DK0973040T3 - Detektor og screening-indretning til ionkanaler - Google Patents

Detektor og screening-indretning til ionkanaler

Info

Publication number
DK0973040T3
DK0973040T3 DK99113933T DK99113933T DK0973040T3 DK 0973040 T3 DK0973040 T3 DK 0973040T3 DK 99113933 T DK99113933 T DK 99113933T DK 99113933 T DK99113933 T DK 99113933T DK 0973040 T3 DK0973040 T3 DK 0973040T3
Authority
DK
Denmark
Prior art keywords
detector
optical
ion channel
screening device
ball lens
Prior art date
Application number
DK99113933T
Other languages
English (en)
Inventor
Roger Y Tsien
Peter J Coassin
Andrew A Pham
Alec Tate Harootunian
Minh Vuong
Original Assignee
Vertex Pharma San Diego Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/118,728 external-priority patent/US6608671B2/en
Priority claimed from US09/122,544 external-priority patent/US6349160B2/en
Application filed by Vertex Pharma San Diego Llc filed Critical Vertex Pharma San Diego Llc
Application granted granted Critical
Publication of DK0973040T3 publication Critical patent/DK0973040T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0638—Refractive parts
    • G01N2201/0639—Sphere lens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Testing Of Optical Devices Or Fibers (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Optical Measuring Cells (AREA)
  • Light Guides In General And Applications Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Alarm Systems (AREA)
  • Burglar Alarm Systems (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
DK99113933T 1998-07-17 1999-07-16 Detektor og screening-indretning til ionkanaler DK0973040T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/118,728 US6608671B2 (en) 1998-07-17 1998-07-17 Detector and screening device for ion channels
US09/122,544 US6349160B2 (en) 1998-07-24 1998-07-24 Detector and screening device for ion channels

Publications (1)

Publication Number Publication Date
DK0973040T3 true DK0973040T3 (da) 2004-03-29

Family

ID=26816682

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99113933T DK0973040T3 (da) 1998-07-17 1999-07-16 Detektor og screening-indretning til ionkanaler

Country Status (10)

Country Link
EP (2) EP0973040B1 (da)
JP (1) JP2002520615A (da)
AT (2) ATE255727T1 (da)
AU (1) AU5108199A (da)
CA (1) CA2278045A1 (da)
DE (2) DE69913257T2 (da)
DK (1) DK0973040T3 (da)
ES (1) ES2210911T3 (da)
PT (1) PT973040E (da)
WO (1) WO2000004366A1 (da)

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US6221612B1 (en) 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6214563B1 (en) 1997-08-01 2001-04-10 Aurora Biosciences Corporation Photon reducing agents for reducing undesired light emission in assays
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US6519032B1 (en) * 1998-04-03 2003-02-11 Symyx Technologies, Inc. Fiber optic apparatus and use thereof in combinatorial material science
GB9915034D0 (en) * 1999-06-29 1999-08-25 Cambridge Imaging Ltd Improved assay analysis
DK1081495T3 (da) * 1999-09-01 2004-06-14 Invitrogen Corp Fotondæmpende midler til fluorescensassays
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
DE10057245A1 (de) 1999-12-11 2001-06-13 Qualico Gmbh Vorrichtung zum Erfassen von Eigenschaften einer bewegten Papierbahn
WO2002093144A1 (en) * 2001-05-10 2002-11-21 Regents Of The University Of Minnesota Imaging of biological samples using electronic light detector
WO2003006103A2 (en) * 2001-07-12 2003-01-23 Merck & Co., Inc. Electrical field stimulation of eukaryotic cells
ATE537438T1 (de) * 2002-05-17 2011-12-15 Life Technologies Corp Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge
DE10322443A1 (de) * 2003-05-19 2004-12-30 PRO DESIGN Gesellschaft für Produktentwicklung mbH Multifunktioneller Reader für Biochips
ITMI20050114A1 (it) * 2005-01-27 2006-07-28 Milano Politecnico Apparato e metodo per la stimolazione e la rilevazione ottica in maniera non invasiva dell'attivita' elettrica di almeno una cellula
EP1896831B1 (en) 2005-06-27 2013-04-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES A spatially selective, fixed-optics multicolor fluorescence detection system for a multichannel microfluidic device, and method for detection
DE102007047093B4 (de) * 2007-10-01 2010-07-01 Ferton Holding S.A. Vorrichtung zur Messung von Fluoreszenzstrahlung an biologischen Substanzen mit einer Halbleitersensorenanordnung
CN102203622A (zh) 2008-09-04 2011-09-28 加利尼公司 突触小泡循环的测定和系统
DE102010016382B4 (de) * 2010-04-09 2022-06-02 Leica Microsystems Cms Gmbh Fluoreszenzmikroskop und Verfahren zur Durchführung von Multipositionierungen in einer Screening-Applikation
JP5420725B2 (ja) * 2011-06-28 2014-02-19 株式会社イマック 光学測定装置
DE102011108180B4 (de) * 2011-07-20 2014-12-24 Sensor Instruments Entwicklungs- Und Vertriebs Gmbh Verfahren und Vorrichtung zum Identifizieren eines photolumineszierenden Materials
EP2820429B1 (en) 2012-03-02 2021-02-24 LAXCO, Inc. Multichannel analytical instruments for use with specimen holders
US9387451B2 (en) 2014-02-03 2016-07-12 International Business Machines Corporation Flow cell array and uses thereof
DE102016200271A1 (de) 2016-01-13 2017-07-13 Institut Dr. Foerster Gmbh & Co. Kg Vorrichtung zur Erzeugung und Messung einer Emission
CN110428193B (zh) * 2019-06-14 2022-03-04 上海中旖能源科技有限公司 基于车辆轨迹数据的多模式液化天然气运输车辆筛选方法
WO2021170364A1 (en) * 2020-02-26 2021-09-02 Robert Bosch Gmbh An optical filter holder for a bio-analyte device
EP4168804A4 (en) * 2020-06-17 2024-06-26 Nanopec, Inc. Nano-porous ceramic films for high density bioassay multiplexed arrays
DE102024201487A1 (de) * 2024-02-19 2025-08-21 Robert Bosch Gesellschaft mit beschränkter Haftung Optische Einheit zur Fluoreszenzlichtbilddarstellung, insbesondere für eine Analyseeinrichtung zum Nachweis von Krankheitserregern und Verfahren zum Herstellen einer optischen Einheit

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4984456A (da) * 1972-12-19 1974-08-14
DE3036638C2 (de) * 1980-09-29 1983-11-03 Vanzetti Infrared & Computer Systems, Inc., Canton, Mass. Bandverhältnis-Radiometer
EP0230679B1 (en) * 1986-01-30 1990-08-08 The Dow Chemical Company Fiber-optic probe
FR2567538B1 (fr) * 1984-07-12 1986-12-26 Inst Nat Sante Rech Med Automate pour l'analyse et le clonage de cultures cellulaires ainsi que pour l'analyse bacteriologique
EP0396115A3 (en) * 1989-05-03 1991-07-24 Abbott Laboratories Method of forming agglutinates in blood samples
FR2661986B1 (fr) * 1990-05-14 1992-07-17 Commissariat Energie Atomique Appareil autonome de lecture d'un capteur chimique actif a au moins une fibre optique et procede pour sa mise en óoeuvre.
US5086220A (en) * 1991-02-05 1992-02-04 The Babcock & Wilcox Company Radiation imaging fiber optic temperature distribution monitor
US5217285A (en) * 1991-03-15 1993-06-08 The United States Of America As Represented By United States Department Of Energy Apparatus for synthesis of a solar spectrum
JP2912957B2 (ja) * 1991-06-18 1999-06-28 東ソー株式会社 酵素活性測定方法及び装置
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5436718A (en) * 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers

Also Published As

Publication number Publication date
ATE255727T1 (de) 2003-12-15
EP0973040B1 (en) 2003-12-03
DE69937126D1 (de) 2007-10-25
JP2002520615A (ja) 2002-07-09
DE69937126T2 (de) 2008-06-12
DE69913257D1 (de) 2004-01-15
WO2000004366A9 (en) 2000-06-02
EP1403645B1 (en) 2007-09-12
EP0973040A3 (en) 2000-03-15
DE69913257T2 (de) 2004-09-02
PT973040E (pt) 2004-04-30
CA2278045A1 (en) 2000-01-17
ES2210911T3 (es) 2004-07-01
EP1403645A1 (en) 2004-03-31
WO2000004366A1 (en) 2000-01-27
AU5108199A (en) 2000-02-07
ATE373241T1 (de) 2007-09-15
EP0973040A2 (en) 2000-01-19

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