DK0902085T3 - Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil - Google Patents

Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil

Info

Publication number: DK0902085T3
Authority: DK; Denmark
Prior art keywords: dna sequences; vectors; polypeptides; glycosylation profile; erythropoietin
Prior art date: 1997-09-01

Application number

DK97115081T

Other languages

English (en)

Inventor

Mathias Dr Fibi

Peter Dr Hermentin

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-01

Filing date

1997-09-01

Publication date

2004-04-05

1997-09-01 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2004-04-05 Application granted granted Critical

2004-04-05 Publication of DK0902085T3 publication Critical patent/DK0902085T3/da

Links

230000013595 glycosylation Effects 0.000 title abstract 2
238000006206 glycosylation reaction Methods 0.000 title abstract 2
101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 title 1
101000920686 Homo sapiens Erythropoietin Proteins 0.000 title 1
230000002349 favourable effect Effects 0.000 title 1
102000044890 human EPO Human genes 0.000 title 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 6
229920001184 polypeptide Polymers 0.000 abstract 5
102000004196 processed proteins & peptides Human genes 0.000 abstract 5
108090000765 processed proteins & peptides Proteins 0.000 abstract 5
239000013598 vector Substances 0.000 abstract 4
102000003951 Erythropoietin Human genes 0.000 abstract 2
108090000394 Erythropoietin Proteins 0.000 abstract 2
230000004071 biological effect Effects 0.000 abstract 2
229940105423 erythropoietin Drugs 0.000 abstract 2
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 2
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
208000007502 anemia Diseases 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK97115081T 1997-09-01 1997-09-01 Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil DK0902085T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97115081A EP0902085B1 (en)	1997-09-01	1997-09-01	Recombinant human erythropoietin with advantageous glycosylation profile

Publications (1)

Publication Number	Publication Date
DK0902085T3 true DK0902085T3 (da)	2004-04-05

Family

ID=8227297

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97115081T DK0902085T3 (da)	1997-09-01	1997-09-01	Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil

Country Status (12)

Country	Link
US (1)	US6673609B1 (da)
EP (2)	EP0902085B1 (da)
JP (1)	JP4345077B2 (da)
KR (1)	KR100563017B1 (da)
AT (1)	ATE255634T1 (da)
AU (1)	AU743833B2 (da)
CA (1)	CA2303476A1 (da)
DE (1)	DE69726571T2 (da)
DK (1)	DK0902085T3 (da)
ES (1)	ES2208798T3 (da)
PT (1)	PT902085E (da)
WO (1)	WO1999011781A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US7304150B1 (en)	1998-10-23	2007-12-04	Amgen Inc.	Methods and compositions for the prevention and treatment of anemia
ATE355303T1 (de) *	1998-10-23	2006-03-15	Amgen Inc	Methoden und zusammensetzungen zur prävention und behandlung der anämie
JP2003523940A (ja) *	1999-05-11	2003-08-12	オーソ−マクネイルファーマシューティカルインコーポレイテッド	エリスロポエチン投与の薬物速度論的および薬力学的モデリング
CZ299516B6 (cs)	1999-07-02	2008-08-20	F. Hoffmann-La Roche Ag	Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
EP1274720A4 (en)	2000-04-12	2004-08-18	Human Genome Sciences Inc	FUSION PROTEINS CONTAINING ALBUMIN
NZ548578A (en)	2001-02-02	2008-03-28	Ortho Mcneil Pharm Inc	Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin
US6818613B2 (en)	2001-11-07	2004-11-16	Ortho-Mcneil Pharmaceutical, Inc.	Aqueous sustained-release formulations of proteins
US7232797B2 (en)	2001-11-28	2007-06-19	Ortho-Mcneil Pharmaceutical, Inc.	Erythropoietin dosing regimen for treating anemia
PT1463751E (pt)	2001-12-21	2013-08-26	Human Genome Sciences Inc	Proteínas de fusão de albumina
WO2003078959A2 (en)	2002-03-11	2003-09-25	Ortho Mcneil Pharmaceutical, Inc	Methods for shp1 mediated neuroprotection
US7553930B2 (en)	2003-01-06	2009-06-30	Xencor, Inc.	BAFF variants and methods thereof
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
SI1957630T2 (sl)	2005-12-08	2023-07-31	Amgen Inc.	Izboljšana proizvodnja glikoproteinov z uporabo mangana
CN101062407A (zh)	2006-04-29	2007-10-31	中国科学院上海生命科学研究院	促红细胞生成素在预防或治疗视网膜损伤中的用途
NZ602170A (en)	2008-02-08	2014-03-28	Ambrx Inc	Modified leptin polypeptides and their uses
PL2342223T3 (pl)	2008-09-26	2017-09-29	Ambrx, Inc.	Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL77081A (en) *	1984-12-04	1999-10-28	Genetics Inst	Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin
US5641663A (en) *	1985-11-06	1997-06-24	Cangene Corporation	Expression system for the secretion of bioactive human granulocyte macrophage colony stimulating factor (GM-CSF) and other heterologous proteins from steptomyces
US4954437A (en) *	1986-09-15	1990-09-04	Integrated Genetics, Inc.	Cell encoding recombinant human erythropoietin
DE3923963A1 (de) *	1989-07-20	1991-01-31	Behringwerke Ag	Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung
JPH03151399A (ja) *	1989-11-07	1991-06-27	Snow Brand Milk Prod Co Ltd	変異ヒトエリスロポエチン
JPH05502463A (ja) *	1990-09-28	1993-04-28	オーソ・フアーマシユーチカル・コーポレーシヨン	ハイブリツド成長因子
IL192290A0 (en) *	1993-08-17	2008-12-29	Kirin Amgen Inc	Erythropoietin analogs
US9505465B2 (en) *	2014-12-15	2016-11-29	Fundamental Consulting Services Inc.	Apparatus and method for attaching watercraft

1997
- 1997-09-01 DE DE69726571T patent/DE69726571T2/de not_active Expired - Lifetime
- 1997-09-01 ES ES97115081T patent/ES2208798T3/es not_active Expired - Lifetime
- 1997-09-01 EP EP97115081A patent/EP0902085B1/en not_active Expired - Lifetime
- 1997-09-01 DK DK97115081T patent/DK0902085T3/da active
- 1997-09-01 AT AT97115081T patent/ATE255634T1/de active
- 1997-09-01 PT PT97115081T patent/PT902085E/pt unknown
1998
- 1998-08-26 EP EP98948868A patent/EP1007679A1/en not_active Ceased
- 1998-08-26 AU AU95337/98A patent/AU743833B2/en not_active Ceased
- 1998-08-26 KR KR1020007002146A patent/KR100563017B1/ko not_active Expired - Fee Related
- 1998-08-26 CA CA002303476A patent/CA2303476A1/en not_active Abandoned
- 1998-08-26 WO PCT/EP1998/005399 patent/WO1999011781A1/en not_active Ceased
- 1998-08-26 US US09/486,222 patent/US6673609B1/en not_active Expired - Fee Related
- 1998-08-26 JP JP2000508791A patent/JP4345077B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2001514851A (ja)	2001-09-18
EP1007679A1 (en)	2000-06-14
JP4345077B2 (ja)	2009-10-14
KR20010023500A (ko)	2001-03-26
EP0902085A1 (en)	1999-03-17
PT902085E (pt)	2004-02-27
DE69726571D1 (de)	2004-01-15
DE69726571T2 (de)	2004-11-04
EP0902085B1 (en)	2003-12-03
US6673609B1 (en)	2004-01-06
KR100563017B1 (ko)	2006-03-22
ATE255634T1 (de)	2003-12-15
WO1999011781A1 (en)	1999-03-11
CA2303476A1 (en)	1999-03-11
AU743833B2 (en)	2002-02-07
AU9533798A (en)	1999-03-22
ES2208798T3 (es)	2004-06-16

Publication	Publication Date	Title
DE69726571D1 (de)	2004-01-15	Rekombinantes humanes Erythropoietin mit vorteilhaftem Glykosylierungsmuster
Marder et al.	1984	Molecular architecture of the rapidly metabolized 32-kilodalton protein of photosystem II. Indications for COOH-terminal processing of a chloroplast membrane polypeptide.
CY1112655T1 (el)	2016-02-10	Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις
ATE182901T1 (de)	1999-08-15	Für androgen-rezeptor-protein kodierende dna
MXPA03007619A (es)	2003-12-04	Nuevas moleculas similares a interferon beta.
RU95115239A (ru)	1997-03-27	Аналог эритропоэтина
DE60033138D1 (de)	2007-03-15	Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
DE69833784D1 (de)	2006-05-04	Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren
DE60018171D1 (de)	2005-03-24	Verwendung von adenovirus e1 protein sequenzen kodierenden, zur herstellung von rekombinanten proteinen in menschlichen zellen.
BRPI0109494B8 (pt)	2021-05-25	muteína de fator viii, sequência de dna, vetor, processo para produção da muteína de fator viii, composição farmacêutica e uso da muteína do fator viii
DE69020335D1 (de)	1995-07-27	B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
NO943949D0 (no)	1994-10-18	DNA som koder for proteinkomplekser med faktor VIII-C-aktivitet, samt fremstilling derav
FI20075338A7 (fi)	2007-05-10	gp350/220:n ei silmukoivia muutoksia
NZ503235A (en)	2002-08-28	Amino-terminally truncated RANTES as chemokine antagonists
DE69206301D1 (de)	1996-01-11	Protein mit der Aktivität vom Typ von Cytokin, dafür kodierende rekombinante DNS, transformierte Zellen und Mikroorganismen.
DE69837475D1 (de)	2007-05-16	Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren
ES2170747T3 (es)	2002-08-16	Analogos superiores de trombomodulina para uso farmaceutico.
PT704527E (pt)	2003-09-30	Sequencias de adn que codificam precursores de insulina biossinteticos e processo para a preparacao de insulina
ATE490324T1 (de)	2010-12-15	Nukleinsäuren kodierend für polypeptide mit chips aktivität
NO874704D0 (no)	1987-11-11	Minaktivin fremstilt ved rekombinant dna-teknikk.
PT914417E (pt)	2004-12-31	Dnase ii humana
WO1998050423A3 (fr)	1999-08-19	Analogues peptidiques et leurs utilisations notamment dans des compositions pharmaceutiques et pour le diagnostic
DE602004019556D1 (de)	2009-04-02	Neues plexin-polypeptid, dieses codierende dna und verwendung davon