-01
DE69616593D1 (de)	2001-12-06
JP2000502669A (ja)	2000-03-07
DE69616593T2 (de)	2002-06-27
US6242611B1 (en)	2001-06-05
EP0869946A1 (fr)	1998-10-14
AU1180797A (en)	1997-07-17
FR2742749B1 (fr)	1998-02-06
FR2742749A1 (fr)	1997-06-27
WO1997023464A1 (fr)	1997-07-03
ATE207906T1 (de)	2001-11-15

Publication	Publication Date	Title
PT869946E (pt)	2002-04-29	Fenilimidazolidinas e sua utilizacao como agentes anti-androgenicos
DK0682659T3 (da)	1997-05-12	4-Benzoylisoxazolderivater, deres fremstilling samt deres anvendelse som herbicider
YU6593A (sh)	1996-05-20	Herbicidi
DK0656887T3 (da)	1999-07-05	Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
NO20050199L (no)	2005-03-04	Azadisyklo-oktan og nonanderivater med DDP-IV-inhiberende aktivitet
ATE444065T1 (de)	2009-10-15	4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidon-deriva e als pde-4-hemmer zur behandlung von neurologischen syndromen
DE60017440D1 (de)	2005-02-17	Elektrochrome vorrichtung
DK1257553T3 (da)	2004-10-04	Pyrrolopyrimidinonderivater, fremgangsmåder til fremstilling og anvendelse
DK0931788T3 (da)	2002-11-25	Metalloproteasehæmmere
NO20050870L (no)	2005-03-31	Fosfodiesterase 4-inhibitorer, inkludert N-substituerte anilin- og difenylaminanaloger
CO4700469A1 (es)	1998-12-29	3-[4-(4(4-cianofenil)-1-piperazinanil)butil]-5]ciannoindol y su proceso de obtencion .
BR0211078A (pt)	2004-06-15	Compostos, processo papa a preparação e uso dos mesmos, composições herbicidas, e, método para o controle de ervas daninhas em áreas cultivadas
DK1036074T3 (da)	2003-06-23	S-Oxid-tetrahydrothiopyran-phenyloxazolidinoner
ATE163921T1 (de)	1998-03-15	Azoxycyanbenzol-derivate
DK83789D0 (da)	1989-02-23	Substituerede 1,2,4-triazindioner, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
BR0114812A (pt)	2003-09-30	Derivados de 2-pirimidinilóxi-n-aril-benzilamina, seus processos de preparo e uso
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
NO20050871L (no)	2005-02-18	6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
DK0734380T3 (da)	2002-11-04	4-Benzoylisoxazoler samt deres anvendelse som herbicider
DE60213087D1 (de)	2006-08-24	Pyrimidin-derivate als selektive inhibitoren von cox-2
DE60122559D1 (de)	2006-10-05	Indolderivate als pde5-inhibitoren
DK1165485T3 (da)	2004-07-19	Fremgangsmåde til fremstilling af pesticidmellemprodukter
AR001259A1 (es)	1997-09-24	Proceso para preparar 1,2-bencisotiazolin-3-onas