DK0909562T3 - Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf - Google Patents

Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf

Info

Publication number: DK0909562T3
Authority: DK; Denmark
Prior art keywords: preparation; lipid; analog; injection; preparing
Prior art date: 1996-07-03

Application number

DK97929518T

Other languages

English (en)

Inventor

Yasuyuki Asai

Katsumi Onai

Kazuhide Ashizawa

Kiyoshi Iwamoto

Yasuo Ishibashi

Sumio Watanabe

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-03

Filing date

1997-07-03

Publication date

2005-08-22

1997-07-03 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2005-08-22 Application granted granted Critical

2005-08-22 Publication of DK0909562T3 publication Critical patent/DK0909562T3/da

Links

238000002347 injection Methods 0.000 title abstract 3
239000007924 injection Substances 0.000 title abstract 3
GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title 1
238000004519 manufacturing process Methods 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK97929518T 1996-07-03 1997-07-03 Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf DK0909562T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP17361596		1996-07-03
EP97929518A EP0909562B1 (en)	1996-07-03	1997-07-03	Injections containing lipid a analogues and process for the preparation thereof

Publications (1)

Publication Number	Publication Date
DK0909562T3 true DK0909562T3 (da)	2005-08-22

Family

ID=15963903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97929518T DK0909562T3 (da)	1996-07-03	1997-07-03	Injektionspræparat indeholdende en lipid A analog og fremgangsmåde til fremstilling deraf

Country Status (9)

Country	Link
US (1)	US6235724B1 (da)
EP (1)	EP0909562B1 (da)
CN (1)	CN1150001C (da)
AT (1)	ATE298578T1 (da)
CA (1)	CA2259520C (da)
DE (1)	DE69733651T2 (da)
DK (1)	DK0909562T3 (da)
ES (1)	ES2242226T3 (da)
WO (1)	WO1998001139A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7799198A (en) *	1997-05-23	1998-12-21	Eisai Co. Ltd.	Method for preparing pharmaceutical formulation
AU763770B2 (en) *	1998-07-14	2003-07-31	Wyeth Holdings Corporation	Adjuvant and vaccine compositions containing monophosphoryl lipid A
US6306404B1 (en)	1998-07-14	2001-10-23	American Cyanamid Company	Adjuvant and vaccine compositions containing monophosphoryl lipid A
US6635261B2 (en)	1999-07-13	2003-10-21	Wyeth Holdings Corporation	Adjuvant and vaccine compositions containing monophosphoryl lipid A
KR100841813B1 (ko) *	2000-02-18	2008-06-26	에자이 알앤드디 매니지먼트 가부시키가이샤	미셀
DK1889630T3 (da)	2000-10-18	2012-03-05	Glaxosmithkline Biolog Sa	Vacciner omfattende MAGE-antigen koblet til protein D-fragment
US7759323B2 (en) *	2001-05-22	2010-07-20	Eisai R & D Management Co., Ltd.	Highly purified antiendotoxin compound
US20090181078A1 (en)	2006-09-26	2009-07-16	Infectious Disease Research Institute	Vaccine composition containing synthetic adjuvant
KR101378872B1 (ko)	2006-09-26	2014-04-11	인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이)	합성 애주번트를 함유하는 백신 조성물
KR101701198B1 (ko)	2008-06-19	2017-02-01	배리에이션 바이오테크놀로지스 아이엔씨.	인플루엔자를 치료하기 위한 조성물 및 방법
SI2437753T1 (sl)	2009-06-05	2016-12-30	Infectious Disease Research Institute	Sintetični glukopiranozil-lipidni adjuvansi in cepivni sestavki, ki jih vsebujejo
CN102482666B (zh)	2009-07-06	2017-02-08	变异生物技术公司	制备囊泡的方法和由其产生的制剂
CA2803282C (en)	2009-07-06	2018-05-01	David E. Anderson	Methods for preparing vesicles and formulations produced therefrom
CN103096922B (zh)	2010-07-06	2019-08-06	变异生物技术公司	用于治疗流行性感冒的组合物和方法
BR112013017939B1 (pt)	2011-01-13	2022-11-16	Variation Biotechnologies Inc	Composição imunogênica liofilizada termoestável, uso e método para preparação da mesma
US20130323280A1 (en)	2011-01-13	2013-12-05	Variation Biotechnologies, Inc.	Methods for preparing vesicles and formulations produced therefrom
AU2012243039B2 (en)	2011-04-08	2017-07-13	Immune Design Corp.	Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
EP2802353A4 (en)	2012-01-12	2015-12-02	Variation Biotechnologies Inc	COMPOSITIONS AND METHOD FOR THE TREATMENT OF VIRUS INFECTIONS
CN104244984B (zh)	2012-01-27	2020-03-31	变异生物技术公司	用于治疗剂的方法和组合物
PT2850431T (pt)	2012-05-16	2018-07-23	Immune Design Corp	Vacinas para hsv-2
EP3711768A1 (en)	2013-04-18	2020-09-23	Immune Design Corp.	Gla monotherapy for use in cancer treatment
US9463198B2 (en)	2013-06-04	2016-10-11	Infectious Disease Research Institute	Compositions and methods for reducing or preventing metastasis
CN107531736B (zh)	2015-01-06	2022-04-15	免疫疫苗科技公司	脂质a模拟物、其制备方法和用途
CN111315406A (zh)	2017-09-08	2020-06-19	传染病研究所	包括皂苷的脂质体调配物及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1216686B (it) *	1988-04-01	1990-03-08	Chiesi Farma Spa	Formulazioni farmaceutiche acquose di piroxicam e procedimento per laloro preparazione.
JPH04198192A (ja) *	1990-11-28	1992-07-17	Japan Tobacco Inc	リピッドａ類縁体の水溶液
US5530113A (en) *	1991-10-11	1996-06-25	Eisai Co., Ltd.	Anti-endotoxin compounds
AU660325B2 (en) *	1991-10-11	1995-06-22	Eisai Co. Ltd.	Anti-endotoxin compounds and related molecules and methods
US5681824A (en) *	1995-06-05	1997-10-28	Eisai Co., Ltd.	Substituted liposaccharides useful in the treatment and prevention of endotoxemia

1997
- 1997-07-03 DK DK97929518T patent/DK0909562T3/da active
- 1997-07-03 US US09/194,704 patent/US6235724B1/en not_active Expired - Fee Related
- 1997-07-03 DE DE69733651T patent/DE69733651T2/de not_active Expired - Lifetime
- 1997-07-03 AT AT97929518T patent/ATE298578T1/de active
- 1997-07-03 EP EP97929518A patent/EP0909562B1/en not_active Expired - Lifetime
- 1997-07-03 WO PCT/JP1997/002316 patent/WO1998001139A1/ja not_active Ceased
- 1997-07-03 CN CNB971960518A patent/CN1150001C/zh not_active Expired - Fee Related
- 1997-07-03 CA CA002259520A patent/CA2259520C/en not_active Expired - Fee Related
- 1997-07-03 ES ES97929518T patent/ES2242226T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2259520A1 (en)	1998-01-15
CA2259520C (en)	2007-09-11
DE69733651D1 (de)	2005-08-04
US6235724B1 (en)	2001-05-22
ES2242226T3 (es)	2005-11-01
CN1224355A (zh)	1999-07-28
DE69733651T2 (de)	2006-05-18
ATE298578T1 (de)	2005-07-15
EP0909562B1 (en)	2005-06-29
EP0909562A1 (en)	1999-04-21
CN1150001C (zh)	2004-05-19
EP0909562A4 (en)	1999-12-29
WO1998001139A1 (fr)	1998-01-15

Publication	Publication Date	Title
EP0909562A4 (en)	1999-12-29	INJECTIONS CONTAINING LIPID A-ANALOG AND METHOD FOR THE PRODUCTION THEREOF
NO901399D0 (no)	1990-03-27	Aminosyrederivater.
DE69001730D1 (de)	1993-07-01	Pastenfoermige, waesserige pharmazeutische zusammensetzungen.
NO903832D0 (no)	1990-09-03	Aminosyrederivater.
ATE469910T1 (de)	2010-06-15	Azithromycinmonohydrat
DK15089D0 (da)	1989-01-13	Aminofunktionelle forbindelser, fremgangsmaade til fremstilling heraf samt vaskemidler omfattende samme.
NO903757L (no)	1991-03-01	Kitin.kitosan-oligomer med 2,5-anhydromannitol endegruppeeller 2,5-anhydromannose endegruppe og fremgangsmaate til fremstilling derav.
NO900309L (no)	1990-07-25	Benzocykloalkenyldihydroksyalkansyrederivater, og fremgangsmaate til fremstilling derav.
DE69019572D1 (de)	1995-06-29	Gasauflösung.
NO894549D0 (no)	1989-11-15	Titandioksyd, fremgangsmaate for fremstilling derav og anvendelse derav.
DE3877802D1 (de)	1993-03-11	Phenoxypropionsaeure-derivate, anwendbar als herbizide.
NO901533D0 (no)	1990-04-04	Aminosyrederivater.
NO910200D0 (no)	1991-01-17	Fremgangsmaate for fremstilling av polypeptider.
NO903780L (no)	1991-03-04	Fremgangsmaate til fremstilling av epipodofyllotoksinaltrosid-derivater.
DE69110750D1 (de)	1995-08-03	Zytotoxisches Testverfahren.
NO912537L (no)	1991-12-30	Aminosyrederivater.
DE59009872D1 (de)	1995-12-21	(4-Arylbutyl)cyclohexan-Derivate.
NO932823L (no)	1993-10-08	Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler og fremgangsmåter for deres fremstilling
DE69018816D1 (de)	1995-05-24	Aminosäurederivate.
EP0636611A3 (en)	1995-03-01	Optically active 1,4-dihydropyridine derivatives and process for preparing the same.
NO905244L (no)	1991-06-10	Fremgangsmaate for fremstilling av des(64,65)-proinsulin.
DK191290A (da)	1991-03-30	Extracellulaer exopolymer, fremgangsmaade til fremstilling af samme og farmaceutiske praeparater indeholdende exopolymeren
NO901519L (no)	1990-10-05	Aminosyrederivater.
NO904034L (no)	1991-03-19	Fremgangsmaate for fremstilling av 1-etylfenoksatiin-10,10-dioksyd.
IT9067139A0 (it)	1990-02-23	Procedimento per convertire ,lattoni alfa-acetil-sostituiti in lattoni alfa-alchiliden-sostituiti.