DK0902085T3 - Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil - Google Patents

Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil

Info

Publication number: DK0902085T3
Authority: DK; Denmark
Prior art keywords: dna sequences; vectors; polypeptides; glycosylation profile; erythropoietin
Prior art date: 1997-09-01

Application number

DK97115081T

Other languages

English (en)

Inventor

Mathias Dr Fibi

Peter Dr Hermentin

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-01

Filing date

1997-09-01

Publication date

2004-04-05

1997-09-01 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2004-04-05 Application granted granted Critical

2004-04-05 Publication of DK0902085T3 publication Critical patent/DK0902085T3/da

Links

230000013595 glycosylation Effects 0.000 title abstract 2
238000006206 glycosylation reaction Methods 0.000 title abstract 2
101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 title 1
101000920686 Homo sapiens Erythropoietin Proteins 0.000 title 1
230000002349 favourable effect Effects 0.000 title 1
102000044890 human EPO Human genes 0.000 title 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 6
229920001184 polypeptide Polymers 0.000 abstract 5
102000004196 processed proteins & peptides Human genes 0.000 abstract 5
108090000765 processed proteins & peptides Proteins 0.000 abstract 5
239000013598 vector Substances 0.000 abstract 4
102000003951 Erythropoietin Human genes 0.000 abstract 2
108090000394 Erythropoietin Proteins 0.000 abstract 2
230000004071 biological effect Effects 0.000 abstract 2
229940105423 erythropoietin Drugs 0.000 abstract 2
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 2
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
208000007502 anemia Diseases 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK97115081T 1997-09-01 1997-09-01 Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil DK0902085T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97115081A EP0902085B1 (en)	1997-09-01	1997-09-01	Recombinant human erythropoietin with advantageous glycosylation profile

Publications (1)

Publication Number	Publication Date
DK0902085T3 true DK0902085T3 (da)	2004-04-05

Family

ID=8227297

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97115081T DK0902085T3 (da)	1997-09-01	1997-09-01	Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil

Country Status (12)

Country	Link
US (1)	US6673609B1 (da)
EP (2)	EP0902085B1 (da)
JP (1)	JP4345077B2 (da)
KR (1)	KR100563017B1 (da)
AT (1)	ATE255634T1 (da)
AU (1)	AU743833B2 (da)
CA (1)	CA2303476A1 (da)
DE (1)	DE69726571T2 (da)
DK (1)	DK0902085T3 (da)
ES (1)	ES2208798T3 (da)
PT (1)	PT902085E (da)
WO (1)	WO1999011781A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US7304150B1 (en)	1998-10-23	2007-12-04	Amgen Inc.	Methods and compositions for the prevention and treatment of anemia
HK1040944B (en) *	1998-10-23	2007-09-07	Amgen Inc.	Methods and compositions for the prevention and treatment of anemia
CN1367701A (zh) *	1999-05-11	2002-09-04	奥索－麦克尼尔药物公司	红细胞生成素给药的药代动力学和药效模型
CZ299516B6 (cs) *	1999-07-02	2008-08-20	F. Hoffmann-La Roche Ag	Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
EP1803730A1 (en)	2000-04-12	2007-07-04	Human Genome Sciences, Inc.	Albumin fusion proteins
EP1471871B1 (en)	2001-02-02	2007-05-02	Ortho-McNeil Pharmaceutical, Inc.	Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin
US6818613B2 (en)	2001-11-07	2004-11-16	Ortho-Mcneil Pharmaceutical, Inc.	Aqueous sustained-release formulations of proteins
AU2002357019A1 (en)	2001-11-28	2003-06-10	Ortho-Mcneil Pharmaceutical, Inc.	Erythropoietin dosing regimen for treating anemia
EP1997829A1 (en)	2001-12-21	2008-12-03	Human Genome Sciences, Inc.	Albumin fusion proteins
WO2003078959A2 (en)	2002-03-11	2003-09-25	Ortho Mcneil Pharmaceutical, Inc	Methods for shp1 mediated neuroprotection
US7553930B2 (en)	2003-01-06	2009-06-30	Xencor, Inc.	BAFF variants and methods thereof
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
EP4155385A1 (en)	2005-12-08	2023-03-29	Amgen Inc.	Improved production of glycoproteins using manganese
CN101062407A (zh)	2006-04-29	2007-10-31	中国科学院上海生命科学研究院	促红细胞生成素在预防或治疗视网膜损伤中的用途
NZ602170A (en)	2008-02-08	2014-03-28	Ambrx Inc	Modified leptin polypeptides and their uses
DK2342223T3 (da)	2008-09-26	2017-07-24	Ambrx Inc	Modificerede dyre-erythropoietin-polypeptider og deres anvendelser

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL77081A (en) *	1984-12-04	1999-10-28	Genetics Inst	Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin
US5641663A (en) *	1985-11-06	1997-06-24	Cangene Corporation	Expression system for the secretion of bioactive human granulocyte macrophage colony stimulating factor (GM-CSF) and other heterologous proteins from steptomyces
US4954437A (en) *	1986-09-15	1990-09-04	Integrated Genetics, Inc.	Cell encoding recombinant human erythropoietin
DE3923963A1 (de) *	1989-07-20	1991-01-31	Behringwerke Ag	Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung
JPH03151399A (ja) *	1989-11-07	1991-06-27	Snow Brand Milk Prod Co Ltd	変異ヒトエリスロポエチン
JPH05502463A (ja) *	1990-09-28	1993-04-28	オーソ・フアーマシユーチカル・コーポレーシヨン	ハイブリツド成長因子
CN1057534C (zh) *	1993-08-17	2000-10-18	柯瑞英-艾格公司	促红细胞生成素类似物
US9505465B2 (en) *	2014-12-15	2016-11-29	Fundamental Consulting Services Inc.	Apparatus and method for attaching watercraft

1997
- 1997-09-01 DE DE69726571T patent/DE69726571T2/de not_active Expired - Lifetime
- 1997-09-01 PT PT97115081T patent/PT902085E/pt unknown
- 1997-09-01 DK DK97115081T patent/DK0902085T3/da active
- 1997-09-01 ES ES97115081T patent/ES2208798T3/es not_active Expired - Lifetime
- 1997-09-01 AT AT97115081T patent/ATE255634T1/de active
- 1997-09-01 EP EP97115081A patent/EP0902085B1/en not_active Expired - Lifetime
1998
- 1998-08-26 KR KR1020007002146A patent/KR100563017B1/ko not_active Expired - Fee Related
- 1998-08-26 EP EP98948868A patent/EP1007679A1/en not_active Ceased
- 1998-08-26 AU AU95337/98A patent/AU743833B2/en not_active Ceased
- 1998-08-26 US US09/486,222 patent/US6673609B1/en not_active Expired - Fee Related
- 1998-08-26 JP JP2000508791A patent/JP4345077B2/ja not_active Expired - Fee Related
- 1998-08-26 CA CA002303476A patent/CA2303476A1/en not_active Abandoned
- 1998-08-26 WO PCT/EP1998/005399 patent/WO1999011781A1/en not_active Ceased

Also Published As

Publication number	Publication date
PT902085E (pt)	2004-02-27
EP1007679A1 (en)	2000-06-14
JP2001514851A (ja)	2001-09-18
DE69726571T2 (de)	2004-11-04
KR100563017B1 (ko)	2006-03-22
AU9533798A (en)	1999-03-22
CA2303476A1 (en)	1999-03-11
WO1999011781A1 (en)	1999-03-11
EP0902085B1 (en)	2003-12-03
JP4345077B2 (ja)	2009-10-14
ES2208798T3 (es)	2004-06-16
US6673609B1 (en)	2004-01-06
AU743833B2 (en)	2002-02-07
DE69726571D1 (de)	2004-01-15
ATE255634T1 (de)	2003-12-15
KR20010023500A (ko)	2001-03-26
EP0902085A1 (en)	1999-03-17

Publication	Publication Date	Title
DK0902085T3 (da)	2004-04-05	Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil
Marder et al.	1984	Molecular architecture of the rapidly metabolized 32-kilodalton protein of photosystem II. Indications for COOH-terminal processing of a chloroplast membrane polypeptide.
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ATE182901T1 (de)	1999-08-15	Für androgen-rezeptor-protein kodierende dna
RU95115239A (ru)	1997-03-27	Аналог эритропоэтина
IS6927A (is)	2003-08-26	Nýjar sameindir skyldar interferon-beta
DE69833784D1 (de)	2006-05-04	Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren
ATE352626T1 (de)	2007-02-15	Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
DE60018171D1 (de)	2005-03-24	Verwendung von adenovirus e1 protein sequenzen kodierenden, zur herstellung von rekombinanten proteinen in menschlichen zellen.
DK0559884T4 (da)	2004-08-02	Rekombinante virusvektorer til ekspression i muskelceller
DE69020335D1 (de)	1995-07-27	B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
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NZ503235A (en)	2002-08-28	Amino-terminally truncated RANTES as chemokine antagonists
DE69837475D1 (de)	2007-05-16	Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren
ES2170747T3 (es)	2002-08-16	Analogos superiores de trombomodulina para uso farmaceutico.
ATE490324T1 (de)	2010-12-15	Nukleinsäuren kodierend für polypeptide mit chips aktivität
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HRP940432B1 (en)	2003-10-31	Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
NO874704D0 (no)	1987-11-11	Minaktivin fremstilt ved rekombinant dna-teknikk.
WO1998050423A3 (fr)	1999-08-19	Analogues peptidiques et leurs utilisations notamment dans des compositions pharmaceutiques et pour le diagnostic
DE602004019556D1 (de)	2009-04-02	Neues plexin-polypeptid, dieses codierende dna und verwendung davon