DK0969833T3 - Forlængelse af ekspressionen af transgene proteiner ved immunmodulerende behandling med 15-deoxyspergualin - Google Patents

Forlængelse af ekspressionen af transgene proteiner ved immunmodulerende behandling med 15-deoxyspergualin

Info

Publication number: DK0969833T3
Authority: DK; Denmark
Prior art keywords: expression; deoxyspergualin; elongation; transgenic; immunomodulatory therapy
Prior art date: 1997-03-21

Application number

DK98913712T

Other languages

English (en)

Inventor

Gerhard Seemann

Guenter Cichon

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-21

Filing date

1998-03-12

Publication date

2003-09-15

1998-03-12 Application filed by Hoechst Ag filed Critical Hoechst Ag

2003-09-15 Application granted granted Critical

2003-09-15 Publication of DK0969833T3 publication Critical patent/DK0969833T3/da

Links

230000009261 transgenic effect Effects 0.000 title abstract 3
230000002519 immonomodulatory effect Effects 0.000 title abstract 2
102000004169 proteins and genes Human genes 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
IDINUJSAMVOPCM-UHFFFAOYSA-N 15-Deoxyspergualin Natural products NCCCNCCCCNC(=O)C(O)NC(=O)CCCCCCN=C(N)N IDINUJSAMVOPCM-UHFFFAOYSA-N 0.000 title 1
BLUYEPLOXLPVCJ-INIZCTEOSA-N n-[(1s)-2-[4-(3-aminopropylamino)butylamino]-1-hydroxyethyl]-7-(diaminomethylideneamino)heptanamide Chemical compound NCCCNCCCCNC[C@H](O)NC(=O)CCCCCCNC(N)=N BLUYEPLOXLPVCJ-INIZCTEOSA-N 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 3
239000003018 immunosuppressive agent Substances 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000001861 immunosuppressant effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
238000012250 transgenic expression Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK98913712T 1997-03-21 1998-03-12 Forlængelse af ekspressionen af transgene proteiner ved immunmodulerende behandling med 15-deoxyspergualin DK0969833T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19711800A DE19711800A1 (de)	1997-03-21	1997-03-21	Verlängerung der Expression von transgenen Proteinen durch immunmodulierende Behandlung
PCT/EP1998/001438 WO1998042338A1 (de)	1997-03-21	1998-03-12	Verlängerung der expression von transgenen proteinen durch immunmodulierende behandlung

Publications (1)

Publication Number	Publication Date
DK0969833T3 true DK0969833T3 (da)	2003-09-15

Family

ID=7824118

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98913712T DK0969833T3 (da)	1997-03-21	1998-03-12	Forlængelse af ekspressionen af transgene proteiner ved immunmodulerende behandling med 15-deoxyspergualin

Country Status (10)

Country	Link
US (2)	US20030082151A1 (da)
EP (1)	EP0969833B1 (da)
JP (1)	JP2001518917A (da)
AT (1)	ATE241356T1 (da)
AU (1)	AU6831198A (da)
DE (2)	DE19711800A1 (da)
DK (1)	DK0969833T3 (da)
ES (1)	ES2201473T3 (da)
PT (1)	PT969833E (da)
WO (1)	WO1998042338A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7691890B2 (en)	1998-03-11	2010-04-06	James W. Williams	Anti-viral uses of leflunomide products
AU3080299A (en) *	1998-03-11	1999-09-27	Ohio State University Research Foundation, The	Anti-viral uses of leflunomide products
HUP0204069A3 (en) *	1999-12-16	2005-01-28	Teva Pharma	Novel processes for making- and a new crystalline form of- leflunomide and pharmaceutical composition containing it
CN1310679C (zh) *	1999-12-28	2007-04-18	诺瓦提斯公司	获得持续的转基因表达的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9200275D0 (en) *	1992-01-08	1992-02-26	Roussel Lab Ltd	Chemical compounds
ES2124800T3 (es) *	1993-01-08	1999-02-16	Hoechst Ag	Empleo de leflunomida para la inhibicion de interleuquina 1 beta.
WO1996040170A2 (en) *	1995-06-07	1996-12-19	Procept, Inc.	Metal-containing compounds and their use for inhibiting the immune response
US6011051A (en) *	1996-07-31	2000-01-04	Hoechst Aktiengesellschaft	Use of isoxazole and crotonamide derivatives for the modulation of apoptosis

1997
- 1997-03-21 DE DE19711800A patent/DE19711800A1/de not_active Withdrawn
1998
- 1998-03-12 JP JP54481698A patent/JP2001518917A/ja active Pending
- 1998-03-12 AT AT98913712T patent/ATE241356T1/de active
- 1998-03-12 DK DK98913712T patent/DK0969833T3/da active
- 1998-03-12 ES ES98913712T patent/ES2201473T3/es not_active Expired - Lifetime
- 1998-03-12 PT PT98913712T patent/PT969833E/pt unknown
- 1998-03-12 EP EP98913712A patent/EP0969833B1/de not_active Expired - Lifetime
- 1998-03-12 US US09/381,344 patent/US20030082151A1/en not_active Abandoned
- 1998-03-12 DE DE59808541T patent/DE59808541D1/de not_active Expired - Lifetime
- 1998-03-12 WO PCT/EP1998/001438 patent/WO1998042338A1/de not_active Ceased
- 1998-03-12 AU AU68311/98A patent/AU6831198A/en not_active Abandoned
2007
- 2007-04-05 US US11/696,782 patent/US20070191299A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE241356T1 (de)	2003-06-15
DE19711800A1 (de)	1998-09-24
ES2201473T3 (es)	2004-03-16
DE59808541D1 (de)	2003-07-03
JP2001518917A (ja)	2001-10-16
EP0969833A1 (de)	2000-01-12
US20070191299A1 (en)	2007-08-16
US20030082151A1 (en)	2003-05-01
WO1998042338A1 (de)	1998-10-01
PT969833E (pt)	2003-10-31
AU6831198A (en)	1998-10-20
EP0969833B1 (de)	2003-05-28

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