PT940385E - Processo para a separacao do isomero do (rr,ss)-2-(dimetilamino)-metil-1-(3-metoxifenil)-ciclo-hexanol a partir do isomero (rs,sr) mediante precipitacao selectiva - Google Patents

Processo para a separacao do isomero do (rr,ss)-2-(dimetilamino)-metil-1-(3-metoxifenil)-ciclo-hexanol a partir do isomero (rs,sr) mediante precipitacao selectiva

Info

Publication number: PT940385E
Authority: PT; Portugal
Prior art keywords: methoxyphenyl; dimethylamino; methyl; isomer; selective precipitation
Prior art date: 1998-03-06

Application number

PT99104275T

Other languages

English (en)

Inventor

Walter Cabri

Domenico Magrone

Original Assignee

Dinamite Dipharma S P A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-06

Filing date

1999-03-03

Publication date

2003-10-31

1999-03-03 Application filed by Dinamite Dipharma S P A filed Critical Dinamite Dipharma S P A

2003-10-31 Publication of PT940385E publication Critical patent/PT940385E/pt

Links

238000001556 precipitation Methods 0.000 title abstract 2
238000000926 separation method Methods 0.000 title 1
TVYLLZQTGLZFBW-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol Chemical compound COC1=CC=CC(C2(O)C(CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT99104275T 1998-03-06 1999-03-03 Processo para a separacao do isomero do (rr,ss)-2-(dimetilamino)-metil-1-(3-metoxifenil)-ciclo-hexanol a partir do isomero (rs,sr) mediante precipitacao selectiva PT940385E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT98MI000457A IT1298597B1 (it)	1998-03-06	1998-03-06	Processo per la purificazione dell'(rr,ss)-2-(dimetilammino)metil- 1-(3-metossifenil)-cicloesanolo dall'(rs,sr)-2-(dimetilammino)

Publications (1)

Publication Number	Publication Date
PT940385E true PT940385E (pt)	2003-10-31

Family

ID=11379210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99104275T PT940385E (pt)	1998-03-06	1999-03-03	Processo para a separacao do isomero do (rr,ss)-2-(dimetilamino)-metil-1-(3-metoxifenil)-ciclo-hexanol a partir do isomero (rs,sr) mediante precipitacao selectiva

Country Status (8)

Country	Link
US (1)	US6169205B1 (pt)
EP (1)	EP0940385B1 (pt)
AT (1)	ATE243675T1 (pt)
DE (1)	DE69908994T2 (pt)
DK (1)	DK0940385T3 (pt)
ES (1)	ES2201581T3 (pt)
IT (1)	IT1298597B1 (pt)
PT (1)	PT940385E (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19758576C2 (de) *	1997-12-22	2002-01-24	Gruenenthal Gmbh	Verfahren zur Diastereomerentrennung für substituierte Aminoalkohole
US6649783B2 (en)	2001-10-03	2003-11-18	Euro-Celtique, S.A.	Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
EP1346978A1 (en) *	2002-03-21	2003-09-24	Jubilant Organosys Limited	Process for preparing tramadol hydrochloride and/or tramadol monohydrate
EP1785412A1 (en)	2005-11-14	2007-05-16	IPCA Laboratories Limited	Tramadol recovery process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3652589A (en) *	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL103096A (en) *	1992-09-08	1996-12-05	Chemagis Ltd	Process for purification 2 -]) Dimethylamino (methyl-1-) 3-methoxycinyl (cyclohexanol and its salts.
IL116281A (en) *	1995-12-07	1999-06-20	Chemagis Ltd	Process for the purification of (rr,ss)-2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol and its salts
IL119121A (en) *	1996-08-22	2000-11-21	Chemagis Ltd	Process for the purification of (RR-SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol hydrochloride

1998
- 1998-03-06 IT IT98MI000457A patent/IT1298597B1/it active IP Right Grant
1999
- 1999-03-03 EP EP99104275A patent/EP0940385B1/en not_active Expired - Lifetime
- 1999-03-03 PT PT99104275T patent/PT940385E/pt unknown
- 1999-03-03 ES ES99104275T patent/ES2201581T3/es not_active Expired - Lifetime
- 1999-03-03 DK DK99104275T patent/DK0940385T3/da active
- 1999-03-03 AT AT99104275T patent/ATE243675T1/de not_active IP Right Cessation
- 1999-03-03 DE DE69908994T patent/DE69908994T2/de not_active Expired - Fee Related
- 1999-03-04 US US09/262,043 patent/US6169205B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ITMI980457A1 (it)	1999-09-06
US6169205B1 (en)	2001-01-02
ATE243675T1 (de)	2003-07-15
IT1298597B1 (it)	2000-01-12
ES2201581T3 (es)	2004-03-16
DE69908994T2 (de)	2004-05-19
DK0940385T3 (da)	2003-10-20
EP0940385B1 (en)	2003-06-25
DE69908994D1 (de)	2003-07-31
EP0940385A1 (en)	1999-09-08

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