DK0916663T3 - 18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3,13(16), 14-clerodatrien-2-on (Esculentin A) og 18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3, 12, 14-clerodatrien-2beta-isovaleryloxy-6beta, 7alpha-diol (Esculentin B), fremgangsmåde........ - Google Patents

18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3,13(16), 14-clerodatrien-2-on (Esculentin A) og 18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3, 12, 14-clerodatrien-2beta-isovaleryloxy-6beta, 7alpha-diol (Esculentin B), fremgangsmåde........

Info

Publication number: DK0916663T3
Authority: DK; Denmark
Prior art keywords: esculentin; diacetyloxy; epoxy; 19beta; 18alpha
Prior art date: 1997-11-18

Application number

DK98121657T

Other languages

English (en)

Inventor

Swati Dr Bal-Tembe

Kumar Erra Koteswara Sa Vijaya

Deore Vijay Dipex-Kira Bhagwan

Joshi Kalpana Dr Sanjay

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-18

Filing date

1998-11-12

Publication date

2003-07-28

1998-11-12 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2003-07-28 Application granted granted Critical

2003-07-28 Publication of DK0916663T3 publication Critical patent/DK0916663T3/da

Links

VXDGLMKJOZOWRO-UHFFFAOYSA-N esculentin A Natural products O=C1CC2C(CCC(=C)C=C)(C)C(C)CCC32C(OC(C)=O)OC(OC(C)=O)C3=C1 VXDGLMKJOZOWRO-UHFFFAOYSA-N 0.000 title abstract 4
LPSTZZWXOOHMOA-UHFFFAOYSA-N esculentin B Natural products OC1C(O)C(C)C(CC=C(C)C=C)(C)C2C31C(OC(C)=O)OC(OC(C)=O)C3=CC(OC(=O)CC(C)C)C2 LPSTZZWXOOHMOA-UHFFFAOYSA-N 0.000 title abstract 3
LPSTZZWXOOHMOA-OZUCLCINSA-N [(1s,3r,5r,6as,7s,8s,9r,10r,10as)-1,3-diacetyloxy-9,10-dihydroxy-7,8-dimethyl-7-[(2z)-3-methylpenta-2,4-dienyl]-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate Chemical compound [C@H]1([C@]([C@H](C)[C@@H](O)[C@@H]2O)(C)C\C=C(\C)C=C)[C@]32[C@H](OC(C)=O)O[C@H](OC(C)=O)C3=C[C@H](OC(=O)CC(C)C)C1 LPSTZZWXOOHMOA-OZUCLCINSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
241000169616 Casearia Species 0.000 abstract 1
241000196324 Embryophyta Species 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Furan Compounds (AREA)
Steroid Compounds (AREA)
Epoxy Compounds (AREA)

DK98121657T 1997-11-18 1998-11-12 18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3,13(16), 14-clerodatrien-2-on (Esculentin A) og 18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3, 12, 14-clerodatrien-2beta-isovaleryloxy-6beta, 7alpha-diol (Esculentin B), fremgangsmåde........ DK0916663T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97120143		1997-11-18

Publications (1)

Publication Number	Publication Date
DK0916663T3 true DK0916663T3 (da)	2003-07-28

Family

ID=8227636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98121657T DK0916663T3 (da)	1997-11-18	1998-11-12	18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3,13(16), 14-clerodatrien-2-on (Esculentin A) og 18beta, 19beta-diacetyloxy-18alpha, 19alpha-epoxy-3, 12, 14-clerodatrien-2beta-isovaleryloxy-6beta, 7alpha-diol (Esculentin B), fremgangsmåde........

Country Status (8)

Country	Link
US (1)	US6107335A (da)
EP (1)	EP0916663B1 (da)
JP (1)	JP4373510B2 (da)
AT (1)	ATE239715T1 (da)
DE (1)	DE69814307T2 (da)
DK (1)	DK0916663T3 (da)
ES (1)	ES2198631T3 (da)
PT (1)	PT916663E (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20140066210A (ko) *	2004-08-04	2014-05-30	포움 서플라이즈 인코포레이션	폴리우레탄 폼에서의 반응도 변동 및 촉매 분해
CN104418829A (zh) *	2013-09-07	2015-03-18	山东大学（威海）	一种具有抗肿瘤作用的化合物单叶蔓荆素b的结构与制备方法及其用途
CN112239439A (zh) *	2019-07-17	2021-01-19	南开大学	四种具有抗癌活性的烈味脚骨脆二萜的制备方法和用途
IT201900018938A1 (it)	2019-10-16	2021-04-16	Univ Degli Studi Roma La Sapienza	Uso di esculentina e suoi derivati per uso per il trattamento della fibrosi cistica

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5468772A (en) *	1993-03-10	1995-11-21	Pharmagenesis, Inc.	Tripterinin compound and method

1998
- 1998-11-12 DE DE69814307T patent/DE69814307T2/de not_active Expired - Lifetime
- 1998-11-12 PT PT98121657T patent/PT916663E/pt unknown
- 1998-11-12 DK DK98121657T patent/DK0916663T3/da active
- 1998-11-12 AT AT98121657T patent/ATE239715T1/de not_active IP Right Cessation
- 1998-11-12 EP EP98121657A patent/EP0916663B1/en not_active Expired - Lifetime
- 1998-11-12 ES ES98121657T patent/ES2198631T3/es not_active Expired - Lifetime
- 1998-11-17 US US09/192,501 patent/US6107335A/en not_active Expired - Lifetime
- 1998-11-17 JP JP32647698A patent/JP4373510B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0916663A1 (en)	1999-05-19
PT916663E (pt)	2003-09-30
US6107335A (en)	2000-08-22
ATE239715T1 (de)	2003-05-15
JP4373510B2 (ja)	2009-11-25
DE69814307T2 (de)	2004-07-01
ES2198631T3 (es)	2004-02-01
JPH11236383A (ja)	1999-08-31
EP0916663B1 (en)	2003-05-07
DE69814307D1 (de)	2003-06-12

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