DK0912185T3 - Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler - Google Patents

Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler

Info

Publication number
DK0912185T3
DK0912185T3 DK97921224T DK97921224T DK0912185T3 DK 0912185 T3 DK0912185 T3 DK 0912185T3 DK 97921224 T DK97921224 T DK 97921224T DK 97921224 T DK97921224 T DK 97921224T DK 0912185 T3 DK0912185 T3 DK 0912185T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical compositions
compositions containing
nitrate ester
inflammatory drugs
ester derivatives
Prior art date
Application number
DK97921224T
Other languages
Danish (da)
English (en)
Inventor
Foe S Tjoeng
Mark G Currie
Mark E Zupec
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0912185T3 publication Critical patent/DK0912185T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97921224T 1996-05-02 1997-04-28 Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler DK0912185T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/642,128 US5985862A (en) 1996-05-02 1996-05-02 Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
PCT/US1997/006374 WO1997040836A1 (en) 1996-05-02 1997-04-28 Novel pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs

Publications (1)

Publication Number Publication Date
DK0912185T3 true DK0912185T3 (da) 2003-08-04

Family

ID=24575322

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97921224T DK0912185T3 (da) 1996-05-02 1997-04-28 Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler

Country Status (11)

Country Link
US (1) US5985862A (de)
EP (1) EP0912185B1 (de)
JP (1) JP2000509388A (de)
AT (1) ATE237334T1 (de)
AU (1) AU2732597A (de)
CA (1) CA2252876A1 (de)
DE (1) DE69720996T2 (de)
DK (1) DK0912185T3 (de)
ES (1) ES2197341T3 (de)
PT (1) PT912185E (de)
WO (1) WO1997040836A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
WO2000049993A2 (en) * 1999-02-24 2000-08-31 Nitromed, Inc. Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
WO2002012266A1 (en) 2000-08-05 2002-02-14 Glaxo Group Limited 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
PT1383786E (pt) 2001-04-30 2008-12-30 Glaxo Group Ltd Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
US6627602B2 (en) * 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
US20040110691A1 (en) * 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
EP1336602A1 (de) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrat-Prodrugs zur Freisetzung von Stickstoffmonoxid in kontrollierter und selektiver Weise sowie deren Verwendung zur Prävention und Behandlung inflammatorischer, ischämischer und proliferativer Erkrankungen
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US8226987B2 (en) * 2005-02-22 2012-07-24 Zoorob George K Herbal preparation to relieve inflammation and smooth muscle contraction
EP1940863B1 (de) * 2005-09-02 2012-09-05 Nicox S.A. Nitrooxy-derivate von glukokortikoiden
ES2442720T3 (es) * 2008-07-31 2014-02-13 Nicox S.A. Glucocorticoides unidos a ésteres de nitrato por medio de un enlazador aromático en posición 21 y su uso en oftalmología

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1082573A (en) * 1965-02-12 1967-09-06 Boots Pure Drug Co Ltd Improvements in the preparation of steroid esters
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
HU164115B (de) * 1971-05-07 1973-12-28
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
DE4223800A1 (de) * 1992-07-20 1994-01-27 Cassella Farbwerke Mainkur Ag Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen
DE69321596T2 (de) * 1992-07-30 1999-04-22 Cal International Ltd., Dublin Ester und kombinationen von einem organischen nitrat und einem salicyclat
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
DE69412109T2 (de) * 1993-10-06 1999-01-21 Nicox S.A., Paris Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung

Also Published As

Publication number Publication date
DE69720996T2 (de) 2004-02-05
ES2197341T3 (es) 2004-01-01
WO1997040836A1 (en) 1997-11-06
PT912185E (pt) 2003-08-29
AU2732597A (en) 1997-11-19
CA2252876A1 (en) 1997-11-06
JP2000509388A (ja) 2000-07-25
ATE237334T1 (de) 2003-05-15
EP0912185B1 (de) 2003-04-16
US5985862A (en) 1999-11-16
DE69720996D1 (de) 2003-05-22
EP0912185A1 (de) 1999-05-06

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