DK0984000T3 - Fremgangsmåde til fremstilling af amidderivater og intermediatforbindelser - Google Patents
Fremgangsmåde til fremstilling af amidderivater og intermediatforbindelserInfo
- Publication number
- DK0984000T3 DK0984000T3 DK96931297T DK96931297T DK0984000T3 DK 0984000 T3 DK0984000 T3 DK 0984000T3 DK 96931297 T DK96931297 T DK 96931297T DK 96931297 T DK96931297 T DK 96931297T DK 0984000 T3 DK0984000 T3 DK 0984000T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- producing
- amide derivatives
- intermediate compounds
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 150000001408 amides Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24818495 | 1995-09-26 | ||
| PCT/JP1996/002757 WO1997011938A1 (en) | 1995-09-26 | 1996-09-24 | Process for producing amide derivatives and intermediate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0984000T3 true DK0984000T3 (da) | 2009-04-06 |
Family
ID=17174459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96931297T DK0984000T3 (da) | 1995-09-26 | 1996-09-24 | Fremgangsmåde til fremstilling af amidderivater og intermediatforbindelser |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6121468A (da) |
| EP (1) | EP0984000B1 (da) |
| JP (1) | JP3611332B2 (da) |
| AT (1) | ATE416158T1 (da) |
| AU (1) | AU717710B2 (da) |
| DE (1) | DE69637770D1 (da) |
| DK (1) | DK0984000T3 (da) |
| ES (1) | ES2318852T3 (da) |
| PT (1) | PT984000E (da) |
| WO (1) | WO1997011938A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000516210A (ja) | 1996-07-12 | 2000-12-05 | ロイコサイト，インコーポレーテッド | ケモカインレセプターアンタゴニストとその使用方法 |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| UA67727C2 (uk) * | 1996-09-05 | 2004-07-15 | Агурон Фармасевтікелс, Інк. | Проміжні сполуки для одержання інгібіторів віл-протеази і способи одержання інгібіторів віл-протеази |
| US6130348A (en) * | 1997-04-10 | 2000-10-10 | Hoffmann-La Roche Inc. | Process for a phenylthiobutyl-isoquinoline and intermediates therefor |
| JP3467043B2 (ja) | 1997-04-10 | 2003-11-17 | エフ・ホフマン−ラ ロシュ アーゲー | ブチルチオ−イソキノリン及びそれの中間体を製造するための方法 |
| US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| IN188157B (da) | 1998-01-16 | 2002-08-24 | Japan Tobacco Inc | |
| WO1999054297A1 (en) * | 1998-04-16 | 1999-10-28 | Nagase & Company, Ltd. | Process for preparing chloro alcohol derivatives and intermediates |
| US6403799B1 (en) | 1999-10-21 | 2002-06-11 | Agouron Pharmaceuticals, Inc. | Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors |
| JP2004115510A (ja) * | 2002-09-05 | 2004-04-15 | Toray Fine Chemicals Co Ltd | ピペラジン誘導体の製造方法 |
| AU2004236038A1 (en) | 2003-05-08 | 2004-11-18 | Pfizer Inc. | Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same |
| US20070192711A1 (en) * | 2006-02-13 | 2007-08-16 | Research In Motion Limited | Method and arrangement for providing a primary actions menu on a handheld communication device |
| DK1814858T3 (da) * | 2004-08-23 | 2015-05-26 | Mylan Lab Ltd | Hidtil ukendte krystallinske former af nelfinavirmesylat |
| WO2009091941A1 (en) | 2008-01-17 | 2009-07-23 | Purdue Research Foundation | Small molecule inhibitors of hiv proteases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341756A (en) * | 1980-01-31 | 1982-07-27 | The Regents Of The University Of California | Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media |
| JPS56127373A (en) * | 1980-01-31 | 1981-10-06 | Univ California | Novel amino-dioxepane intermediate for synthesizing novel nonionic contrast agent |
| DE3150917A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung" |
| US5733906A (en) * | 1993-10-12 | 1998-03-31 | Eli Lilly And Company | Inhibitors of HIV Protease useful for the treatment of Aids |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| ATE170183T1 (de) * | 1994-02-21 | 1998-09-15 | Pliva Pharm & Chem Works | Sulfonamidodioxepane mit hypoglykämischen eigenschaften, methoden zu ihrer herstellung, ihre zwischenprodukte und salze |
-
1996
- 1996-09-24 DK DK96931297T patent/DK0984000T3/da active
- 1996-09-24 WO PCT/JP1996/002757 patent/WO1997011938A1/ja not_active Ceased
- 1996-09-24 JP JP51328397A patent/JP3611332B2/ja not_active Expired - Fee Related
- 1996-09-24 ES ES96931297T patent/ES2318852T3/es not_active Expired - Lifetime
- 1996-09-24 AT AT96931297T patent/ATE416158T1/de not_active IP Right Cessation
- 1996-09-24 EP EP96931297A patent/EP0984000B1/en not_active Expired - Lifetime
- 1996-09-24 AU AU70021/96A patent/AU717710B2/en not_active Ceased
- 1996-09-24 US US09/043,667 patent/US6121468A/en not_active Expired - Fee Related
- 1996-09-24 DE DE69637770T patent/DE69637770D1/de not_active Expired - Fee Related
- 1996-09-24 PT PT96931297T patent/PT984000E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0984000B1 (en) | 2008-12-03 |
| ATE416158T1 (de) | 2008-12-15 |
| PT984000E (pt) | 2009-02-06 |
| US6121468A (en) | 2000-09-19 |
| DE69637770D1 (de) | 2009-01-15 |
| AU717710B2 (en) | 2000-03-30 |
| EP0984000A1 (en) | 2000-03-08 |
| EP0984000A4 (en) | 2004-08-11 |
| WO1997011938A1 (en) | 1997-04-03 |
| AU7002196A (en) | 1997-04-17 |
| JP3611332B2 (ja) | 2005-01-19 |
| ES2318852T3 (es) | 2009-05-01 |
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