DK0883619T3 - Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype - Google Patents

Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype

Info

Publication number: DK0883619T3
Authority: DK; Denmark
Prior art keywords: salts; substituted carboxylic; morphine; pct; narcotic analgesics
Prior art date: 1996-02-28

Application number

DK97903288T

Other languages

English (en)

Inventor

Bodo Asmussen

Walter Mueller

Walter Riess

Original Assignee

Lohmann Therapie Syst Lts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-28

Filing date

1997-02-15

Publication date

2002-04-29

1997-02-15 Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts

2002-04-29 Application granted granted Critical

2002-04-29 Publication of DK0883619T3 publication Critical patent/DK0883619T3/da

Links

BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 6
GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical class O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 title abstract 3
229960005181 morphine Drugs 0.000 title abstract 3
125000000129 anionic group Chemical group 0.000 title abstract 2
239000000730 antalgic agent Substances 0.000 title abstract 2
150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
150000001735 carboxylic acids Chemical class 0.000 abstract 1
DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 abstract 1
229960001259 diclofenac Drugs 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK97903288T 1996-02-28 1997-02-15 Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype DK0883619T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19607395A DE19607395C2 (de)	1996-02-28	1996-02-28	Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate
PCT/EP1997/000711 WO1997031918A1 (de)	1996-02-28	1997-02-15	Morphin- und diamorphinsalze anionischer nicht-narkotischer analgetika vom typ der substituierten carbonsäuren

Publications (1)

Publication Number	Publication Date
DK0883619T3 true DK0883619T3 (da)	2002-04-29

Family

ID=7786595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97903288T DK0883619T3 (da)	1996-02-28	1997-02-15	Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype

Country Status (20)

Country	Link
US (1)	US6156764A (da)
EP (1)	EP0883619B1 (da)
JP (1)	JP4624497B2 (da)
KR (1)	KR100422276B1 (da)
CN (1)	CN1064363C (da)
AT (1)	ATE212024T1 (da)
AU (1)	AU712255B2 (da)
CZ (1)	CZ294401B6 (da)
DE (2)	DE19607395C2 (da)
DK (1)	DK0883619T3 (da)
ES (1)	ES2171886T3 (da)
HU (1)	HU225268B1 (da)
IL (1)	IL125819A (da)
NO (1)	NO983864L (da)
NZ (1)	NZ331485A (da)
PL (1)	PL185915B1 (da)
PT (1)	PT883619E (da)
SK (1)	SK104398A3 (da)
WO (1)	WO1997031918A1 (da)
ZA (1)	ZA971740B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1017696E (pt) *	1997-09-25	2002-09-30	Lohmann Therapie Syst Lts	Sais de adicao de acido de alcaloides de morfina e sua utilizacao
NZ529661A (en) *	2001-06-05	2006-03-31	Control Delivery Systems	Sustained-release analgesic compounds
CN1571668A (zh) *	2001-10-18	2005-01-26	诺瓦提斯公司	At1－受体拮抗剂和心血管药物形成的盐
US20030118528A1 (en) *	2001-11-19	2003-06-26	Walters Kenneth A.	Topical delivery of codrugs
WO2003061626A1 (en) *	2002-01-18	2003-07-31	Control Delivery Systems, Inc.	Polymeric gel system for the controlled delivery of codrugs
US10004729B2 (en)	2002-07-05	2018-06-26	Collegium Pharmaceutical, Inc.	Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2004004693A1 (en)	2002-07-05	2004-01-15	Collgegium Pharmaceutical	Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US8840928B2 (en) *	2002-07-05	2014-09-23	Collegium Pharmaceutical, Inc.	Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8557291B2 (en)	2002-07-05	2013-10-15	Collegium Pharmaceutical, Inc.	Abuse-deterrent pharmaceutical compositions of opioids and other drugs
TW200500067A (en) *	2003-01-21	2005-01-01	Control Delivery Sys Inc	Salts of codrugs and uses related thereto
ATE410186T1 (de) *	2003-06-26	2008-10-15	Control Delivery Sys Inc	In-situ gelierendes arzneimittelabgabesystem
JP5628467B2 (ja)	2003-06-26	2014-11-19	シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａＵｓ，Ｉｎｃ．	生体分解性徐放性ドラッグデリバリーシステム
US20050196455A1 (en) *	2003-10-27	2005-09-08	Jianbing Chen	Suspension delivery system for the sustained and controlled local release of pharmaceuticals
ES2653568T3 (es)	2004-06-12	2018-02-07	Collegium Pharmaceutical, Inc.	Formulaciones de fármacos para la prevención del abuso
US10668060B2 (en)	2009-12-10	2020-06-02	Collegium Pharmaceutical, Inc.	Tamper-resistant pharmaceutical compositions of opioids and other drugs
US9737530B1 (en)	2016-06-23	2017-08-22	Collegium Pharmaceutical, Inc.	Process of making stable abuse-deterrent oral formulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4404209A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and sulindac
GB8319546D0 (en) *	1983-07-20	1983-08-24	Euro Celtique Sa	Pharmaceutical active salts
ZA893422B (en) *	1988-02-24	1991-01-30	Adcock Ingram Lab Ltd	Pharmaceutical composition
TW225536B (da) *	1990-08-23	1994-06-21	Ciba Geigy Ag
CA2104684A1 (en) *	1991-03-04	1992-09-05	Mahdi B. Fawzi	Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5256669A (en) *	1992-08-07	1993-10-26	Aminotek Sciences, Inc.	Methods and compositions for treating acute or chronic pain and drug addiction
SE9301057L (sv) *	1993-03-30	1994-10-01	Pharmacia Ab	Beredning med kontrollerad frisättning
FR2708611B1 (fr) *	1993-07-29	1995-10-27	Meram Lab	Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
GB9319568D0 (en) *	1993-09-22	1993-11-10	Euro Celtique Sa	Pharmaceutical compositions and usages
US5460826A (en) *	1994-06-27	1995-10-24	Alza Corporation	Morphine therapy

1996
- 1996-02-28 DE DE19607395A patent/DE19607395C2/de not_active Expired - Fee Related
1997
- 1997-02-15 SK SK1043-98A patent/SK104398A3/sk unknown
- 1997-02-15 JP JP53054797A patent/JP4624497B2/ja not_active Expired - Fee Related
- 1997-02-15 AU AU17695/97A patent/AU712255B2/en not_active Ceased
- 1997-02-15 PT PT97903288T patent/PT883619E/pt unknown
- 1997-02-15 HU HU9900568A patent/HU225268B1/hu not_active IP Right Cessation
- 1997-02-15 IL IL12581997A patent/IL125819A/en not_active IP Right Cessation
- 1997-02-15 EP EP97903288A patent/EP0883619B1/de not_active Expired - Lifetime
- 1997-02-15 US US09/137,078 patent/US6156764A/en not_active Expired - Fee Related
- 1997-02-15 ES ES97903288T patent/ES2171886T3/es not_active Expired - Lifetime
- 1997-02-15 AT AT97903288T patent/ATE212024T1/de active
- 1997-02-15 DK DK97903288T patent/DK0883619T3/da active
- 1997-02-15 WO PCT/EP1997/000711 patent/WO1997031918A1/de not_active Ceased
- 1997-02-15 PL PL97328712A patent/PL185915B1/pl not_active IP Right Cessation
- 1997-02-15 KR KR10-1998-0706752A patent/KR100422276B1/ko not_active Expired - Fee Related
- 1997-02-15 CN CN97192619A patent/CN1064363C/zh not_active Expired - Fee Related
- 1997-02-15 NZ NZ331485A patent/NZ331485A/xx not_active IP Right Cessation
- 1997-02-15 DE DE59706015T patent/DE59706015D1/de not_active Expired - Lifetime
- 1997-02-15 CZ CZ19982657A patent/CZ294401B6/cs not_active IP Right Cessation
- 1997-02-27 ZA ZA9701740A patent/ZA971740B/xx unknown
1998
- 1998-08-21 NO NO983864A patent/NO983864L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE59706015D1 (de)	2002-02-21
NZ331485A (en)	1999-03-29
CZ294401B6 (cs)	2004-12-15
PT883619E (pt)	2002-07-31
HU225268B1 (en)	2006-08-28
KR100422276B1 (ko)	2004-07-30
WO1997031918A1 (de)	1997-09-04
AU712255B2 (en)	1999-11-04
DE19607395C2 (de)	2002-11-21
KR19990087343A (ko)	1999-12-27
ES2171886T3 (es)	2002-09-16
CN1212698A (zh)	1999-03-31
HUP9900568A2 (hu)	1999-06-28
US6156764A (en)	2000-12-05
SK104398A3 (en)	1998-12-02
DE19607395A1 (de)	1997-09-04
HUP9900568A3 (en)	2001-08-28
EP0883619B1 (de)	2002-01-16
NO983864D0 (no)	1998-08-21
IL125819A0 (en)	1999-04-11
EP0883619A1 (de)	1998-12-16
PL185915B1 (pl)	2003-08-29
PL328712A1 (en)	1999-02-15
CN1064363C (zh)	2001-04-11
JP4624497B2 (ja)	2011-02-02
ZA971740B (en)	1997-09-04
NO983864L (no)	1998-08-21
IL125819A (en)	2002-04-21
CZ265798A3 (cs)	1998-11-11
JP2000505463A (ja)	2000-05-09
ATE212024T1 (de)	2002-02-15
AU1769597A (en)	1997-09-16

Publication	Publication Date	Title
PT883619E (pt)	2002-07-31	Sais de morfina e de diamorfina de analgesicos anionicos nao-narcoticos do tipo dos acidos carboxilicos substituidos
MY133647A (en)	2007-11-30	Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
DE59712642D1 (de)	2006-06-08	Substituierte aminoalkanphosphonsäuren
UA42869C2 (uk)	2001-11-15	Похідні саліцилової кислоти, спосіб одержання, фармацевтична композиція для лікування аутоімунного захворювання та спосіб лікування
BR9406941A (pt)	1996-09-10	Formulação oral com revestimento entèrico processo para a preparação da formulação processo para a inibição da secreção de acido gástrico em mamiferos e no homem e processo para o tratamento de doencas relacionados ao ácidos gástrico em mamiferos e no homem
DK0760661T3 (da)	1999-08-30	Farmaceutiske sammensætninger omfattende en opiat-antagonist og calciumsalte, deres anvendelse til behandling af endorfin-m
KR960701051A (ko)	1996-02-24	이미다조피리딘 및 이를 위장 질환의 치료에 사용하는 방법(imidazopyridines and their use in treating castrointestinal diseases)
SE9401728D0 (sv)	1994-05-18	New compounds II
YU71500A (sh)	2003-02-28	Metod za dobijanje 4-karboksiamino-2-supstituisanog -1,2,3,4-tetrahidrohinolina
NO982778D0 (no)	1998-06-16	Morfinderivater med smertestillende virkning
HUP0103712A2 (hu)	2002-05-29	Paroxetin sók, eljárás az előállításukra és gyógyászati alkalmazásuk
MY133169A (en)	2007-10-31	Substituted heterocyclic benzocycloalkenes and the use thereof as substances having an analgesic effect
NO983103L (no)	1998-07-03	Nye monofunksjonelle EDTA-, DTPA- og TTHA-derivater og deres anvendelse i medisinsk diagnostikk og terapi
BR9911969A (pt)	2001-03-27	Sal e processos para a preparação de um sal, para a preparação de acetato de n-terc-butilhidroxilamina, para o isolamento de acetato de n-terc- butilhidroxilamina, e para a purificação do acetato de n-terc- butilhidroxilamina
CA2247616A1 (en)	1997-09-04	Morphine and diamorphine salts of anionic non-narcotic analgesics of the substituted carboxylic acid type
ZA961044B (en)	1997-08-11	New pyridine and pyridazine derivatives, processes for the production thereof and pharmaceutical agents containing these compounds.
SE9404438D0 (sv)	1994-12-21	New process
DE69626276D1 (de)	2003-03-27	Tetronsäurederivate zur behandlung von hiv- und anderen retroviruserkrankungen
ATE198315T1 (de)	2001-01-15	Dimethyl-substituierte cyclohexandienderivate
ATE221068T1 (de)	2002-08-15	Anellierte beta-carboline
DE59605367D1 (de)	2000-07-06	Verwendung des alpha,alpha-diphenylessigsäure-4-(n-methyl-piperidyl)esters als spasmoanalgetikum