DK0964860T3 - Atropisomerer af 3-heteroaryl-4-(3H)-quinazolinoner til behandling af neurodegenerative og CNS-trauma-relaterede tilstande - Google Patents
Atropisomerer af 3-heteroaryl-4-(3H)-quinazolinoner til behandling af neurodegenerative og CNS-trauma-relaterede tilstandeInfo
- Publication number
- DK0964860T3 DK0964860T3 DK98901424T DK98901424T DK0964860T3 DK 0964860 T3 DK0964860 T3 DK 0964860T3 DK 98901424 T DK98901424 T DK 98901424T DK 98901424 T DK98901424 T DK 98901424T DK 0964860 T3 DK0964860 T3 DK 0964860T3
- Authority
- DK
- Denmark
- Prior art keywords
- quinazolinones
- atropisomers
- heteroaryl
- related conditions
- treat neurodegenerative
- Prior art date
Links
- 208000014674 injury Diseases 0.000 title 1
- 230000000626 neurodegenerative effect Effects 0.000 title 1
- 230000008733 trauma Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3854097P | 1997-02-28 | 1997-02-28 | |
| PCT/IB1998/000151 WO1998038187A1 (en) | 1997-02-28 | 1998-02-06 | Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0964860T3 true DK0964860T3 (da) | 2004-07-26 |
Family
ID=21900535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98901424T DK0964860T3 (da) | 1997-02-28 | 1998-02-06 | Atropisomerer af 3-heteroaryl-4-(3H)-quinazolinoner til behandling af neurodegenerative og CNS-trauma-relaterede tilstande |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6380204B1 (de) |
| EP (1) | EP0964860B1 (de) |
| JP (1) | JP3299990B2 (de) |
| KR (1) | KR20000075812A (de) |
| CN (1) | CN1248254A (de) |
| AP (1) | AP9801202A0 (de) |
| AR (1) | AR011886A1 (de) |
| AT (1) | ATE264854T1 (de) |
| AU (1) | AU732448B2 (de) |
| BG (1) | BG103687A (de) |
| BR (1) | BR9807807A (de) |
| CA (1) | CA2282279C (de) |
| CO (1) | CO4950615A1 (de) |
| DE (1) | DE69823339T2 (de) |
| DK (1) | DK0964860T3 (de) |
| DZ (1) | DZ2438A1 (de) |
| EA (1) | EA001961B1 (de) |
| ES (1) | ES2218801T3 (de) |
| GT (1) | GT199800039A (de) |
| HN (1) | HN1998000028A (de) |
| HR (1) | HRP980108B1 (de) |
| HU (1) | HUP0000935A3 (de) |
| ID (1) | ID23435A (de) |
| IL (1) | IL130897A0 (de) |
| IS (1) | IS5141A (de) |
| MA (1) | MA24485A1 (de) |
| NO (1) | NO994178D0 (de) |
| NZ (1) | NZ336627A (de) |
| OA (1) | OA11088A (de) |
| PA (1) | PA8446901A1 (de) |
| PE (1) | PE57999A1 (de) |
| PL (1) | PL335307A1 (de) |
| PT (1) | PT964860E (de) |
| SK (1) | SK113199A3 (de) |
| TN (1) | TNSN98034A1 (de) |
| TR (1) | TR199902094T2 (de) |
| TW (1) | TW530055B (de) |
| UA (1) | UA58536C2 (de) |
| WO (1) | WO1998038187A1 (de) |
| ZA (1) | ZA981665B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| JPH11279158A (ja) * | 1998-02-09 | 1999-10-12 | Pfizer Prod Inc | キナゾリン―４―オン誘導体の製造方法 |
| US6890930B1 (en) * | 1999-09-28 | 2005-05-10 | 3-Dimensional Pharmaceuticals, Inc. | Quinazolinones |
| EP1660486A4 (de) * | 2003-08-08 | 2006-12-13 | Ulysses Pharmaceutical Product | Halogenierte chinazolinylnitrofurane als antibakterielle mittel |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| GB0416730D0 (en) | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US7893260B2 (en) | 2005-11-04 | 2011-02-22 | Hydra Biosciences, Inc. | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function |
| WO2008041118A2 (en) * | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| WO2008140750A1 (en) * | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| CA2756347A1 (en) * | 2009-03-24 | 2010-09-30 | Gilead Calistoga Llc | Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| ES2739973T3 (es) | 2009-05-29 | 2020-02-05 | Merck Sharp & Dohme | Inhibidores de PDE10 radiomarcados |
| WO2013105985A1 (en) | 2011-02-28 | 2013-07-18 | Philadelphia Health & Education Corporation | Small molecule inhibitors of rad51 recombinase and methods thereof |
| EP4096661B1 (de) | 2020-01-29 | 2025-04-02 | Kamari Pharma Ltd. | Verbindungen und zusammensetzungen zur verwendung beim behandeln von hauterkrankungen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1298603A (en) | 1970-04-06 | 1972-12-06 | Karamchand Premchand Private | Quinazolinone derivatives |
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| WO1992013535A1 (en) | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
| DE69716810T2 (de) * | 1996-05-15 | 2003-02-27 | Pfizer Inc., New York | 2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one |
| KR100375155B1 (ko) * | 1996-05-15 | 2003-08-19 | 화이자 인코포레이티드 | 신규한2,3-이치환된-4(3에이치)-퀴나졸리논 |
-
1998
- 1998-02-06 NZ NZ336627A patent/NZ336627A/xx unknown
- 1998-02-06 PT PT98901424T patent/PT964860E/pt unknown
- 1998-02-06 EA EA199900689A patent/EA001961B1/ru not_active IP Right Cessation
- 1998-02-06 AT AT98901424T patent/ATE264854T1/de not_active IP Right Cessation
- 1998-02-06 BR BR9807807-0A patent/BR9807807A/pt not_active Application Discontinuation
- 1998-02-06 IL IL13089798A patent/IL130897A0/xx unknown
- 1998-02-06 EP EP98901424A patent/EP0964860B1/de not_active Expired - Lifetime
- 1998-02-06 HU HU0000935A patent/HUP0000935A3/hu unknown
- 1998-02-06 ES ES98901424T patent/ES2218801T3/es not_active Expired - Lifetime
- 1998-02-06 PL PL98335307A patent/PL335307A1/xx unknown
- 1998-02-06 DK DK98901424T patent/DK0964860T3/da active
- 1998-02-06 DE DE69823339T patent/DE69823339T2/de not_active Expired - Fee Related
- 1998-02-06 CA CA002282279A patent/CA2282279C/en not_active Expired - Fee Related
- 1998-02-06 SK SK1131-99A patent/SK113199A3/sk unknown
- 1998-02-06 TR TR1999/02094T patent/TR199902094T2/xx unknown
- 1998-02-06 JP JP53744998A patent/JP3299990B2/ja not_active Expired - Fee Related
- 1998-02-06 ID IDW990935D patent/ID23435A/id unknown
- 1998-02-06 WO PCT/IB1998/000151 patent/WO1998038187A1/en not_active Ceased
- 1998-02-06 CN CN98802796A patent/CN1248254A/zh active Pending
- 1998-02-06 AU AU57759/98A patent/AU732448B2/en not_active Ceased
- 1998-02-06 KR KR1019997007885A patent/KR20000075812A/ko not_active Abandoned
- 1998-02-06 US US09/380,114 patent/US6380204B1/en not_active Expired - Fee Related
- 1998-02-09 HN HN1998000028A patent/HN1998000028A/es unknown
- 1998-02-17 PA PA19988446901A patent/PA8446901A1/es unknown
- 1998-02-19 GT GT199800039A patent/GT199800039A/es unknown
- 1998-02-23 PE PE1998000127A patent/PE57999A1/es not_active Application Discontinuation
- 1998-02-25 CO CO98010303A patent/CO4950615A1/es unknown
- 1998-02-25 MA MA24979A patent/MA24485A1/fr unknown
- 1998-02-25 DZ DZ980048A patent/DZ2438A1/xx active
- 1998-02-25 TN TNTNSN98034A patent/TNSN98034A1/fr unknown
- 1998-02-25 TW TW087102713A patent/TW530055B/zh not_active IP Right Cessation
- 1998-02-26 AR ARP980100872A patent/AR011886A1/es unknown
- 1998-02-26 AP APAP/P/1998/001202A patent/AP9801202A0/en unknown
- 1998-02-27 HR HR980108A patent/HRP980108B1/xx not_active IP Right Cessation
- 1998-02-27 ZA ZA9801665A patent/ZA981665B/xx unknown
- 1998-06-02 UA UA99084850A patent/UA58536C2/uk unknown
-
1999
- 1999-07-30 IS IS5141A patent/IS5141A/is unknown
- 1999-08-20 OA OA9900186A patent/OA11088A/fr unknown
- 1999-08-24 BG BG103687A patent/BG103687A/xx unknown
- 1999-08-27 NO NO994178A patent/NO994178D0/no unknown
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