DK0986548T3 - Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser - Google Patents

Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser

Info

Publication number: DK0986548T3
Authority: DK; Denmark
Prior art keywords: bis; mono; hydroxyalkyl; cycle; preparation
Prior art date: 1997-06-02

Application number

DK98934857T

Other languages

English (en)

Inventor

Orlin Petrov

Peter Blaszkiewicz

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-02

Filing date

1998-05-28

Publication date

2003-11-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7831875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0986548(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-05-28 Application filed by Schering Ag filed Critical Schering Ag

2003-11-17 Application granted granted Critical

2003-11-17 Publication of DK0986548T3 publication Critical patent/DK0986548T3/da

Links

229910003002 lithium salt Inorganic materials 0.000 title 1
159000000002 lithium salts Chemical class 0.000 title 1
ZPDFIIGFYAHNSK-CTHHTMFSSA-K 2-[4,10-bis(carboxylatomethyl)-7-[(2r,3s)-1,3,4-trihydroxybutan-2-yl]-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+) Chemical compound [Gd+3].OC[C@@H](O)[C@@H](CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-CTHHTMFSSA-K 0.000 abstract 1
229960003411 gadobutrol Drugs 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Inorganic materials [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 abstract 1
RRBYUSWBLVXTQN-UHFFFAOYSA-N tricyclene Chemical compound C12CC3CC2C1(C)C3(C)C RRBYUSWBLVXTQN-UHFFFAOYSA-N 0.000 abstract 1
RRBYUSWBLVXTQN-VZCHMASFSA-N tricyclene Natural products C([C@@H]12)C3C[C@H]1C2(C)C3(C)C RRBYUSWBLVXTQN-VZCHMASFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK98934857T 1997-06-02 1998-05-28 Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser DK0986548T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19724186A DE19724186C2 (de)	1997-06-02	1997-06-02	Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
PCT/DE1998/001523 WO1998055467A1 (de)	1997-06-02	1998-05-28	Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen

Publications (1)

Publication Number	Publication Date
DK0986548T3 true DK0986548T3 (da)	2003-11-17

Family

ID=7831875

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98934857T DK0986548T3 (da)	1997-06-02	1998-05-28	Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser

Country Status (15)

Country	Link
US (1)	US5994536A (da)
EP (1)	EP0986548B1 (da)
JP (1)	JP4503709B2 (da)
AT (1)	ATE246178T1 (da)
AU (1)	AU8432798A (da)
CA (1)	CA2291782C (da)
DE (2)	DE19724186C2 (da)
DK (1)	DK0986548T3 (da)
ES (1)	ES2205523T3 (da)
NO (1)	NO313459B1 (da)
PT (1)	PT986548E (da)
SI (1)	SI0986548T1 (da)
TW (1)	TW450965B (da)
WO (1)	WO1998055467A1 (da)
ZA (1)	ZA984734B (da)

Families Citing this family (27)

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US6271325B1 (en)	1999-05-17	2001-08-07	Univation Technologies, Llc	Method of polymerization
US6380328B1 (en)	1999-12-10	2002-04-30	Univation Technologies, Llc	Catalyst systems and their use in a polymerization process
US6300438B1 (en)	1999-10-22	2001-10-09	Univation Technolgies, Llc	Hafnium transition metal catalyst compounds, catalyst systems and their use in a polymerization process
US6624107B2 (en)	1999-10-22	2003-09-23	Univation Technologies, Llc	Transition metal catalyst compounds having deuterium substituted ligand and catalyst systems thereof
US6271323B1 (en)	1999-10-28	2001-08-07	Univation Technologies, Llc	Mixed catalyst compounds, catalyst systems and their use in a polymerization process
US6417304B1 (en)	1999-11-18	2002-07-09	Univation Technologies, Llc	Method of polymerization and polymer produced therefrom
US6300439B1 (en)	1999-11-08	2001-10-09	Univation Technologies, Llc	Group 15 containing transition metal catalyst compounds, catalyst systems and their use in a polymerization process
US6274684B1 (en)	1999-10-22	2001-08-14	Univation Technologies, Llc	Catalyst composition, method of polymerization, and polymer therefrom
US6265505B1 (en)	1999-11-18	2001-07-24	Univation Technologies, Llc	Catalyst system and its use in a polymerization process
US6281306B1 (en) *	1999-12-16	2001-08-28	Univation Technologies, Llc	Method of polymerization
DE60136476D1 (de)	2000-09-29	2008-12-18	Anormed Inc	-stickstoffhaltigen zyklischen polyaminen und deren verbindungen
DE10064467C2 (de) *	2000-12-15	2002-10-31	Schering Ag	Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
CA2645668A1 (en) *	2006-03-14	2007-09-20	Mallinckrodt Inc.	Metal complexes of tetraazamacrocycle derivatives
DE102009053171B4 (de) *	2009-11-04	2011-07-21	Bayer Schering Pharma Aktiengesellschaft, 13353	Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
WO2011054480A1 (de)	2009-11-09	2011-05-12	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels keramischer membran
DE102009053252B3 (de) *	2009-11-09	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels keramischer Membran
DE102009057274B4 (de)	2009-12-02	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102010013833A1 (de)	2010-03-29	2011-09-29	Bayer Schering Pharma Aktiengesellschaft	Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) *	2010-06-04	2011-12-08	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
US9233971B2 (en)	2010-08-26	2016-01-12	Kunyuan Cui	Lipomacrocycles and uses thereof
EP2896405B1 (en) *	2011-04-21	2020-02-19	Bayer Intellectual Property GmbH	Preparation of high-purity gadobutrol
HRP20200922T1 (hr)	2016-09-27	2020-09-18	Bayer Pharma Aktiengesellschaft	Postupak za proizvodnju kristalnog oblika modifikacije a kalkobutrola
CN106543094A (zh) *	2016-11-04	2017-03-29	嘉实（湖南）医药科技有限公司	高纯度钆布醇的制备方法
KR101971435B1 (ko)	2017-08-29	2019-04-24	주식회사 엔지켐생명과학	가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) *	2018-01-19	2019-10-18	주식회사 엔지켐생명과학	가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
US12227527B2 (en) *	2018-07-10	2025-02-18	Biophore India Pharmaceuticals Pvt. Ltd	Process for the preparation of 2,2′,2″-(10-((2R,3S)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR20210112910A (ko) *	2020-03-06	2021-09-15	주식회사 엔지켐생명과학	가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5064633A (en) *	1984-06-04	1991-11-12	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes, their formulations and use
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) *	1990-11-08	1992-05-14	Schering Ag	Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4237943C2 (de) *	1992-11-06	1997-10-23	Schering Ag	Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
US5410043A (en) *	1991-12-06	1995-04-25	Schering Aktiengesellschaft	Process for the production of mono-N-substituted tetraaza macrocycles
DE4140779A1 (de) *	1991-12-06	1993-06-09	Schering Ag Berlin Und Bergkamen, 1000 Berlin, De	Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
DE4218744C2 (de) *	1992-06-04	1997-11-06	Schering Ag	Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4318369C1 (de) *	1993-05-28	1995-02-09	Schering Ag	Verwendung von makrocyclischen Metallkomplexen als Temperatursonden

1997
- 1997-06-02 DE DE19724186A patent/DE19724186C2/de not_active Expired - Lifetime
1998
- 1998-05-28 DE DE59809163T patent/DE59809163D1/de not_active Expired - Lifetime
- 1998-05-28 AT AT98934857T patent/ATE246178T1/de active
- 1998-05-28 EP EP98934857A patent/EP0986548B1/de not_active Expired - Lifetime
- 1998-05-28 PT PT98934857T patent/PT986548E/pt unknown
- 1998-05-28 WO PCT/DE1998/001523 patent/WO1998055467A1/de not_active Ceased
- 1998-05-28 AU AU84327/98A patent/AU8432798A/en not_active Abandoned
- 1998-05-28 SI SI9830534T patent/SI0986548T1/xx unknown
- 1998-05-28 ES ES98934857T patent/ES2205523T3/es not_active Expired - Lifetime
- 1998-05-28 CA CA002291782A patent/CA2291782C/en not_active Expired - Lifetime
- 1998-05-28 JP JP50129999A patent/JP4503709B2/ja not_active Expired - Lifetime
- 1998-05-28 DK DK98934857T patent/DK0986548T3/da active
- 1998-06-01 TW TW087108521A patent/TW450965B/zh not_active IP Right Cessation
- 1998-06-02 ZA ZA984734A patent/ZA984734B/xx unknown
- 1998-06-02 US US09/088,700 patent/US5994536A/en not_active Expired - Lifetime
1999
- 1999-12-01 NO NO19995870A patent/NO313459B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE19724186A1 (de)	1998-12-03
ES2205523T3 (es)	2004-05-01
AU8432798A (en)	1998-12-21
EP0986548B1 (de)	2003-07-30
US5994536A (en)	1999-11-30
ATE246178T1 (de)	2003-08-15
SI0986548T1 (en)	2003-12-31
ZA984734B (en)	1998-12-29
NO995870L (no)	2000-02-01
NO313459B1 (no)	2002-10-07
WO1998055467A1 (de)	1998-12-10
DE59809163D1 (de)	2003-09-04
NO995870D0 (no)	1999-12-01
PT986548E (pt)	2003-12-31
EP0986548A1 (de)	2000-03-22
DE19724186C2 (de)	2002-07-18
CA2291782C (en)	2009-05-26
JP2002508755A (ja)	2002-03-19
JP4503709B2 (ja)	2010-07-14
TW450965B (en)	2001-08-21
CA2291782A1 (en)	1998-12-10

Publication	Publication Date	Title
DK0986548T3 (da)	2003-11-17	Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser
IL86456A0 (en)	1988-11-15	Tetrazole derivatives useful as intermediates for preparing antihypertensive compounds
MX9800867A (es)	1998-04-30	Halogenobencimidazoles y su empleo como microbicidas.
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BG102616A (en)	1999-04-30	Substituted aza- and diazacycloheptane and cyclooctane derivatives and their application
TR199902082T2 (xx)	2000-04-21	Pirazin bile�ikleri.
BR9811551A (pt)	2000-08-29	Derivados de ácido triazolintion-fosfórico
ATE240336T1 (de)	2003-05-15	Metallierung von makrozyklen mit 2,4-dicarbonyl- metallkomplexen
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ATE223894T1 (de)	2002-09-15	Prolyl-endopeptidaseinhibitoren
GR3033350T3 (en)	2000-09-29	Use of Beta-aminopropionic acid derivatives as fungicides
BG104232A (bg)	2000-10-31	Заместени 1,2,3,4,5,6-хексахидро-2,6-метано-3-бензазоцин- 10-оли, метод за тяхното получаване и приложението им като лекарствени средства
ATE242236T1 (de)	2003-06-15	N-substituierte 3-azabicyclo(3.2.0)heptan- derivate als neuroleptika
CA2356985A1 (en)	2000-07-06	5ht1 antagonists for antidepressant therapy
BG101328A (en)	1997-08-29	New derivatives of imidazoloquinaxalon with heterocyclic substituents, their preparation and use
PL318724A1 (en)	1997-12-08	Novel substituted derivatives of 2-(1-naphtoyl) guanidine, method of obtaining them and their application in production of pharmaceitic agents as well as pharmaceutic agent as such
ATE221542T1 (de)	2002-08-15	Wasserlösliche glykolisierte derivate von 1,2- dithiinverbindungen
PL316441A1 (en)	1997-05-26	Novel sulphonylamino substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
TR200001976T2 (tr)	2000-11-21	İzopropil-Metil [2-(3-n-propoksifenoksi)etil] amin'in hazırlanmasına yönelik usul
JO2187B1 (en)	2003-12-23	Production and use of complex lithium compounds for N- (1- hydroxy methyl -2-3-dihydroxypropyl) -1,4,7- tri-carboxy methyl -1,4,7,10- tetra-azaclododecane
PL346003A1 (en)	2002-01-14	N-substituted azabicycloheptane derivatives, production and use thereof