NO943348L - Kondenserte indolderivater som 5HT4-reseptorantagonister - Google Patents

Kondenserte indolderivater som 5HT4-reseptorantagonister

Info

Publication number: NO943348L
Authority: NO; Norway
Prior art keywords: receptor antagonists; indole derivatives; condensed indole; condensed; derivatives
Prior art date: 1992-03-12

Application number

NO943348A

Other languages

English (en)

Other versions

NO303638B1 (no

NO943348D0 (no

Inventor

Laramie Mary Gaster

Paul Adrian Wyman

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-12

Filing date

1994-09-09

Publication date

1994-11-09

1992-03-12 Priority claimed from GB929205428A external-priority patent/GB9205428D0/en

1992-09-05 Priority claimed from GB929218846A external-priority patent/GB9218846D0/en

1992-12-29 Priority claimed from GB929227045A external-priority patent/GB9227045D0/en

1994-09-09 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1994-09-09 Publication of NO943348D0 publication Critical patent/NO943348D0/no

1994-11-09 Publication of NO943348L publication Critical patent/NO943348L/no

1998-08-10 Publication of NO303638B1 publication Critical patent/NO303638B1/no

Links

108091005482 5-HT4 receptors Proteins 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO943348A 1992-03-12 1994-09-09 Kondenserte indolderivater, farmas°ytiske preparater inneholdende disse og anvendelse av derivatene NO303638B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB929205428A GB9205428D0 (en)	1992-03-12	1992-03-12	Pharmaceuticals
GB929218846A GB9218846D0 (en)	1992-09-05	1992-09-05	Pharmaceuticals
GB929227045A GB9227045D0 (en)	1992-12-29	1992-12-29	Pharmaceuticals
PCT/GB1993/000506 WO1993018036A1 (en)	1992-03-12	1993-03-10	Condensed indole derivatives as 5ht4-receptor antagonists

Publications (3)

Publication Number	Publication Date
NO943348D0 NO943348D0 (no)	1994-09-09
NO943348L true NO943348L (no)	1994-11-09
NO303638B1 NO303638B1 (no)	1998-08-10

Family

ID=27266092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO943348A NO303638B1 (no)	1992-03-12	1994-09-09	Kondenserte indolderivater, farmas°ytiske preparater inneholdende disse og anvendelse av derivatene

Country Status (29)

Country	Link
EP (2)	EP0884319B1 (no)
JP (1)	JP2831467B2 (no)
KR (1)	KR100282730B1 (no)
CN (2)	CN1043893C (no)
AP (1)	AP401A (no)
AT (2)	ATE266033T1 (no)
AU (1)	AU671102B2 (no)
CA (1)	CA2131797C (no)
CY (1)	CY2510B1 (no)
CZ (1)	CZ286194B6 (no)
DE (2)	DE69333504T2 (no)
DK (2)	DK0630376T3 (no)
ES (2)	ES2219813T3 (no)
FI (1)	FI107158B (no)
GR (1)	GR3030668T3 (no)
HU (1)	HU219121B (no)
IL (1)	IL105003A (no)
MA (1)	MA22819A1 (no)
MX (1)	MX9301348A (no)
MY (1)	MY110110A (no)
NO (1)	NO303638B1 (no)
NZ (1)	NZ249565A (no)
PT (1)	PT884319E (no)
RU (1)	RU2104279C1 (no)
SG (1)	SG50693A1 (no)
SI (1)	SI9300114B (no)
SK (1)	SK281423B6 (no)
UA (1)	UA41311C2 (no)
WO (1)	WO1993018036A1 (no)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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US5852014A (en) *	1992-03-12	1998-12-22	Smithkline Beecham P.L.C.	Condensed indole derivatives as 5HT4 -receptor antagonists
GB9316195D0 (en) *	1993-08-05	1993-09-22	Smithkline Beecham Plc	Pharmaceuticals
US5998409A (en) *	1992-03-12	1999-12-07	Smithkline Beecham Plc	Condensed indole derivatives as 5HT4 -receptor antagonists
MX9305947A (es) *	1992-09-29	1994-06-30	Smithkline Beecham Plc	Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
EP0664794A1 (en) *	1992-10-16	1995-08-02	Smithkline Beecham Plc	N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
US5705498A (en) *	1992-11-05	1998-01-06	Smithkline Beecham Plc.	Piperidine derivatives as 5-HT4 receptor antagonists
FR2699921B1 (fr) *	1992-12-30	1995-02-10	Synthelabo	Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) *	1993-02-19	1993-04-07	Smithkline Beecham Plc	Pharmaceuticals
GB9310582D0 (en) *	1993-05-22	1993-07-07	Smithkline Beecham Plc	Pharmaceuticals
GB9312348D0 (en) *	1993-06-16	1993-07-28	Smithkline Beecham Plc	Pharmaceuticals
KR100219922B1 (ko) *	1996-05-16	1999-09-01	이서봉	신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
AU3464397A (en) *	1996-07-02	1998-01-21	Sang Sup Jew	Oxirane carboxylic acid derivative and its manufacturing method
TR199900321T2 (xx) *	1996-08-16	1999-04-21	Smithkline Beecham P.L.C.	N-(1-nbutil - 4 - piperidil)metil) -3,4-dihidro -2H- (1,3) oksazino (3.2A) indol-10- Karboksamit haz�rlama prosesi ve prosesteki tuzlar ve ara �r�nler.
US6100397A (en) *	1996-08-16	2000-08-08	Smithkline Beecham Plc	Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
GB9618967D0 (en) *	1996-09-11	1996-10-23	Smithkline Beecham Plc	Pharmaceuticals
GB9725933D0 (en) *	1997-12-05	1998-02-04	Smithkline Beecham Plc	Pharmaceuticals
US6277870B1 (en) *	1998-05-04	2001-08-21	Astra Ab	Use
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US20020091271A1 (en)	1998-07-16	2002-07-11	Smithkline Beecham Plc	Process for the preparation of an indole derivative
GB9819035D0 (en)	1998-09-01	1998-10-28	Cerebrus Res Ltd	Chemical compounds VII
CA2340952C (en) *	1998-09-10	2009-12-08	F. Hoffmann-La Roche Ag	Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
GB9820294D0 (en) *	1998-09-17	1998-11-11	Smithkline Beecham Plc	Pharmaceuticals
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
AU782870C (en) *	2000-08-07	2007-03-15	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
BR0113073A (pt) *	2000-08-07	2004-06-22	Glaxosmithkline Lab Sas	Uso de antagonistas receptores 5ht4 na fabricação de um medicamento para a profilaxia ou tratamento de fibrilação atrial
AU782863C (en) *	2000-08-07	2006-08-31	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU2005203196B9 (en) *	2000-08-07	2009-04-09	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
EP1313481B1 (en) *	2000-08-08	2007-09-26	Smithkline Beecham Plc	Pharmaceutical composition comprising condensed indole compound
NZ535261A (en)	2000-08-08	2004-12-24	Smithkline Beecham P	A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
JP2005523276A (ja) *	2002-02-14	2005-08-04	グラクソ　グループ　リミテッド	Ｎ−［（１−ｎ−ブチル−４−ピペリジニル）メチル］−３，４−ジヒドロ−２ｈ−［１，３］オキサジノ［３，２−ａ］インドール−１０−カルボキシアミド（ｓｂ２０７２６６）またはその塩および乾燥造粒操作を含む方法
AU2003213092A1 (en)	2002-02-15	2003-09-09	Smithkline Beecham Corporation	Syntheses of quinazolinones
EP1503993A4 (en)	2002-05-09	2006-05-03	Cytokinetics Inc	COMPOUNDS, METHODS AND COMPOSITIONS
JP2005530785A (ja)	2002-05-09	2005-10-13	サイトキネティクス・インコーポレーテッド	化合物、組成物、及び方法
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
EP1513820A4 (en)	2002-05-23	2006-09-13	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
EP1556357A4 (en)	2002-06-14	2006-09-13	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
US7211580B2 (en)	2002-07-23	2007-05-01	Cytokinetics, Incorporated	Compounds, compositions, and methods
JP2006501306A (ja)	2002-09-30	2006-01-12	サイトキネティクス・インコーポレーテッド	化合物、組成物および方法
ITMI20031468A1 (it)	2003-07-18	2005-01-19	Acraf	Farmaco ativo nel dolore neuropatico
ITMI20031467A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco attivo nel dolore neuropatico
JP2007513154A (ja)	2003-12-08	2007-05-24	サイトキネティクス・インコーポレーテッド	化合物、組成物及び方法
DE602004025508D1 (de)	2003-12-23	2010-03-25	Serodus As	Modulatoren von peripheren 5-ht-rezeptoren
JP4612301B2 (ja) *	2003-12-26	2011-01-12	広栄化学工業株式会社	１−アルキル−４−アミノメチルピペリジンの製造法
RU2401257C2 (ru) *	2004-12-07	2010-10-10	Янссен Фармацевтика Н.В.	Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена
RU2320662C1 (ru) *	2006-08-24	2008-03-27	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ ПИРРОЛО[4,3-b]ИНДОЛЫ, КОМБИНАТОРНАЯ И ФОКУСИРОВАННАЯ БИБЛИОТЕКИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
CN101801937A (zh)	2007-06-22	2010-08-11	艾科尔公司	喹唑啉酮化合物及其使用方法
GB0905641D0 (en) *	2009-04-01	2009-05-13	Serodus As	Compounds
WO2021116487A1 (en)	2019-12-13	2021-06-17	Som Innovation Biotech, S.A.	Compounds for use in the treatment of niemann-pick c disease
AU2024358558A1 (en) *	2023-10-13	2026-05-07	Fauna Bio Incorporated	Methods and compositions for treating cardio-pulmonary disorders

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DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung
AU622330B2 (en) *	1989-06-23	1992-04-02	Takeda Chemical Industries Ltd.	Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
CA2030051C (en) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Indole derivatives
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists
GB9103862D0 (en) *	1991-02-25	1991-04-10	Glaxo Group Ltd	Chemical compounds
US5206382A (en) *	1991-06-27	1993-04-27	Fidia Georgetown Institute For The Neurosciences	Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders

1993
- 1993-03-10 AT AT98114130T patent/ATE266033T1/de active
- 1993-03-10 UA UA94095780A patent/UA41311C2/uk unknown
- 1993-03-10 WO PCT/GB1993/000506 patent/WO1993018036A1/en not_active Ceased
- 1993-03-10 PT PT98114130T patent/PT884319E/pt unknown
- 1993-03-10 IL IL10500393A patent/IL105003A/en not_active IP Right Cessation
- 1993-03-10 ES ES98114130T patent/ES2219813T3/es not_active Expired - Lifetime
- 1993-03-10 DK DK93905561T patent/DK0630376T3/da active
- 1993-03-10 CZ CZ19942210A patent/CZ286194B6/cs not_active IP Right Cessation
- 1993-03-10 HU HU9402601A patent/HU219121B/hu unknown
- 1993-03-10 SI SI9300114A patent/SI9300114B/sl active Search and Examination
- 1993-03-10 MA MA23113A patent/MA22819A1/fr unknown
- 1993-03-10 DE DE69333504T patent/DE69333504T2/de not_active Expired - Lifetime
- 1993-03-10 DK DK98114130T patent/DK0884319T3/da active
- 1993-03-10 KR KR1019940703167A patent/KR100282730B1/ko not_active Expired - Fee Related
- 1993-03-10 EP EP98114130A patent/EP0884319B1/en not_active Expired - Lifetime
- 1993-03-10 EP EP93905561A patent/EP0630376B1/en not_active Expired - Lifetime
- 1993-03-10 AU AU36448/93A patent/AU671102B2/en not_active Expired
- 1993-03-10 AT AT93905561T patent/ATE180785T1/de active
- 1993-03-10 ES ES93905561T patent/ES2132223T3/es not_active Expired - Lifetime
- 1993-03-10 RU RU94040864A patent/RU2104279C1/ru not_active IP Right Cessation
- 1993-03-10 NZ NZ249565A patent/NZ249565A/en not_active IP Right Cessation
- 1993-03-10 JP JP5515490A patent/JP2831467B2/ja not_active Expired - Lifetime
- 1993-03-10 AP APAP/P/1993/000494A patent/AP401A/en active
- 1993-03-10 SG SG1996008846A patent/SG50693A1/en unknown
- 1993-03-10 DE DE69325167T patent/DE69325167T2/de not_active Expired - Lifetime
- 1993-03-10 MY MYPI93000436A patent/MY110110A/en unknown
- 1993-03-10 CA CA2131797A patent/CA2131797C/en not_active Expired - Fee Related
- 1993-03-10 SK SK1078-94A patent/SK281423B6/sk not_active IP Right Cessation
- 1993-03-11 MX MX9301348A patent/MX9301348A/es not_active IP Right Cessation
- 1993-03-11 CN CN93102648A patent/CN1043893C/zh not_active Expired - Fee Related
- 1993-05-22 CN CN93107234A patent/CN1085083A/zh active Pending
1994
- 1994-09-09 NO NO943348A patent/NO303638B1/no not_active IP Right Cessation
- 1994-09-12 FI FI944204A patent/FI107158B/fi not_active IP Right Cessation
1999
- 1999-06-30 GR GR990401755T patent/GR3030668T3/el unknown
2005
- 2005-04-12 CY CY0500021A patent/CY2510B1/xx unknown

Also Published As

Publication number	Publication date
HU9402601D0 (en)	1994-12-28
FI107158B (fi)	2001-06-15
CY2510B1 (en)	2005-12-23
SK107894A3 (en)	1995-04-12
EP0630376A1 (en)	1994-12-28
JPH07504433A (ja)	1995-05-18
IL105003A (en)	1996-09-12
KR950700304A (ko)	1995-01-16
CN1078471A (zh)	1993-11-17
CA2131797A1 (en)	1993-09-16
EP0630376B1 (en)	1999-06-02
JP2831467B2 (ja)	1998-12-02
CN1085083A (zh)	1994-04-13
MY110110A (en)	1998-01-27
SG50693A1 (en)	1998-07-20
WO1993018036A1 (en)	1993-09-16
IL105003A0 (en)	1993-07-08
GR3030668T3 (en)	1999-10-29
CZ286194B6 (cs)	2000-02-16
MA22819A1 (fr)	1993-10-01
AP401A (en)	1995-08-29
RU2104279C1 (ru)	1998-02-10
HU219121B (hu)	2001-02-28
HUT71121A (en)	1995-11-28
DK0884319T3 (da)	2004-08-30
SI9300114A (sl)	1993-12-31
AP9300494A0 (en)	1993-04-30
AU671102B2 (en)	1996-08-15
NZ249565A (en)	1997-07-27
NO303638B1 (no)	1998-08-10
ES2132223T3 (es)	1999-08-16
AU3644893A (en)	1993-10-05
ATE266033T1 (de)	2004-05-15
ATE180785T1 (de)	1999-06-15
EP0884319A2 (en)	1998-12-16
DE69325167T2 (de)	2000-01-20
FI944204A0 (fi)	1994-09-12
CN1043893C (zh)	1999-06-30
DE69333504T2 (de)	2005-05-12
UA41311C2 (uk)	2001-09-17
CA2131797C (en)	2010-05-18
KR100282730B1 (ko)	2001-02-15
SK281423B6 (sk)	2001-03-12
ES2219813T3 (es)	2004-12-01
PT884319E (pt)	2004-09-30
RU94040864A (ru)	1996-07-20
EP0884319A3 (en)	1999-02-10
MX9301348A (es)	1993-09-01
CZ221094A3 (en)	1995-09-13
DE69325167D1 (de)	1999-07-08
DE69333504D1 (de)	2004-06-09
DK0630376T3 (da)	1999-06-23
FI944204L (fi)	1994-09-12
SI9300114B (sl)	2006-08-31
EP0884319B1 (en)	2004-05-06
NO943348D0 (no)	1994-09-09
HK1012352A1 (en)	1999-07-30

Legal Events

Date	Code	Title	Description
2013-04-15	MK1K	Patent expired

Publication	Publication Date	Title
NO943348D0 (no)	1994-09-09	Kondenserte indolderivater som 5HT4-reseptorantagonister
NO985225L (no)	1998-11-09	Indolderivater nyttige som endotelinreseptorantagonister
FI973205A0 (fi)	1997-08-01	Indolijohdannaisia 5-HT-reseptoriantagonisteina
FI943247L (fi)	1994-07-07	Piperatsiinijohdannaisia 5-HT-reseptoriantagonisteina
DK0856001T3 (da)	2002-12-30	Pyrimidinderivater som 5-HT2C-receptor-antagonister
NO965036L (no)	1997-01-24	Kinolinderivater som techykinin NK3 reseptor-antagonister
FI961628A0 (fi)	1996-04-12	Indolijohdannaisia NMDA-antagonisteina
NO974043L (no)	1997-11-03	Indolderivater som EAA-antagonister
NO985970D0 (no)	1998-12-18	Indolinderivater anvendelige som 5_HT-2C-reseptor-antagonister
FI951798A0 (fi)	1995-04-13	Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
NO985972L (no)	1998-12-18	Indolinderivater anvendelige som 5-HT-2C reseptorantagonister
DK0815105T3 (da)	2002-01-21	Heterocyklisk substituerede piperazinonderivater som tachykininreceptor-antagonister
ATE208764T1 (de)	2001-11-15	Isazole derivate als fibrinogen-rezeptor- antagonisten
NO943101D0 (no)	1994-08-23	2,6-metano-2H-kinolizinderivat som 5-HT3-reseptorantagonist
NO963775L (no)	1996-09-09	Indol-derivater som CCK-reseptorantagonister
FI941117A7 (fi)	1994-09-11	Bentsyyli-imidatsopyridiinijohdannaiset angiotensiini II reseptoriantagonisteina