DK0935417T3 - Enteroformuleringer af proanthocyanidin-polymer-sammensætninger mod diarré - Google Patents

Enteroformuleringer af proanthocyanidin-polymer-sammensætninger mod diarré

Info

Publication number
DK0935417T3
DK0935417T3 DK97912779T DK97912779T DK0935417T3 DK 0935417 T3 DK0935417 T3 DK 0935417T3 DK 97912779 T DK97912779 T DK 97912779T DK 97912779 T DK97912779 T DK 97912779T DK 0935417 T3 DK0935417 T3 DK 0935417T3
Authority
DK
Denmark
Prior art keywords
proanthocyanidin polymer
polymer composition
stomach acid
formulations
diarrhea
Prior art date
Application number
DK97912779T
Other languages
English (en)
Inventor
Edward J Rozhon
Atul S Khandwala
Akram Sabouni
Original Assignee
Napo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napo Pharmaceuticals Inc filed Critical Napo Pharmaceuticals Inc
Application granted granted Critical
Publication of DK0935417T3 publication Critical patent/DK0935417T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK97912779T 1996-10-16 1997-10-14 Enteroformuleringer af proanthocyanidin-polymer-sammensætninger mod diarré DK0935417T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73077296A 1996-10-16 1996-10-16
PCT/US1997/018845 WO1998016111A1 (en) 1996-10-16 1997-10-14 Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Publications (1)

Publication Number Publication Date
DK0935417T3 true DK0935417T3 (da) 2009-08-10

Family

ID=24936755

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97912779T DK0935417T3 (da) 1996-10-16 1997-10-14 Enteroformuleringer af proanthocyanidin-polymer-sammensætninger mod diarré

Country Status (14)

Country Link
US (5) US7341744B1 (da)
EP (3) EP2255661A3 (da)
JP (1) JP4195728B2 (da)
KR (1) KR100467532B1 (da)
AT (1) ATE430477T1 (da)
AU (1) AU4988197A (da)
CA (1) CA2269078C (da)
DE (1) DE69739394D1 (da)
DK (1) DK0935417T3 (da)
ES (1) ES2326933T3 (da)
NZ (1) NZ335317A (da)
PT (1) PT935417E (da)
TW (1) TW537898B (da)
WO (1) WO1998016111A1 (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4195728B2 (ja) * 1996-10-16 2008-12-10 ナポ ファーマシューティカルズ，インコーポレーテッド プロアントシアニジンポリマー止瀉組成物の腸溶製剤
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
KR20010108193A (ko) * 1999-02-15 2001-12-07 마사토시 노다 활성성분으로서 프로안토시아니딘을 함유하는에이디피-리보실화 억제제 및 엔테로톡신 타입 세균감염성질환 치료용 조성물
JP2002544220A (ja) * 1999-05-17 2002-12-24 デー．ベー．エフ． 植物物質を含有する顆粒及びその製造方法
WO2002078726A1 (en) * 2001-03-28 2002-10-10 Asahi Breweries,Ltd. Proteotoxin neutralizer
CO5400144A1 (es) 2002-03-11 2004-05-31 Novartis Ag Compuestos organicos
GB0321996D0 (en) * 2003-09-19 2003-10-22 Novartis Nutrition Ag Organic compounds
EP1689373B1 (en) 2003-10-10 2019-04-03 Ethypharm Sustained-release microgranules containing ginkgo biloba extract and the process for manufacturing these
KR100720817B1 (ko) * 2003-12-26 2007-05-21 (주)아모레퍼시픽 식물 추출물을 함유하는 제제 및 그 제조방법
JP2006232752A (ja) * 2005-02-25 2006-09-07 Tokyo Univ Of Marine Science & Technology コレステロール及び中性脂肪吸収抑制剤及びこれを含む食品
PT1698630E (pt) 2005-03-03 2014-09-15 Alfa Wassermann Spa Novas formas polimorfas de rifaximina, processos para a sua produção e a sua utilização nas preparações medicinais
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
US20090076132A1 (en) * 2005-03-11 2009-03-19 Gary Pekoe Antiviral compositions and methods of treatment
JP5167461B2 (ja) * 2005-09-16 2013-03-21 国立医薬品食品衛生研究所長 炎症性腸疾患予防剤
US7351853B2 (en) * 2006-01-23 2008-04-01 Albion Advanced Nutrition Method of manufacturing a granular mineral composition
US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
PT2529626T (pt) 2006-05-01 2018-02-27 Napo Pharmaceuticals Inc Composições e métodos para tratamento ou prevenção do cancro do cólon
NZ572049A (en) * 2006-05-01 2012-08-31 Napo Pharmaceuticals Inc Method for treatment of constipation-predominant irritable bowel syndrome
US8048413B2 (en) * 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
CN101102783B (zh) * 2006-12-13 2010-11-17 北京绿色金可生物技术股份有限公司 黑大豆皮提取物及其提取方法和应用
WO2008115605A1 (en) * 2007-03-22 2008-09-25 Ibix Clear bismuth treatments and methods for making
CN101715349B (zh) * 2007-05-08 2012-07-18 美国Rq生物科技有限公司 治疗革兰氏阴性细菌感染的治疗组合物及方法
US8734867B2 (en) 2007-12-28 2014-05-27 Liveleaf, Inc. Antibacterial having an extract of pomegranate combined with hydrogen peroxide
WO2009094169A1 (en) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2278879B1 (en) 2008-04-21 2016-06-15 PATH Drug Solutions Compounds, compositions and methods comprising oxadiazole derivatives
US20090270398A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
US8236838B2 (en) * 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
WO2009131958A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising triazine derivatives
US8807070B2 (en) * 2008-08-07 2014-08-19 Vector Corporation Rotor processor for dry powders
US20100034967A1 (en) * 2008-08-07 2010-02-11 Vector Corporation Dry polymer layering using a rotor processor
US20100034968A1 (en) * 2008-08-07 2010-02-11 Vector Corporation Polymer coating process using dry glidant in a rotor processor
JP2012503005A (ja) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。
FR2938430B1 (fr) * 2008-11-14 2011-05-20 Debregeas Et Associes Pharma Granules a base de plantes
SG10201503255SA (en) * 2009-03-04 2015-06-29 Liveleaf Inc Method and material for site activated complexing of biologic molecules
US8511216B2 (en) * 2009-03-30 2013-08-20 Kanzaki Kokyukoki Mfg. Co., Ltd. Hydraulic actuator unit
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
WO2011024049A2 (en) * 2009-08-26 2011-03-03 Glenmark Pharmaceuticals Ltd Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations
US8652534B2 (en) 2009-10-14 2014-02-18 Berry Pharmaceuticals, LLC Compositions and methods for treatment of mammalian skin
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
WO2012058664A1 (en) 2010-10-31 2012-05-03 Salix Pharmaceuticals, Ltd. Methods and compositions for treating hiv-associated diarrhea
WO2012101008A1 (en) 2011-01-27 2012-08-02 Glenmark Pharmaceuticals Limited Process for the production of proanthocyanidin polymeric composition
WO2012135702A1 (en) * 2011-04-01 2012-10-04 Ocean Spray Cranberries, Inc. Inflammation and immunity treatments
US8722040B2 (en) 2011-06-24 2014-05-13 Liveleaf, Inc. Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites
US9192635B2 (en) 2011-06-24 2015-11-24 Liveleaf, Inc. Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
JP2015509976A (ja) * 2012-03-13 2015-04-02 ピラマル エンタープライジーズ リミテッド 代謝障害の治療用薬草組成物
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
US8716351B1 (en) 2012-12-23 2014-05-06 Liveleaf, Inc. Methods of treating gastrointestinal spasms
ITMI20130476A1 (it) 2013-03-28 2014-09-29 Novintethical Pharma Sagl Composizioni per il trattamento di disturbi gastro-intestinali a base di complessi di tannini con proteine
CN103536583B (zh) * 2013-11-01 2015-02-25 潍坊医学院 一种原花青素缓释纳米微球及制备方法和应用
AU2015260837B2 (en) 2014-05-12 2019-02-28 Alfasigma S.P.A. New solvated crystal form of rifaximin, production, compositions and uses thereof
US20170095442A1 (en) * 2014-05-29 2017-04-06 Jaguar Animal Health, Inc. Methods of Treating Salmonella-Induced Diarrhea in Non-Human Animals
WO2015184101A1 (en) * 2014-05-29 2015-12-03 Jaguar Animal Health, Inc. Methods of treating diarrhea in neonatal and young non-human animals
US20170119834A1 (en) * 2014-05-29 2017-05-04 Jaguar Animal Health, Inc. Methods of Treating Diarrhea in Adult Non-Human Animals
EP3242557A4 (en) * 2015-01-09 2018-09-05 Jaguar Health, Inc. Methods of treating diarrhea in companion animals
HK1246719A1 (zh) * 2015-02-26 2018-09-14 捷豹健康股份有限公司 在非人动物中治疗腹泻和促进肠道健康的方法
WO2016138118A1 (en) * 2015-02-26 2016-09-01 Jaguar Animal Health, Inc. Use of croton- or calophyllum-derived proanthocyanidin polymers or botanical extracts in combination with rifaximin for the treatment of diarrhea in non-human animals
WO2018022475A1 (en) * 2016-07-25 2018-02-01 Jaguar Health, Inc Methods of treating porcine epidemic diarrheal virus in piglets
IT201600122310A1 (it) 2016-12-01 2018-06-01 Sofar Spa Composizione per uso nella terapia di alterazioni dell'intestino
MX2018015344A (es) 2016-12-15 2019-04-29 Nestec Sa Composiciones y metodos que modulan las bacterias en un animal de compañía.
AU2018275685B2 (en) * 2017-05-31 2025-04-17 Napo Pharmaceuticals, Inc. Methods and compositions for treating bile acid diarrhea, diarrhea associated with small intestine resection or gallbladder removal, and short bowel syndrome
JP2020525407A (ja) * 2017-05-31 2020-08-27 ナポ ファーマシューティカルズ インク．Ｎａｐｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 先天性下痢障害を治療するための方法及び組成物
CA3086826A1 (en) * 2017-12-27 2019-07-04 Suntory Holdings Limited Composition for improving intestinal barrier function
KR20200008826A (ko) 2018-07-17 2020-01-29 성균관대학교산학협력단 대장균을 이용한 단백질가수분해효소 k의 생산 방법
CN109464491B (zh) * 2018-12-03 2022-02-01 四川省畜牧科学研究院 诃子组合物及其在制备预防和/或治疗腹泻和/或乳房炎的产品中的应用
WO2022115481A1 (en) * 2020-11-24 2022-06-02 Napo Pharmaceuticals, Inc. Methods and compositions for treating post-acute infection gastrointestinal disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377201A1 (fr) * 1977-01-18 1978-08-11 Fabre Sa Pierre Composition pharmaceutique a activite anti-inflammatoire et vasculotrope
SE446940B (sv) 1983-02-16 1986-10-20 Carl Axel Virdalm Medel for bekempande av sjukdomstillstand i matsmeltningsapparaten innehallande skal eller ytterdelar av ber eller frukter
US4698360B1 (en) * 1985-04-09 1997-11-04 D Investigations Pharmacologiq Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
EP0214317B1 (fr) 1985-08-30 1988-08-17 Societe Des Produits Nestle S.A. Produit diététique à activité dépurative et anti-diarrhéique et son procédé de préparation
US5141735A (en) * 1990-06-18 1992-08-25 Hoffman-La Roche, Inc. Substituted amino-benzodiazepines having anitviral activity
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
SI9011933A (sl) 1990-10-15 1998-06-30 TANIN SEVNICA Kemična industrija p.o. Kostanjev taninski ekstrakt, postopek za njegovo pridobivanje in njegova uporaba
US5234922A (en) 1992-09-28 1993-08-10 University Of Iowa Research Foundation Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea
US5750496A (en) * 1996-08-12 1998-05-12 Utah State University Method of controlling cryptosporidium infectons using protease inhibitors
JP4195728B2 (ja) * 1996-10-16 2008-12-10 ナポ ファーマシューティカルズ，インコーポレーテッド プロアントシアニジンポリマー止瀉組成物の腸溶製剤

Also Published As

Publication number Publication date
US20140329896A1 (en) 2014-11-06
EP0935417B1 (en) 2009-05-06
JP4195728B2 (ja) 2008-12-10
TW537898B (en) 2003-06-21
AU4988197A (en) 1998-05-11
KR100467532B1 (ko) 2005-01-24
US7323195B2 (en) 2008-01-29
CA2269078A1 (en) 1998-04-23
WO1998016111A1 (en) 1998-04-23
KR20000049206A (ko) 2000-07-25
DE69739394D1 (de) 2009-06-18
NZ335317A (en) 2001-02-23
EP2060183A3 (en) 2009-06-03
US8574634B2 (en) 2013-11-05
EP0935417A4 (en) 2006-08-30
EP2255661A2 (en) 2010-12-01
JP2001524938A (ja) 2001-12-04
US20090148397A1 (en) 2009-06-11
EP2255661A3 (en) 2010-12-22
ES2326933T3 (es) 2009-10-21
US20050019389A1 (en) 2005-01-27
PT935417E (pt) 2009-07-17
EP2060183A2 (en) 2009-05-20
US20140011869A1 (en) 2014-01-09
ATE430477T1 (de) 2009-05-15
US7341744B1 (en) 2008-03-11
EP0935417A1 (en) 1999-08-18
CA2269078C (en) 2012-01-24

Similar Documents

Publication Publication Date Title
DE69739394D1 (de) Enteral-formulierungen von proanthocyanidzusammensetzungen gegen diarrhöe
WO2001054501A3 (en) Herbicidal composition
AU1974692A (en) Oral-administration forms of a medicament containing pantoprazol
CA2271623A1 (en) Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
CO4780014A1 (es) Composiciones dentifricas y metodos do y un vehiculo dentrifico bucalmente aceptable y metodo pa ra reducir el manchado y/o la placa y la gingivitis utilizan do dichas composiciones
IL154501A0 (en) Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia
DK0716606T3 (da) Phosphatbindende polymerer til oral indgivelse
PL357089A1 (en) Tartar control denture adhesive compositions
AU7535798A (en) Novel cyclosporin derivatives, preparation and pharmaceutical compositions containing same
AU5669198A (en) Cyclosporin derivative, its preparation and pharmaceutical compositions containing same
CA2402401A1 (en) Compositions containing molecular iodine
CA2214090A1 (en) Oral compositions
EP0807633A3 (en) Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones
CA2241464A1 (en) Nisin in combination with glycerol monolaurate active against helicobacter
UA72909C2 (en) Cinnamide derivatives useful in the treatment of inflammatory and immune diseases, a composition containing such derivatives and a method for the preparation of cinnamide derivatives
HUP9903166A3 (en) Medicinal compositions for the prophylaxis or treatment of arteriosclerosis
WO2004011477A3 (en) 6,11-4-carbon bridged ketolides
AU2001242876A1 (en) Compositions suitable for the treatment of damage caused by ischemia/reperfusionor oxidative stress
BR1100143A (pt) Composto, e, composição farmacêutica.
EP0104768A3 (en) Oral compositions comprising ng-acyl derivatives of arginine
AU1816500A (en) Bleaching compositions
IL99471A0 (en) Pharmaceutical compositions containing pyridylmethylsulphinyl-1h-benzimidazole derivatives as active ingredient therein
LT96093A (en) The active ingredient of pharmaceutical composition for treating aphtae and stomatitis
AU5704800A (en) Medicinal compositions for preventing or treating diarrhea
NZ290236A (en) Inhibition ofleucotriene biosynthesis and pharmaceutical compositions comprising aryl-urea derivatives