ATE375393T1 - Verfahren zur herstellung eines peptids mittels eines hilfspeptids - Google Patents

Verfahren zur herstellung eines peptids mittels eines hilfspeptids

Info

Publication number: ATE375393T1
Authority: AT; Austria
Prior art keywords: peptide; target; protein; producing; solubility
Prior art date: 1998-01-30

Application number

AT99901926T

Other languages

English (en)

Inventor

Kazuhiro Ohsuye

Masayuki Yabuta

Yuji Suzuki

Original Assignee

Asubio Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-30

Filing date

1999-01-29

Publication date

2007-10-15

1999-01-29 Application filed by Asubio Pharma Co Ltd filed Critical Asubio Pharma Co Ltd

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE375393T1 publication Critical patent/ATE375393T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
238000004519 manufacturing process Methods 0.000 title 1
108090000623 proteins and genes Proteins 0.000 abstract 5
102000004169 proteins and genes Human genes 0.000 abstract 4
238000006911 enzymatic reaction Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000000746 purification Methods 0.000 abstract 2
230000004520 agglutination Effects 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
230000003028 elevating effect Effects 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
238000004255 ion exchange chromatography Methods 0.000 abstract 1
230000006798 recombination Effects 0.000 abstract 1
238000005215 recombination Methods 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Endocrinology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT99901926T 1998-01-30 1999-01-29 Verfahren zur herstellung eines peptids mittels eines hilfspeptids ATE375393T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3227298		1998-01-30

Publications (1)

Publication Number	Publication Date
ATE375393T1 true ATE375393T1 (de)	2007-10-15

Family

ID=12354362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99901926T ATE375393T1 (de)	1998-01-30	1999-01-29	Verfahren zur herstellung eines peptids mittels eines hilfspeptids

Country Status (12)

Country	Link
EP (1)	EP0978565B1 (de)
JP (1)	JP4331270B2 (de)
KR (1)	KR100627590B1 (de)
CN (1)	CN1198937C (de)
AT (1)	ATE375393T1 (de)
AU (1)	AU765206B2 (de)
CA (1)	CA2284847A1 (de)
DE (1)	DE69937272T2 (de)
DK (1)	DK0978565T3 (de)
IL (1)	IL132030A (de)
NZ (1)	NZ338004A (de)
WO (1)	WO1999038984A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000052193A1 (fr)	1999-03-04	2000-09-08	Suntory Limited	Procede de controle de clivage par la protease de l'ompt
AU7559500A (en) *	1999-10-15	2001-04-23	Shionogi & Co., Ltd.	Process for producing adrenomedulin precursor
KR100407792B1 (ko) *	2000-08-02	2003-12-01	한국생명공학연구원	인간 글루카곤 유사펩타이드를 융합파트너로 이용한재조합 단백질의 제조방법
GB0121591D0 (en)	2001-09-06	2001-10-24	Chiron Spa	Hybrid and tandem expression of neisserial proteins
ATE469915T1 (de)	2001-07-27	2010-06-15	Novartis Vaccines & Diagnostic	Antikörper gegen das meningokokken adhäsin app
US7176278B2 (en)	2001-08-30	2007-02-13	Biorexis Technology, Inc.	Modified transferrin fusion proteins
US8129504B2 (en)	2001-08-30	2012-03-06	Biorexis Technology, Inc.	Oral delivery of modified transferrin fusion proteins
IL162780A0 (en)	2002-04-11	2005-11-20	Kenji Kangawa	Method for producing modified peptide
WO2003099854A2 (en)	2002-05-24	2003-12-04	Nps Allelix Corp.	Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
EP1513945A4 (de)	2002-05-24	2008-12-24	Restoragen Inc	Verfahren zur universellen enzymatischen herstellung bioaktiver peptide
EP1551435A4 (de) *	2002-05-24	2007-08-08	Restoragen Inc	Verfahren f r die enzymatische erzeugung von glp-1 (7-36) amidpeptiden
KR20050049525A (ko) *	2002-10-11	2005-05-25	가부시키가이샤산와카가쿠켄큐쇼	Ｇｌｐ-1 유도체 및 그의 경점막 흡수형 제제
CN1809380B (zh)	2002-10-11	2010-05-12	启龙有限公司	广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗
WO2004078777A2 (en) *	2003-03-04	2004-09-16	Biorexis Pharmaceutical Corporation	Dipeptidyl-peptidase protected proteins
HRP20120315T1 (hr)	2003-11-21	2012-05-31	Nps Pharmaceuticals	Proizvodnja peptida 2 nalik glukagonu i analoga
US8178495B2 (en)	2008-06-27	2012-05-15	Duke University	Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
US20130172274A1 (en)	2005-12-20	2013-07-04	Duke University	Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en)	2005-12-20	2014-09-23	Duke University	Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US8114632B2 (en)	2006-06-21	2012-02-14	Biocon Limited	Method of producing biologically active polypeptide having insulinotropic activity
KR101193722B1 (ko)	2006-07-24	2013-01-11	바이오렉시스 파마슈티칼 코포레이션	엑센딘 융합 단백질
CA2663047A1 (en) *	2006-09-06	2008-03-13	Phase Bioscience, Inc.	Therapeutic elastin-like polypeptide (elp) fusion proteins
CN104936610A (zh) *	2012-11-13	2015-09-23	益普生制药股份有限公司	Glp-1类似物的纯化方法
CN104592381A (zh) *	2013-10-31	2015-05-06	江苏万邦生化医药股份有限公司	一种利拉鲁肽中间体多肽的制备方法
RU2544959C1 (ru) *	2014-04-04	2015-03-20	Александр Владимирович Бубнов	Способ получения пептидов
WO2016089782A1 (en)	2014-12-01	2016-06-09	Pfenex Inc.	Fusion partners for peptide production
CN105669856A (zh) *	2016-02-13	2016-06-15	王大勇	一种基因重组长效人促肾上腺皮质激素及其制备方法
HUE066356T2 (hu)	2017-08-24	2024-07-28	Novo Nordisk As	GLP-1 készítmények és alkalmazásaik
CN111378027B (zh) *	2018-12-29	2022-04-15	万新医药科技(苏州)有限公司	一种索玛鲁肽前体的制备方法
PE20221575A1 (es)	2020-02-18	2022-10-06	Novo Nordisk As	Formulaciones farmaceuticas

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3531947B2 (ja) *	1991-08-19	2004-05-31	第一サントリーファーマ株式会社	ペプチドの製造方法
JP3995279B2 (ja) *	1994-09-07	2007-10-24	アスビオファーマ株式会社	蛋白の製造方法
CA2198966C (en) *	1996-03-04	2011-06-21	Yuji Suzuki	Method for cleaving chimeric protein using processing enzyme

1999
- 1999-01-29 DK DK99901926T patent/DK0978565T3/da active
- 1999-01-29 IL IL132030A patent/IL132030A/en not_active IP Right Cessation
- 1999-01-29 JP JP53918299A patent/JP4331270B2/ja not_active Expired - Fee Related
- 1999-01-29 AT AT99901926T patent/ATE375393T1/de active
- 1999-01-29 KR KR1019997008935A patent/KR100627590B1/ko not_active Expired - Fee Related
- 1999-01-29 CA CA002284847A patent/CA2284847A1/en not_active Abandoned
- 1999-01-29 EP EP99901926A patent/EP0978565B1/de not_active Expired - Lifetime
- 1999-01-29 NZ NZ338004A patent/NZ338004A/en not_active IP Right Cessation
- 1999-01-29 DE DE69937272T patent/DE69937272T2/de not_active Expired - Lifetime
- 1999-01-29 CN CNB998001139A patent/CN1198937C/zh not_active Expired - Fee Related
- 1999-01-29 AU AU21857/99A patent/AU765206B2/en not_active Ceased
- 1999-01-29 WO PCT/JP1999/000406 patent/WO1999038984A1/ja not_active Ceased

Also Published As

Publication number	Publication date
JP4331270B2 (ja)	2009-09-16
KR100627590B1 (ko)	2006-09-25
NZ338004A (en)	2001-08-31
AU765206B2 (en)	2003-09-11
EP0978565A1 (de)	2000-02-09
DE69937272D1 (de)	2007-11-22
CN1198937C (zh)	2005-04-27
DE69937272T2 (de)	2008-07-10
CA2284847A1 (en)	1999-08-05
EP0978565A4 (de)	2003-05-02
IL132030A0 (en)	2001-03-19
EP0978565B1 (de)	2007-10-10
KR20010005859A (ko)	2001-01-15
IL132030A (en)	2009-06-15
DK0978565T3 (da)	2008-02-04
AU2185799A (en)	1999-08-16
WO1999038984A1 (fr)	1999-08-05
CN1255945A (zh)	2000-06-07

Legal Events

Date

Code

Title

Description

2008-03-15

UEP

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