DK0912495T3 - Asymmetrisk syntese af chirale beta-aminosyrer - Google Patents

Asymmetrisk syntese af chirale beta-aminosyrer

Info

Publication number: DK0912495T3
Authority: DK; Denmark
Prior art keywords: amino; trimethylsilyl; pentynoate; dimethylethyl; produce
Prior art date: 1996-07-12

Application number

DK97932388T

Other languages

English (en)

Inventor

James R Behling

Mark L Boys

Kimberly J Cain-Janicki

Pierre-Jean Colson

Wendel W Doubleday

Joseph E Duran

Payman N Farid

Carl M Knable

Frank W Muellner

Sean T Nugent

Ravindra S Topgi

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-12

Filing date

1997-07-10

Publication date

2002-05-21

1997-07-10 Application filed by Searle & Co filed Critical Searle & Co

2002-05-21 Application granted granted Critical

2002-05-21 Publication of DK0912495T3 publication Critical patent/DK0912495T3/da

Links

238000011914 asymmetric synthesis Methods 0.000 title 1
150000001576 beta-amino acids Chemical class 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 5
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 abstract 2
IJXJGQCXFSSHNL-MRVPVSSYSA-N (2s)-2-amino-2-phenylethanol Chemical compound OC[C@@H](N)C1=CC=CC=C1 IJXJGQCXFSSHNL-MRVPVSSYSA-N 0.000 abstract 1
LJRWLSKYGWLYIM-UHFFFAOYSA-N 3-trimethylsilylprop-2-ynal Chemical compound C[Si](C)(C)C#CC=O LJRWLSKYGWLYIM-UHFFFAOYSA-N 0.000 abstract 1
OWVBKVUUDMFVCR-UHFFFAOYSA-M bromozinc(1+);tert-butyl acetate Chemical compound Br[Zn+].CC(C)(C)OC([CH2-])=O OWVBKVUUDMFVCR-UHFFFAOYSA-M 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

DK97932388T 1996-07-12 1997-07-10 Asymmetrisk syntese af chirale beta-aminosyrer DK0912495T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2163196P	1996-07-12	1996-07-12
PCT/US1997/011366 WO1998002410A1 (en)	1996-07-12	1997-07-10	Asymetric synthesis of chiral beta-amino acids

Publications (1)

Publication Number	Publication Date
DK0912495T3 true DK0912495T3 (da)	2002-05-21

Family

ID=21805290

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97932388T DK0912495T3 (da)	1996-07-12	1997-07-10	Asymmetrisk syntese af chirale beta-aminosyrer

Country Status (14)

Country	Link
US (1)	US5840961A (da)
EP (1)	EP0912495B1 (da)
JP (1)	JP2000514809A (da)
CN (1)	CN1119321C (da)
AT (1)	ATE209179T1 (da)
AU (1)	AU3586097A (da)
CA (1)	CA2258712C (da)
DE (1)	DE69709742T2 (da)
DK (1)	DK0912495T3 (da)
ES (1)	ES2167758T3 (da)
PT (1)	PT912495E (da)
TW (1)	TW404936B (da)
WO (1)	WO1998002410A1 (da)
ZA (1)	ZA976138B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7359198A (en) *	1997-05-01	1998-11-27	G.D. Searle & Co.	Method and apparatus for preparation of chiral beta amino acids
ZA991105B (en)	1998-03-04	2000-02-11	Searle & Co	Synthesis of chiral beta-amino acids.
BR9916536A (pt)	1998-12-23	2002-01-02	Searle & Co	Método para o tratamento ou prevenção de um distúrbio de neoplasia em um mamìfero em necessidade deste tratamento ou prevenção, e, combinação
KR20020015031A (ko)	1999-03-22	2002-02-27	오르토-맥네일 파마슈티칼, 인코퍼레이티드	3-아미노-3-아릴 프로파노에이트의 합성
NZ514383A (en)	1999-03-22	2004-01-30	Ortho Mcneil Pharm Inc	Process of preparing 3S-3-amino-3-aryl propionic acid and derivatives thereof
CA2368024A1 (en)	1999-03-22	2000-09-28	Ortho-Mcneil Pharmaceutical, Inc.	Process for preparing [s-(r,s)]-.beta.-[[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives
EP1235786B1 (en) *	1999-12-08	2007-08-29	DSM IP Assets B.V.	Method for the preparation of enantiomerically enriched compounds
NL1013789C2 (nl) *	1999-12-08	2001-06-12	Dsm Nv	Werkwijze voor de bereiding van enantiomeer verrijkte verbindingen.
US6586612B2 (en) *	2001-11-16	2003-07-01	Crompton Corporation	Process for the preparation of secondary and tertiary amino-functional silanes, iminoorganosilanes and/or imidoorganosilanes
CN1639130B (zh)	2002-01-10	2012-07-18	武田药品工业株式会社	制备稠合咪唑化合物的方法、稳定形式的里福马斯基试剂及其制备方法
NI200300043A (es)	2002-03-28	2003-11-05	Warner Lambert Co	AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
EP1670750A1 (en) *	2003-09-25	2006-06-21	Warner-Lambert Company LLC	Prodrugs of amino acids with affinity for the alpha2delta- protein
WO2006069798A1 (en) *	2004-12-28	2006-07-06	Dsm Ip Assets B.V.	Process for the preparation of chiral amines
FR2969604B1 (fr) *	2010-12-23	2013-01-18	Diverchim	Procede de preparation d'acides amines chiraux
WO2014015054A1 (en)	2012-07-18	2014-01-23	Saint Louis University	Beta amino acid derivatives as integrin antagonists
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
BR112018012981A2 (pt)	2015-12-30	2018-12-04	Saint Louis University	derivados do ácido meta-azacíclico amino benzoico como antagonistas de pan integrina com melhores propriedades farmacocinéticas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5239113A (en) *	1991-10-15	1993-08-24	Monsanto Company	Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5536869A (en) *	1995-07-14	1996-07-16	G. D. Searle & Co.	Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate

1997
- 1997-07-10 JP JP10506053A patent/JP2000514809A/ja not_active Ceased
- 1997-07-10 DK DK97932388T patent/DK0912495T3/da active
- 1997-07-10 US US08/890,907 patent/US5840961A/en not_active Expired - Lifetime
- 1997-07-10 AU AU35860/97A patent/AU3586097A/en not_active Abandoned
- 1997-07-10 CA CA002258712A patent/CA2258712C/en not_active Expired - Fee Related
- 1997-07-10 ES ES97932388T patent/ES2167758T3/es not_active Expired - Lifetime
- 1997-07-10 CN CN97196251A patent/CN1119321C/zh not_active Expired - Fee Related
- 1997-07-10 EP EP97932388A patent/EP0912495B1/en not_active Expired - Lifetime
- 1997-07-10 ZA ZA976138A patent/ZA976138B/xx unknown
- 1997-07-10 AT AT97932388T patent/ATE209179T1/de not_active IP Right Cessation
- 1997-07-10 WO PCT/US1997/011366 patent/WO1998002410A1/en not_active Ceased
- 1997-07-10 PT PT97932388T patent/PT912495E/pt unknown
- 1997-07-10 DE DE69709742T patent/DE69709742T2/de not_active Expired - Fee Related
- 1997-07-25 TW TW086109863A patent/TW404936B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1019874A1 (en)	2000-03-03
AU3586097A (en)	1998-02-09
EP0912495B1 (en)	2001-11-21
ES2167758T3 (es)	2002-05-16
DE69709742T2 (de)	2002-08-08
CA2258712A1 (en)	1998-01-22
DE69709742D1 (de)	2002-02-21
ZA976138B (en)	1998-07-10
CN1225084A (zh)	1999-08-04
CN1119321C (zh)	2003-08-27
EP0912495A1 (en)	1999-05-06
CA2258712C (en)	2008-01-08
TW404936B (en)	2000-09-11
PT912495E (pt)	2002-04-29
JP2000514809A (ja)	2000-11-07
US5840961A (en)	1998-11-24
WO1998002410A1 (en)	1998-01-22
ATE209179T1 (de)	2001-12-15

Publication	Publication Date	Title
DK0912495T3 (da)	2002-05-21	Asymmetrisk syntese af chirale beta-aminosyrer
EP1005526A4 (en)	2005-02-09	DIRECT EXPRESSION OF PEPTIDES IN CULTURAL MEDIUM.
CA2054980A1 (en)	1992-05-21	Hair fixatives
DE69942160D1 (de)	2010-04-29	Verfahren zur Herstellung von L-Aminosäure
AU7491498A (en)	1998-12-08	Methods of producing protein hydrolysates
AUPO787897A0 (en)	1997-08-07	Silicon-containing chain extenders
DE69716767D1 (de)	2002-12-05	Verfahren zur herstellung von tolterodin
DZ1997A1 (fr)	2002-07-20	Procédé enzymatique d'enrichissement en acides polyinsatures.
EA199700170A1 (ru)	1997-12-30	Способ получения некоторых азациклогексапетидов
ATE131843T1 (de)	1996-01-15	Verfahren zur herstellung von organopolysiloxanharz
ES2059161T3 (es)	1994-11-01	Liposomas de aguas termales estabilizados en un gel de adn.
MX9707502A (es)	1997-11-29	Intermediario de aminonitrilo para la preparacion de acido diacetico de alanina.
ATE341640T1 (de)	2006-10-15	Verfahren zur herstellung von nicht-proteinogenen l-aminosäuren
FR2765884B1 (fr)	2001-07-27	Composition silicone pour l'enduction de substrats en matiere souple, notamment textile
ATE478055T1 (de)	2010-09-15	Verfahren zur herstellung von monofunktionalisiertem 1,4,7,10- tetraazacyclododecan
ATE265541T1 (de)	2004-05-15	Verfahren zur fermentativen herstellung von nicht-proteinogenen l-aminosäuren
AU7022796A (en)	1997-04-24	2,3-dihydroxypropyl 2-(1-oxoalkyl)amino-2- deoxyglucopyranosides, a process for their preparation and their uses
HU0102041D0 (en)	2001-07-30	Pharmacological compounds which bind to [3h]-gabapentine binding protein
UA48993C2 (uk)	2002-09-16	СПОСІБ ОТРИМАННЯ N-АЦЕТИЛ-(L)-4-ЦІАНОФЕНІЛАЛАНІНУ Аc-(L)-Phe(4-CN)-OH І N-АЦЕТИЛ-(L)-П-АМІДИНФЕНІЛАЛАНІН-ЦИКЛОГЕКСИЛГЛІЦИН-<font face="Symbol">b</font>-(3-N-МЕТИЛПІРИДИН)-АЛАНІНУ Аc-(L)-pАph-Сhg-PalMe(3)-NH<sub>2</sub>
DE69513414D1 (de)	1999-12-23	Verfahren zur herstellung von (e)-2-fluormethylen-4-(4-fluorphenyl)butan-1-ol
JPS6485141A (en)	1989-03-30	Manufacture of catalyst with surface layer of noble metal carried by silica
JPS5419966A (en)	1979-02-15	Production of pyroglutamine peptide
ATE187450T1 (de)	1999-12-15	Verfahren zur herstellung von benzo(b)thiophenen
MX9603450A (es)	1997-03-29	Procedimiento para la obtencion de aminotriazolinas substituidas.
CA2225198A1 (en)	1998-07-13	Method for the synthesis of deoxypyridinoline