DK0983251T3 - Anti-inflammatorisk piperazinylbenzyltetrazolderivater og mellemprodukter derfor - Google Patents

Anti-inflammatorisk piperazinylbenzyltetrazolderivater og mellemprodukter derfor

Info

Publication number
DK0983251T3
DK0983251T3 DK98924137T DK98924137T DK0983251T3 DK 0983251 T3 DK0983251 T3 DK 0983251T3 DK 98924137 T DK98924137 T DK 98924137T DK 98924137 T DK98924137 T DK 98924137T DK 0983251 T3 DK0983251 T3 DK 0983251T3
Authority
DK
Denmark
Prior art keywords
piperazinylbenzyl
intermediates
inflammatory
tetrazole derivatives
tetrazole
Prior art date
Application number
DK98924137T
Other languages
Danish (da)
English (en)
Inventor
Graham Nigel Maw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0983251T3 publication Critical patent/DK0983251T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK98924137T 1997-05-19 1998-04-17 Anti-inflammatorisk piperazinylbenzyltetrazolderivater og mellemprodukter derfor DK0983251T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9709972.5A GB9709972D0 (en) 1997-05-19 1997-05-19 Tetrazoles

Publications (1)

Publication Number Publication Date
DK0983251T3 true DK0983251T3 (da) 2004-09-27

Family

ID=10812431

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98924137T DK0983251T3 (da) 1997-05-19 1998-04-17 Anti-inflammatorisk piperazinylbenzyltetrazolderivater og mellemprodukter derfor

Country Status (19)

Country Link
US (1) US6514975B1 (fr)
EP (1) EP0983251B1 (fr)
JP (1) JP2000513024A (fr)
AR (1) AR015679A1 (fr)
AT (1) ATE269852T1 (fr)
AU (1) AU7644998A (fr)
BR (1) BR9809648A (fr)
CA (1) CA2290501C (fr)
DE (1) DE69824724T2 (fr)
DK (1) DK0983251T3 (fr)
ES (1) ES2221985T3 (fr)
GB (1) GB9709972D0 (fr)
HR (1) HRP980267A2 (fr)
MA (1) MA26499A1 (fr)
PA (1) PA8451601A1 (fr)
PT (1) PT983251E (fr)
TN (1) TNSN98066A1 (fr)
WO (1) WO1998052929A1 (fr)
ZA (1) ZA984158B (fr)

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US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
GB9804734D0 (en) * 1998-03-05 1998-04-29 Pfizer Ltd Compounds
US6054623A (en) 1998-12-18 2000-04-25 Alliedsignal Inc. Hydroxythiol grignard reaction synthesis
US6503905B1 (en) 1998-12-29 2003-01-07 Pfizer Inc 3,3-biarylpiperidine and 2,2-biarylmorpholine derivatives
US6455055B1 (en) 1999-02-12 2002-09-24 The Procter & Gamble Company Cosmetic compositions
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
JP4340437B2 (ja) * 2000-10-31 2009-10-07 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
EA006507B1 (ru) 2001-10-15 2005-12-29 Янссен Фармацевтика Н.В. Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов
CN1596113B (zh) * 2001-10-29 2010-05-26 蒙特库克生物科学公司 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用
EP1469850B1 (fr) 2002-01-02 2013-01-02 Versi Group, LLC Methode de traitement de dysfonctions sexuelles au moyen de composes d'agoniste du recepteur delta opioide
JP4665379B2 (ja) * 2002-06-28 2011-04-06 Ｄｉｃ株式会社 ヘリカルツイスティングパワーの増大方法、光学活性化合物、それを含有した液晶組成物及び液晶表示素子
TW200504033A (en) 2002-10-23 2005-02-01 Procter & Gamble Melanocortin receptor ligands
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
WO2006113468A2 (fr) * 2005-04-14 2006-10-26 Mount Cook Biosciences, Inc. Compositions de nouveaux composes opioides et methode d'utilisation associee
US7210814B2 (en) * 2005-04-29 2007-05-01 Ultradent Products, Inc. Dental curing light with specially arranged LEDs
US20100029681A1 (en) * 2006-05-26 2010-02-04 Hassan Pajouhesh Heterocyclic compounds as calcium channel blockers
AU2007265467C1 (en) 2006-06-28 2013-11-07 Amgen Inc. Glycine transporter-1 inhibitors
EP2435264B1 (fr) 2009-05-29 2013-09-11 Hydrema Produktion A/S Système de suspension avec stabilisation de l'inclinaison
US9119848B2 (en) 2009-12-04 2015-09-01 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
AU2011232628B2 (en) 2010-03-22 2015-04-09 Rensselaer Polytechnic Institute Morphinane derivatives containing a carboxamide group as opioid receptor ligands
HUE065427T2 (hu) 2010-08-23 2024-05-28 Alkermes Pharma Ireland Ltd Eljárások antipszichotikum által indukált súlygyarapodás kezelésére
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
SMT201700400T1 (it) 2011-06-29 2017-09-07 Alkermes Inc Composti oppioidi ad azione periferica
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
MX375348B (es) 2011-12-15 2025-03-06 Alkermes Pharma Ireland Ltd Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu.
CA2911231C (fr) 2013-05-24 2021-12-07 Alkermes Pharma Ireland Limited Analogues de morphane et morphinane, et procedes d'utilisation
EP3003311A2 (fr) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Méthodes de traitement de symptômes de la dépression
CN106588873B (zh) * 2016-11-21 2019-11-12 云南省药物研究所 一种三芳基二甲基哌嗪乙二磺酸盐的多晶型物及其制备方法和应用
WO2022101444A1 (fr) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Comprimé multicouche à libération immédiate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3453285A (en) * 1967-11-29 1969-07-01 Miles Lab Tetrazolyl alkanoic acids
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
EP0585500A1 (fr) * 1992-09-04 1994-03-09 Merrell Dow Pharmaceuticals Inc. Diaryl préperazinacétamide comme agents antimuscariniques
PT711289E (pt) * 1993-07-30 2001-02-28 Delta Pharmaceuticals Inc Compostos piperazina utilizados em terapia
JPH07247274A (ja) * 1994-03-10 1995-09-26 Wakamoto Pharmaceut Co Ltd ピバル酸 テトラゾリルフェニルエステル誘導体、それらを有効成分として含有するエラスターゼ阻害剤及び肺障害治療剤
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines

Also Published As

Publication number Publication date
CA2290501C (fr) 2003-07-08
AU7644998A (en) 1998-12-11
ZA984158B (en) 1999-11-19
CA2290501A1 (fr) 1998-11-26
GB9709972D0 (en) 1997-07-09
JP2000513024A (ja) 2000-10-03
EP0983251A1 (fr) 2000-03-08
HRP980267A2 (en) 1999-02-28
PT983251E (pt) 2004-08-31
AR015679A1 (es) 2001-05-16
DE69824724T2 (de) 2005-08-25
WO1998052929A1 (fr) 1998-11-26
TNSN98066A1 (fr) 2005-03-15
DE69824724D1 (de) 2004-07-29
EP0983251B1 (fr) 2004-06-23
ES2221985T3 (es) 2005-01-16
ATE269852T1 (de) 2004-07-15
BR9809648A (pt) 2000-07-11
US6514975B1 (en) 2003-02-04
PA8451601A1 (es) 2000-05-24
MA26499A1 (fr) 2004-12-20

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