DK0942962T3 - Kemisk modificerede enzymer - Google Patents

Kemisk modificerede enzymer

Info

Publication number: DK0942962T3
Authority: DK; Denmark
Prior art keywords: modified enzymes; alkyl; substituted; replaced; chemically modified
Prior art date: 1996-11-26

Application number

DK97949562T

Other languages

Danish (da)

English (en)

Inventor

Thomas P Graycar

Colin Mitchinson

J Bryan Jones

Richard R Bott

Grace Desantis

Original Assignee

Genencor Int

Univ Toronto

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-26

Filing date

1997-11-24

Publication date

2007-05-07

1997-11-24 Application filed by Genencor Int, Univ Toronto filed Critical Genencor Int

2007-05-07 Application granted granted Critical

2007-05-07 Publication of DK0942962T3 publication Critical patent/DK0942962T3/da

Links

102000004190 Enzymes Human genes 0.000 title abstract 6
108090000790 Enzymes Proteins 0.000 title abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
229940024606 amino acid Drugs 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000003674 animal food additive Substances 0.000 abstract 1
229960001230 asparagine Drugs 0.000 abstract 1
235000009582 asparagine Nutrition 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
239000004753 textile Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38663—Stabilised liquid enzyme compositions
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Detergent Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Chemical Or Physical Treatment Of Fibers (AREA)

DK97949562T 1996-11-26 1997-11-24 Kemisk modificerede enzymer DK0942962T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75666496A	1996-11-26	1996-11-26
PCT/US1997/021446 WO1998023732A2 (en)	1996-11-26	1997-11-24	Chemically modified enzymes

Publications (1)

Publication Number	Publication Date
DK0942962T3 true DK0942962T3 (da)	2007-05-07

Family

ID=25044504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97949562T DK0942962T3 (da)	1996-11-26	1997-11-24	Kemisk modificerede enzymer

Country Status (12)

Country	Link
US (1)	US6277617B1 (de)
EP (1)	EP0942962B1 (de)
JP (1)	JP2002506342A (de)
CN (1)	CN1246146A (de)
AT (1)	ATE349514T1 (de)
AU (1)	AU733082B2 (de)
CA (2)	CA2273079C (de)
DE (1)	DE69737148T2 (de)
DK (1)	DK0942962T3 (de)
ES (1)	ES2277364T3 (de)
NZ (1)	NZ336434A (de)
WO (1)	WO1998023732A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2368718T3 (es) *	1997-10-23	2011-11-21	Danisco Us Inc.	Variantes de subtilisina con múltiples sustituciones.
US6908757B1 (en)	1998-03-26	2005-06-21	The Procter & Gamble Company	Serine protease variants having amino acid deletions and substitutions
US6495136B1 (en)	1998-03-26	2002-12-17	The Procter & Gamble Company	Proteases having modified amino acid sequences conjugated to addition moieties
WO1999049056A1 (en)	1998-03-26	1999-09-30	The Procter & Gamble Company	Serine protease variants having amino acid substitutions
ATE407941T1 (de)	1998-07-02	2008-09-15	Univ Toronto	Mit einer kohlenhydratgruppe chemisch modifizierte proteine
JP4932990B2 (ja) *	1998-11-10	2012-05-16	ダニスコ・ユーエス・インコーポレイテッド	化学修飾突然変異体セリンヒドロラーゼは改良された触媒活性およびキラル選択性を示す
JP2002533087A (ja) *	1998-12-21	2002-10-08	ジェネンカーインターナショナル，インコーポレイティド	複数荷電変種を有する化学修飾酵素
EP1185302B1 (de)	1999-04-28	2013-07-24	Genencor International, Inc.	Spezifischer zielrichtung von katalytische antagoniste und deren verwendungen
US6627744B2 (en)	1999-07-02	2003-09-30	Genencor International, Inc.	Synthesis of glycodendrimer reagents
CZ2002171A3 (cs) *	1999-07-22	2002-06-12	The Procter & Gamble Company	Proteinázový konjugát, čistící prostředek a prostředek osobní péče
CA2376045A1 (en)	1999-07-22	2001-02-01	The Procter & Gamble Company	Subtilisin protease variants having amino acid substitutions in defined epitope regions
US6946128B1 (en)	1999-07-22	2005-09-20	The Procter & Gamble Company	Protease conjugates having sterically protected epitope regions
CA2379712A1 (en)	1999-07-22	2001-02-01	The Procter & Gamble Company	Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions
MXPA02000837A (es) *	1999-07-22	2002-07-30	Procter & Gamble	Conjugados de proteasa que tienen regiones epitopes protegidas estericamente.
EE200300089A (et) *	2000-09-08	2005-02-15	Gryphon Therapeutics, Inc.	Sünteetilised erütropoeesi stimuleerivad valgud, nende valmistamismeetodid ning kasutamine
EP2159279A3 (de)	2001-05-15	2010-05-12	Novozymes A/S	Alpha-amylase-variante mit veränderten Eigenschaften
US20030157645A1 (en) *	2001-12-21	2003-08-21	Direvo Bio Tech Ag.	Subtilisin variants with improved characteristics
US20090060933A1 (en) *	2004-06-14	2009-03-05	Estell David A	Proteases producing an altered immunogenic response and methods of making and using the same
EP2215201A2 (de)	2007-11-05	2010-08-11	Danisco US Inc.	Alpha-amylase-varianten mit veränderten eigenschaften
KR20100088675A (ko)	2007-11-05	2010-08-10	다니스코 유에스 인크.	변경된 특성을 지닌 바실러스 종 ｔｓ-23 알파-아밀라아제의 변이체
ITMI20072215A1 (it) *	2007-11-22	2009-05-23	Sulfidris S R L	Nuovi composti anticancro
WO2009098229A2 (en)	2008-02-04	2009-08-13	Danisco Us Inc., Genencor Division	A method of preparing food products using ts23 alpha-amylase
CN102057040A (zh)	2008-06-06	2011-05-11	丹尼斯科美国公司	具有改良特性的嗜热脂肪土芽孢杆菌α-淀粉酶(AMYS)变体
CN102224234B (zh)	2008-09-25	2014-04-16	丹尼斯科美国公司	α-淀粉酶混合物和使用所述混合物的方法
DK2414514T3 (en)	2009-04-01	2015-08-24	Danisco Us Inc	FORMATIONS AND PROCEDURES COMPREHENSIVE Alpha- amylase variants WITH CHANGED PROPERTIES
ES2834102T3 (es)	2011-06-30	2021-06-16	Novozymes As	Variantes de alfa-amilasa
DE102011118027A1 (de) *	2011-09-12	2013-03-14	Henkel Ag & Co. Kgaa	Verfahren zur Anpassung eines Hydrolytischen Enzyms an eine das hydrolytische Enzym stabilisierende Komponente
EP3234093B1 (de) *	2014-12-19	2020-05-27	Novozymes A/S	Proteasevarianten und dafür codierende polynukleotide
CN106192395B (zh) *	2016-07-04	2018-09-07	浙江理工大学	改性棉织物表面增强纳米银抗菌棉织物耐洗性能的方法
CN115851670B (zh) *	2022-11-30	2024-04-12	山东龙昌动物保健品股份有限公司	木聚糖酶突变体及与杜仲叶提取物的复配制剂和在饲料添加剂的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1056187C (zh) *	1988-02-11	2000-09-06	金克克国际有限公司	新的蛋白水解酶及其在洗涤剂中的应用
DK97190D0 (da) *	1990-04-19	1990-04-19	Novo Nordisk As	Oxidationsstabile detergentenzymer
US5316935A (en)	1992-04-06	1994-05-31	California Institute Of Technology	Subtilisin variants suitable for hydrolysis and synthesis in organic media
US5837516A (en) *	1995-03-03	1998-11-17	Genentech, Inc.	Subtilisin variants capable of cleaving substrates containing basic residues

1997
- 1997-11-24 DE DE69737148T patent/DE69737148T2/de not_active Expired - Lifetime
- 1997-11-24 WO PCT/US1997/021446 patent/WO1998023732A2/en not_active Ceased
- 1997-11-24 JP JP52478698A patent/JP2002506342A/ja active Pending
- 1997-11-24 DK DK97949562T patent/DK0942962T3/da active
- 1997-11-24 NZ NZ336434A patent/NZ336434A/xx not_active IP Right Cessation
- 1997-11-24 CA CA2273079A patent/CA2273079C/en not_active Expired - Lifetime
- 1997-11-24 ES ES97949562T patent/ES2277364T3/es not_active Expired - Lifetime
- 1997-11-24 AT AT97949562T patent/ATE349514T1/de not_active IP Right Cessation
- 1997-11-24 EP EP97949562A patent/EP0942962B1/de not_active Expired - Lifetime
- 1997-11-24 CA CA2763810A patent/CA2763810C/en not_active Expired - Lifetime
- 1997-11-24 AU AU74173/98A patent/AU733082B2/en not_active Ceased
- 1997-11-24 CN CN97181388A patent/CN1246146A/zh active Pending
- 1997-11-25 US US08/978,509 patent/US6277617B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0942962A2 (de)	1999-09-22
ATE349514T1 (de)	2007-01-15
JP2002506342A (ja)	2002-02-26
DE69737148D1 (de)	2007-02-08
DE69737148T2 (de)	2007-10-04
AU733082B2 (en)	2001-05-03
CA2273079C (en)	2012-04-10
CA2763810C (en)	2013-04-02
EP0942962B1 (de)	2006-12-27
CA2273079A1 (en)	1998-06-04
AU7417398A (en)	1998-06-22
WO1998023732A3 (en)	1998-10-22
US6277617B1 (en)	2001-08-21
ES2277364T3 (es)	2007-07-01
CN1246146A (zh)	2000-03-01
CA2763810A1 (en)	1998-06-04
WO1998023732A2 (en)	1998-06-04
NZ336434A (en)	2001-03-30

Publication	Publication Date	Title
DK0942962T3 (da)	2007-05-07	Kemisk modificerede enzymer
ATE233552T1 (de)	2003-03-15	Thiol-sulfonen als metalloproteinaseinhibitoren
EA200500472A1 (ru)	2005-10-27	Ацетил 2-гидрокси-1,3-диаминоалканы
NO990855D0 (no)	1999-02-23	Substituerte sykliske amin-metallprotease-inhibitorer
ATE216360T1 (de)	2002-05-15	Sulfinsäurederivate und deren herstellung und verwendung
ATE326454T1 (de)	2006-06-15	Neue bernsteinsäure derivative als cysteine- protease-inhibitoren
DE69432035D1 (de)	2003-02-27	Saccharinderivate als proteolytische Enzyminhibitoren
ATE441704T1 (de)	2009-09-15	Varianten eines lipolytischen enzyms
DE69413167D1 (de)	1998-10-15	Peptid-Phosphinyloxymethyl-Ketonen als Inhibitoren von Interleukin-1 beta-konvertierenden Enzymen
PE71599A1 (es)	1999-09-15	Inhibidores de proteasas
ATE368645T1 (de)	2007-08-15	Aminosäurederivate als hiv-protease-inhibitoren
ATE349543T1 (de)	2007-01-15	Verfahren, umfassend die indirekte elektrochemische regeneration von nad(p)h
MY139322A (en)	2009-09-30	Method for producing 2-azetidinone derivative
MA24197A1 (fr)	1997-12-31	Nouvelles fungarrestines
DE69815380D1 (de)	2003-07-10	N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind
TR200002755T2 (tr)	2002-05-21	Aracı hazırlamak için süreç.
TW335392B (en)	1998-07-01	Process for preparing optically active amines
ATE253125T1 (de)	2003-11-15	Verfahren zur herstellung von optisch aktiven 1- amino-4- (hydroxymethyl)- cyclopent-2- en- derivaten
ATE284411T1 (de)	2004-12-15	Pflanzenzelluläre wachstumsfaktoren
RU95113138A (ru)	1997-06-27	Гидрохлориды серосодержащих 2-аминоимидазолов или 2-аминотиазолов, обладающие цитотоксической и противоопухолевой активностью и проявляющие ингибирующее действие в отношении некоторых ферментов
ATE238781T1 (de)	2003-05-15	Verwendung von katecholderivaten als proteinaseinhibitoren
TWI256383B (en)	2006-06-11	Anthraquinone compound
BG106174A (en)	2003-06-30	Method for the production of highly purified monocomponent insulin
DE60306768D1 (de)	2006-08-24	Prozess für die dehydrogenierung von azaandrostan verbindungen
ES2104762T3 (es)	1997-10-16	Derivados de superoxido dismutasa.