DK0884319T3 - N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2H-1,3-oxazino-3,2a-indol-10-carboxamid eller et farmaceutisk acceptabelt salt deraf - Google Patents

N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2H-1,3-oxazino-3,2a-indol-10-carboxamid eller et farmaceutisk acceptabelt salt deraf

Info

Publication number: DK0884319T3
Authority: DK; Denmark
Prior art keywords: oxazino; nbutyl; piperidyl; carboxamide; indole
Prior art date: 1992-03-12

Application number

DK98114130T

Other languages

English (en)

Inventor

Laramie Mary Gaster

Paul Adrian Wyman

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-12

Filing date

1993-03-10

Publication date

2004-08-30

1992-03-12 Priority claimed from GB929205428A external-priority patent/GB9205428D0/en

1992-09-05 Priority claimed from GB929218846A external-priority patent/GB9218846D0/en

1992-12-29 Priority claimed from GB929227045A external-priority patent/GB9227045D0/en

1993-03-10 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2004-08-30 Application granted granted Critical

2004-08-30 Publication of DK0884319T3 publication Critical patent/DK0884319T3/da

Links

150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

DK98114130T 1992-03-12 1993-03-10 N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2H-1,3-oxazino-3,2a-indol-10-carboxamid eller et farmaceutisk acceptabelt salt deraf DK0884319T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB929205428A GB9205428D0 (en)	1992-03-12	1992-03-12	Pharmaceuticals
GB929218846A GB9218846D0 (en)	1992-09-05	1992-09-05	Pharmaceuticals
GB929227045A GB9227045D0 (en)	1992-12-29	1992-12-29	Pharmaceuticals
EP93905561A EP0630376B1 (en)	1992-03-12	1993-03-10	Condensed indole derivatives as 5-ht4-receptor antagonists

Publications (1)

Publication Number	Publication Date
DK0884319T3 true DK0884319T3 (da)	2004-08-30

Family

ID=27266092

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK98114130T DK0884319T3 (da)	1992-03-12	1993-03-10	N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2H-1,3-oxazino-3,2a-indol-10-carboxamid eller et farmaceutisk acceptabelt salt deraf
DK93905561T DK0630376T3 (da)	1992-03-12	1993-03-10	Kondenserede indolderivater som 5-HT4-receptorantagonister

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK93905561T DK0630376T3 (da)	1992-03-12	1993-03-10	Kondenserede indolderivater som 5-HT4-receptorantagonister

Country Status (29)

Country	Link
EP (2)	EP0884319B1 (da)
JP (1)	JP2831467B2 (da)
KR (1)	KR100282730B1 (da)
CN (2)	CN1043893C (da)
AP (1)	AP401A (da)
AT (2)	ATE266033T1 (da)
AU (1)	AU671102B2 (da)
CA (1)	CA2131797C (da)
CY (1)	CY2510B1 (da)
CZ (1)	CZ286194B6 (da)
DE (2)	DE69333504T2 (da)
DK (2)	DK0884319T3 (da)
ES (2)	ES2219813T3 (da)
FI (1)	FI107158B (da)
GR (1)	GR3030668T3 (da)
HU (1)	HU219121B (da)
IL (1)	IL105003A (da)
MA (1)	MA22819A1 (da)
MX (1)	MX9301348A (da)
MY (1)	MY110110A (da)
NO (1)	NO303638B1 (da)
NZ (1)	NZ249565A (da)
PT (1)	PT884319E (da)
RU (1)	RU2104279C1 (da)
SG (1)	SG50693A1 (da)
SI (1)	SI9300114B (da)
SK (1)	SK281423B6 (da)
UA (1)	UA41311C2 (da)
WO (1)	WO1993018036A1 (da)

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US5998409A (en) *	1992-03-12	1999-12-07	Smithkline Beecham Plc	Condensed indole derivatives as 5HT4 -receptor antagonists
US5852014A (en) *	1992-03-12	1998-12-22	Smithkline Beecham P.L.C.	Condensed indole derivatives as 5HT4 -receptor antagonists
GB9316195D0 (en) *	1993-08-05	1993-09-22	Smithkline Beecham Plc	Pharmaceuticals
MX9305947A (es) *	1992-09-29	1994-06-30	Smithkline Beecham Plc	Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
WO1994008965A1 (en) *	1992-10-16	1994-04-28	Smithkline Beecham Plc	N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
US5705498A (en) *	1992-11-05	1998-01-06	Smithkline Beecham Plc.	Piperidine derivatives as 5-HT4 receptor antagonists
FR2699921B1 (fr) *	1992-12-30	1995-02-10	Synthelabo	Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) *	1993-02-19	1993-04-07	Smithkline Beecham Plc	Pharmaceuticals
GB9310582D0 (en) *	1993-05-22	1993-07-07	Smithkline Beecham Plc	Pharmaceuticals
GB9312348D0 (en) *	1993-06-16	1993-07-28	Smithkline Beecham Plc	Pharmaceuticals
KR100219922B1 (ko) *	1996-05-16	1999-09-01	이서봉	신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US6013666A (en) *	1996-07-02	2000-01-11	Sang Sup Jew	Oxirane carboxylic acid derivative and its manufacturing method
US6100397A (en) *	1996-08-16	2000-08-08	Smithkline Beecham Plc	Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
WO1998007728A1 (en) *	1996-08-16	1998-02-26	Smithkline Beecham Plc	PROCESS FOR THE PREPARATION OF N-[(1-nBUTYL-4-PIPERIDYL)METHYL] -3,4-DIHYDRO -2H-[1,3] OXAZINO[3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS
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GB9725933D0 (en) *	1997-12-05	1998-02-04	Smithkline Beecham Plc	Pharmaceuticals
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US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US20020091271A1 (en)	1998-07-16	2002-07-11	Smithkline Beecham Plc	Process for the preparation of an indole derivative
GB9819035D0 (en) *	1998-09-01	1998-10-28	Cerebrus Res Ltd	Chemical compounds VII
JP3366323B2 (ja) *	1998-09-10	2003-01-14	エフ．ホフマン−ラロシュアーゲー	５−ｈｔ４受容体アンタゴニストとしてのジヒドロベンゾジオキシンカルボキサミド及びケトン誘導体
GB9820294D0 (en) *	1998-09-17	1998-11-11	Smithkline Beecham Plc	Pharmaceuticals
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
AU2005203196B9 (en) *	2000-08-07	2009-04-09	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782863C (en) *	2000-08-07	2006-08-31	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
MXPA03001210A (es) *	2000-08-07	2004-08-12	Smithkline Beecham Corp	Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial.
AU782870C (en) *	2000-08-07	2007-03-15	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
NZ535261A (en)	2000-08-08	2004-12-24	Smithkline Beecham P	A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
CA2418921C (en) *	2000-08-08	2010-10-26	Smithkline Beecham P.L.C.	Novel composition
BR0307666A (pt) *	2002-02-14	2005-01-11	Glaxo Group Ltd	Composição farmacêutica compreendendo n-[(1-n-butil-4-piperidinil)metil]-3,4-diidro-2h[1-3]oxazi no(3,2-a) indol-10-carboxamida ou sal e processo para esta compreendendo granulação seca
US7009049B2 (en)	2002-02-15	2006-03-07	Cytokinetics, Inc.	Syntheses of quinazolinones
AU2003270015A1 (en)	2002-05-09	2003-12-02	Cytokinetics, Inc.	Compounds, compositions, and methods
US7166595B2 (en)	2002-05-09	2007-01-23	Cytokinetics, Inc.	Compounds, methods and compositions
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
WO2003103575A2 (en)	2002-05-23	2003-12-18	Cytokinetics, Inc.	Compounds, compositions, and methods
CA2489367A1 (en)	2002-06-14	2003-12-24	Cytokinetics, Inc.	Compounds, compositions, and methods
WO2004009036A2 (en)	2002-07-23	2004-01-29	Cytokinetics, Inc.	Compounds compositions and methods
WO2004034972A2 (en)	2002-09-30	2004-04-29	Cytokinetics, Inc.	Compounds, compositions, and methods
ITMI20031468A1 (it)	2003-07-18	2005-01-19	Acraf	Farmaco ativo nel dolore neuropatico
ITMI20031467A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco attivo nel dolore neuropatico
EP1692112A4 (en)	2003-12-08	2008-09-24	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS, AND METHODS
WO2005061483A2 (en)	2003-12-23	2005-07-07	Bio-Medisinsk Innovasjon As	Modulators of peripheral 5-ht receptors
JP4612301B2 (ja) *	2003-12-26	2011-01-12	広栄化学工業株式会社	１−アルキル−４−アミノメチルピペリジンの製造法
RU2401257C2 (ru) *	2004-12-07	2010-10-10	Янссен Фармацевтика Н.В.	Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена
RU2320662C1 (ru) *	2006-08-24	2008-03-27	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ ПИРРОЛО[4,3-b]ИНДОЛЫ, КОМБИНАТОРНАЯ И ФОКУСИРОВАННАЯ БИБЛИОТЕКИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
CN101801937A (zh)	2007-06-22	2010-08-11	艾科尔公司	喹唑啉酮化合物及其使用方法
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WO2021116487A1 (en)	2019-12-13	2021-06-17	Som Innovation Biotech, S.A.	Compounds for use in the treatment of niemann-pick c disease
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DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung
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1993
- 1993-03-10 RU RU94040864A patent/RU2104279C1/ru not_active IP Right Cessation
- 1993-03-10 WO PCT/GB1993/000506 patent/WO1993018036A1/en not_active Ceased
- 1993-03-10 KR KR1019940703167A patent/KR100282730B1/ko not_active Expired - Fee Related
- 1993-03-10 EP EP98114130A patent/EP0884319B1/en not_active Expired - Lifetime
- 1993-03-10 PT PT98114130T patent/PT884319E/pt unknown
- 1993-03-10 DE DE69333504T patent/DE69333504T2/de not_active Expired - Lifetime
- 1993-03-10 DK DK98114130T patent/DK0884319T3/da active
- 1993-03-10 EP EP93905561A patent/EP0630376B1/en not_active Expired - Lifetime
- 1993-03-10 NZ NZ249565A patent/NZ249565A/en not_active IP Right Cessation
- 1993-03-10 DE DE69325167T patent/DE69325167T2/de not_active Expired - Lifetime
- 1993-03-10 JP JP5515490A patent/JP2831467B2/ja not_active Expired - Lifetime
- 1993-03-10 MY MYPI93000436A patent/MY110110A/en unknown
- 1993-03-10 AT AT98114130T patent/ATE266033T1/de active
- 1993-03-10 DK DK93905561T patent/DK0630376T3/da active
- 1993-03-10 SK SK1078-94A patent/SK281423B6/sk not_active IP Right Cessation
- 1993-03-10 AU AU36448/93A patent/AU671102B2/en not_active Expired
- 1993-03-10 UA UA94095780A patent/UA41311C2/uk unknown
- 1993-03-10 ES ES98114130T patent/ES2219813T3/es not_active Expired - Lifetime
- 1993-03-10 CZ CZ19942210A patent/CZ286194B6/cs not_active IP Right Cessation
- 1993-03-10 MA MA23113A patent/MA22819A1/fr unknown
- 1993-03-10 AP APAP/P/1993/000494A patent/AP401A/en active
- 1993-03-10 CA CA2131797A patent/CA2131797C/en not_active Expired - Fee Related
- 1993-03-10 HU HU9402601A patent/HU219121B/hu unknown
- 1993-03-10 SG SG1996008846A patent/SG50693A1/en unknown
- 1993-03-10 IL IL10500393A patent/IL105003A/en not_active IP Right Cessation
- 1993-03-10 SI SI9300114A patent/SI9300114B/sl active Search and Examination
- 1993-03-10 ES ES93905561T patent/ES2132223T3/es not_active Expired - Lifetime
- 1993-03-10 AT AT93905561T patent/ATE180785T1/de active
- 1993-03-11 CN CN93102648A patent/CN1043893C/zh not_active Expired - Fee Related
- 1993-03-11 MX MX9301348A patent/MX9301348A/es not_active IP Right Cessation
- 1993-05-22 CN CN93107234A patent/CN1085083A/zh active Pending
1994
- 1994-09-09 NO NO943348A patent/NO303638B1/no not_active IP Right Cessation
- 1994-09-12 FI FI944204A patent/FI107158B/fi not_active IP Right Cessation
1999
- 1999-06-30 GR GR990401755T patent/GR3030668T3/el unknown
2005
- 2005-04-12 CY CY0500021A patent/CY2510B1/xx unknown

Also Published As

Publication number	Publication date
MX9301348A (es)	1993-09-01
FI944204A0 (fi)	1994-09-12
SG50693A1 (en)	1998-07-20
WO1993018036A1 (en)	1993-09-16
SK107894A3 (en)	1995-04-12
HUT71121A (en)	1995-11-28
CZ286194B6 (cs)	2000-02-16
KR100282730B1 (ko)	2001-02-15
FI107158B (fi)	2001-06-15
NO303638B1 (no)	1998-08-10
DK0630376T3 (da)	1999-06-23
HU9402601D0 (en)	1994-12-28
JPH07504433A (ja)	1995-05-18
CN1043893C (zh)	1999-06-30
CN1085083A (zh)	1994-04-13
JP2831467B2 (ja)	1998-12-02
DE69333504D1 (de)	2004-06-09
PT884319E (pt)	2004-09-30
ES2132223T3 (es)	1999-08-16
AP401A (en)	1995-08-29
NO943348D0 (no)	1994-09-09
CA2131797C (en)	2010-05-18
RU2104279C1 (ru)	1998-02-10
RU94040864A (ru)	1996-07-20
ATE266033T1 (de)	2004-05-15
AU671102B2 (en)	1996-08-15
DE69333504T2 (de)	2005-05-12
CN1078471A (zh)	1993-11-17
NO943348L (no)	1994-11-09
NZ249565A (en)	1997-07-27
MA22819A1 (fr)	1993-10-01
FI944204L (fi)	1994-09-12
SI9300114A (sl)	1993-12-31
GR3030668T3 (en)	1999-10-29
SI9300114B (sl)	2006-08-31
EP0884319A3 (en)	1999-02-10
EP0630376A1 (en)	1994-12-28
DE69325167D1 (de)	1999-07-08
SK281423B6 (sk)	2001-03-12
KR950700304A (ko)	1995-01-16
MY110110A (en)	1998-01-27
AP9300494A0 (en)	1993-04-30
IL105003A (en)	1996-09-12
HK1012352A1 (en)	1999-07-30
AU3644893A (en)	1993-10-05
CY2510B1 (en)	2005-12-23
IL105003A0 (en)	1993-07-08
DE69325167T2 (de)	2000-01-20
EP0884319B1 (en)	2004-05-06
ES2219813T3 (es)	2004-12-01
EP0630376B1 (en)	1999-06-02
UA41311C2 (uk)	2001-09-17
ATE180785T1 (de)	1999-06-15
CA2131797A1 (en)	1993-09-16
HU219121B (hu)	2001-02-28
EP0884319A2 (en)	1998-12-16
CZ221094A3 (en)	1995-09-13

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