ATE226194T1 - 1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel - Google Patents

1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel

Info

Publication number: ATE226194T1
Authority: AT; Austria
Prior art keywords: acryloylindoline; derivatives; prodrugs; anticancer prodrugs; prodrug therapy
Prior art date: 1996-12-13

Application number

AT97948036T

Other languages

English (en)

Inventor

William Alexander Denny

Moana Tercel

Graham John Atwell

Jared Milbank

Original Assignee

Auckland Uniservices Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1997-12-12

Publication date

2002-11-15

1997-12-12 Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE226194T1 publication Critical patent/ATE226194T1/de

Links

229940002612 prodrug Drugs 0.000 title abstract 3
239000000651 prodrug Substances 0.000 title abstract 3
MBODXUXQQPORNR-UHFFFAOYSA-N 1-(2,3-dihydroindol-1-yl)prop-2-en-1-one Chemical class C1=CC=C2N(C(=O)C=C)CCC2=C1 MBODXUXQQPORNR-UHFFFAOYSA-N 0.000 title 1
230000001093 anti-cancer Effects 0.000 title 1
238000010914 gene-directed enzyme pro-drug therapy Methods 0.000 abstract 2
INCAQIRDTKGRNM-UHFFFAOYSA-N 2-cyclopropyl-1h-indole Chemical class C1CC1C1=CC2=CC=CC=C2N1 INCAQIRDTKGRNM-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
235000018734 Sambucus australis Nutrition 0.000 abstract 1
244000180577 Sambucus australis Species 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)

AT97948036T 1996-12-13 1997-12-12 1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel ATE226194T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9625913.0A GB9625913D0 (en)	1996-12-13	1996-12-13	Novel cyclopropylindoles and their seco precursors,and their use as prodrugs
PCT/NZ1997/000166 WO1998025898A1 (en)	1996-12-13	1997-12-12	Seco precursors of cyclopropylindolines and their use as prodrugs

Publications (1)

Publication Number	Publication Date
ATE226194T1 true ATE226194T1 (de)	2002-11-15

Family

ID=10804392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97948036T ATE226194T1 (de)	1996-12-13	1997-12-12	1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel

Country Status (12)

Country	Link
EP (1)	EP0944596B1 (de)
JP (1)	JP2001506623A (de)
AT (1)	ATE226194T1 (de)
AU (1)	AU728053B2 (de)
CA (1)	CA2272952A1 (de)
DE (1)	DE69716463T2 (de)
DK (1)	DK0944596T3 (de)
ES (1)	ES2186006T3 (de)
GB (1)	GB9625913D0 (de)
NZ (1)	NZ335841A (de)
PT (1)	PT944596E (de)
WO (1)	WO1998025898A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9909612D0 (en) *	1999-04-26	1999-06-23	Cancer Res Campaign Tech	N-protected amines and their use as prodrugs
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
ES2647317T3 (es)	2008-11-03	2017-12-20	Syntarga B.V.	Análogos de CC-1065 y sus conjugados
CN102574843B (zh) *	2009-10-22	2015-06-17	法博太科制药有限公司	抗纤维化剂的稠环类似物
PT3056203T (pt)	2010-04-21	2018-02-15	Syntarga Bv	Conjugados de análogos de cc-1065 e ligantes bifuncionais
RU2680404C2 (ru)	2014-01-10	2019-02-21	Синтон Байофармасьютикалс Б. В.	Способ очистки cys-связанных конъюгатов антитело-лекарственное средство

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8705477D0 (en) *	1987-03-09	1987-04-15	Carlton Med Prod	Drug delivery systems
US5214065A (en) *	1990-06-11	1993-05-25	Kyowa Hakko Kogyo Co., Ltd.	Dc-89 derivatives
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives

1996
- 1996-12-13 GB GBGB9625913.0A patent/GB9625913D0/en active Pending
1997
- 1997-12-12 ES ES97948036T patent/ES2186006T3/es not_active Expired - Lifetime
- 1997-12-12 AT AT97948036T patent/ATE226194T1/de not_active IP Right Cessation
- 1997-12-12 AU AU54192/98A patent/AU728053B2/en not_active Ceased
- 1997-12-12 EP EP97948036A patent/EP0944596B1/de not_active Expired - Lifetime
- 1997-12-12 PT PT97948036T patent/PT944596E/pt unknown
- 1997-12-12 JP JP52653298A patent/JP2001506623A/ja active Pending
- 1997-12-12 NZ NZ335841A patent/NZ335841A/xx unknown
- 1997-12-12 WO PCT/NZ1997/000166 patent/WO1998025898A1/en not_active Ceased
- 1997-12-12 CA CA002272952A patent/CA2272952A1/en not_active Abandoned
- 1997-12-12 DE DE69716463T patent/DE69716463T2/de not_active Expired - Fee Related
- 1997-12-12 DK DK97948036T patent/DK0944596T3/da active

Also Published As

Publication number	Publication date
DK0944596T3 (da)	2002-12-16
CA2272952A1 (en)	1998-06-18
ES2186006T3 (es)	2003-05-01
WO1998025898A1 (en)	1998-06-18
DE69716463T2 (de)	2003-06-05
AU728053B2 (en)	2001-01-04
JP2001506623A (ja)	2001-05-22
PT944596E (pt)	2003-03-31
AU5419298A (en)	1998-07-03
EP0944596A1 (de)	1999-09-29
NZ335841A (en)	2000-08-25
DE69716463D1 (de)	2002-11-21
GB9625913D0 (en)	1997-01-29
EP0944596B1 (de)	2002-10-16

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Legal Events

Date

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Title

Description

2003-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0944596

Country of ref document: EP

2009-09-15

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Ceased due to non-payment of the annual fee