DK0877752T3 - Fremgangsmåder til screening af transdominante effektorpeptider og RNA molekyler - Google Patents

Fremgangsmåder til screening af transdominante effektorpeptider og RNA molekyler

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Publication number
DK0877752T3
DK0877752T3 DK97903068T DK97903068T DK0877752T3 DK 0877752 T3 DK0877752 T3 DK 0877752T3 DK 97903068 T DK97903068 T DK 97903068T DK 97903068 T DK97903068 T DK 97903068T DK 0877752 T3 DK0877752 T3 DK 0877752T3
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DK
Denmark
Prior art keywords
screening
methods
rna molecules
effector peptides
transdominant
Prior art date
Application number
DK97903068T
Other languages
English (en)
Inventor
Garry P Noaln
S Michael Rothenberg
Original Assignee
Univ Leland Stanford Junior
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/589,109 external-priority patent/US6365344B1/en
Application filed by Univ Leland Stanford Junior, Rigel Pharmaceuticals Inc filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of DK0877752T3 publication Critical patent/DK0877752T3/da

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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DK97903068T 1996-01-23 1997-01-23 Fremgangsmåder til screening af transdominante effektorpeptider og RNA molekyler DK0877752T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58991196A 1996-01-23 1996-01-23
US08/589,109 US6365344B1 (en) 1996-01-23 1996-01-23 Methods for screening for transdominant effector peptides and RNA molecules
PCT/US1997/001048 WO1997027213A1 (en) 1996-01-23 1997-01-23 Methods for screening for transdominant effector peptides and rna molecules

Publications (1)

Publication Number Publication Date
DK0877752T3 true DK0877752T3 (da) 2003-09-15

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DK97903068T DK0877752T3 (da) 1996-01-23 1997-01-23 Fremgangsmåder til screening af transdominante effektorpeptider og RNA molekyler

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US (5) US6455247B1 (da)
EP (2) EP0877752B1 (da)
JP (2) JP2001509661A (da)
AU (2) AU1707497A (da)
CA (1) CA2244222A1 (da)
DE (1) DE69722176T2 (da)
DK (1) DK0877752T3 (da)
ES (1) ES2200150T3 (da)
WO (2) WO1997027213A1 (da)

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ES2210306T3 (es) * 1994-07-20 2004-07-01 The General Hospital Corporation Sistemas de trampa para interacciones, para detectar interacciones de proteinas.
CA2196419C (en) 1994-08-20 2007-08-21 Yen Choo Improvements in or relating to binding proteins for recognition of dna
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
US20050002902A1 (en) * 1995-12-28 2005-01-06 Liming Yu Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections
US6365344B1 (en) * 1996-01-23 2002-04-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
EP0877752B1 (en) 1996-01-23 2003-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and rna molecules
US5955275A (en) 1997-02-14 1999-09-21 Arcaris, Inc. Methods for identifying nucleic acid sequences encoding agents that affect cellular phenotypes
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6623922B1 (en) 1997-02-14 2003-09-23 Deltagen Proteomics Methods for identifying, characterizing, and evolving cell-type specific CIS regulatory elements
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6969584B2 (en) * 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
DE19737562A1 (de) * 1997-08-28 1999-05-06 Otogene Biotechnologische Fors Verfahren zur Identifizierung von Wechselwirkungen zwischen Proteinen bzw. Peptiden
EP0966528A1 (en) * 1997-11-07 1999-12-29 Iconix Pharmaceuticals, Inc. Surrogate genetics target characterization method
US6197502B1 (en) * 1997-11-17 2001-03-06 Cytos Biotechnology Ag Expression cloning processes for the discovery characterization, and isolation of genes encoding polypeptides with a predetermined property
US6475726B1 (en) 1998-01-09 2002-11-05 Cubist Pharmaceuticals, Inc. Method for identifying validated target and assay combinations for drug development
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