DK0975648T3 - Morfinderivater - Google Patents

Morfinderivater

Info

Publication number: DK0975648T3
Authority: DK; Denmark
Prior art keywords: morphine; glucuronide; adducts; formula; acid
Prior art date: 1997-04-14

Application number

DK98917345T

Other languages

English (en)

Inventor

Feodor Scheinmann

Andrew Valentine Stachulski

Simon Joel

Original Assignee

Ufc Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-14

Filing date

1998-04-14

Publication date

2003-09-29

1997-04-14 Priority claimed from US08/833,203 external-priority patent/US5977326A/en

1997-10-07 Priority claimed from GBGB9721137.9A external-priority patent/GB9721137D0/en

1998-04-14 Application filed by Ufc Ltd filed Critical Ufc Ltd

2003-09-29 Application granted granted Critical

2003-09-29 Publication of DK0975648T3 publication Critical patent/DK0975648T3/da

Links

BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 4
GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical compound O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
UYUXSRADSPPKRZ-UHFFFAOYSA-N D-glucuronic acid gamma-lactone Natural products O=CC(O)C1OC(=O)C(O)C1O UYUXSRADSPPKRZ-UHFFFAOYSA-N 0.000 abstract 1
UYUXSRADSPPKRZ-SKNVOMKLSA-N D-glucurono-6,3-lactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 abstract 1
IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical class O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000002843 carboxylic acid group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229950002441 glucurolactone Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
229960005181 morphine Drugs 0.000 abstract 1
229960004715 morphine sulfate Drugs 0.000 abstract 1
GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DK98917345T 1997-04-14 1998-04-14 Morfinderivater DK0975648T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/833,203 US5977326A (en)	1991-08-06	1997-04-14	Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
GBGB9721137.9A GB9721137D0 (en)	1997-10-07	1997-10-07	Morphine derivatives
PCT/GB1998/001071 WO1998046618A1 (en)	1997-04-14	1998-04-14	Morphine derivatives

Publications (1)

Publication Number	Publication Date
DK0975648T3 true DK0975648T3 (da)	2003-09-29

Family

ID=26312371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98917345T DK0975648T3 (da)	1997-04-14	1998-04-14	Morfinderivater

Country Status (9)

Country	Link
EP (1)	EP0975648B1 (da)
JP (1)	JP2001518912A (da)
AT (1)	ATE242257T1 (da)
AU (1)	AU723859B2 (da)
DE (1)	DE69815336T2 (da)
DK (1)	DK0975648T3 (da)
ES (1)	ES2201482T3 (da)
GB (1)	GB2339196B (da)
WO (1)	WO1998046618A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9914382D0 (en) *	1999-06-21	1999-08-18	Ufc Limited	New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
FR2907121B1 (fr)	2006-10-12	2012-05-04	Neorphys	Nouveaux derives morphiniques
EP2116539A1 (en)	2008-04-25	2009-11-11	Laboratorios Del. Dr. Esteve, S.A.	1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
FR2939436B1 (fr)	2008-12-10	2010-12-17	Sanofi Aventis	Synthese de morphine-6-glucuronide ou de l'un de ses derives
FR2939437B1 (fr) *	2008-12-10	2010-12-17	Sanofi Aventis	Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939796B1 (fr) *	2008-12-11	2010-12-17	Sanofi Aventis	Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
EP2353591A1 (en)	2010-02-04	2011-08-10	Laboratorios Del. Dr. Esteve, S.A.	Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2353598A1 (en)	2010-02-04	2011-08-10	Laboratorios Del. Dr. Esteve, S.A.	Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2388005A1 (en)	2010-05-21	2011-11-23	Laboratorios Del. Dr. Esteve, S.A.	Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en)	2010-08-03	2012-02-08	Laboratorios Del. Dr. Esteve, S.A.	Use of sigma ligands in opioid-induced hyperalgesia
EP2524694A1 (en)	2011-05-19	2012-11-21	Laboratorios Del. Dr. Esteve, S.A.	Use of sigma ligands in diabetes type-2 associated pain
TN2016000228A1 (en)	2013-12-17	2017-10-06	Esteve Labor Dr	SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9116909D0 (en) *	1991-08-06	1991-09-18	Salford Ultrafine Chem & Res	Morphine derivatives
GB9325065D0 (en) *	1993-12-07	1994-02-02	Salford Ultrafine Chem & Res	An enzymatic process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
DE4403709A1 (de) *	1994-02-07	1995-08-10	Lohmann Therapie Syst Lts	Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
EP0816375A1 (en) *	1995-11-29	1998-01-07	Rolabo Sl	Glycoconjugates of opiated substances

1998
- 1998-04-14 AU AU70590/98A patent/AU723859B2/en not_active Ceased
- 1998-04-14 ES ES98917345T patent/ES2201482T3/es not_active Expired - Lifetime
- 1998-04-14 GB GB9924287A patent/GB2339196B/en not_active Revoked
- 1998-04-14 JP JP54361498A patent/JP2001518912A/ja active Pending
- 1998-04-14 DK DK98917345T patent/DK0975648T3/da active
- 1998-04-14 AT AT98917345T patent/ATE242257T1/de not_active IP Right Cessation
- 1998-04-14 EP EP98917345A patent/EP0975648B1/en not_active Expired - Lifetime
- 1998-04-14 DE DE69815336T patent/DE69815336T2/de not_active Expired - Lifetime
- 1998-04-14 WO PCT/GB1998/001071 patent/WO1998046618A1/en not_active Ceased

Also Published As

Publication number	Publication date
GB2339196A (en)	2000-01-19
WO1998046618A1 (en)	1998-10-22
DE69815336D1 (de)	2003-07-10
AU7059098A (en)	1998-11-11
GB2339196A8 (en)	2000-01-24
EP0975648A1 (en)	2000-02-02
GB2339196B (en)	2001-11-07
JP2001518912A (ja)	2001-10-16
EP0975648B1 (en)	2003-06-04
DE69815336T2 (de)	2004-05-06
GB9924287D0 (en)	1999-12-15
ATE242257T1 (de)	2003-06-15
ES2201482T3 (es)	2004-03-16
AU723859B2 (en)	2000-09-07

Similar Documents

Publication	Publication Date	Title
DE69815336D1 (de)	2003-07-10	Morphin-derivate
MX9707879A (es)	1997-11-29	Derivados de piperazina sustituidos novedosos que tienen actividad antagonista de receptor de taquinina.
UA49869C2 (uk)	2002-10-15	Нафтил-заміщені похідні бензимідазолу, фармацевтична композиція, спосіб лікування (варіанти) та спосіб інгібування людського фактора
PT1071702E (pt)	2003-01-31	Derivados de acidos gordos de acidos biliares e derivados de acidos biliares
GR3020483T3 (en)	1996-10-31	Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use
BR9710737A (pt)	2000-01-11	Pentafluorobenzenosulfonamidas e análogos.
UA43391C2 (uk)	2001-12-17	Спосіб інгібування міжклітинного зчеплення і спосіб інгібування запального процесу та порушеного процесу нормальної коагуляції у пацієнтів з розладами васкулярного ендотелію
PL340551A1 (en)	2001-02-12	Derivatives of hydroxamic and carboxylic acids exhibiting mmp & tnf inhibitive action
HU9301155D0 (en)	1993-07-28	Methods for producing steroide derivatives and for their application in medical treatment
PT1144365E (pt)	2004-06-30	Inibidores da adesao de celulas mediada por alfa4beta1
ATE253061T1 (de)	2003-11-15	Zur behandlung von krebs nützliche thiophen- und furan-2,5-dicarboxamide
FI971711A0 (fi)	1997-04-22	Levobupivakaiinin ja sen analogien kiteyttäminen
ES2184318T3 (es)	2003-04-01	6-alquilfenantridinas sustituidas.
ATE180669T1 (de)	1999-06-15	Verwendung von pregnanderivaten zur behandlung von tumoren
KR970703761A (ko)	1997-08-09	암 전이 억제제(cancerous metastasis inhibitor)
EP0659763A3 (en)	1995-12-20	Esters of quinoline-carboxylic acids with 21-pregnane derivatives and bactericidal and anti-inflammatory compositions containing them.
PT659082E (pt)	2002-07-31	Utilizacao de inibidores de citocromo p450 para inibir o metabolismo de acridina substituida com azoto
ES2074946A1 (es)	1995-09-16	Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
EP0766963A4 (en)	1997-10-29	ACTIVE AGAINST ARTERIOSCLEROSIS
SE0004462D0 (sv)	2000-12-04	Novel method and use
BR0015082A (pt)	2003-04-15	Derivado de ácido hidroxâmico como inibidor da formação de cd 23 humano solúvel
ID22762A (id)	1999-12-09	Komposisi untuk mengobati atau mencegah kanker prostat
EA199900174A1 (ru)	1999-08-26	Способ лечения биполярного расстройства
MY103537A (en)	1993-07-31	Treatment of cardiac arrhythmias.
DE69826287D1 (de)	2004-10-21	Verwendung von phospholambanhemmer zur steigerung der koronäre durchblutung