DK0912495T3 - Asymmetrisk syntese af chirale beta-aminosyrer - Google Patents

Asymmetrisk syntese af chirale beta-aminosyrer

Info

Publication number: DK0912495T3
Authority: DK; Denmark
Prior art keywords: amino; trimethylsilyl; pentynoate; dimethylethyl; produce
Prior art date: 1996-07-12

Application number

DK97932388T

Other languages

Danish (da)

English (en)

Inventor

James R Behling

Mark L Boys

Kimberly J Cain-Janicki

Pierre-Jean Colson

Wendel W Doubleday

Joseph E Duran

Payman N Farid

Carl M Knable

Frank W Muellner

Sean T Nugent

Ravindra S Topgi

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-12

Filing date

1997-07-10

Publication date

2002-05-21

1997-07-10 Application filed by Searle & Co filed Critical Searle & Co

2002-05-21 Application granted granted Critical

2002-05-21 Publication of DK0912495T3 publication Critical patent/DK0912495T3/da

Links

238000011914 asymmetric synthesis Methods 0.000 title 1
150000001576 beta-amino acids Chemical class 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 5
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 5
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 abstract 2
IJXJGQCXFSSHNL-MRVPVSSYSA-N (2s)-2-amino-2-phenylethanol Chemical compound OC[C@@H](N)C1=CC=CC=C1 IJXJGQCXFSSHNL-MRVPVSSYSA-N 0.000 abstract 1
LJRWLSKYGWLYIM-UHFFFAOYSA-N 3-trimethylsilylprop-2-ynal Chemical compound C[Si](C)(C)C#CC=O LJRWLSKYGWLYIM-UHFFFAOYSA-N 0.000 abstract 1
OWVBKVUUDMFVCR-UHFFFAOYSA-M bromozinc(1+);tert-butyl acetate Chemical compound Br[Zn+].CC(C)(C)OC([CH2-])=O OWVBKVUUDMFVCR-UHFFFAOYSA-M 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

DK97932388T 1996-07-12 1997-07-10 Asymmetrisk syntese af chirale beta-aminosyrer DK0912495T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2163196P	1996-07-12	1996-07-12
PCT/US1997/011366 WO1998002410A1 (fr)	1996-07-12	1997-07-10	Synthese asymetrique de beta-aminoacides chiraux

Publications (1)

Publication Number	Publication Date
DK0912495T3 true DK0912495T3 (da)	2002-05-21

Family

ID=21805290

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97932388T DK0912495T3 (da)	1996-07-12	1997-07-10	Asymmetrisk syntese af chirale beta-aminosyrer

Country Status (14)

Country	Link
US (1)	US5840961A (fr)
EP (1)	EP0912495B1 (fr)
JP (1)	JP2000514809A (fr)
CN (1)	CN1119321C (fr)
AT (1)	ATE209179T1 (fr)
AU (1)	AU3586097A (fr)
CA (1)	CA2258712C (fr)
DE (1)	DE69709742T2 (fr)
DK (1)	DK0912495T3 (fr)
ES (1)	ES2167758T3 (fr)
PT (1)	PT912495E (fr)
TW (1)	TW404936B (fr)
WO (1)	WO1998002410A1 (fr)
ZA (1)	ZA976138B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2287171A1 (fr) *	1997-05-01	1998-11-12	G.D. Searle & Co.	Procede et appareil de preparation de beta amino-acides chiraux
ZA991105B (en)	1998-03-04	2000-02-11	Searle & Co	Synthesis of chiral beta-amino acids.
AU2592600A (en)	1998-12-23	2000-07-31	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
BR0010652A (pt)	1999-03-22	2002-07-16	Ortho Mcneil Pharm Inc	Processo de preparação de ácido [s-(r,s)]-beta-[[[1-[1-oxo-3-(4-piperidinil)propil]-3-piperi dinil]carbonil]amino]-3-piridinapropanóico e derivados
RU2225859C2 (ru)	1999-03-22	2004-03-20	Орто-Макнейл Фармасьютикал, Инк.	Синтез 3-амино-3-арилпропаноатов
BR0009277A (pt) *	1999-03-22	2002-02-05	Ortho Mcneil Pharm Inc	Processo de preparação de ácido propiÈnico de 3s-3-amino-3-arila e derivados deste
NL1013789C2 (nl) *	1999-12-08	2001-06-12	Dsm Nv	Werkwijze voor de bereiding van enantiomeer verrijkte verbindingen.
US6794542B2 (en)	1999-12-08	2004-09-21	Dsm N.V.	Method for the preparation of enantiomerically enriched compounds
US6586612B2 (en) *	2001-11-16	2003-07-01	Crompton Corporation	Process for the preparation of secondary and tertiary amino-functional silanes, iminoorganosilanes and/or imidoorganosilanes
US7662974B2 (en) *	2002-01-10	2010-02-16	Takeda Pharmaceutical Company Limited	Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same
NI200300043A (es) *	2002-03-28	2003-11-05	Warner Lambert Co	AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
EP1670750A1 (fr) *	2003-09-25	2006-06-21	Warner-Lambert Company LLC	Promedicaments d'acides amines a affinite pour la proteine alpha2delta
WO2006069798A1 (fr) *	2004-12-28	2006-07-06	Dsm Ip Assets B.V.	Procede de preparation d’amines chirales
FR2969604B1 (fr) *	2010-12-23	2013-01-18	Diverchim	Procede de preparation d'acides amines chiraux
WO2014015054A1 (fr)	2012-07-18	2014-01-23	Saint Louis University	Dérivés d'acides bêta aminés en tant qu'antagonistes d'intégrine
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
SG11201805387RA (en)	2015-12-30	2018-07-30	Univ Saint Louis	Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5239113A (en) *	1991-10-15	1993-08-24	Monsanto Company	Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5536869A (en) *	1995-07-14	1996-07-16	G. D. Searle & Co.	Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate

1997
- 1997-07-10 EP EP97932388A patent/EP0912495B1/fr not_active Expired - Lifetime
- 1997-07-10 JP JP10506053A patent/JP2000514809A/ja not_active Ceased
- 1997-07-10 WO PCT/US1997/011366 patent/WO1998002410A1/fr not_active Ceased
- 1997-07-10 AT AT97932388T patent/ATE209179T1/de not_active IP Right Cessation
- 1997-07-10 PT PT97932388T patent/PT912495E/pt unknown
- 1997-07-10 ZA ZA976138A patent/ZA976138B/xx unknown
- 1997-07-10 AU AU35860/97A patent/AU3586097A/en not_active Abandoned
- 1997-07-10 CN CN97196251A patent/CN1119321C/zh not_active Expired - Fee Related
- 1997-07-10 DE DE69709742T patent/DE69709742T2/de not_active Expired - Fee Related
- 1997-07-10 US US08/890,907 patent/US5840961A/en not_active Expired - Lifetime
- 1997-07-10 DK DK97932388T patent/DK0912495T3/da active
- 1997-07-10 ES ES97932388T patent/ES2167758T3/es not_active Expired - Lifetime
- 1997-07-10 CA CA002258712A patent/CA2258712C/fr not_active Expired - Fee Related
- 1997-07-25 TW TW086109863A patent/TW404936B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1998002410A1 (fr)	1998-01-22
JP2000514809A (ja)	2000-11-07
DE69709742T2 (de)	2002-08-08
PT912495E (pt)	2002-04-29
CA2258712A1 (fr)	1998-01-22
TW404936B (en)	2000-09-11
HK1019874A1 (en)	2000-03-03
EP0912495A1 (fr)	1999-05-06
AU3586097A (en)	1998-02-09
ES2167758T3 (es)	2002-05-16
CA2258712C (fr)	2008-01-08
US5840961A (en)	1998-11-24
CN1119321C (zh)	2003-08-27
DE69709742D1 (de)	2002-02-21
ATE209179T1 (de)	2001-12-15
ZA976138B (en)	1998-07-10
EP0912495B1 (fr)	2001-11-21
CN1225084A (zh)	1999-08-04

Publication	Publication Date	Title
DK0912495T3 (da)	2002-05-21	Asymmetrisk syntese af chirale beta-aminosyrer
DK1005526T3 (da)	2011-02-07	Direkte ekspression af peptider i kulturmedium
CA2054980A1 (fr)	1992-05-21	Fixatifs capillaires
DE69942160D1 (de)	2010-04-29	Verfahren zur Herstellung von L-Aminosäure
AUPO787897A0 (en)	1997-08-07	Silicon-containing chain extenders
DE69716767D1 (de)	2002-12-05	Verfahren zur herstellung von tolterodin
CA2134766A1 (fr)	1993-11-25	Procede de preparation de resine a base d'organopolysiloxane
DK0582790T3 (da)	1999-08-23	Ny fremgangsmåde til fremstilling af 7-substituerede-9-[(substitueret glycyl)-amino]-6-demethyl-6-deoxytetracycliner
EP0815125A4 (fr)	2002-01-02	RECEPTEUR gC1q, ZONE DE LIAISON DE gp120 DE VIH-1 A CE DERNIER, ET PEPTIDES ET ANTICORPS DE CIBLAGE ASSOCIES
MX9707502A (es)	1997-11-29	Intermediario de aminonitrilo para la preparacion de acido diacetico de alanina.
DK0554343T3 (da)	1994-11-14	Liposomer af kurvand stabiliseret i en DNA-gel
ATE341640T1 (de)	2006-10-15	Verfahren zur herstellung von nicht-proteinogenen l-aminosäuren
FR2765884B1 (fr)	2001-07-27	Composition silicone pour l'enduction de substrats en matiere souple, notamment textile
ATE478055T1 (de)	2010-09-15	Verfahren zur herstellung von monofunktionalisiertem 1,4,7,10- tetraazacyclododecan
ES2015432A6 (es)	1990-08-16	Metodo de preparacion de 2', 3'-dideoxi-nucleosidos.
ATE265541T1 (de)	2004-05-15	Verfahren zur fermentativen herstellung von nicht-proteinogenen l-aminosäuren
AU7022796A (en)	1997-04-24	2,3-dihydroxypropyl 2-(1-oxoalkyl)amino-2- deoxyglucopyranosides, a process for their preparation and their uses
UA42024C2 (uk)	2001-10-15	Спосіб біоконверсії для синтезу транс-гідроксисульфону
HU0102041D0 (en)	2001-07-30	Pharmacological compounds which bind to [3h]-gabapentine binding protein
MX9804997A (es)	1998-09-30	Proceso novedoso para la preparacion de n-acetil(l)-4-cianofenilalanina ac-((l)-phe(4-cn)-oh y n-acetil-(l)-p-amidinofenilalanina-ciclohexilglicina-b-(3-n- metilpiridinio)-alanina ac-(l)-paph-chg-palme(3)-nh2.
DE69513414D1 (de)	1999-12-23	Verfahren zur herstellung von (e)-2-fluormethylen-4-(4-fluorphenyl)butan-1-ol
JPS5419966A (en)	1979-02-15	Production of pyroglutamine peptide
ATE187450T1 (de)	1999-12-15	Verfahren zur herstellung von benzo(b)thiophenen
MX9603450A (es)	1997-03-29	Procedimiento para la obtencion de aminotriazolinas substituidas.
DE69623710D1 (de)	2002-10-24	Herstellung von silylierten Cyanohydrinen