DK0914331T3 - Neuroaktive peptider - Google Patents

Neuroaktive peptider

Info

Publication number: DK0914331T3
Authority: DK; Denmark
Prior art keywords: neuroactive peptides; specific identification; neuroactive; peptides; nmda
Prior art date: 1996-05-17

Application number

DK97927691T

Other languages

English (en)

Inventor

Joseph R Moskal

Hirotaka Yamamoto

Patricia A Colley

Original Assignee

Nyxis Neurotherapies Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-17

Filing date

1997-05-16

Publication date

2001-02-12

1997-05-16 Application filed by Nyxis Neurotherapies Inc filed Critical Nyxis Neurotherapies Inc

2001-02-12 Application granted granted Critical

2001-02-12 Publication of DK0914331T3 publication Critical patent/DK0914331T3/da

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK97927691T 1996-05-17 1997-05-16 Neuroaktive peptider DK0914331T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/649,272 US5763393A (en)	1996-05-17	1996-05-17	Neuroactive peptides
PCT/US1997/008667 WO1997043306A1 (en)	1996-05-17	1997-05-16	Neuroactive peptides

Publications (1)

Publication Number	Publication Date
DK0914331T3 true DK0914331T3 (da)	2001-02-12

Family

ID=24604116

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97927691T DK0914331T3 (da)	1996-05-17	1997-05-16	Neuroaktive peptider

Country Status (12)

Country	Link
US (2)	US5763393A (da)
EP (2)	EP1077217A3 (da)
JP (1)	JP2000501746A (da)
AT (1)	ATE197307T1 (da)
AU (1)	AU3209097A (da)
CA (1)	CA2255659C (da)
DE (1)	DE69703449T2 (da)
DK (1)	DK0914331T3 (da)
ES (1)	ES2153671T3 (da)
GR (1)	GR3035227T3 (da)
PT (1)	PT914331E (da)
WO (1)	WO1997043306A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1296999A2 (en) *	2000-06-22	2003-04-02	NYXIS NeuroTherapies, Inc.	Neuroactive peptides for treatment of hypoxia and related conditions
US20030022253A1 (en) *	2001-07-25	2003-01-30	Nyxis Neurotherapies, Inc.	Method for identifying, isolating and producing neuroactive binding agents and binding agents derived thereby
MX2011003015A (es)	2008-09-18	2011-11-18	Univ Northwestern	Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos.
US8951968B2 (en)	2009-10-05	2015-02-10	Northwestern University	Methods of treating depression and other related diseases
EP2485751B1 (en)	2009-10-05	2014-05-21	Northwestern University	GLYX-13 for use in a method of treating refractory depression
SG10201501050RA (en)	2010-02-11	2015-04-29	Univ Northwestern	Secondary Structure Stabilized NMDA Receptor Modulators And Uses Thereof
KR101692275B1 (ko)	2010-02-11	2017-01-04	노오쓰웨스턴 유니버시티	２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
MX357761B (es)	2011-04-27	2018-07-23	Univ Northwestern	Métodos para tratar la enfermedad de alzheimer, enfermedad de huntington, autismo u otros trastornos.
US8798716B1 (en)	2011-11-03	2014-08-05	Solstice Corporation	Fiducial markers and related methods
US8974365B2 (en)	2012-11-25	2015-03-10	Steven Richard Devore Best	Treatment of thalamocortical dysrhythmia
CA3216579A1 (en)	2013-01-22	2014-07-31	Vistagen Therapeutics, Inc.	Dosage forms and therapeutic uses of l-4-chlorokynurenine
JP6419087B2 (ja)	2013-01-29	2018-11-07	アプティニックスインコーポレイテッド	スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
CA2898861C (en)	2013-01-29	2021-07-20	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
SG11201505937SA (en)	2013-01-29	2015-09-29	Naurex Inc	Spiro-lactam nmda receptor modulators and uses thereof
CN105308049A (zh)	2013-01-29	2016-02-03	阿普廷伊克斯股份有限公司	螺-内酰胺nmda受体调节剂及其用途
WO2014120784A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
GB201319437D0 (en) *	2013-11-04	2013-12-18	Nanomerics Ltd	Delivery of drugs
AU2015249222A1 (en)	2014-04-25	2016-11-17	Naurex, Inc.	Stable compositions of neuroactive peptides
JP2017525684A (ja) *	2014-07-24	2017-09-07	ノーレックスインコーポレイテッド	Ｎ−メチル−ｄ−アスパラギン酸受容体モジュレーターならびにその製造方法及び使用方法
KR20170040351A (ko)	2014-08-14	2017-04-12	노렉스, 인크.	Nmda 조절인자를 사용하여 우울증을 치료하는 방법
PE20190174A1 (es)	2016-05-19	2019-02-01	Aptinyx Inc	Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos
WO2017201285A1 (en)	2016-05-19	2017-11-23	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
CN109890825B (zh)	2016-08-01	2022-03-11	阿普廷伊克斯股份有限公司	螺-内酰胺nmda受体调节剂及其用途
JP2019527235A (ja)	2016-08-01	2019-09-26	アプティニックスインコーポレイテッド	スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
PE20190501A1 (es)	2016-08-01	2019-04-10	Aptinyx Inc	Moduladores nmda espiro-lactam y metodos de uso de los mismos
EP3490992B1 (en)	2016-08-01	2023-03-22	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
CA3031534C (en)	2016-08-01	2023-10-17	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
EP3706734A1 (en)	2017-11-10	2020-09-16	Naurex Inc.	Methods of administration of nmda receptor agonists
US20200368310A1 (en)	2017-12-05	2020-11-26	Naurex, INC	Treatment with nmda receptor modulators
PE20210455A1 (es)	2018-01-31	2021-03-08	Aptinyx Inc	Moduladores del receptor nmda espiro-lactama y usos de los mismos
US12012413B2 (en)	2019-11-11	2024-06-18	Tenacia Biotechnology (Hong Kong) Co., Limited	Methods of treating painful diabetic peripheral neuropathy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5854217A (en) *	1992-09-28	1998-12-29	Bearsden Bio, Inc.	Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
US5428069A (en) *	1993-01-11	1995-06-27	The United States Of America As Represented By The Department Of Health & Human Services	Treating cognition with, aminocyclopropanecarboxylic derivatives
JPH07101999A (ja) *	1993-10-06	1995-04-18	Hagiwara Yoshihide	抗癌ヒトモノクローナル抗体に対する抗イデイオタイプ抗体のアミノ酸配列およびそれをコードするｄｎａ塩基配列

1996
- 1996-05-17 US US08/649,272 patent/US5763393A/en not_active Expired - Lifetime
1997
- 1997-05-16 AU AU32090/97A patent/AU3209097A/en not_active Abandoned
- 1997-05-16 EP EP00118013A patent/EP1077217A3/en not_active Withdrawn
- 1997-05-16 CA CA002255659A patent/CA2255659C/en not_active Expired - Lifetime
- 1997-05-16 WO PCT/US1997/008667 patent/WO1997043306A1/en not_active Ceased
- 1997-05-16 AT AT97927691T patent/ATE197307T1/de not_active IP Right Cessation
- 1997-05-16 EP EP97927691A patent/EP0914331B1/en not_active Expired - Lifetime
- 1997-05-16 DE DE69703449T patent/DE69703449T2/de not_active Expired - Fee Related
- 1997-05-16 PT PT97927691T patent/PT914331E/pt unknown
- 1997-05-16 DK DK97927691T patent/DK0914331T3/da active
- 1997-05-16 ES ES97927691T patent/ES2153671T3/es not_active Expired - Lifetime
- 1997-05-16 JP JP9541206A patent/JP2000501746A/ja not_active Ceased
1998
- 1998-06-08 US US09/105,799 patent/US6107271A/en not_active Expired - Fee Related
2001
- 2001-01-11 GR GR20010400043T patent/GR3035227T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2255659A1 (en)	1997-11-20
CA2255659C (en)	2005-03-15
EP1077217A2 (en)	2001-02-21
DE69703449T2 (de)	2001-06-07
EP1077217A3 (en)	2004-01-02
AU3209097A (en)	1997-12-05
DE69703449D1 (de)	2000-12-07
GR3035227T3 (en)	2001-04-30
JP2000501746A (ja)	2000-02-15
EP0914331A1 (en)	1999-05-12
EP0914331B1 (en)	2000-11-02
US6107271A (en)	2000-08-22
ES2153671T3 (es)	2001-03-01
ATE197307T1 (de)	2000-11-15
PT914331E (pt)	2001-04-30
WO1997043306A1 (en)	1997-11-20
US5763393A (en)	1998-06-09

Publication	Publication Date	Title
ES2153671T3 (es)	2001-03-01	Peptidos neuroactivos.
DE59710609D1 (de)	2003-09-25	Mittel zur Herstellung von Leder
CY1114164T1 (el)	2016-08-31	Μεθοδος ελεγχου της δραστικοτητας ανοσολογικα λειτουργικου μοριου
ITTO950367A0 (it)	1995-05-10	Proteine di prrsv ricombinanti, corredi diagnostici e vaccini contenenti tali proteine di prrsv ricombinanti.
DE69739245D1 (de)	2009-03-26	System zur Identifizierung von Material mittels NIR-Spektrometrie
BR0009206A (pt)	2001-12-26	Isolamento e análise de proteina
FI963461A0 (fi)	1996-09-04	Häiriönpoistoaineet immunologisia määrityksiä varten
DE69739219D1 (de)	2009-03-05	Peptide und zusammensetzungen, die an den thrombopoietin-rezeptor binden
TR199600357A2 (tr)	1996-11-21	Rekombinant simanlik (Ob) proteinleri.
DE69737948D1 (de)	2007-09-06	Vorrichtung zur rekonstruktion von sehnen
EP0918787A4 (en)	2001-10-04	COMPOSITIONS AND METHODS FOR ANTISENSE INHIBITION OF PROTEIN TRANSLATION
NO984644D0 (no)	1998-10-02	Ikke-dendrittisk ryggradpeptidbµrer
ATE242264T1 (de)	2003-06-15	Heptapeptid oxytocin analogen
WO1999025843A3 (en)	1999-08-05	Human checkpoint kinase, hcds1, compositions and methods
DE59711900D1 (de)	2004-10-14	Vorrichtung zur kuppelprojektion
GB9816514D0 (en)	1998-09-30	Novel method
ATE412747T1 (de)	2008-11-15	Neues tumor-antigen-protein sart-3 und tumor- antigen-peptid davon
EP0749320A4 (en)	1997-06-18	FIBRIN-SPECIFIC ANTIBODIES FOR USE AS ANTITHROMBOSE AGENT
PT929299E (pt)	2004-02-27	1,2,3,4-tetra-hidro-2-dibenzofuranaminas e 2-aminociclo-hepta ¬b\| benzofuranos substituidos
DE59711564D1 (de)	2004-06-03	Wiederlösbare, selbstklebende Vorrichtung
DE69938130D1 (de)	2008-03-27	Neue peptide
AU2172597A (en)	1997-10-22	Protein phosphatase-1 catalytic subunit interactions
FI973469L (fi)	1997-08-22	Menetelmä tekijän IX valmistamiseksi biologisista lähteistä
TR199701666A3 (tr)	1999-10-21	Sismanliga karsi proteinler
EP1032411A4 (en)	2002-01-09	HYPUSINE REAGENT FOR THE SYNTHESIS OF PEPTIDES