DK0876366T3 - Angiogenese-inhiberende pyridazinaminer - Google Patents
Angiogenese-inhiberende pyridazinaminerInfo
- Publication number
- DK0876366T3 DK0876366T3 DK97901059T DK97901059T DK0876366T3 DK 0876366 T3 DK0876366 T3 DK 0876366T3 DK 97901059 T DK97901059 T DK 97901059T DK 97901059 T DK97901059 T DK 97901059T DK 0876366 T3 DK0876366 T3 DK 0876366T3
- Authority
- DK
- Denmark
- Prior art keywords
- 6alkyl
- alk
- amino
- 6alkyloxy
- hydrogen
- Prior art date
Links
- -1 pyridazine amines Chemical class 0.000 title abstract 5
- 230000033115 angiogenesis Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96200085 | 1996-01-15 | ||
| PCT/EP1997/000201 WO1997026258A1 (en) | 1996-01-15 | 1997-01-14 | Angiogenesis inhibiting pyridazinamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0876366T3 true DK0876366T3 (da) | 2001-11-05 |
Family
ID=8223585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97901059T DK0876366T3 (da) | 1996-01-15 | 1997-01-14 | Angiogenese-inhiberende pyridazinaminer |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5985878A (da) |
| EP (1) | EP0876366B1 (da) |
| JP (1) | JP4169368B2 (da) |
| KR (1) | KR100443893B1 (da) |
| CN (1) | CN1104430C (da) |
| AT (1) | ATE203534T1 (da) |
| AU (1) | AU717744B2 (da) |
| CA (1) | CA2237273C (da) |
| DE (1) | DE69705819T2 (da) |
| DK (1) | DK0876366T3 (da) |
| ES (1) | ES2162235T3 (da) |
| GR (1) | GR3036900T3 (da) |
| IL (1) | IL124461A (da) |
| MY (1) | MY117098A (da) |
| NO (1) | NO309653B1 (da) |
| NZ (1) | NZ326354A (da) |
| PT (1) | PT876366E (da) |
| SI (1) | SI0876366T1 (da) |
| TW (1) | TW480256B (da) |
| WO (1) | WO1997026258A1 (da) |
| ZA (1) | ZA97288B (da) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6228871B1 (en) | 1995-07-10 | 2001-05-08 | Merck & Co., Inc. | Angiogenesis inhibitors |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CN1275596C (zh) | 1997-05-14 | 2006-09-20 | 阿特罗吉尼克斯公司 | 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用 |
| US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
| US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| US6265407B1 (en) | 1997-06-24 | 2001-07-24 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting thiadiazolyl pyridazine derivatives |
| US6833369B2 (en) | 1997-06-24 | 2004-12-21 | Janssen Pharmaceutica, Nv | Angiogenesis inhibiting 5-substituted-1,2,4,-thiadiazolyl derivatives |
| TR199903082T2 (xx) * | 1997-06-24 | 2000-07-21 | Janssen Pharmaceutica N.V. | Anjiogenez inhibit�r� 5-s�bstit�e-1,2,4,-tiadiazolil t�revleri. |
| ES2195374T3 (es) * | 1997-06-24 | 2003-12-01 | Janssen Pharmaceutica Nv | Derivados de tiadiazolil-piridazina que impiden la angiogenesis. |
| US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| AR013693A1 (es) * | 1997-10-23 | 2001-01-10 | Uriach & Cia Sa J | Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria |
| EE04588B1 (et) * | 1997-10-27 | 2006-02-15 | Neurosearch A/S | Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon |
| WO1999043658A1 (en) * | 1998-02-27 | 1999-09-02 | Warner-Lambert Company | Heterocyclic substituted aniline calcium channel blockers |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| US6833370B1 (en) * | 1999-05-21 | 2004-12-21 | Abbott Laboratories | Heterocycle substituted aminoazacycles useful as central nervous system agents |
| US6887870B1 (en) * | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| US6906072B1 (en) * | 2000-01-20 | 2005-06-14 | Eisai Co., Ltd. | Piperazine compound and pharmaceutical composition containing the compound |
| IT1316986B1 (it) * | 2000-01-25 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica. |
| US6881860B2 (en) | 2000-04-11 | 2005-04-19 | Atherogenics, Inc. | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality |
| US7208503B2 (en) | 2000-04-21 | 2007-04-24 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives |
| MXPA02011319A (es) * | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| GB0111078D0 (en) | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| PL1648874T3 (pl) | 2003-07-30 | 2012-04-30 | Xenon Pharmaceuticals Inc | Pochodne piperazyny i ich zastosowanie jako środków leczniczych |
| US7754711B2 (en) * | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| US20050065178A1 (en) * | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| DE102004003812A1 (de) * | 2004-01-25 | 2005-08-11 | Aventis Pharma Deutschland Gmbh | Arylsubstituierte Heterozyklen, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
| TW200533356A (en) * | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| BRPI0515500A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| BRPI0515482A (pt) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| EP1827438B2 (en) * | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazin derivatives for inhibiting human stearoyl-coa-desaturase |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| WO2006071875A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| JP4873352B2 (ja) * | 2005-02-16 | 2012-02-08 | シェーリング コーポレイション | Ｃｘｃｒ３アンタゴニスト活性を有する、複素環で置換されたピペラジン |
| WO2007046867A2 (en) * | 2005-05-19 | 2007-04-26 | Xenon Pharmaceuticals Inc. | Piperidine derivatives and their uses as therapeutic agents |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US20090118296A1 (en) * | 2005-07-20 | 2009-05-07 | Merck Frosst Canada Ltd. | Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase |
| EP1966183A4 (en) * | 2005-12-20 | 2010-12-29 | Merck Frosst Canada Ltd | HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A-DELTA-9-DESATURASE |
| TW200826936A (en) | 2006-12-01 | 2008-07-01 | Merck Frosst Canada Ltd | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| AR064965A1 (es) | 2007-01-26 | 2009-05-06 | Merck Frosst Canada Inc | Derivados de azacicloalcanos como inhibidores de estearoil - coenzima a delta -9 desaturasa |
| EP2139320A4 (en) | 2007-03-26 | 2010-09-08 | Salutria Pharmaceuticals Llc | METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES |
| SG2012079653A (en) | 2007-10-25 | 2014-05-29 | Exelixis Inc | Tropane compounds |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| MX2011004683A (es) | 2008-11-03 | 2011-06-20 | Lilly Co Eli | Antagonistas de la via hedgehog de ftalazina disustituida. |
| KR101342184B1 (ko) | 2008-11-17 | 2013-12-19 | 일라이 릴리 앤드 캄파니 | 사치환된 피리다진 헷지호그 경로 길항제 |
| BRPI0921777A2 (pt) | 2008-11-17 | 2016-01-12 | Lilly Co Eli | antagonistas da via hedgehog de piridazina tetrassubstituída |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| WO2011002067A1 (ja) * | 2009-07-02 | 2011-01-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| WO2013085957A1 (en) * | 2011-12-06 | 2013-06-13 | Janssen Pharmaceutica Nv | Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors |
| WO2013085954A1 (en) | 2011-12-06 | 2013-06-13 | Janssen Pharmaceutica Nv | Substituted piperidinyl-carboxamide derivatives useful as scd 1 inhibitors |
| GB201309508D0 (en) * | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB201311953D0 (en) * | 2013-07-03 | 2013-08-14 | Redx Pharma Ltd | Compounds |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CN108912116A (zh) * | 2018-08-15 | 2018-11-30 | 翟学旭 | 一种含氮杂环类衍生物及其在视网膜疾病中的应用 |
| US12605377B2 (en) | 2020-10-13 | 2026-04-21 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| JP2023546536A (ja) | 2020-10-13 | 2023-11-02 | エンデバー バイオメディシンズ， インコーポレイテッド | 線維症を処置する方法 |
| WO2023034836A1 (en) * | 2021-08-30 | 2023-03-09 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| GB202202297D0 (en) | 2022-02-21 | 2022-04-06 | Verona Pharma Plc | Formulation production process |
| AU2024309346C1 (en) | 2023-06-26 | 2026-03-12 | Verona Pharma Plc | Particulate composition comprising ensifentrine |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
| US4992433A (en) * | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
| US5461053A (en) * | 1989-02-07 | 1995-10-24 | Sanofi | Pyridazine derivatives |
| FR2663326B2 (fr) * | 1989-11-17 | 1992-10-16 | Sanofi Sa | Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant. |
| GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
| NZ233526A (en) * | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Pyridazine derivatives and their pharmaceutical compositions |
| ZA9010357B (en) * | 1989-12-26 | 1992-08-26 | Janssen Pharmaceutica Nv | Antipicornaviral pyridazinamines |
| JO1645B1 (en) * | 1989-12-26 | 1991-11-27 | شركة جانسين فارماسوتيكا ان. في | Pyridazine compounds are antibacterial viruses |
| US5100893A (en) * | 1990-04-18 | 1992-03-31 | Janssen Pharmaceutica N.V. | Antipicornaviral pyridazinamines |
| US5242924A (en) * | 1992-07-02 | 1993-09-07 | Sterling Winthrop Inc. | Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents |
-
1997
- 1997-01-14 MY MYPI97000130A patent/MY117098A/en unknown
- 1997-01-14 JP JP52465697A patent/JP4169368B2/ja not_active Expired - Lifetime
- 1997-01-14 CA CA002237273A patent/CA2237273C/en not_active Expired - Lifetime
- 1997-01-14 NZ NZ326354A patent/NZ326354A/xx unknown
- 1997-01-14 CN CN97191705A patent/CN1104430C/zh not_active Expired - Lifetime
- 1997-01-14 IL IL12446197A patent/IL124461A/xx not_active IP Right Cessation
- 1997-01-14 ZA ZA97288A patent/ZA97288B/xx unknown
- 1997-01-14 DE DE69705819T patent/DE69705819T2/de not_active Expired - Lifetime
- 1997-01-14 PT PT97901059T patent/PT876366E/pt unknown
- 1997-01-14 AT AT97901059T patent/ATE203534T1/de not_active IP Right Cessation
- 1997-01-14 DK DK97901059T patent/DK0876366T3/da active
- 1997-01-14 WO PCT/EP1997/000201 patent/WO1997026258A1/en not_active Ceased
- 1997-01-14 ES ES97901059T patent/ES2162235T3/es not_active Expired - Lifetime
- 1997-01-14 SI SI9730191T patent/SI0876366T1/xx unknown
- 1997-01-14 EP EP97901059A patent/EP0876366B1/en not_active Expired - Lifetime
- 1997-01-14 KR KR10-1998-0703682A patent/KR100443893B1/ko not_active Expired - Fee Related
- 1997-01-14 AU AU14439/97A patent/AU717744B2/en not_active Expired
- 1997-01-23 TW TW086100703A patent/TW480256B/zh not_active IP Right Cessation
-
1998
- 1998-05-05 NO NO982037A patent/NO309653B1/no unknown
- 1998-07-09 US US09/119,075 patent/US5985878A/en not_active Expired - Lifetime
-
2001
- 2001-10-16 GR GR20010401770T patent/GR3036900T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1104430C (zh) | 2003-04-02 |
| CA2237273C (en) | 2009-01-13 |
| JP4169368B2 (ja) | 2008-10-22 |
| AU1443997A (en) | 1997-08-11 |
| ATE203534T1 (de) | 2001-08-15 |
| DE69705819T2 (de) | 2002-04-11 |
| US5985878A (en) | 1999-11-16 |
| NZ326354A (en) | 1999-05-28 |
| PT876366E (pt) | 2002-01-30 |
| JP2000503014A (ja) | 2000-03-14 |
| ES2162235T3 (es) | 2001-12-16 |
| KR19990067654A (ko) | 1999-08-25 |
| EP0876366A2 (en) | 1998-11-11 |
| EP0876366B1 (en) | 2001-07-25 |
| CN1208415A (zh) | 1999-02-17 |
| ZA97288B (en) | 1998-07-14 |
| KR100443893B1 (ko) | 2004-10-15 |
| TW480256B (en) | 2002-03-21 |
| GR3036900T3 (en) | 2002-01-31 |
| AU717744B2 (en) | 2000-03-30 |
| WO1997026258A1 (en) | 1997-07-24 |
| NO309653B1 (no) | 2001-03-05 |
| SI0876366T1 (en) | 2001-12-31 |
| NO982037L (no) | 1998-09-15 |
| IL124461A (en) | 2000-07-26 |
| NO982037D0 (no) | 1998-05-05 |
| IL124461A0 (en) | 1998-12-06 |
| CA2237273A1 (en) | 1997-07-24 |
| MY117098A (en) | 2004-05-31 |
| DE69705819D1 (de) | 2001-08-30 |
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