DK0878548T3 - Flertrinsfremgangsmåde til fremstilling af (1S,4R)- og/eller (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyclopenten-1-methanol - Google Patents

Flertrinsfremgangsmåde til fremstilling af (1S,4R)- og/eller (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyclopenten-1-methanol

Info

Publication number: DK0878548T3
Authority: DK; Denmark
Prior art keywords: amino; cyclopentene; cyclopenten; purin; chloro
Prior art date: 1997-05-13

Application number

DK98108721T

Other languages

Danish (da)

English (en)

Inventor

Christine Bernegger

Eva-Maria Urban

Olwen Mary Birch

Kurt Burgdorf

Frank Brux

Kay-Sara Etter

Pierre Bossard

Walter Brieden

Laurent Duc

John Gordon

Colm O'murchu

Yves Guggisberg

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-13

Filing date

1998-05-13

Publication date

2004-12-06

1998-05-13 Application filed by Lonza Ag filed Critical Lonza Ag

2004-12-06 Application granted granted Critical

2004-12-06 Publication of DK0878548T3 publication Critical patent/DK0878548T3/da

Links

238000000034 method Methods 0.000 title abstract 2
OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 abstract 2
230000010933 acylation Effects 0.000 abstract 2
238000005917 acylation reaction Methods 0.000 abstract 2
UXKZFJDNFBNQHE-UHFFFAOYSA-N (4-aminocyclopent-2-en-1-yl)methanol Chemical class NC1CC(CO)C=C1 UXKZFJDNFBNQHE-UHFFFAOYSA-N 0.000 abstract 1
VTCHZFWYUPZZKL-UHFFFAOYSA-N 4-azaniumylcyclopent-2-ene-1-carboxylate Chemical compound NC1CC(C(O)=O)C=C1 VTCHZFWYUPZZKL-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
-1 carboxylic acid halide Chemical class 0.000 abstract 1
LMYOLOWXQDLHKQ-UHFFFAOYSA-N cyclopent-2-en-1-ylmethanol Chemical class OCC1CCC=C1 LMYOLOWXQDLHKQ-UHFFFAOYSA-N 0.000 abstract 1
XVSYDLITVYBCBD-UHFFFAOYSA-N cyclopent-3-ene-1-carboxylic acid Chemical class OC(=O)C1CC=CC1 XVSYDLITVYBCBD-UHFFFAOYSA-N 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK98108721T 1997-05-13 1998-05-13 Flertrinsfremgangsmåde til fremstilling af (1S,4R)- og/eller (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyclopenten-1-methanol DK0878548T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH111697		1997-05-13
CH274097		1997-11-27
EP98108721A EP0878548B1 (fr)	1997-05-13	1998-05-13	Procédé à étapes multiples pour la préparation de (1S,4R)- et/ou (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentene-1-methanol

Publications (1)

Publication Number	Publication Date
DK0878548T3 true DK0878548T3 (da)	2004-12-06

Family

ID=25686703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98108721T DK0878548T3 (da)	1997-05-13	1998-05-13	Flertrinsfremgangsmåde til fremstilling af (1S,4R)- og/eller (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyclopenten-1-methanol

Country Status (16)

Country	Link
US (4)	US6156893A (fr)
EP (2)	EP1502914A1 (fr)
JP (3)	JP4540136B2 (fr)
KR (2)	KR100577886B1 (fr)
CN (2)	CN1115343C (fr)
AT (1)	ATE275206T1 (fr)
CA (1)	CA2237297C (fr)
CZ (3)	CZ297894B6 (fr)
DE (1)	DE59811884D1 (fr)
DK (1)	DK0878548T3 (fr)
ES (1)	ES2223095T3 (fr)
HU (1)	HU226327B1 (fr)
NO (1)	NO324679B1 (fr)
PL (1)	PL197848B1 (fr)
PT (1)	PT878548E (fr)
SK (3)	SK285228B6 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0705263T3 (da) *	1993-06-21	1997-05-05	Merrell Pharma Inc	Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
GB9717928D0 (en) *	1997-08-22	1997-10-29	Glaxo Group Ltd	Process for the enatioselective hydrolysis of n-derivatised lactams
GB9721780D0 (en) *	1997-10-14	1997-12-10	Glaxo Group Ltd	Process for the synthesis of chloropurine intermediates
CZ298144B6 (cs) *	1997-11-27	2007-07-04	Lonza Ag	Zpusob výroby (1S,4R)- nebo (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyklopenten-1-methanolu
CZ301107B6 (cs)	1998-12-23	2009-11-11	Lonza Ag	Zpusob výroby enantiomerne obohacených derivátu 1-amino-4-(hydroxymethyl)-cyklopent-2-enu
PT1648851E (pt) *	2003-07-25	2007-05-31	Prometic Biosciences Inc	Praparação de sais metálicos de ácidos gordos de cadeia média
DE102005061756B4 (de) *	2005-12-21	2008-01-03	Sanofi-Aventis Deutschland Gmbh	Verbessertes Verfahren zur Herstellung von Ramipril
US8236853B1 (en)	2007-12-03	2012-08-07	University Of South Florida	Formation of cyclopentene nitro-ester and derivatives
WO2012099904A1 (fr)	2011-01-18	2012-07-26	General Atomics	Substrats d'enzyme hydrolase et leurs utilisations
CN102557990B (zh) *	2011-04-25	2014-06-25	开原亨泰制药股份有限公司	(1s，4r)n-叔丁氧羰基-4-氨基-2-环戊烯-1-羧酸甲酯的制备方法
CN119350339A (zh) *	2024-11-25	2025-01-24	安徽贝克制药股份有限公司	一种阿巴卡韦杂质的制备方法及用途

Family Cites Families (12)

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US4950758A (en) *	1988-01-20	1990-08-21	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
US4931559A (en) *	1988-01-20	1990-06-05	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
MY104575A (en) *	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
CA2055086A1 (fr) *	1991-02-12	1992-08-13	Chikara Kaneko	Derives de cyclopentene et leur emploi
US5200527A (en) *	1991-04-08	1993-04-06	Lonza Ltd.	Process for the production of 2-azabicyclo [2.2.1] hept-5-en-3-one
GB9204015D0 (en) *	1992-02-25	1992-04-08	Wellcome Found	Therapeutic nucleosides
GB9205071D0 (en) *	1992-03-09	1992-04-22	Wellcome Found	Therapeutic nucleosides
GB9217823D0 (en) *	1992-08-21	1992-10-07	Glaxo Group Ltd	Chemical process
JPH06116217A (ja) *	1992-10-02	1994-04-26	Kuraray Co Ltd	（±）−シス−４−アミノシクロペント−２−エンカルボン酸誘導体の光学分割法
GB9402161D0 (en) *	1994-02-04	1994-03-30	Wellcome Found	Chloropyrimidine intermediates
CN1224697C (zh) *	1996-05-30	2005-10-26	隆萨股份公司	氨基醇及其衍生物的制备方法
GB9625455D0 (en) *	1996-12-07	1997-01-22	Glaxo Group Ltd	Process for resolving mixtures of carbocyclic steroisomers

1998
- 1998-05-04 SK SK53-2005A patent/SK285228B6/sk not_active IP Right Cessation
- 1998-05-04 SK SK54-2005A patent/SK285229B6/sk not_active IP Right Cessation
- 1998-05-04 SK SK589-98A patent/SK284810B6/sk not_active IP Right Cessation
- 1998-05-06 US US09/073,553 patent/US6156893A/en not_active Expired - Fee Related
- 1998-05-11 CA CA002237297A patent/CA2237297C/fr not_active Expired - Fee Related
- 1998-05-11 CZ CZ0145898A patent/CZ297894B6/cs not_active IP Right Cessation
- 1998-05-11 KR KR1019980016803A patent/KR100577886B1/ko not_active Expired - Fee Related
- 1998-05-11 CZ CZ20060695A patent/CZ297888B6/cs not_active IP Right Cessation
- 1998-05-11 CZ CZ20060694A patent/CZ297887B6/cs not_active IP Right Cessation
- 1998-05-12 NO NO19982149A patent/NO324679B1/no not_active IP Right Cessation
- 1998-05-12 JP JP12933898A patent/JP4540136B2/ja not_active Expired - Fee Related
- 1998-05-13 ES ES98108721T patent/ES2223095T3/es not_active Expired - Lifetime
- 1998-05-13 PT PT98108721T patent/PT878548E/pt unknown
- 1998-05-13 HU HU9801083A patent/HU226327B1/hu not_active IP Right Cessation
- 1998-05-13 PL PL326267A patent/PL197848B1/pl not_active IP Right Cessation
- 1998-05-13 AT AT98108721T patent/ATE275206T1/de active
- 1998-05-13 EP EP04020273A patent/EP1502914A1/fr not_active Withdrawn
- 1998-05-13 DK DK98108721T patent/DK0878548T3/da active
- 1998-05-13 EP EP98108721A patent/EP0878548B1/fr not_active Expired - Lifetime
- 1998-05-13 CN CN98108865A patent/CN1115343C/zh not_active Expired - Fee Related
- 1998-05-13 DE DE59811884T patent/DE59811884D1/de not_active Expired - Lifetime
- 1998-05-13 CN CNB03123433XA patent/CN1302116C/zh not_active Expired - Fee Related
1999
- 1999-08-13 US US09/373,857 patent/US6252112B1/en not_active Expired - Fee Related
- 1999-08-13 US US09/373,856 patent/US6262295B1/en not_active Expired - Fee Related
- 1999-08-13 US US09/373,862 patent/US6137007A/en not_active Expired - Fee Related
2005
- 2005-10-19 KR KR1020050098642A patent/KR100601764B1/ko not_active Expired - Fee Related
2009
- 2009-11-09 JP JP2009256398A patent/JP2010116397A/ja active Pending
- 2009-11-09 JP JP2009256399A patent/JP2010106025A/ja active Pending

Also Published As

Publication number	Publication date
PL197848B1 (pl)	2008-05-30
CA2237297C (fr)	2008-03-11
SK285229B6 (sk)	2006-09-07
CN1115343C (zh)	2003-07-23
HU226327B1 (en)	2008-08-28
EP0878548A2 (fr)	1998-11-18
CN1201794A (zh)	1998-12-16
HUP9801083A2 (hu)	1999-11-29
CZ297888B6 (cs)	2007-04-18
KR100577886B1 (ko)	2006-08-30
NO982149L (no)	1998-11-16
HUP9801083A3 (en)	2001-09-28
JP4540136B2 (ja)	2010-09-08
ATE275206T1 (de)	2004-09-15
EP1502914A1 (fr)	2005-02-02
SK285228B6 (sk)	2006-09-07
KR19980086933A (ko)	1998-12-05
PT878548E (pt)	2005-01-31
KR100601764B1 (ko)	2006-07-19
SK58998A3 (en)	1998-12-02
JPH115793A (ja)	1999-01-12
US6252112B1 (en)	2001-06-26
ES2223095T3 (es)	2005-02-16
US6137007A (en)	2000-10-24
JP2010116397A (ja)	2010-05-27
CZ297887B6 (cs)	2007-04-18
US6156893A (en)	2000-12-05
JP2010106025A (ja)	2010-05-13
NO982149D0 (no)	1998-05-12
US6262295B1 (en)	2001-07-17
HK1092782A1 (en)	2007-02-16
CZ297894B6 (cs)	2007-04-25
PL326267A1 (en)	1998-11-23
CA2237297A1 (fr)	1998-11-13
SK284810B6 (sk)	2005-12-01
NO324679B1 (no)	2007-12-03
CN1302116C (zh)	2007-02-28
DE59811884D1 (de)	2004-10-07
EP0878548A3 (fr)	1999-10-13
CN1515673A (zh)	2004-07-28
CZ145898A3 (cs)	1998-12-16
HU9801083D0 (en)	1998-07-28
EP0878548B1 (fr)	2004-09-01

Publication	Publication Date	Title
DK0878548T3 (da)	2004-12-06	Flertrinsfremgangsmåde til fremstilling af (1S,4R)- og/eller (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyclopenten-1-methanol
CY1110919T1 (el)	2015-06-10	Μεθοδος για τον ενζυματικο διαχωρισμο εναντιομερων της 3(r)- kai 3(s)-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-1,2,3,6-τετραϋδρο-πυριδινης ή των εστερων καρβοξυλικου οξεος αυτης.
DE602004010820D1 (de)	2008-01-31	Verfahren zur herstellung von 4-aryl-nicotinamidderivaten
DK0926131T3 (da)	2004-05-24	Fremgangsmåde til fremstilling af 1-amino-4-(hydroxymethyl)-2-cyclopenten
ATE158579T1 (de)	1997-10-15	Verfahren zur herstellung von (3r,5s)6-hydroxy- 3,5-0-isopropyliden-3,5-dihydroxy-hexansäure- tert.-butylester
ATE319701T1 (de)	2006-03-15	Prozess für die herstellung von 2-(6- substituierten-1,3-dioxan-4-yl) essigsäure derivaten
ATE217869T1 (de)	2002-06-15	Verfahren zur herstellung von fluoralkenylthio heterozyclische derivate
DE60312214D1 (de)	2007-04-12	Verfahren zur herstellung von(4e)-5-chloro-2-isopropyl-4-pentensäureester und optischaktivem isomer davon
DE50212728D1 (de)	2008-10-16	Verfahren zur herstellung von 2-azetidinonderivaten
EP0983999B8 (fr)	2005-06-08	Procede de production de derives amides et de leurs intermediaires
DK0464488T3 (da)	1996-02-12	Optisk aktive N-alfa-fluoracryloylaminosyre-derivater, deres fremstilling, de deraf fremstillede optisk aktive polymerer og deres anvendelse til spaltning af racemater
DE60122539D1 (de)	2006-10-05	Neues verfahren zur herstellung einer chinolon-carbonsäure
DE59303746D1 (de)	1996-10-17	Verfahren zur Herstellung von Phenylessigsäureester-Derivaten
NO20013984L (no)	2001-10-17	Ny fremgangsmåte for fremstilling av alendronsyre
EA200000279A1 (ru)	2000-08-28	Способ повышения оптической чистоты 2r-[1-гидрокси-1-трифторметил-3-циклопропилпропин-2-ил]-4-хлоранилина
ATE402940T1 (de)	2008-08-15	Verfahren zur herstellung von 3-cephem- verbindungen
DE59107093D1 (de)	1996-01-25	Herstellung von acylaminomethanphosphonsäuren und acylaminomethanphosphinsäuren
ATE439333T1 (de)	2009-08-15	Verfahren zur herstellung optisch aktiver propoxyanilinderivate
NO970281L (no)	1997-07-28	Fremgangsmåte for stereoselektiv fremstilling av heterobicyklisk alkohol enantiomer
DE3789411D1 (de)	1994-04-28	Dihydropyridin-5-phosphonsaure zyklische Ester.
ATE445605T1 (de)	2009-10-15	Neues verfahren zur herstellung von 3-fluorierten chinolinen
NO20034072L (no)	2003-11-19	Transformant som produserer FP1022 substansderivater og fremgangsmate til fremstilling av samme.
ATE83479T1 (de)	1993-01-15	Herstellung von pyridazinon.
MX9700590A (es)	1997-07-31	Procedimiento para la preparacion de acidos carboxilicos organicos alfa, beta-insaturados.
ATE249449T1 (de)	2003-09-15	Verfahren zur herstellung von substituierten furancarboxylaten