DK0940385T3 - Fremgangsmåde til separation af (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanol-isomeren fra (RS,SR)-isomeren ved selektiv udfældning - Google Patents

Fremgangsmåde til separation af (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanol-isomeren fra (RS,SR)-isomeren ved selektiv udfældning

Info

Publication number
DK0940385T3
DK0940385T3 DK99104275T DK99104275T DK0940385T3 DK 0940385 T3 DK0940385 T3 DK 0940385T3 DK 99104275 T DK99104275 T DK 99104275T DK 99104275 T DK99104275 T DK 99104275T DK 0940385 T3 DK0940385 T3 DK 0940385T3
Authority
DK
Denmark
Prior art keywords
isomer
methoxyphenyl
dimethylamino
methyl
cyclohexanol
Prior art date
Application number
DK99104275T
Other languages
English (en)
Inventor
Walter Cabri
Domenico Magrone
Original Assignee
Dinamite Dipharma S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dinamite Dipharma S P A filed Critical Dinamite Dipharma S P A
Application granted granted Critical
Publication of DK0940385T3 publication Critical patent/DK0940385T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK99104275T 1998-03-06 1999-03-03 Fremgangsmåde til separation af (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanol-isomeren fra (RS,SR)-isomeren ved selektiv udfældning DK0940385T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI000457A IT1298597B1 (it) 1998-03-06 1998-03-06 Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)

Publications (1)

Publication Number Publication Date
DK0940385T3 true DK0940385T3 (da) 2003-10-20

Family

ID=11379210

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99104275T DK0940385T3 (da) 1998-03-06 1999-03-03 Fremgangsmåde til separation af (RR,SS)-2-(dimethylamino)methyl-1-(3-methoxyphenyl)-cyclohexanol-isomeren fra (RS,SR)-isomeren ved selektiv udfældning

Country Status (8)

Country Link
US (1) US6169205B1 (da)
EP (1) EP0940385B1 (da)
AT (1) ATE243675T1 (da)
DE (1) DE69908994T2 (da)
DK (1) DK0940385T3 (da)
ES (1) ES2201581T3 (da)
IT (1) IT1298597B1 (da)
PT (1) PT940385E (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19758576C2 (de) * 1997-12-22 2002-01-24 Gruenenthal Gmbh Verfahren zur Diastereomerentrennung für substituierte Aminoalkohole
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
EP1346978A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Process for preparing tramadol hydrochloride and/or tramadol monohydrate
EP1785412A1 (en) 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL103096A (en) * 1992-09-08 1996-12-05 Chemagis Ltd Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
IL116281A (en) * 1995-12-07 1999-06-20 Chemagis Ltd Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
IL119121A (en) * 1996-08-22 2000-11-21 Chemagis Ltd Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride

Also Published As

Publication number Publication date
ITMI980457A1 (it) 1999-09-06
EP0940385A1 (en) 1999-09-08
ATE243675T1 (de) 2003-07-15
DE69908994D1 (de) 2003-07-31
DE69908994T2 (de) 2004-05-19
ES2201581T3 (es) 2004-03-16
IT1298597B1 (it) 2000-01-12
EP0940385B1 (en) 2003-06-25
US6169205B1 (en) 2001-01-02
PT940385E (pt) 2003-10-31

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