ATE416158T1 - Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen - Google Patents

Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen

Info

Publication number: ATE416158T1
Authority: AT; Austria
Prior art keywords: compounds; producing; amide derivatives; intermediate compounds; xvi
Prior art date: 1995-09-26

Application number

AT96931297T

Other languages

English (en)

Inventor

Takashi Inaba

Yasuki Yamada

James Shanley

Michael Deason

Original Assignee

Japan Tobacco Inc

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-26

Filing date

1996-09-24

Publication date

2008-12-15

1996-09-24 Application filed by Japan Tobacco Inc, Agouron Pharma filed Critical Japan Tobacco Inc

2008-12-15 Application granted granted Critical

2008-12-15 Publication of ATE416158T1 publication Critical patent/ATE416158T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 6
150000001408 amides Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
108010010369 HIV Protease Proteins 0.000 abstract 1
239000002872 contrast media Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT96931297T 1995-09-26 1996-09-24 Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen ATE416158T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP24818495		1995-09-26

Publications (1)

Publication Number	Publication Date
ATE416158T1 true ATE416158T1 (de)	2008-12-15

Family

ID=17174459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96931297T ATE416158T1 (de)	1995-09-26	1996-09-24	Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen

Country Status (10)

Country	Link
US (1)	US6121468A (de)
EP (1)	EP0984000B1 (de)
JP (1)	JP3611332B2 (de)
AT (1)	ATE416158T1 (de)
AU (1)	AU717710B2 (de)
DE (1)	DE69637770D1 (de)
DK (1)	DK0984000T3 (de)
ES (1)	ES2318852T3 (de)
PT (1)	PT984000E (de)
WO (1)	WO1997011938A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6281212B1 (en)	1996-07-12	2001-08-28	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US5925759A (en)	1996-09-05	1999-07-20	Agouron Pharmaceuticals, Inc.	Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5962725A (en)	1996-09-05	1999-10-05	Agouron Pharmaceuticals, Inc.	Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
UA67727C2 (uk) *	1996-09-05	2004-07-15	Агурон Фармасевтікелс, Інк.	Проміжні сполуки для одержання інгібіторів віл-протеази і способи одержання інгібіторів віл-протеази
DE69812079T2 (de) *	1997-04-10	2003-12-18	F. Hoffmann-La Roche Ag, Basel	Verfahren zur herstellung eines buthylthuio-isochinolinderivates und zwischenprodukte dafür
US6130348A (en) *	1997-04-10	2000-10-10	Hoffmann-La Roche Inc.	Process for a phenylthiobutyl-isoquinoline and intermediates therefor
US6084107A (en) *	1997-09-05	2000-07-04	Agouron Pharmaceuticals, Inc.	Intermediates for making HIV-protease inhibitors
IN188157B (de)	1998-01-16	2002-08-24	Japan Tobacco Inc
WO1999054297A1 (en) *	1998-04-16	1999-10-28	Nagase & Company, Ltd.	Process for preparing chloro alcohol derivatives and intermediates
US6403799B1 (en)	1999-10-21	2002-06-11	Agouron Pharmaceuticals, Inc.	Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
JP2004115510A (ja) *	2002-09-05	2004-04-15	Toray Fine Chemicals Co Ltd	ピペラジン誘導体の製造方法
CN1819993A (zh) *	2003-05-08	2006-08-16	美国辉瑞有限公司	用于合成hiv－蛋白酶抑制剂的中间体及其制备方法
US20070192711A1 (en) *	2006-02-13	2007-08-16	Research In Motion Limited	Method and arrangement for providing a primary actions menu on a handheld communication device
EP1814858B1 (de)	2004-08-23	2015-03-18	Mylan Laboratories Limited	Neue kristalline formen von nelfinavirmesylat
WO2009091941A1 (en) *	2008-01-17	2009-07-23	Purdue Research Foundation	Small molecule inhibitors of hiv proteases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS56127373A (en) *	1980-01-31	1981-10-06	Univ California	Novel amino-dioxepane intermediate for synthesizing novel nonionic contrast agent
US4341756A (en) *	1980-01-31	1982-07-27	The Regents Of The University Of California	Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media
DE3150917A1 (de) *	1981-12-18	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	"2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
US5733906A (en) *	1993-10-12	1998-03-31	Eli Lilly And Company	Inhibitors of HIV Protease useful for the treatment of Aids
MX9308016A (es) *	1992-12-22	1994-08-31	Lilly Co Eli	Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.
US5484926A (en) *	1993-10-07	1996-01-16	Agouron Pharmaceuticals, Inc.	HIV protease inhibitors
SK22795A3 (en) *	1994-02-21	1995-09-13	Pliva Pharm & Chem Works	Sulfonamidodioxepanes, method of their preparation, intermediates, salts and their using

1996
- 1996-09-24 ES ES96931297T patent/ES2318852T3/es not_active Expired - Lifetime
- 1996-09-24 DK DK96931297T patent/DK0984000T3/da active
- 1996-09-24 DE DE69637770T patent/DE69637770D1/de not_active Expired - Fee Related
- 1996-09-24 WO PCT/JP1996/002757 patent/WO1997011938A1/ja not_active Ceased
- 1996-09-24 AT AT96931297T patent/ATE416158T1/de not_active IP Right Cessation
- 1996-09-24 JP JP51328397A patent/JP3611332B2/ja not_active Expired - Fee Related
- 1996-09-24 US US09/043,667 patent/US6121468A/en not_active Expired - Fee Related
- 1996-09-24 EP EP96931297A patent/EP0984000B1/de not_active Expired - Lifetime
- 1996-09-24 AU AU70021/96A patent/AU717710B2/en not_active Ceased
- 1996-09-24 PT PT96931297T patent/PT984000E/pt unknown

Also Published As

Publication number	Publication date
AU717710B2 (en)	2000-03-30
ES2318852T3 (es)	2009-05-01
EP0984000B1 (de)	2008-12-03
PT984000E (pt)	2009-02-06
EP0984000A4 (de)	2004-08-11
US6121468A (en)	2000-09-19
DE69637770D1 (de)	2009-01-15
EP0984000A1 (de)	2000-03-08
DK0984000T3 (da)	2009-04-06
AU7002196A (en)	1997-04-17
WO1997011938A1 (en)	1997-04-03
JP3611332B2 (ja)	2005-01-19

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2009-08-15

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2010-12-15

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