ATE226194T1 - 1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel - Google Patents

1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel

Info

Publication number: ATE226194T1
Authority: AT; Austria
Prior art keywords: acryloylindoline; derivatives; prodrugs; anticancer prodrugs; prodrug therapy
Prior art date: 1996-12-13

Application number

AT97948036T

Other languages

English (en)

Inventor

William Alexander Denny

Moana Tercel

Graham John Atwell

Jared Milbank

Original Assignee

Auckland Uniservices Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1997-12-12

Publication date

2002-11-15

1997-12-12 Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE226194T1 publication Critical patent/ATE226194T1/de

Links

229940002612 prodrug Drugs 0.000 title abstract 3
239000000651 prodrug Substances 0.000 title abstract 3
MBODXUXQQPORNR-UHFFFAOYSA-N 1-(2,3-dihydroindol-1-yl)prop-2-en-1-one Chemical class C1=CC=C2N(C(=O)C=C)CCC2=C1 MBODXUXQQPORNR-UHFFFAOYSA-N 0.000 title 1
230000001093 anti-cancer Effects 0.000 title 1
238000010914 gene-directed enzyme pro-drug therapy Methods 0.000 abstract 2
INCAQIRDTKGRNM-UHFFFAOYSA-N 2-cyclopropyl-1h-indole Chemical class C1CC1C1=CC2=CC=CC=C2N1 INCAQIRDTKGRNM-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
235000018734 Sambucus australis Nutrition 0.000 abstract 1
244000180577 Sambucus australis Species 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

AT97948036T 1996-12-13 1997-12-12 1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel ATE226194T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9625913.0A GB9625913D0 (en)	1996-12-13	1996-12-13	Novel cyclopropylindoles and their seco precursors,and their use as prodrugs
PCT/NZ1997/000166 WO1998025898A1 (en)	1996-12-13	1997-12-12	Seco precursors of cyclopropylindolines and their use as prodrugs

Publications (1)

Publication Number	Publication Date
ATE226194T1 true ATE226194T1 (de)	2002-11-15

Family

ID=10804392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97948036T ATE226194T1 (de)	1996-12-13	1997-12-12	1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel

Country Status (12)

Country	Link
EP (1)	EP0944596B1 (de)
JP (1)	JP2001506623A (de)
AT (1)	ATE226194T1 (de)
AU (1)	AU728053B2 (de)
CA (1)	CA2272952A1 (de)
DE (1)	DE69716463T2 (de)
DK (1)	DK0944596T3 (de)
ES (1)	ES2186006T3 (de)
GB (1)	GB9625913D0 (de)
NZ (1)	NZ335841A (de)
PT (1)	PT944596E (de)
WO (1)	WO1998025898A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9909612D0 (en) *	1999-04-26	1999-06-23	Cancer Res Campaign Tech	N-protected amines and their use as prodrugs
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
EP2344478B1 (de)	2008-11-03	2017-09-27	Syntarga B.V.	Cc-1065 analoga und ihre konjugate
SG10201501272SA (en) *	2009-10-22	2015-04-29	Fibrotech Therapeutics Pty Ltd	Fused ring analogues of anti-fibrotic agents
EP2560645B1 (de)	2010-04-21	2016-07-13	Syntarga B.V.	Konjugate von cc-1065 analoga und bifunktionellen linkern
PL3092010T3 (pl)	2014-01-10	2019-01-31	Synthon Biopharmaceuticals B.V.	Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8705477D0 (en) *	1987-03-09	1987-04-15	Carlton Med Prod	Drug delivery systems
US5214065A (en) *	1990-06-11	1993-05-25	Kyowa Hakko Kogyo Co., Ltd.	Dc-89 derivatives
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives

1996
- 1996-12-13 GB GBGB9625913.0A patent/GB9625913D0/en active Pending
1997
- 1997-12-12 AU AU54192/98A patent/AU728053B2/en not_active Ceased
- 1997-12-12 CA CA002272952A patent/CA2272952A1/en not_active Abandoned
- 1997-12-12 ES ES97948036T patent/ES2186006T3/es not_active Expired - Lifetime
- 1997-12-12 WO PCT/NZ1997/000166 patent/WO1998025898A1/en not_active Ceased
- 1997-12-12 NZ NZ335841A patent/NZ335841A/xx unknown
- 1997-12-12 PT PT97948036T patent/PT944596E/pt unknown
- 1997-12-12 EP EP97948036A patent/EP0944596B1/de not_active Expired - Lifetime
- 1997-12-12 DK DK97948036T patent/DK0944596T3/da active
- 1997-12-12 AT AT97948036T patent/ATE226194T1/de not_active IP Right Cessation
- 1997-12-12 DE DE69716463T patent/DE69716463T2/de not_active Expired - Fee Related
- 1997-12-12 JP JP52653298A patent/JP2001506623A/ja active Pending

Also Published As

Publication number	Publication date
EP0944596A1 (de)	1999-09-29
JP2001506623A (ja)	2001-05-22
ES2186006T3 (es)	2003-05-01
CA2272952A1 (en)	1998-06-18
DK0944596T3 (da)	2002-12-16
PT944596E (pt)	2003-03-31
GB9625913D0 (en)	1997-01-29
EP0944596B1 (de)	2002-10-16
WO1998025898A1 (en)	1998-06-18
AU728053B2 (en)	2001-01-04
DE69716463T2 (de)	2003-06-05
AU5419298A (en)	1998-07-03
DE69716463D1 (de)	2002-11-21
NZ335841A (en)	2000-08-25

Similar Documents

Publication	Publication Date	Title
HU9402342D0 (en)	1994-10-28	Phosphono-oxymethyl-ethers of taxane derivatives
DE69530606D1 (de)	2003-06-05	Verwendung von pramipexole als neuroschutzmittel
DE69807074D1 (de)	2002-09-12	Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden
ATE248824T1 (de)	2003-09-15	Substituierte phenylderivate, ihre herstellung und verwendung
IL88531A (en)	1993-02-21	Cognitive enhancing compositions containing d-cycloserine
ATE156858T1 (de)	1997-08-15	Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
FI970150A0 (fi)	1997-01-14	Substituoituja pyrimidiiniyhdisteitä ja niiden käyttö
NL1002835A1 (nl)	1996-10-14	Synergistisch stabilisatormengsel.
ATE26835T1 (de)	1987-05-15	Tris(piperidylaminotriazylamino) verbindungen, ihre herstellung und ihre verwendung als stabilisierungsmittel fuer polymere.
FI955643A0 (fi)	1995-11-23	N-alkyylitiopolyaminnijohdannaiset säteilyltä suojaavina aineina
FI925988A0 (fi)	1992-12-31	Foerfarande foer framstaellning av b-laktamer
PT1028950E (pt)	2003-09-30	Quinazolina-2,4-dionas 7-substituidas uteis como agentes antibacterianos
ATE220679T1 (de)	2002-08-15	Porphyrine und ihre verwendung als photosensitizer
ATE226194T1 (de)	2002-11-15	1-acryloylindolin-derivate und ihre verwendung als prodrugs von antikrebsmittel
TR200000174T2 (tr)	2000-07-21	Bir poliorganosiloksana bağlı bir bağlayıcı içeren titanyum partiküllerinin (lakuna) dağılımı.
ATE228980T1 (de)	2002-12-15	Verwendung von alkoholen als additive für putze und/oder mörtel
ES2099879T3 (es)	1997-06-01	5-oxo-dibenzo(a,d)ciclohepta-1,4-dienos y su uso como agentes retrovirales.
DE69433856D1 (de)	2004-07-22	C10 Taxan Derivate und pharmazeutische Zusammensetzungen
ES2104174T3 (es)	1997-10-01	Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
MX9705738A (es)	1998-02-28	Compuestos de hule que contienen acidos aril-bis-citraconamicos.
ATE165594T1 (de)	1998-05-15	Triarylethylenderivate zur therapeutischen verwendung
CA2206104A1 (en)	1997-11-28	Adamantyl substituted oxindoles as pharmaceuticals agents
SU1584356A1 (ru)	2005-10-10	ПЕРФТОРАЛКИЛЗАМЕЩЕННЫЕ β,β'-ДИКЕТОЭФИРАТЫ ТРЕХВАЛЕНТНОГО ЖЕЛЕЗА КАК КАТАЛИЗАТОРЫ РЕАКЦИИ ОБРАЗОВАНИЯ ПОЛИУРЕТАНОВ
GT199300023A (es)	1994-11-11	Derivados de aminoacidos
MX9708155A (es)	1998-01-31	Inhibicion de la fotodescomposicion de 2-oxindoles 3-sustituidos.

Legal Events

Date

Code

Title

Description

2003-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0944596

Country of ref document: EP

2009-09-15

REN

Ceased due to non-payment of the annual fee