DK0978565T3 - Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptid - Google Patents
Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptidInfo
- Publication number
- DK0978565T3 DK0978565T3 DK99901926T DK99901926T DK0978565T3 DK 0978565 T3 DK0978565 T3 DK 0978565T3 DK 99901926 T DK99901926 T DK 99901926T DK 99901926 T DK99901926 T DK 99901926T DK 0978565 T3 DK0978565 T3 DK 0978565T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- target
- protein
- producing
- solubility
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 101800000324 Immunoglobulin A1 protease translocator Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 238000006911 enzymatic reaction Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 230000004520 agglutination Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000003028 elevating effect Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
- 238000005215 recombination Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3227298 | 1998-01-30 | ||
| PCT/JP1999/000406 WO1999038984A1 (fr) | 1998-01-30 | 1999-01-29 | Procede de production de peptide au moyen d'un peptide accessoire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0978565T3 true DK0978565T3 (da) | 2008-02-04 |
Family
ID=12354362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99901926T DK0978565T3 (da) | 1998-01-30 | 1999-01-29 | Fremgangsmåde til fremstilling af peptid under anvendelse af et hjælperpeptid |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0978565B1 (da) |
| JP (1) | JP4331270B2 (da) |
| KR (1) | KR100627590B1 (da) |
| CN (1) | CN1198937C (da) |
| AT (1) | ATE375393T1 (da) |
| AU (1) | AU765206B2 (da) |
| CA (1) | CA2284847A1 (da) |
| DE (1) | DE69937272T2 (da) |
| DK (1) | DK0978565T3 (da) |
| IL (1) | IL132030A (da) |
| NZ (1) | NZ338004A (da) |
| WO (1) | WO1999038984A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000052193A1 (fr) | 1999-03-04 | 2000-09-08 | Suntory Limited | Procede de controle de clivage par la protease de l'ompt |
| AU7559500A (en) * | 1999-10-15 | 2001-04-23 | Shionogi & Co., Ltd. | Process for producing adrenomedulin precursor |
| KR100407792B1 (ko) * | 2000-08-02 | 2003-12-01 | 한국생명공학연구원 | 인간 글루카곤 유사펩타이드를 융합파트너로 이용한재조합 단백질의 제조방법 |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| ATE469915T1 (de) | 2001-07-27 | 2010-06-15 | Novartis Vaccines & Diagnostic | Antikörper gegen das meningokokken adhäsin app |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
| IL162780A0 (en) | 2002-04-11 | 2005-11-20 | Kenji Kangawa | Method for producing modified peptide |
| WO2003099854A2 (en) | 2002-05-24 | 2003-12-04 | Nps Allelix Corp. | Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides |
| EP1513945A4 (en) | 2002-05-24 | 2008-12-24 | Restoragen Inc | Method for universal enzymatic production of bioactive peptides |
| EP1551435A4 (en) * | 2002-05-24 | 2007-08-08 | Restoragen Inc | Method for enzymatic production of glp-1 (7-36) amide peptides |
| KR20050049525A (ko) * | 2002-10-11 | 2005-05-25 | 가부시키가이샤산와카가쿠켄큐쇼 | Ｇｌｐ-1 유도체 및 그의 경점막 흡수형 제제 |
| CN1809380B (zh) | 2002-10-11 | 2010-05-12 | 启龙有限公司 | 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗 |
| WO2004078777A2 (en) * | 2003-03-04 | 2004-09-16 | Biorexis Pharmaceutical Corporation | Dipeptidyl-peptidase protected proteins |
| HRP20120315T1 (hr) | 2003-11-21 | 2012-05-31 | Nps Pharmaceuticals | Proizvodnja peptida 2 nalik glukagonu i analoga |
| US8178495B2 (en) | 2008-06-27 | 2012-05-15 | Duke University | Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| US8114632B2 (en) | 2006-06-21 | 2012-02-14 | Biocon Limited | Method of producing biologically active polypeptide having insulinotropic activity |
| KR101193722B1 (ko) | 2006-07-24 | 2013-01-11 | 바이오렉시스 파마슈티칼 코포레이션 | 엑센딘 융합 단백질 |
| CA2663047A1 (en) * | 2006-09-06 | 2008-03-13 | Phase Bioscience, Inc. | Therapeutic elastin-like polypeptide (elp) fusion proteins |
| CN104936610A (zh) * | 2012-11-13 | 2015-09-23 | 益普生制药股份有限公司 | Glp-1类似物的纯化方法 |
| CN104592381A (zh) * | 2013-10-31 | 2015-05-06 | 江苏万邦生化医药股份有限公司 | 一种利拉鲁肽中间体多肽的制备方法 |
| RU2544959C1 (ru) * | 2014-04-04 | 2015-03-20 | Александр Владимирович Бубнов | Способ получения пептидов |
| WO2016089782A1 (en) | 2014-12-01 | 2016-06-09 | Pfenex Inc. | Fusion partners for peptide production |
| CN105669856A (zh) * | 2016-02-13 | 2016-06-15 | 王大勇 | 一种基因重组长效人促肾上腺皮质激素及其制备方法 |
| HUE066356T2 (hu) | 2017-08-24 | 2024-07-28 | Novo Nordisk As | GLP-1 készítmények és alkalmazásaik |
| CN111378027B (zh) * | 2018-12-29 | 2022-04-15 | 万新医药科技(苏州)有限公司 | 一种索玛鲁肽前体的制备方法 |
| PE20221575A1 (es) | 2020-02-18 | 2022-10-06 | Novo Nordisk As | Formulaciones farmaceuticas |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3531947B2 (ja) * | 1991-08-19 | 2004-05-31 | 第一サントリーファーマ株式会社 | ペプチドの製造方法 |
| JP3995279B2 (ja) * | 1994-09-07 | 2007-10-24 | アスビオファーマ株式会社 | 蛋白の製造方法 |
| CA2198966C (en) * | 1996-03-04 | 2011-06-21 | Yuji Suzuki | Method for cleaving chimeric protein using processing enzyme |
-
1999
- 1999-01-29 DK DK99901926T patent/DK0978565T3/da active
- 1999-01-29 IL IL132030A patent/IL132030A/en not_active IP Right Cessation
- 1999-01-29 JP JP53918299A patent/JP4331270B2/ja not_active Expired - Fee Related
- 1999-01-29 AT AT99901926T patent/ATE375393T1/de active
- 1999-01-29 KR KR1019997008935A patent/KR100627590B1/ko not_active Expired - Fee Related
- 1999-01-29 CA CA002284847A patent/CA2284847A1/en not_active Abandoned
- 1999-01-29 EP EP99901926A patent/EP0978565B1/en not_active Expired - Lifetime
- 1999-01-29 NZ NZ338004A patent/NZ338004A/en not_active IP Right Cessation
- 1999-01-29 DE DE69937272T patent/DE69937272T2/de not_active Expired - Lifetime
- 1999-01-29 CN CNB998001139A patent/CN1198937C/zh not_active Expired - Fee Related
- 1999-01-29 AU AU21857/99A patent/AU765206B2/en not_active Ceased
- 1999-01-29 WO PCT/JP1999/000406 patent/WO1999038984A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4331270B2 (ja) | 2009-09-16 |
| KR100627590B1 (ko) | 2006-09-25 |
| NZ338004A (en) | 2001-08-31 |
| AU765206B2 (en) | 2003-09-11 |
| EP0978565A1 (en) | 2000-02-09 |
| DE69937272D1 (de) | 2007-11-22 |
| CN1198937C (zh) | 2005-04-27 |
| DE69937272T2 (de) | 2008-07-10 |
| CA2284847A1 (en) | 1999-08-05 |
| EP0978565A4 (en) | 2003-05-02 |
| IL132030A0 (en) | 2001-03-19 |
| EP0978565B1 (en) | 2007-10-10 |
| KR20010005859A (ko) | 2001-01-15 |
| IL132030A (en) | 2009-06-15 |
| ATE375393T1 (de) | 2007-10-15 |
| AU2185799A (en) | 1999-08-16 |
| WO1999038984A1 (fr) | 1999-08-05 |
| CN1255945A (zh) | 2000-06-07 |
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