DK0975348T3 - Stabiliserede tibolon-sammensætninger - Google Patents

Stabiliserede tibolon-sammensætninger

Info

Publication number: DK0975348T3
Authority: DK; Denmark
Prior art keywords: stabilized; compositions; tibolone compositions; stabilized tibolone; tibolone
Prior art date: 1997-04-22

Application number

DK98928214T

Other languages

English (en)

Inventor

Jocominus Antonius Ma Zwinkels

Adrianus Cornelis Petru Rovers

Hurk Theodora Ant Lambregts-De

Ryoichi Morita

De Pieter Haan

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-22

Filing date

1998-04-20

Publication date

2005-03-07

1998-04-20 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2005-03-07 Application granted granted Critical

2005-03-07 Publication of DK0975348T3 publication Critical patent/DK0975348T3/da

Links

239000000203 mixture Substances 0.000 title 1
WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 title 1
229960001023 tibolone Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK98928214T 1997-04-22 1998-04-20 Stabiliserede tibolon-sammensætninger DK0975348T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP97201180		1997-04-22
EP98928214A EP0975348B1 (en)	1997-04-22	1998-04-20	Stabilized tibolone compositions
PCT/EP1998/002361 WO1998047517A1 (en)	1997-04-22	1998-04-20	Stabilized tibolone compositions

Publications (1)

Publication Number	Publication Date
DK0975348T3 true DK0975348T3 (da)	2005-03-07

Family

ID=8228228

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98928214T DK0975348T3 (da)	1997-04-22	1998-04-20	Stabiliserede tibolon-sammensætninger

Country Status (25)

Country	Link
US (6)	US6399594B2 (da)
EP (1)	EP0975348B1 (da)
JP (1)	JPH10316573A (da)
KR (1)	KR100580855B1 (da)
CN (2)	CN1146424C (da)
AR (1)	AR012480A1 (da)
AT (1)	ATE281836T1 (da)
AU (1)	AU742037B2 (da)
BR (1)	BR9809268A (da)
CA (1)	CA2288070A1 (da)
DE (1)	DE69827484T2 (da)
DK (1)	DK0975348T3 (da)
ES (1)	ES2232949T3 (da)
HU (1)	HUP0001780A3 (da)
ID (1)	ID22763A (da)
IL (1)	IL123984A (da)
NO (1)	NO995127D0 (da)
NZ (1)	NZ338028A (da)
PL (1)	PL190227B1 (da)
PT (1)	PT975348E (da)
RU (1)	RU2207133C2 (da)
TR (1)	TR199902530T2 (da)
TW (1)	TW570798B (da)
WO (1)	WO1998047517A1 (da)
ZA (1)	ZA983169B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002527525A (ja) *	1998-10-16	2002-08-27	アクゾ・ノベル・エヌ・ベー	（７α，１７α）−１７−ヒドロキシ−７−メチル−１９−ノル−１７−プレグヌ−５（１０）−エン−２０−イン−３−オンを含む高純度組成物
EP1163901B1 (en) *	1999-02-26	2008-09-10	Shionogi & Co., Ltd.	Chewable soft capsules having improved administration properties and process for producing the same
US20040229854A1 (en) *	2000-11-28	2004-11-18	Pieter Haan De	Immediate release dosage form for HRT
US20070098784A1 (en) *	2001-09-28	2007-05-03	Nutraceutix, Inc.	Delivery system for biological component
KR100979877B1 (ko) *	2001-09-28	2010-09-02	뉴트라슈틱스 인코포레이티드	생물학적 성분의 전달 시스템
GB0125061D0 (en) *	2001-10-18	2001-12-12	Norton Healthcare Ltd	Pharmaceutical composition
TW200418525A (en) *	2002-11-20	2004-10-01	Akzo Nobel Nv	Coated pharmaceutical tablets containing Tibolone
CN1324041C (zh) *	2003-04-01	2007-07-04	上海迪赛诺医药科技开发有限公司	替勃龙晶型i的制备方法
KR20060006949A (ko) *	2003-04-29	2006-01-20	아크조 노벨 엔.브이.	반용매 고화 방법
ES2243919T3 (es) *	2003-05-23	2005-12-01	Akzo Nobel N.V.	Formulacion solida farmaceutica que contiene tibolona.
WO2005105278A2 (en) *	2004-05-05	2005-11-10	Akzo Nobel N.V.	Antisolvent emulsion solidification process
WO2005117899A1 (en) *	2004-06-02	2005-12-15	Cipla Limited	Pharmaceutical composition comprising tibolone and process for procuding the same
WO2005120517A1 (en) *	2004-06-07	2005-12-22	Strides Arcolab Limited	Stable liquid suspension formulation comprising synthetic steroids and process for producing the same
CZ300465B6 (cs) *	2007-07-25	2009-05-27	Zentiva, A. S.	Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
CN102085193B (zh) *	2009-12-08	2013-11-06	北京以岭生物工程技术有限公司	一种替勃龙口腔崩解片及其制备方法
CN104345098B (zh) *	2013-08-05	2016-04-13	华润紫竹药业有限公司	一种测定替勃龙片剂中抗氧剂含量的方法
MX381207B (es)	2016-05-04	2025-03-12	Novalon S A	Uso de alcoholes de azucar en composiciones de tibolona

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4701450A (en) *	1984-03-21	1987-10-20	Akzo N.V.	Steroids for use as immunomodulators
CH676470A5 (da) *	1988-02-03	1991-01-31	Nestle Sa
IE63051B1 (en) *	1989-03-18	1995-03-22	Akzo Nv	Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
EP0613687B1 (en)	1993-03-05	1999-06-02	Akzo Nobel N.V.	Use of a pregnane derivatives for the treatment of tumours
ES2185666T3 (es)	1993-09-03	2003-05-01	Smithkline Beecham Corp	Formulacion estabilizada para comprimidos.
CA2159419C (en)	1994-10-17	2006-07-04	Pieter De Haan	Solid pharmaceutical composition comprising an excipient capable of binding water

1998
- 1998-04-07 IL IL12398498A patent/IL123984A/en active IP Right Grant
- 1998-04-15 ZA ZA983169A patent/ZA983169B/xx unknown
- 1998-04-20 AU AU80146/98A patent/AU742037B2/en not_active Ceased
- 1998-04-20 BR BR9809268-5A patent/BR9809268A/pt not_active Application Discontinuation
- 1998-04-20 HU HU0001780A patent/HUP0001780A3/hu unknown
- 1998-04-20 EP EP98928214A patent/EP0975348B1/en not_active Expired - Lifetime
- 1998-04-20 DK DK98928214T patent/DK0975348T3/da active
- 1998-04-20 CN CNB988044579A patent/CN1146424C/zh not_active Expired - Fee Related
- 1998-04-20 DE DE69827484T patent/DE69827484T2/de not_active Expired - Fee Related
- 1998-04-20 WO PCT/EP1998/002361 patent/WO1998047517A1/en not_active Ceased
- 1998-04-20 CA CA002288070A patent/CA2288070A1/en not_active Abandoned
- 1998-04-20 KR KR1019997009726A patent/KR100580855B1/ko not_active Expired - Fee Related
- 1998-04-20 PT PT98928214T patent/PT975348E/pt unknown
- 1998-04-20 ES ES98928214T patent/ES2232949T3/es not_active Expired - Lifetime
- 1998-04-20 RU RU99121407/14A patent/RU2207133C2/ru not_active IP Right Cessation
- 1998-04-20 ID IDW991204A patent/ID22763A/id unknown
- 1998-04-20 NZ NZ338028A patent/NZ338028A/en unknown
- 1998-04-20 AT AT98928214T patent/ATE281836T1/de not_active IP Right Cessation
- 1998-04-20 US US09/403,139 patent/US6399594B2/en not_active Expired - Fee Related
- 1998-04-20 PL PL98336658A patent/PL190227B1/pl not_active IP Right Cessation
- 1998-04-20 CN CNA2003101026335A patent/CN1494908A/zh active Pending
- 1998-04-20 TR TR1999/02530T patent/TR199902530T2/xx unknown
- 1998-04-21 AR ARP980101819A patent/AR012480A1/es not_active Application Discontinuation
- 1998-04-22 JP JP10112312A patent/JPH10316573A/ja active Pending
- 1998-05-11 TW TW087107211A patent/TW570798B/zh not_active IP Right Cessation
1999
- 1999-10-21 NO NO995127A patent/NO995127D0/no unknown
2002
- 2002-04-08 US US10/117,899 patent/US6514958B1/en not_active Expired - Fee Related
- 2002-11-25 US US10/303,494 patent/US20030119801A1/en not_active Abandoned
2004
- 2004-01-08 US US10/754,685 patent/US20040142030A1/en not_active Abandoned
- 2004-01-08 US US10/754,732 patent/US20040142028A1/en not_active Abandoned
- 2004-01-08 US US10/754,733 patent/US20040142031A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0975348A1 (en)	2000-02-02
US20040142028A1 (en)	2004-07-22
WO1998047517A1 (en)	1998-10-29
US6399594B2 (en)	2002-06-04
KR20010020163A (ko)	2001-03-15
JPH10316573A (ja)	1998-12-02
NZ338028A (en)	2001-10-26
TW570798B (en)	2004-01-11
ID22763A (id)	1999-12-09
CN1146424C (zh)	2004-04-21
HUP0001780A3 (en)	2001-02-28
US20010005513A1 (en)	2001-06-28
CA2288070A1 (en)	1998-10-29
BR9809268A (pt)	2000-06-27
HUP0001780A2 (hu)	2000-12-28
ATE281836T1 (de)	2004-11-15
DE69827484T2 (de)	2005-03-17
PT975348E (pt)	2005-01-31
NO995127L (no)	1999-10-21
NO995127D0 (no)	1999-10-21
US20030119801A1 (en)	2003-06-26
RU2207133C2 (ru)	2003-06-27
US6514958B1 (en)	2003-02-04
US20040142030A1 (en)	2004-07-22
AR012480A1 (es)	2000-10-18
CN1253503A (zh)	2000-05-17
KR100580855B1 (ko)	2006-05-17
DE69827484D1 (de)	2004-12-16
AU8014698A (en)	1998-11-13
EP0975348B1 (en)	2004-11-10
PL190227B1 (pl)	2005-11-30
PL336658A1 (en)	2000-07-03
US20040142031A1 (en)	2004-07-22
TR199902530T2 (xx)	2000-05-22
IL123984A (en)	2004-09-27
CN1494908A (zh)	2004-05-12
HK1023508A1 (en)	2000-09-15
AU742037B2 (en)	2001-12-13
ZA983169B (en)	1998-10-20
ES2232949T3 (es)	2005-06-01

Publication	Publication Date	Title
ID22931A (id)	1999-12-16	Komposisi-komposisi herbisidal
DK1298194T3 (da)	2006-11-27	Staniolholdige sammensætninger
DE69832516D1 (de)	2005-12-29	Isoflavon-enthaltende zusammensetzungen
ID26549A (id)	2001-01-18	Komposisi-komposisi epotilon
ATE367793T1 (de)	2007-08-15	Schweisshemmende zusammensetzungen
TR199800375A3 (tr)	1999-05-21	Selant kompozisyonlari.
ID16251A (id)	1997-09-18	Komposisi-komposisi pembasmi kuman
DE69830160D1 (de)	2005-06-16	Bleichmittelzusammensetzungen
IS5430A (is)	2000-04-06	Ný samsetning
ID28694A (id)	2001-06-28	Komposisi sampo
ATE351896T1 (de)	2007-02-15	Brennstoffzusammensetzung
ATE469550T1 (de)	2010-06-15	Antiparasitäre zusammensetzungen
ID25508A (id)	2000-10-05	Komposisi dematologis
DE69807602D1 (de)	2002-10-10	Resistzusammensetzungen
DE69806978D1 (de)	2002-09-12	Einpressmutter
DE69935172D1 (de)	2007-03-29	Imidosilan Zusammensetzungen
ATE209959T1 (de)	2001-12-15	Mikroverkapselte zusammensetzungen
DE69628052D1 (de)	2003-06-12	Brennstoffzusammensetzungen
ATE293672T1 (de)	2005-05-15	Farbschonende zusammensetzungen
DE59911148D1 (de)	2004-12-30	Propoxilat enthaltende kraftstoffzusammensetzungen
DE69719442D1 (de)	2003-04-10	Frisierschaum-Zusammensetzungen
ID21009A (id)	1999-04-08	Komposisi untuk supositori
ID27889A (id)	2001-05-03	Komposisi-komposisi kopolimer polisiklik
NO995127L (no)	1999-10-21	Stabiliserte tibolonblandinger
ID25650A (id)	2000-10-19	Komposisi-komposisi sampo