DK0930873T3 - Farmaceutisk gelpræparat, der kan anvendes på slimhindeoverflader og legemsvæv - Google Patents
Farmaceutisk gelpræparat, der kan anvendes på slimhindeoverflader og legemsvævInfo
- Publication number
- DK0930873T3 DK0930873T3 DK97910118T DK97910118T DK0930873T3 DK 0930873 T3 DK0930873 T3 DK 0930873T3 DK 97910118 T DK97910118 T DK 97910118T DK 97910118 T DK97910118 T DK 97910118T DK 0930873 T3 DK0930873 T3 DK 0930873T3
- Authority
- DK
- Denmark
- Prior art keywords
- body tissues
- mucosal surfaces
- gel preparation
- residence time
- pharmaceutical
- Prior art date
Links
- 239000008252 pharmaceutical gel Substances 0.000 title 1
- 229920013820 alkyl cellulose Polymers 0.000 abstract 1
- 239000000227 bioadhesive Substances 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/733,454 US5955097A (en) | 1996-10-18 | 1996-10-18 | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
| PCT/US1997/018606 WO1998017252A1 (en) | 1996-10-18 | 1997-10-16 | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0930873T3 true DK0930873T3 (da) | 2002-11-18 |
Family
ID=24947672
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97910118T DK0930873T3 (da) | 1996-10-18 | 1997-10-16 | Farmaceutisk gelpræparat, der kan anvendes på slimhindeoverflader og legemsvæv |
| DK02004079T DK1210934T3 (da) | 1996-10-18 | 1997-10-16 | Farmaceutisk bærestofpræparat, der kan påföres på slimhindeoverflader |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02004079T DK1210934T3 (da) | 1996-10-18 | 1997-10-16 | Farmaceutisk bærestofpræparat, der kan påföres på slimhindeoverflader |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5955097A (de) |
| EP (2) | EP1210934B1 (de) |
| JP (2) | JP2001508038A (de) |
| AT (2) | ATE338537T1 (de) |
| AU (1) | AU731645B2 (de) |
| CA (1) | CA2268140C (de) |
| DE (2) | DE69736641T2 (de) |
| DK (2) | DK0930873T3 (de) |
| ES (2) | ES2179308T3 (de) |
| PT (2) | PT1210934E (de) |
| WO (1) | WO1998017252A1 (de) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955097A (en) * | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
| US5908631A (en) | 1997-02-27 | 1999-06-01 | L'oreal S.A. | Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose |
| US6153210A (en) * | 1997-08-14 | 2000-11-28 | Periodontix, Inc. | Use of locally delivered metal ions for treatment of periodontal disease |
| TWI243687B (en) | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
| CN1297344A (zh) * | 1998-10-19 | 2001-05-30 | 济拉公司 | 在机体组织上原位形成保护性和/或药性膜的方法及组合物 |
| DE19925519A1 (de) | 1999-06-04 | 2000-12-07 | Lohmann Therapie Syst Lts | Wundauflage zur gesteuerten Abgabe von Wirkstoff an Wunden und Verfahren zu ihrer Herstellung |
| US6375963B1 (en) | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
| AR026073A1 (es) | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica acuosa que contiene ciclesonida |
| JP5072159B2 (ja) | 1999-10-26 | 2012-11-14 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 粘膜アジュバントとしての植物レクチン |
| US6863896B1 (en) | 1999-10-26 | 2005-03-08 | Chiron Corporation | Plant lectins as mucosal adjuvants |
| US6555125B2 (en) * | 1999-11-30 | 2003-04-29 | Phillip Campbell | Lesion and ulcer medication |
| US6706781B2 (en) * | 1999-12-08 | 2004-03-16 | The Procter & Gamble Company | Denture adhesive compositions with antimicrobial agents |
| US6432415B1 (en) * | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
| US20020013331A1 (en) | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
| US7803392B2 (en) * | 2000-12-27 | 2010-09-28 | University Of Kentucky Research Foundation | pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules |
| US20030017133A1 (en) * | 2001-06-15 | 2003-01-23 | Wyeth (Formerly American Home Products Corporation) | Mucoadhesive composition |
| WO2003005889A2 (en) * | 2001-07-10 | 2003-01-23 | Ams Research Corporation | Surgical kit for treating prostate tissue |
| US20060073174A1 (en) * | 2001-08-16 | 2006-04-06 | Access Pharmaceuticals, Inc. | Adherent and erodible film to treat a moist surface of a body tissue |
| US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US8425892B2 (en) | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| US20030118655A1 (en) * | 2001-12-21 | 2003-06-26 | Nikhil Kundel | Film forming liquid composition |
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| US20040028744A1 (en) * | 2002-06-17 | 2004-02-12 | Sauwaluxana Tongaree | Mucoadhesive composition |
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| MXPA06001776A (es) * | 2003-08-15 | 2007-09-07 | Qlt Usa Inc | Sistema de suministro de farmaco transmucosal biocorrosivo, adhesivo. |
| JP2007522077A (ja) * | 2003-08-21 | 2007-08-09 | アクセス ファーマシューティカルズ, インコーポレイテッド | 粘膜の疾患および障害の予防および処置のための液体製剤 |
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| US20070196457A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Two or more volatile solvent-containing compositions and methods for dermal delivery of drugs |
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| US11154535B2 (en) | 2012-07-31 | 2021-10-26 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| US10045965B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
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| EP3542788A1 (de) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topische zusammensetzung enthaltend calcipotriol und betamethason dipropionat |
| US12465564B2 (en) | 2021-10-25 | 2025-11-11 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
| CN117298071A (zh) * | 2023-11-13 | 2023-12-29 | 力品药业(厦门)股份有限公司 | 一种用于治疗口腔溃疡的口腔贴膜及其制备方法 |
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|---|---|---|---|---|
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| CA1208558A (en) * | 1982-10-07 | 1986-07-29 | Kazuo Kigasawa | Soft buccal |
| EP0186019B1 (de) * | 1984-12-22 | 1993-10-06 | Schwarz Pharma Ag | Wirkstoffpflaster |
| US4713243A (en) * | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
| US4906463A (en) * | 1986-12-22 | 1990-03-06 | Cygnus Research Corporation | Transdermal drug-delivery composition |
| JPH0744940B2 (ja) * | 1986-12-24 | 1995-05-17 | ライオン株式会社 | 口腔貼付用基材 |
| DE3714074A1 (de) * | 1987-04-28 | 1988-11-10 | Hoechst Ag | Grundlage fuer schleimhaut- und prothesenhaft-pasten, verfahren zu ihrer herstellung sowie pasten auf basis dieser grundlage |
| EP0289900A1 (de) * | 1987-04-30 | 1988-11-09 | Abbott Laboratories | Topische antibakterielle Zusammensetzungen |
| US4867970A (en) * | 1987-05-21 | 1989-09-19 | E. R. Squibb & Sons, Inc. | Moistureless oral drug delivery formulation and method for preparing same |
| US4915948A (en) * | 1987-08-31 | 1990-04-10 | Warner-Lambert Company | Tablets having improved bioadhesion to mucous membranes |
| US5059189A (en) * | 1987-09-08 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Method of preparing adhesive dressings containing a pharmaceutically active ingredient |
| JPH01151516A (ja) * | 1987-12-08 | 1989-06-14 | Shionogi & Co Ltd | ビタミンe配合外用剤 |
| JPH07116035B2 (ja) * | 1987-12-08 | 1995-12-13 | 塩野義製薬株式会社 | 被膜形成性抗真菌剤組成物 |
| US5081158A (en) * | 1988-05-02 | 1992-01-14 | Zila Pharmaceuticals, Inc. | Compositions and in situ methods for forming films on body tissue |
| US5081157A (en) * | 1988-05-02 | 1992-01-14 | Zila Pharmaceuticals, Inc. | Compositions and in situ methods for forming films on body tissue |
| JPH0645536B2 (ja) * | 1989-01-31 | 1994-06-15 | 日東電工株式会社 | 口腔粘膜貼付剤および口腔粘膜貼付製剤 |
| JP2656338B2 (ja) * | 1989-01-31 | 1997-09-24 | 日東電工株式会社 | 口腔粘膜貼付製剤 |
| US5298258A (en) * | 1989-12-28 | 1994-03-29 | Nitto Denko Corporation | Acrylic oily gel bioadhesive material and acrylic oily gel preparation |
| US5192802A (en) * | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| JP2533723B2 (ja) * | 1992-12-28 | 1996-09-11 | 東興薬品工業株式会社 | 速乾性ゲルタイプ手指消毒剤 |
| US5540930A (en) * | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
| FR2732223B1 (fr) * | 1995-03-30 | 1997-06-13 | Sanofi Sa | Composition pharmaceutique pour administration transdermique |
| US5955097A (en) * | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
| US5885611A (en) | 1997-06-04 | 1999-03-23 | Colgate-Palmolive Company | Bandage-forming gel for oral mucosa |
-
1996
- 1996-10-18 US US08/733,454 patent/US5955097A/en not_active Expired - Lifetime
-
1997
- 1997-10-16 WO PCT/US1997/018606 patent/WO1998017252A1/en not_active Ceased
- 1997-10-16 ES ES97910118T patent/ES2179308T3/es not_active Expired - Lifetime
- 1997-10-16 DE DE69736641T patent/DE69736641T2/de not_active Expired - Lifetime
- 1997-10-16 EP EP02004079A patent/EP1210934B1/de not_active Expired - Lifetime
- 1997-10-16 DK DK97910118T patent/DK0930873T3/da active
- 1997-10-16 DK DK02004079T patent/DK1210934T3/da active
- 1997-10-16 ES ES02004079T patent/ES2272586T3/es not_active Expired - Lifetime
- 1997-10-16 JP JP51946898A patent/JP2001508038A/ja not_active Withdrawn
- 1997-10-16 CA CA002268140A patent/CA2268140C/en not_active Expired - Fee Related
- 1997-10-16 EP EP97910118A patent/EP0930873B1/de not_active Expired - Lifetime
- 1997-10-16 PT PT02004079T patent/PT1210934E/pt unknown
- 1997-10-16 AT AT02004079T patent/ATE338537T1/de active
- 1997-10-16 PT PT97910118T patent/PT930873E/pt unknown
- 1997-10-16 DE DE69715433T patent/DE69715433T2/de not_active Expired - Lifetime
- 1997-10-16 AT AT97910118T patent/ATE223699T1/de active
- 1997-10-16 AU AU47575/97A patent/AU731645B2/en not_active Ceased
-
1999
- 1999-07-30 US US09/364,566 patent/US6290984B1/en not_active Expired - Lifetime
-
2007
- 2007-05-25 JP JP2007139731A patent/JP2007211030A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US5955097A (en) | 1999-09-21 |
| ES2179308T3 (es) | 2003-01-16 |
| JP2007211030A (ja) | 2007-08-23 |
| JP2001508038A (ja) | 2001-06-19 |
| DE69715433D1 (de) | 2002-10-17 |
| EP1210934A3 (de) | 2003-01-08 |
| EP1210934A2 (de) | 2002-06-05 |
| DK1210934T3 (da) | 2007-01-15 |
| DE69736641D1 (de) | 2006-10-19 |
| ES2272586T3 (es) | 2007-05-01 |
| US6290984B1 (en) | 2001-09-18 |
| PT1210934E (pt) | 2006-12-29 |
| CA2268140A1 (en) | 1998-04-30 |
| AU4757597A (en) | 1998-05-15 |
| ATE338537T1 (de) | 2006-09-15 |
| PT930873E (pt) | 2003-01-31 |
| DE69736641T2 (de) | 2007-09-13 |
| CA2268140C (en) | 2005-05-24 |
| DE69715433T2 (de) | 2003-01-09 |
| EP1210934B1 (de) | 2006-09-06 |
| WO1998017252A1 (en) | 1998-04-30 |
| EP0930873A1 (de) | 1999-07-28 |
| AU731645B2 (en) | 2001-04-05 |
| EP0930873B1 (de) | 2002-09-11 |
| ATE223699T1 (de) | 2002-09-15 |
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