ES2171886T3 - Sales de morfina y diamorfina de analgesicos anionicos, no narcoticos, tipo acidos carboxilicos sustituidos. - Google Patents

Sales de morfina y diamorfina de analgesicos anionicos, no narcoticos, tipo acidos carboxilicos sustituidos.

Info

Publication number
ES2171886T3
ES2171886T3 ES97903288T ES97903288T ES2171886T3 ES 2171886 T3 ES2171886 T3 ES 2171886T3 ES 97903288 T ES97903288 T ES 97903288T ES 97903288 T ES97903288 T ES 97903288T ES 2171886 T3 ES2171886 T3 ES 2171886T3
Authority
ES
Spain
Prior art keywords
salts
morphine
anionic
diamorfine
narcotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903288T
Other languages
English (en)
Inventor
Bodo Asmussen
Walter Muller
Walter Riess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Application granted granted Critical
Publication of ES2171886T3 publication Critical patent/ES2171886T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION TIENE POR OBJETO SALES DE MORFINA Y DIAMORFINA DE ANALGESICOS ANIONICOS, NO NARCOTICOS, TIPO ACIDOS CARBOXILICOS SUSTITUIDOS, PREFERENTEMENTE LAS SALES DE MORFINA Y DIAMORFINA DEL DICLOFENAC (FORMULA I). LA INVENCION TRATA ASIMISMO DE UN PROCEDIMIENTO PARA SU PREPARACION, DEL EMPLEO DE DICHAS SALES PARA EL TRATAMIENTO DE ENFERMEDADES, ASI COMO DE PREPARACIONES FARMACEUTICAS QUE CONTIENEN LAS SALES EN CUESTION.
ES97903288T 1996-02-28 1997-02-15 Sales de morfina y diamorfina de analgesicos anionicos, no narcoticos, tipo acidos carboxilicos sustituidos. Expired - Lifetime ES2171886T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19607395A DE19607395C2 (de) 1996-02-28 1996-02-28 Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate

Publications (1)

Publication Number Publication Date
ES2171886T3 true ES2171886T3 (es) 2002-09-16

Family

ID=7786595

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903288T Expired - Lifetime ES2171886T3 (es) 1996-02-28 1997-02-15 Sales de morfina y diamorfina de analgesicos anionicos, no narcoticos, tipo acidos carboxilicos sustituidos.

Country Status (20)

Country Link
US (1) US6156764A (es)
EP (1) EP0883619B1 (es)
JP (1) JP4624497B2 (es)
KR (1) KR100422276B1 (es)
CN (1) CN1064363C (es)
AT (1) ATE212024T1 (es)
AU (1) AU712255B2 (es)
CZ (1) CZ294401B6 (es)
DE (2) DE19607395C2 (es)
DK (1) DK0883619T3 (es)
ES (1) ES2171886T3 (es)
HU (1) HU225268B1 (es)
IL (1) IL125819A (es)
NO (1) NO983864L (es)
NZ (1) NZ331485A (es)
PL (1) PL185915B1 (es)
PT (1) PT883619E (es)
SK (1) SK104398A3 (es)
WO (1) WO1997031918A1 (es)
ZA (1) ZA971740B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1017696E (pt) * 1997-09-25 2002-09-30 Lohmann Therapie Syst Lts Sais de adicao de acido de alcaloides de morfina e sua utilizacao
NZ529661A (en) * 2001-06-05 2006-03-31 Control Delivery Systems Sustained-release analgesic compounds
CN1571668A (zh) * 2001-10-18 2005-01-26 诺瓦提斯公司 At1－受体拮抗剂和心血管药物形成的盐
US20030118528A1 (en) * 2001-11-19 2003-06-26 Walters Kenneth A. Topical delivery of codrugs
WO2003061626A1 (en) * 2002-01-18 2003-07-31 Control Delivery Systems, Inc. Polymeric gel system for the controlled delivery of codrugs
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2004004693A1 (en) 2002-07-05 2004-01-15 Collgegium Pharmaceutical Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US8840928B2 (en) * 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8557291B2 (en) 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
TW200500067A (en) * 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
ATE410186T1 (de) * 2003-06-26 2008-10-15 Control Delivery Sys Inc In-situ gelierendes arzneimittelabgabesystem
JP5628467B2 (ja) 2003-06-26 2014-11-19 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 生体分解性徐放性ドラッグデリバリーシステム
US20050196455A1 (en) * 2003-10-27 2005-09-08 Jianbing Chen Suspension delivery system for the sustained and controlled local release of pharmaceuticals
ES2653568T3 (es) 2004-06-12 2018-02-07 Collegium Pharmaceutical, Inc. Formulaciones de fármacos para la prevención del abuso
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404209A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and sulindac
GB8319546D0 (en) * 1983-07-20 1983-08-24 Euro Celtique Sa Pharmaceutical active salts
ZA893422B (en) * 1988-02-24 1991-01-30 Adcock Ingram Lab Ltd Pharmaceutical composition
TW225536B (es) * 1990-08-23 1994-06-21 Ciba Geigy Ag
CA2104684A1 (en) * 1991-03-04 1992-09-05 Mahdi B. Fawzi Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5256669A (en) * 1992-08-07 1993-10-26 Aminotek Sciences, Inc. Methods and compositions for treating acute or chronic pain and drug addiction
SE9301057L (sv) * 1993-03-30 1994-10-01 Pharmacia Ab Beredning med kontrollerad frisättning
FR2708611B1 (fr) * 1993-07-29 1995-10-27 Meram Lab Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
GB9319568D0 (en) * 1993-09-22 1993-11-10 Euro Celtique Sa Pharmaceutical compositions and usages
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy

Also Published As

Publication number Publication date
DE59706015D1 (de) 2002-02-21
NZ331485A (en) 1999-03-29
CZ294401B6 (cs) 2004-12-15
PT883619E (pt) 2002-07-31
HU225268B1 (en) 2006-08-28
KR100422276B1 (ko) 2004-07-30
WO1997031918A1 (de) 1997-09-04
AU712255B2 (en) 1999-11-04
DE19607395C2 (de) 2002-11-21
KR19990087343A (ko) 1999-12-27
CN1212698A (zh) 1999-03-31
HUP9900568A2 (hu) 1999-06-28
US6156764A (en) 2000-12-05
SK104398A3 (en) 1998-12-02
DE19607395A1 (de) 1997-09-04
HUP9900568A3 (en) 2001-08-28
EP0883619B1 (de) 2002-01-16
NO983864D0 (no) 1998-08-21
IL125819A0 (en) 1999-04-11
EP0883619A1 (de) 1998-12-16
PL185915B1 (pl) 2003-08-29
PL328712A1 (en) 1999-02-15
CN1064363C (zh) 2001-04-11
JP4624497B2 (ja) 2011-02-02
ZA971740B (en) 1997-09-04
NO983864L (no) 1998-08-21
IL125819A (en) 2002-04-21
DK0883619T3 (da) 2002-04-29
CZ265798A3 (cs) 1998-11-11
JP2000505463A (ja) 2000-05-09
ATE212024T1 (de) 2002-02-15
AU1769597A (en) 1997-09-16

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