DK0914331T3 - Neuroaktive peptider - Google Patents

Neuroaktive peptider

Info

Publication number: DK0914331T3
Authority: DK; Denmark
Prior art keywords: neuroactive peptides; specific identification; neuroactive; peptides; nmda
Prior art date: 1996-05-17

Application number

DK97927691T

Other languages

English (en)

Inventor

Joseph R Moskal

Hirotaka Yamamoto

Patricia A Colley

Original Assignee

Nyxis Neurotherapies Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-17

Filing date

1997-05-16

Publication date

2001-02-12

1997-05-16 Application filed by Nyxis Neurotherapies Inc filed Critical Nyxis Neurotherapies Inc

2001-02-12 Application granted granted Critical

2001-02-12 Publication of DK0914331T3 publication Critical patent/DK0914331T3/da

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK97927691T 1996-05-17 1997-05-16 Neuroaktive peptider DK0914331T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/649,272 US5763393A (en)	1996-05-17	1996-05-17	Neuroactive peptides
PCT/US1997/008667 WO1997043306A1 (en)	1996-05-17	1997-05-16	Neuroactive peptides

Publications (1)

Publication Number	Publication Date
DK0914331T3 true DK0914331T3 (da)	2001-02-12

Family

ID=24604116

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97927691T DK0914331T3 (da)	1996-05-17	1997-05-16	Neuroaktive peptider

Country Status (12)

Country	Link
US (2)	US5763393A (da)
EP (2)	EP1077217A3 (da)
JP (1)	JP2000501746A (da)
AT (1)	ATE197307T1 (da)
AU (1)	AU3209097A (da)
CA (1)	CA2255659C (da)
DE (1)	DE69703449T2 (da)
DK (1)	DK0914331T3 (da)
ES (1)	ES2153671T3 (da)
GR (1)	GR3035227T3 (da)
PT (1)	PT914331E (da)
WO (1)	WO1997043306A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001271366A1 (en) *	2000-06-22	2002-01-02	Nyxis Neurotherapies, Inc.	Neuroactive peptides for treatment of hypoxia and related conditions
WO2003010540A1 (en) *	2001-07-25	2003-02-06	Nyxis Neurotherapies, Inc.	Method of identifying nmda-related agent
JP5702288B2 (ja)	2008-09-18	2015-04-15	ノースウエスタンユニバーシティ	Ｎｍｄａレセプターモジュレータ及びその用途
DK2985032T3 (da) *	2009-10-05	2019-04-15	Univ Northwestern	Glyx til anvendelse til behandling af alzheimers sygdom, parkinsons sygdom eller huntingtons sygdom
US8951968B2 (en)	2009-10-05	2015-02-10	Northwestern University	Methods of treating depression and other related diseases
AU2011215704B2 (en)	2010-02-11	2015-07-23	Northwestern University	Secondary structure stabilized NMDA receptor modulators and uses thereof
KR101692275B1 (ko)	2010-02-11	2017-01-04	노오쓰웨스턴 유니버시티	２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
EA029999B1 (ru)	2011-04-27	2018-06-29	Нортвестерн Юниверсити	Способы лечения аутизма
US8798716B1 (en)	2011-11-03	2014-08-05	Solstice Corporation	Fiducial markers and related methods
US8974365B2 (en)	2012-11-25	2015-03-10	Steven Richard Devore Best	Treatment of thalamocortical dysrhythmia
HRP20240812T1 (hr)	2013-01-22	2024-09-27	Vistagen Therapeutics, Inc.	Oblici doziranja i terapijska primjena l-4-klorokinurenina
LT2951183T (lt)	2013-01-29	2019-05-27	Aptinyx Inc.	Spiro-laktamo nmda receptorių moduliatoriai ir jų panaudojimas
CA2899010A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
AU2014212501A1 (en)	2013-01-29	2015-07-30	Aptinyx, Inc.	Spiro-lactam NMDA receptor modulators and uses thereof
CA2898863A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
MX375286B (es)	2013-01-29	2025-03-06	Aptinyx Inc	Moduladores de receptores nmda de espiro-lactama y sus usos.
GB201319437D0 (en) *	2013-11-04	2013-12-18	Nanomerics Ltd	Delivery of drugs
KR20160144499A (ko)	2014-04-25	2016-12-16	노렉스, 인크.	신경활성 펩타이드의 안정한 조성물
EP3916003A1 (en) *	2014-07-24	2021-12-01	Naurex, Inc.	N-methyl-d-aspartate receptor modulators and methods of making and using same
SG10201810016XA (en)	2014-08-14	2018-12-28	Naurex Inc	Methods of treating depression using nmda modulators
WO2017201285A1 (en)	2016-05-19	2017-11-23	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
JP6823083B2 (ja)	2016-05-19	2021-01-27	アプティニックスインコーポレイテッド	スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
EA201990424A1 (ru)	2016-08-01	2019-08-30	Аптиникс Инк.	Спиролактамовые модуляторы nmda-рецептора и их применение
PE20190504A1 (es)	2016-08-01	2019-04-10	Aptinyx Inc	Moduladores del receptor nmda espiro-lactam y uso de los mismos
AU2017306158B2 (en)	2016-08-01	2021-10-14	Aptinyx Inc.	Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
ES2974090T3 (es)	2016-08-01	2024-06-25	Tenacia Biotechnology Hong Kong Co Ltd	Moduladores de NMDA de espirolactama y métodos de uso de los mismos
MX385336B (es)	2016-08-01	2025-03-18	Aptinyx Inc	Moduladores del receptor nmda espiro-lactam y uso de los mismos.
JP2021512857A (ja)	2017-11-10	2021-05-20	ノーレックスインコーポレイテッド	Ｎｍｄａ受容体アゴニストの投与方法
JP2021505668A (ja)	2017-12-05	2021-02-18	ノーレックスインコーポレイテッド	併用療法（睡眠障害およびｃｎｓ障害）において使用するためのｎｍｄａ受容体モジュレーター（ラパスチネル）の組合せ
JP7210599B2 (ja)	2018-01-31	2023-01-23	アプティニックスインコーポレイテッド	スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用
US12012413B2 (en)	2019-11-11	2024-06-18	Tenacia Biotechnology (Hong Kong) Co., Limited	Methods of treating painful diabetic peripheral neuropathy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5854217A (en) *	1992-09-28	1998-12-29	Bearsden Bio, Inc.	Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
US5428069A (en) *	1993-01-11	1995-06-27	The United States Of America As Represented By The Department Of Health & Human Services	Treating cognition with, aminocyclopropanecarboxylic derivatives
JPH07101999A (ja) *	1993-10-06	1995-04-18	Hagiwara Yoshihide	抗癌ヒトモノクローナル抗体に対する抗イデイオタイプ抗体のアミノ酸配列およびそれをコードするｄｎａ塩基配列

1996
- 1996-05-17 US US08/649,272 patent/US5763393A/en not_active Expired - Lifetime
1997
- 1997-05-16 WO PCT/US1997/008667 patent/WO1997043306A1/en not_active Ceased
- 1997-05-16 AU AU32090/97A patent/AU3209097A/en not_active Abandoned
- 1997-05-16 ES ES97927691T patent/ES2153671T3/es not_active Expired - Lifetime
- 1997-05-16 AT AT97927691T patent/ATE197307T1/de not_active IP Right Cessation
- 1997-05-16 DE DE69703449T patent/DE69703449T2/de not_active Expired - Fee Related
- 1997-05-16 JP JP9541206A patent/JP2000501746A/ja not_active Ceased
- 1997-05-16 DK DK97927691T patent/DK0914331T3/da active
- 1997-05-16 EP EP00118013A patent/EP1077217A3/en not_active Withdrawn
- 1997-05-16 EP EP97927691A patent/EP0914331B1/en not_active Expired - Lifetime
- 1997-05-16 PT PT97927691T patent/PT914331E/pt unknown
- 1997-05-16 CA CA002255659A patent/CA2255659C/en not_active Expired - Lifetime
1998
- 1998-06-08 US US09/105,799 patent/US6107271A/en not_active Expired - Fee Related
2001
- 2001-01-11 GR GR20010400043T patent/GR3035227T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT914331E (pt)	2001-04-30
DE69703449D1 (de)	2000-12-07
CA2255659C (en)	2005-03-15
CA2255659A1 (en)	1997-11-20
AU3209097A (en)	1997-12-05
ES2153671T3 (es)	2001-03-01
EP0914331A1 (en)	1999-05-12
EP1077217A2 (en)	2001-02-21
US6107271A (en)	2000-08-22
ATE197307T1 (de)	2000-11-15
US5763393A (en)	1998-06-09
EP1077217A3 (en)	2004-01-02
EP0914331B1 (en)	2000-11-02
DE69703449T2 (de)	2001-06-07
WO1997043306A1 (en)	1997-11-20
GR3035227T3 (en)	2001-04-30
JP2000501746A (ja)	2000-02-15

Publication	Publication Date	Title
ES2153671T3 (es)	2001-03-01	Peptidos neuroactivos.
DE59710609D1 (de)	2003-09-25	Mittel zur Herstellung von Leder
CY1114164T1 (el)	2016-08-31	Μεθοδος ελεγχου της δραστικοτητας ανοσολογικα λειτουργικου μοριου
ITTO950367A0 (it)	1995-05-10	Proteine di prrsv ricombinanti, corredi diagnostici e vaccini contenenti tali proteine di prrsv ricombinanti.
DE69739245D1 (de)	2009-03-26	System zur Identifizierung von Material mittels NIR-Spektrometrie
BR0009206A (pt)	2001-12-26	Isolamento e análise de proteina
FI963461A0 (fi)	1996-09-04	Häiriönpoistoaineet immunologisia määrityksiä varten
DE69739219D1 (de)	2009-03-05	Peptide und zusammensetzungen, die an den thrombopoietin-rezeptor binden
TR199600357A2 (tr)	1996-11-21	Rekombinant simanlik (Ob) proteinleri.
DE69737948D1 (de)	2007-09-06	Vorrichtung zur rekonstruktion von sehnen
EP0918787A4 (en)	2001-10-04	COMPOSITIONS AND METHODS FOR ANTISENSE INHIBITION OF PROTEIN TRANSLATION
NO984644D0 (no)	1998-10-02	Ikke-dendrittisk ryggradpeptidbµrer
ATE242264T1 (de)	2003-06-15	Heptapeptid oxytocin analogen
WO1999025843A3 (en)	1999-08-05	Human checkpoint kinase, hcds1, compositions and methods
DE59711900D1 (de)	2004-10-14	Vorrichtung zur kuppelprojektion
GB9816514D0 (en)	1998-09-30	Novel method
ATE412747T1 (de)	2008-11-15	Neues tumor-antigen-protein sart-3 und tumor- antigen-peptid davon
EP0749320A4 (en)	1997-06-18	FIBRIN-SPECIFIC ANTIBODIES FOR USE AS ANTITHROMBOSE AGENT
PT929299E (pt)	2004-02-27	1,2,3,4-tetra-hidro-2-dibenzofuranaminas e 2-aminociclo-hepta ¬b\| benzofuranos substituidos
DE59711564D1 (de)	2004-06-03	Wiederlösbare, selbstklebende Vorrichtung
DE69938130D1 (de)	2008-03-27	Neue peptide
AU2172597A (en)	1997-10-22	Protein phosphatase-1 catalytic subunit interactions
FI973469L (fi)	1997-08-22	Menetelmä tekijän IX valmistamiseksi biologisista lähteistä
TR199701666A3 (tr)	1999-10-21	Sismanliga karsi proteinler
EP1032411A4 (en)	2002-01-09	HYPUSINE REAGENT FOR THE SYNTHESIS OF PEPTIDES