ATE349514T1 - Chemisch modifizierte enzyme - Google Patents

Chemisch modifizierte enzyme

Info

Publication number: ATE349514T1
Authority: AT; Austria
Prior art keywords: modified enzymes; alkyl; substituted; replaced; chemically modified
Prior art date: 1996-11-26

Application number

AT97949562T

Other languages

English (en)

Inventor

Richard R Bott

Thomas P Graycar

Colin Mitchinson

Grace Desantis

J Bryan Jones

Original Assignee

Genencor Int

Univ Toronto

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-26

Filing date

1997-11-24

Publication date

2007-01-15

1997-11-24 Application filed by Genencor Int, Univ Toronto filed Critical Genencor Int

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE349514T1 publication Critical patent/ATE349514T1/de

Links

102000004190 Enzymes Human genes 0.000 title abstract 6
108090000790 Enzymes Proteins 0.000 title abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
229940024606 amino acid Drugs 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000003674 animal food additive Substances 0.000 abstract 1
229960001230 asparagine Drugs 0.000 abstract 1
235000009582 asparagine Nutrition 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
239000004753 textile Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38663—Stabilised liquid enzyme compositions
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Detergent Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Chemical Or Physical Treatment Of Fibers (AREA)

AT97949562T 1996-11-26 1997-11-24 Chemisch modifizierte enzyme ATE349514T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75666496A	1996-11-26	1996-11-26

Publications (1)

Publication Number	Publication Date
ATE349514T1 true ATE349514T1 (de)	2007-01-15

Family

ID=25044504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97949562T ATE349514T1 (de)	1996-11-26	1997-11-24	Chemisch modifizierte enzyme

Country Status (12)

Country	Link
US (1)	US6277617B1 (de)
EP (1)	EP0942962B1 (de)
JP (1)	JP2002506342A (de)
CN (1)	CN1246146A (de)
AT (1)	ATE349514T1 (de)
AU (1)	AU733082B2 (de)
CA (2)	CA2273079C (de)
DE (1)	DE69737148T2 (de)
DK (1)	DK0942962T3 (de)
ES (1)	ES2277364T3 (de)
NZ (1)	NZ336434A (de)
WO (1)	WO1998023732A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2368718T3 (es) *	1997-10-23	2011-11-21	Danisco Us Inc.	Variantes de subtilisina con múltiples sustituciones.
CN1301305A (zh)	1998-03-26	2001-06-27	宝洁公司	具有氨基酸取代的丝氨酸蛋白酶变体
US6495136B1 (en)	1998-03-26	2002-12-17	The Procter & Gamble Company	Proteases having modified amino acid sequences conjugated to addition moieties
US6908757B1 (en)	1998-03-26	2005-06-21	The Procter & Gamble Company	Serine protease variants having amino acid deletions and substitutions
EP1093459B1 (de)	1998-07-02	2008-09-10	The Governing Council Of The University Of Toronto	Mit einer kohlenhydratgruppe chemisch modifizierte proteine
DE69940978D1 (de)	1998-11-10	2009-07-23	Univ Toronto	Chemisch modifizierte mutante serinhydrolasen
EP1141335B1 (de) *	1998-12-21	2009-08-05	Genencor International, Inc.	Chemisch modifizierte enzymen mit mehrfachgeladenen varianten
JP5180417B2 (ja)	1999-04-28	2013-04-10	ジェネンコー・インターナショナル・インク	特異的に標的化された触媒性アンタゴニストおよびその使用
US6627744B2 (en)	1999-07-02	2003-09-30	Genencor International, Inc.	Synthesis of glycodendrimer reagents
US6946128B1 (en)	1999-07-22	2005-09-20	The Procter & Gamble Company	Protease conjugates having sterically protected epitope regions
JP2003505067A (ja)	1999-07-22	2003-02-12	ザ、プロクター、エンド、ギャンブル、カンパニー	特定のエピトープ領域にアミノ酸欠失及び置換を有するサブチリシンプロテアーゼの変異体
JP2003505069A (ja) *	1999-07-22	2003-02-12	ザ、プロクター、エンド、ギャンブル、カンパニー	立体的に保護されたエピトープ領域を有するプロテアーゼ抱合体
MXPA02000840A (es)	1999-07-22	2002-07-30	Procter & Gamble	Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas.
EP1196548A2 (de)	1999-07-22	2002-04-17	The Procter & Gamble Company	Proteasekonjugaten mit sterisch geschützten hydrolysierbaren stellen
AU2001273388B2 (en) *	2000-09-08	2005-01-13	Gryphon Therapeutics, Inc.	"Pseudo"-native chemical ligation
EP2159279A3 (de)	2001-05-15	2010-05-12	Novozymes A/S	Alpha-amylase-variante mit veränderten Eigenschaften
US20030157645A1 (en) *	2001-12-21	2003-08-21	Direvo Bio Tech Ag.	Subtilisin variants with improved characteristics
US20090060933A1 (en) *	2004-06-14	2009-03-05	Estell David A	Proteases producing an altered immunogenic response and methods of making and using the same
DK2215202T4 (da)	2007-11-05	2025-01-02	Danisco Us Inc	VARIANTER AF BACILLUS sp. TS-23 ALPHA-AMYLASE MED ÆNDREDE EGENSKABER
CA2704555A1 (en)	2007-11-05	2009-05-14	Danisco Us Inc.	Alpha-amylase variants with altered properties
ITMI20072215A1 (it) *	2007-11-22	2009-05-23	Sulfidris S R L	Nuovi composti anticancro
MX2010008359A (es)	2008-02-04	2010-08-30	Danisco Us Inc	Variantes de alfa-amilasa ts23 con propiedades alteradas.
PL2447361T3 (pl)	2008-06-06	2015-03-31	Danisco Us Inc	Warianty alfa-amylazy (AMYS) z Geobacillus stearothermophilus o poprawionych właściwościach
US8507243B2 (en)	2008-09-25	2013-08-13	Danisco Us Inc.	Alpha-amylase blends and methods for using said blends
EP2902487A3 (de)	2009-04-01	2015-11-18	Danisco US Inc.	Zusammensetzungen und Verfahren mit Alpha-Amylasevarianten mit veränderten Eigenschaften
US9434932B2 (en)	2011-06-30	2016-09-06	Novozymes A/S	Alpha-amylase variants
DE102011118027A1 (de) *	2011-09-12	2013-03-14	Henkel Ag & Co. Kgaa	Verfahren zur Anpassung eines Hydrolytischen Enzyms an eine das hydrolytische Enzym stabilisierende Komponente
EP3741848A3 (de) *	2014-12-19	2021-02-17	Novozymes A/S	Proteasevarianten und dafür codierende polynukleotide
CN106192395B (zh) *	2016-07-04	2018-09-07	浙江理工大学	改性棉织物表面增强纳米银抗菌棉织物耐洗性能的方法
CN115851670B (zh) *	2022-11-30	2024-04-12	山东龙昌动物保健品股份有限公司	木聚糖酶突变体及与杜仲叶提取物的复配制剂和在饲料添加剂的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT89702B (pt) *	1988-02-11	1994-04-29	Gist Brocades Nv	Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem
DK97190D0 (da) *	1990-04-19	1990-04-19	Novo Nordisk As	Oxidationsstabile detergentenzymer
US5316935A (en)	1992-04-06	1994-05-31	California Institute Of Technology	Subtilisin variants suitable for hydrolysis and synthesis in organic media
US5837516A (en) *	1995-03-03	1998-11-17	Genentech, Inc.	Subtilisin variants capable of cleaving substrates containing basic residues

1997
- 1997-11-24 CA CA2273079A patent/CA2273079C/en not_active Expired - Lifetime
- 1997-11-24 JP JP52478698A patent/JP2002506342A/ja active Pending
- 1997-11-24 DE DE69737148T patent/DE69737148T2/de not_active Expired - Lifetime
- 1997-11-24 CN CN97181388A patent/CN1246146A/zh active Pending
- 1997-11-24 CA CA2763810A patent/CA2763810C/en not_active Expired - Lifetime
- 1997-11-24 WO PCT/US1997/021446 patent/WO1998023732A2/en not_active Ceased
- 1997-11-24 DK DK97949562T patent/DK0942962T3/da active
- 1997-11-24 ES ES97949562T patent/ES2277364T3/es not_active Expired - Lifetime
- 1997-11-24 AU AU74173/98A patent/AU733082B2/en not_active Ceased
- 1997-11-24 EP EP97949562A patent/EP0942962B1/de not_active Expired - Lifetime
- 1997-11-24 NZ NZ336434A patent/NZ336434A/xx not_active IP Right Cessation
- 1997-11-24 AT AT97949562T patent/ATE349514T1/de not_active IP Right Cessation
- 1997-11-25 US US08/978,509 patent/US6277617B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1246146A (zh)	2000-03-01
DE69737148T2 (de)	2007-10-04
WO1998023732A3 (en)	1998-10-22
AU7417398A (en)	1998-06-22
NZ336434A (en)	2001-03-30
AU733082B2 (en)	2001-05-03
CA2763810A1 (en)	1998-06-04
DK0942962T3 (da)	2007-05-07
EP0942962B1 (de)	2006-12-27
CA2273079A1 (en)	1998-06-04
US6277617B1 (en)	2001-08-21
EP0942962A2 (de)	1999-09-22
DE69737148D1 (de)	2007-02-08
WO1998023732A2 (en)	1998-06-04
JP2002506342A (ja)	2002-02-26
CA2763810C (en)	2013-04-02
ES2277364T3 (es)	2007-07-01
CA2273079C (en)	2012-04-10

Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69737148D1 (de)	2007-02-08	Chemisch modifizierte enzyme
ATE233552T1 (de)	2003-03-15	Thiol-sulfonen als metalloproteinaseinhibitoren
NO990855D0 (no)	1999-02-23	Substituerte sykliske amin-metallprotease-inhibitorer
MXPA02012046A (es)	2003-04-25	Composicion limpiadora a base de biocida.
ATE326454T1 (de)	2006-06-15	Neue bernsteinsäure derivative als cysteine- protease-inhibitoren
DE59803845D1 (de)	2002-05-23	Sulfinsäurederivate und deren herstellung und verwendung
DE69432035D1 (de)	2003-02-27	Saccharinderivate als proteolytische Enzyminhibitoren
ATE340857T1 (de)	2006-10-15	Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph
ATE441704T1 (de)	2009-09-15	Varianten eines lipolytischen enzyms
PE71599A1 (es)	1999-09-15	Inhibidores de proteasas
ATE368645T1 (de)	2007-08-15	Aminosäurederivate als hiv-protease-inhibitoren
ATE349543T1 (de)	2007-01-15	Verfahren, umfassend die indirekte elektrochemische regeneration von nad(p)h
MY139322A (en)	2009-09-30	Method for producing 2-azetidinone derivative
DE60028927D1 (de)	2006-08-03	Verfahren zur herstellung von optisch aktiven amino-alkoholen
TR200002755T2 (tr)	2002-05-21	Aracı hazırlamak için süreç.
DE69815380D1 (de)	2003-07-10	N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind
TW335392B (en)	1998-07-01	Process for preparing optically active amines
ATE253125T1 (de)	2003-11-15	Verfahren zur herstellung von optisch aktiven 1- amino-4- (hydroxymethyl)- cyclopent-2- en- derivaten
DE69731895D1 (de)	2005-01-13	Pflanzenzelluläre wachstumsfaktoren
DE60044528D1 (de)	2010-07-22	Bazillus zelle für die herstellung von proteinen
TWI256383B (en)	2006-06-11	Anthraquinone compound
ATE238781T1 (de)	2003-05-15	Verwendung von katecholderivaten als proteinaseinhibitoren
BG106174A (en)	2003-06-30	Method for the production of highly purified monocomponent insulin