DK0944596T3 - 1-acryloylindolin-derivater og deres anvendelse som prodrugs til anticancermidler - Google Patents

1-acryloylindolin-derivater og deres anvendelse som prodrugs til anticancermidler

Info

Publication number: DK0944596T3
Authority: DK; Denmark
Prior art keywords: prodrugs; acryloylindoline; derivatives; anticancer agents; prodrug therapy
Prior art date: 1996-12-13

Application number

DK97948036T

Other languages

English (en)

Inventor

William Alexander Denny

Moana Tercel

Graham John Atwell

Jared Milbank

Original Assignee

Auckland Uniservices Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1997-12-12

Publication date

2002-12-16

1997-12-12 Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd

2002-12-16 Application granted granted Critical

2002-12-16 Publication of DK0944596T3 publication Critical patent/DK0944596T3/da

Links

229940002612 prodrug Drugs 0.000 title abstract 3
239000000651 prodrug Substances 0.000 title abstract 3
MBODXUXQQPORNR-UHFFFAOYSA-N 1-(2,3-dihydroindol-1-yl)prop-2-en-1-one Chemical class C1=CC=C2N(C(=O)C=C)CCC2=C1 MBODXUXQQPORNR-UHFFFAOYSA-N 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
238000010914 gene-directed enzyme pro-drug therapy Methods 0.000 abstract 2
INCAQIRDTKGRNM-UHFFFAOYSA-N 2-cyclopropyl-1h-indole Chemical class C1CC1C1=CC2=CC=CC=C2N1 INCAQIRDTKGRNM-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
235000018734 Sambucus australis Nutrition 0.000 abstract 1
244000180577 Sambucus australis Species 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

DK97948036T 1996-12-13 1997-12-12 1-acryloylindolin-derivater og deres anvendelse som prodrugs til anticancermidler DK0944596T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9625913.0A GB9625913D0 (en)	1996-12-13	1996-12-13	Novel cyclopropylindoles and their seco precursors,and their use as prodrugs
PCT/NZ1997/000166 WO1998025898A1 (en)	1996-12-13	1997-12-12	Seco precursors of cyclopropylindolines and their use as prodrugs

Publications (1)

Publication Number	Publication Date
DK0944596T3 true DK0944596T3 (da)	2002-12-16

Family

ID=10804392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97948036T DK0944596T3 (da)	1996-12-13	1997-12-12	1-acryloylindolin-derivater og deres anvendelse som prodrugs til anticancermidler

Country Status (12)

Country	Link
EP (1)	EP0944596B1 (da)
JP (1)	JP2001506623A (da)
AT (1)	ATE226194T1 (da)
AU (1)	AU728053B2 (da)
CA (1)	CA2272952A1 (da)
DE (1)	DE69716463T2 (da)
DK (1)	DK0944596T3 (da)
ES (1)	ES2186006T3 (da)
GB (1)	GB9625913D0 (da)
NZ (1)	NZ335841A (da)
PT (1)	PT944596E (da)
WO (1)	WO1998025898A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9909612D0 (en) *	1999-04-26	1999-06-23	Cancer Res Campaign Tech	N-protected amines and their use as prodrugs
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
EP2344478B1 (en)	2008-11-03	2017-09-27	Syntarga B.V.	Cc-1065 analogs and their conjugates
SG10201501272SA (en) *	2009-10-22	2015-04-29	Fibrotech Therapeutics Pty Ltd	Fused ring analogues of anti-fibrotic agents
EP2560645B1 (en)	2010-04-21	2016-07-13	Syntarga B.V.	Conjugates of cc-1065 analogs and bifunctional linkers
PL3092010T3 (pl)	2014-01-10	2019-01-31	Synthon Biopharmaceuticals B.V.	Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8705477D0 (en) *	1987-03-09	1987-04-15	Carlton Med Prod	Drug delivery systems
US5214065A (en) *	1990-06-11	1993-05-25	Kyowa Hakko Kogyo Co., Ltd.	Dc-89 derivatives
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives

1996
- 1996-12-13 GB GBGB9625913.0A patent/GB9625913D0/en active Pending
1997
- 1997-12-12 AU AU54192/98A patent/AU728053B2/en not_active Ceased
- 1997-12-12 CA CA002272952A patent/CA2272952A1/en not_active Abandoned
- 1997-12-12 ES ES97948036T patent/ES2186006T3/es not_active Expired - Lifetime
- 1997-12-12 WO PCT/NZ1997/000166 patent/WO1998025898A1/en not_active Ceased
- 1997-12-12 NZ NZ335841A patent/NZ335841A/xx unknown
- 1997-12-12 PT PT97948036T patent/PT944596E/pt unknown
- 1997-12-12 EP EP97948036A patent/EP0944596B1/en not_active Expired - Lifetime
- 1997-12-12 DK DK97948036T patent/DK0944596T3/da active
- 1997-12-12 AT AT97948036T patent/ATE226194T1/de not_active IP Right Cessation
- 1997-12-12 DE DE69716463T patent/DE69716463T2/de not_active Expired - Fee Related
- 1997-12-12 JP JP52653298A patent/JP2001506623A/ja active Pending

Also Published As

Publication number	Publication date
EP0944596A1 (en)	1999-09-29
JP2001506623A (ja)	2001-05-22
ES2186006T3 (es)	2003-05-01
CA2272952A1 (en)	1998-06-18
PT944596E (pt)	2003-03-31
GB9625913D0 (en)	1997-01-29
EP0944596B1 (en)	2002-10-16
WO1998025898A1 (en)	1998-06-18
AU728053B2 (en)	2001-01-04
DE69716463T2 (de)	2003-06-05
AU5419298A (en)	1998-07-03
ATE226194T1 (de)	2002-11-15
DE69716463D1 (de)	2002-11-21
NZ335841A (en)	2000-08-25

Publication	Publication Date	Title
NL1002835A1 (nl)	1996-10-14	Synergistisch stabilisatormengsel.
HUT67742A (en)	1995-04-28	Phosphono-oxymethyl-ethers of taxane derivatives
DK0651740T3 (da)	1999-06-28	Aminosyrebundne nitrogensennepsgasderivater og deres anvendelse som pro-drugs ved behandlingstumorer
MY132671A (en)	2007-10-31	Substituted 6,6-hetero-bicyclic derivatives
BG104247A (bg)	2000-11-30	Производни на резорцинола
CA2305313A1 (en)	1999-04-08	Acylsulfamoylbenzamides, crop protection compositions comprising them, and processes for their preparation
AU9102198A (en)	1998-11-27	Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
DK0700380T3 (da)	1998-11-09	N-Alkylthiopolyaminderivater som radioprotektive midler
MX9204233A (es)	1994-06-30	Inhibidores de proteasa retroviral.
ES2181766T3 (es)	2003-03-01	Analogos de delda 12,13-isotaxol, uso antineoplasico y composiciones farmaceuticas que los contienen.
WO1998053050A3 (en)	1999-02-25	Short peptides which selectively modulate the activity of serine/threonine kinases
MY114140A (en)	2002-08-30	Novel enzymes and prodrugs for use in antibody-directed enzyme prodrug therapy.
DK0934065T3 (da)	2006-10-09	Hidtil ukendte cruptophycinderivater som antieoplastiske midler
ATE297904T1 (de)	2005-07-15	Halo-alkoxycarbonylverbindungen
DK0944596T3 (da)	2002-12-16	1-acryloylindolin-derivater og deres anvendelse som prodrugs til anticancermidler
AU1054200A (en)	2000-05-22	Neurological disorders
SE9604582D0 (sv)	1996-12-13	Novel compounds
DK0720597T3 (da)	1998-10-07	Triarylethylenderivater til terapeutisk anvendelse
ES2178830T3 (es)	2003-01-01	Procedimiento para la preparacion de tetraazamacrociclos.
SV1999000159A (es)	2000-10-12	Antibioticos de carbamato y carbazato cetolida ref.pc10406abcz/bb
DK0810223T3 (da)	2001-09-24	Adamantylsubstituerede oxindoler som farmaceutiske midler
MX9708155A (es)	1998-01-31	Inhibicion de la fotodescomposicion de 2-oxindoles 3-sustituidos.