DK0905254T3 - Fremgangsmåde til fremstilling af en lavemolekylær - Google Patents

Fremgangsmåde til fremstilling af en lavemolekylær

Info

Publication number
DK0905254T3
DK0905254T3 DK98117722T DK98117722T DK0905254T3 DK 0905254 T3 DK0905254 T3 DK 0905254T3 DK 98117722 T DK98117722 T DK 98117722T DK 98117722 T DK98117722 T DK 98117722T DK 0905254 T3 DK0905254 T3 DK 0905254T3
Authority
DK
Denmark
Prior art keywords
preparation
molecular weight
low molecular
low
weight
Prior art date
Application number
DK98117722T
Other languages
English (en)
Inventor
Thomas Prof Dr Kissel
Dagmar Dr Fischer
Hans-Peter Dr Elsaesser
Thorsten Bieber
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of DK0905254T3 publication Critical patent/DK0905254T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Lubricants (AREA)
DK98117722T 1997-09-30 1998-09-18 Fremgangsmåde til fremstilling af en lavemolekylær DK0905254T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19743135A DE19743135A1 (de) 1997-09-30 1997-09-30 Biologisch verträgliche niedermolekular Polyethylenimine

Publications (1)

Publication Number Publication Date
DK0905254T3 true DK0905254T3 (da) 2006-08-21

Family

ID=7844109

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98117722T DK0905254T3 (da) 1997-09-30 1998-09-18 Fremgangsmåde til fremstilling af en lavemolekylær

Country Status (19)

Country Link
US (2) US8003734B2 (da)
EP (1) EP0905254B1 (da)
JP (1) JP4399042B2 (da)
KR (1) KR19990030290A (da)
AR (1) AR015726A1 (da)
AT (1) ATE324397T1 (da)
AU (1) AU758239B2 (da)
BR (1) BR9803982A (da)
CA (1) CA2249058A1 (da)
CY (1) CY1105109T1 (da)
CZ (1) CZ310598A3 (da)
DE (2) DE19743135A1 (da)
DK (1) DK0905254T3 (da)
ES (1) ES2264180T3 (da)
HU (1) HUP9802157A3 (da)
ID (1) ID20973A (da)
PL (1) PL328910A1 (da)
PT (1) PT905254E (da)
TR (1) TR199801933A2 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956029A1 (de) * 1999-11-22 2001-05-23 Aventis Pharma Gmbh Trägersysteme enthaltend Hüllsubstanzen mit enzymatisch abspaltbaren Seitengruppen
DE19960206A1 (de) * 1999-12-14 2001-07-19 Frank Czubayko Komplexierung von RNS mit Polyethyleniminen zur deren Stabilisierung und zellulären Einschleusung
FR2805271B1 (fr) * 2000-02-18 2002-04-26 Aventis Pharma Sa Procede de preparation de polyalkylenimines fonctionnalises, compositions les contenant et leurs utilisations
EP1268609B1 (fr) * 2000-02-18 2006-05-17 Centelion Procede de preparation de polyalkylenimines fonctionnalises, compositions les contenant et leur utilisations
US6696038B1 (en) * 2000-09-14 2004-02-24 Expression Genetics, Inc. Cationic lipopolymer as biocompatible gene delivery agent
DE10145134A1 (de) * 2000-10-09 2002-05-16 Bayer Ag Komplexe zur Einführung von Nukleinsäuren in Zellen
CN1479632A (zh) * 2000-10-09 2004-03-03 用于将核酸导入细胞的复合物
WO2003038103A1 (en) * 2001-10-29 2003-05-08 Atso Raasmaja Method for gene transfection using synergistic combinations of cationic lipids and cationic polymers
US7824910B2 (en) 2001-11-29 2010-11-02 Nippon Shokubai Co., Ltd. Method of transducing a protein into cells
EP1476492A1 (en) * 2002-02-22 2004-11-17 Insert Therapeutics Inc. Carbohydrate-modified polymers, compositions and uses related thereto
US20040048260A1 (en) * 2002-09-10 2004-03-11 Fu-Hsiung Chang Transfection of nucleic acid
US20040138154A1 (en) 2003-01-13 2004-07-15 Lei Yu Solid surface for biomolecule delivery and high-throughput assay
US7153905B2 (en) * 2003-03-21 2006-12-26 The General Hospital Corporation Hyperbranched dendron and methods of synthesis and use thereof
JP2007043972A (ja) * 2005-08-10 2007-02-22 Tokyo Institute Of Technology アパタイト粒子及びその作製方法、遺伝子−アパタイト粒子複合体及びその作製方法、並びに遺伝子導入方法及び遺伝子導入用キット
US20080145893A1 (en) * 2006-09-17 2008-06-19 Excellegene Sa Method for producing a recombinant protein at high specific productivity, high batch yield and high volumetric yield by means of transient transfection
US20100197888A1 (en) * 2007-07-31 2010-08-05 Polyplus Transfection Method for Manufacturing Linear Polyethylenimine (PEI) for Transfection Purpose and Linear PEI Obtained with Such Method
FR2928373B1 (fr) * 2008-03-05 2010-12-31 Centre Nat Rech Scient Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
EP2453911A1 (en) 2009-04-30 2012-05-23 Genetic Immunity Kft Immunogenic nanomedicine composition and preparation and uses thereof
US20130079382A1 (en) 2009-10-12 2013-03-28 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
US10722462B2 (en) * 2014-12-10 2020-07-28 Council Of Scientific And Industrial Research Discontinuous reverse micellar composition in cubic FD3M phase for sustained release of therapeutic drugs
JP6873418B2 (ja) * 2016-11-11 2021-05-19 国立大学法人北陸先端科学技術大学院大学 遺伝子導入された細胞の製造方法及びポリエチレンイミンの置換体ポリマー
CN110023755A (zh) 2016-12-01 2019-07-16 诺伯特·格雷茨 用于组织结构的可视化的装置和方法
CN112237633B (zh) * 2020-10-22 2023-06-27 林君玉 一种pei/on复合物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2182306A (en) * 1935-05-10 1939-12-05 Ig Farbenindustrie Ag Polymerization of ethylene imines
NL45673C (da) * 1935-05-11
DE2530042C3 (de) * 1975-07-04 1982-04-22 Institut neftechimičeskogo sinteza imeni A.V. Topčieva Akademii Nauk SSSR, Moskva Verfahren zur Herstellung von linearem Polyäthylenimin
US4032480A (en) * 1975-07-11 1977-06-28 David Solomonovich Zhuk Method of producing linear polyethylenimine
GB2128625B (en) * 1982-10-07 1986-01-08 Inst Neftechimicheskogo Sintez Method for preparing branched polyethylenimine
US4599400A (en) 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
GB8621337D0 (en) * 1986-09-04 1986-10-15 Agricultural Genetics Co Non-radioactive nucleic acid hybridization probes
US5977307A (en) 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
US6036955A (en) 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
FI955320A7 (fi) 1994-03-07 1995-11-24 Univ Michigan Bioaktiivisia ja/tai kohdennettuja dendriimikonjugaatteja
FR2722506B1 (fr) * 1994-07-13 1996-08-14 Rhone Poulenc Rorer Sa Composition contenant des acides nucleiques, preparation et utilisations
US5919442A (en) 1995-08-11 1999-07-06 Dendritech, Inc. Hyper comb-branched polymer conjugates
AU7153296A (en) * 1995-09-18 1997-04-09 Delta Chemical Corporation Polyaluminum chlorides and polyaluminum chlorosulfates methods and compositions
DE19605279A1 (de) 1996-02-13 1997-08-14 Hoechst Ag Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung
US5962429A (en) * 1996-11-22 1999-10-05 University Of Iowa Complexes of adenovirus with cationic molecules
DE19649645A1 (de) 1996-11-29 1998-06-04 Hoechst Ag Mehrfach funktionelles Ligandensystem zur zielzellspezifischen Übertragung von Nukleotidsequenzen
US5830730A (en) 1997-05-08 1998-11-03 The Regents Of The University Of California Enhanced adenovirus-assisted transfection composition and method

Also Published As

Publication number Publication date
AU8714898A (en) 1999-04-22
US20110306656A1 (en) 2011-12-15
EP0905254A2 (de) 1999-03-31
AR015726A1 (es) 2001-05-16
HUP9802157A3 (en) 2003-02-28
DE59813507D1 (de) 2006-06-01
CA2249058A1 (en) 1999-03-30
HUP9802157A2 (hu) 1999-06-28
BR9803982A (pt) 2000-03-28
JPH11187874A (ja) 1999-07-13
US8003734B2 (en) 2011-08-23
EP0905254B1 (de) 2006-04-26
ID20973A (id) 1999-04-01
ES2264180T3 (es) 2006-12-16
CZ310598A3 (cs) 1999-04-14
ATE324397T1 (de) 2006-05-15
HU9802157D0 (en) 1998-12-28
PT905254E (pt) 2006-08-31
AU758239B2 (en) 2003-03-20
EP0905254A3 (de) 2002-01-02
US20030027784A1 (en) 2003-02-06
TR199801933A2 (xx) 1999-04-21
CY1105109T1 (el) 2009-11-04
DE19743135A1 (de) 1999-04-01
KR19990030290A (ko) 1999-04-26
JP4399042B2 (ja) 2010-01-13
PL328910A1 (en) 1999-04-12

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